A Bartke


Affiliation: Southern Illinois University School of Medicine
Country: USA


  1. Bartke A. Growth Hormone and Aging: Updated Review. World J Mens Health. 2018;: pubmed publisher
    ..However, results obtained thus far have been disappointing with few documented benefits and many troublesome side effects. Possible utility of GH in the treatment of sarcopenia and frailty remains to be explored. ..
  2. Masternak M, Darcy J, Victoria B, Bartke A. Dwarf Mice and Aging. Prog Mol Biol Transl Sci. 2018;155:69-83 pubmed publisher
    ..Results of these studies identify novel mechanisms linking reduced GH action with extensions of both life span and health span. ..
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    Bartke A, Masternak M, Al Regaiey K, Bonkowski M. Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice. Interdiscip Top Gerontol. 2007;35:69-82 pubmed
    ..This last category is of particular interest since genes affected in normal but not GHRKO mice may be related to mechanisms by which DR extends longevity. ..
  4. Piazza V, Bartke A, Miquet J, Sotelo A. Analysis of Different Approaches for the Selection of Reference Genes in RT-qPCR Experiments: A Case Study in Skeletal Muscle of Growing Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..Consequently, those reference genes reflecting this dilution effect, which would have been discarded considering their variable relative expression levels, arose as suitable internal controls. ..
  5. Bartke A, List E, Kopchick J. The somatotropic axis and aging: Benefits of endocrine defects. Growth Horm IGF Res. 2016;27:41-45 pubmed publisher
  6. Bartke A. Single-gene mutations and healthy ageing in mammals. Philos Trans R Soc Lond B Biol Sci. 2011;366:28-34 pubmed publisher
  7. Bartke A. Healthy aging: is smaller better? - a mini-review. Gerontology. 2012;58:337-43 pubmed publisher
    ..It is suggested that modest modifications of the diet at different ages may extend human healthspan and lifespan by reducing levels of hormones that stimulate growth. ..
  8. Bartke A. Healthspan and longevity can be extended by suppression of growth hormone signaling. Mamm Genome. 2016;27:289-99 pubmed publisher
    ..Further progress in elucidation of mechanisms that link reduced GH action to delayed and healthy aging should identify targets for lifestyle and pharmacological interventions that could benefit individuals as well as society. ..
  9. Bartke A, Sun L, Longo V. Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev. 2013;93:571-98 pubmed publisher

More Information


  1. Bartke A, Westbrook R, Sun L, Ratajczak M. Links between growth hormone and aging. Endokrynol Pol. 2013;64:46-52 pubmed
    ..Many of the physiological characteristics of long-lived, GH-related mouse mutants are shared by exceptionally long-lived people and by individuals genetically predisposed to longevity. ..
  2. Bartke A. Growth hormone, insulin and aging: the benefits of endocrine defects. Exp Gerontol. 2011;46:108-11 pubmed publisher
    ..The role of GH in the control of human aging continues to be hotly debated, but recent data indicate that reduced somatotropic signaling provides protection from cancer and other age-related diseases and may promote old age survival. ..
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    Bartke A. Insulin and aging. Cell Cycle. 2008;7:3338-43 pubmed
    ..Studies of physiological characteristics and polymorphisms of insulin-related genes in exceptionally long-lived people suggest a role of insulin signaling in the control of human aging. ..
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    Bartke A, Coschigano K, Kopchick J, Chandrashekar V, Mattison J, Kinney B, et al. Genes that prolong life: relationships of growth hormone and growth to aging and life span. J Gerontol A Biol Sci Med Sci. 2001;56:B340-9 pubmed
  5. Bartke A, Sun L, Fang Y, Hill C. Growth hormone actions during development influence adult phenotype and longevity. Exp Gerontol. 2016;86:22-27 pubmed publisher
    ..We suspect that altered "programming" of aging during development may represent one of the mechanisms of the Developmental Origins of Health and Disease (DOHaD) and the detrimental effects of "catch-up" growth. ..
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    Bartke A. Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging. Trends Endocrinol Metab. 2006;17:33-5 pubmed
    ..However, activation of signaling molecules downstream from IGF-1 and insulin receptors is reduced in both Klotho and dwarf mice, suggesting common mechanisms of delayed aging. ..
  7. Bartke A, Darcy J. GH and ageing: Pitfalls and new insights. Best Pract Res Clin Endocrinol Metab. 2017;31:113-125 pubmed publisher
    ..However, the impact of somatotropic signaling on neoplastic disease is difficult to separate from its impact on aging, and IGF-1 levels exhibit opposite associations with different chronic, age-related diseases. ..
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    Bartke A, Peluso M, Moretz N, Wright C, Bonkowski M, Winters T, et al. Effects of Soy-derived diets on plasma and liver lipids, glucose tolerance, and longevity in normal, long-lived and short-lived mice. Horm Metab Res. 2004;36:550-8 pubmed
    ..We conclude that dietary soy protein intake can improve plasma and hepatic lipid profiles, reduce fasting glucose, enhance capacity for glucose tolerance, and prolong life, but all of these effects are strongly genotype-dependent. ..
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    Bartke A. Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology. 2003;78:210-6 pubmed
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    Bartke A, Wright J, Mattison J, Ingram D, Miller R, Roth G. Extending the lifespan of long-lived mice. Nature. 2001;414:412 pubmed
  11. Bartke A. Pleiotropic effects of growth hormone signaling in aging. Trends Endocrinol Metab. 2011;22:437-42 pubmed publisher
    ..This review summarizes the present understanding of the multifaceted relationship between somatotropic signaling and mammalian aging. ..