A Bartke

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Neuroendocrine and reproductive functions in male mice with targeted disruption of the prolactin gene
    R W Steger
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901 6512, USA
    Endocrinology 139:3691-5. 1998
  2. ncbi request reprint Effects of overexpression of growth hormone-releasing hormone on the hypothalamo-pituitary-gonadal function in the mouse
    L Debeljuk
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901, USA
    Endocrine 11:171-9. 1999
  3. ncbi request reprint Prolactin in the male: 25 years later
    Andrzej Bartke
    Department of Physiology, Southern Illinois University School of Medicine, 801 N Rutledge, Springfield, IL 62794 9628, USA
    J Androl 25:661-6. 2004
  4. pmc Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity
    Michael S Bonkowski
    Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 4:e4567. 2009
  5. pmc Metabolic characteristics of long-lived mice
    Andrzej Bartke
    Division of Geriatrics Research, Department of Internal Medicine, Southern Illinois University School of Medicine Springfield, IL, USA
    Front Genet 3:288. 2012
  6. pmc Decreased thyroid follicle size in dwarf mice may suggest the role of growth hormone signaling in thyroid growth regulation
    Adam Gesing
    Department of Oncological Endocrinology, Chair of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland
    Thyroid Res 5:7. 2012
  7. pmc Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1
    Sylwia Słuczanowska-Głąbowska
    Department of Physiology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111, Szczecin, Poland
    J Ovarian Res 5:18. 2012
  8. pmc Somatotropic signaling: trade-offs between growth, reproductive development, and longevity
    Andrzej Bartke
    Southern Illinois University School of Medicine, Department of Internal Medicine, Geriatric Research, Springfield, Illinois 62703, USA
    Physiol Rev 93:571-98. 2013
  9. pmc Links between growth hormone and aging
    Andrzej Bartke
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, United States
    Endokrynol Pol 64:46-52. 2013
  10. pmc Healthy aging: is smaller better? - a mini-review
    Andrzej Bartke
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, 62794 9628, USA
    Gerontology 58:337-43. 2012

Collaborators

Detail Information

Publications122 found, 100 shown here

  1. ncbi request reprint Neuroendocrine and reproductive functions in male mice with targeted disruption of the prolactin gene
    R W Steger
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901 6512, USA
    Endocrinology 139:3691-5. 1998
    ....
  2. ncbi request reprint Effects of overexpression of growth hormone-releasing hormone on the hypothalamo-pituitary-gonadal function in the mouse
    L Debeljuk
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901, USA
    Endocrine 11:171-9. 1999
    ..These results show that high, persistent levels of circulating endogenous GH induce alterations in neuroendocrine functions related to the hypothalamo-pituitary-gonadal and the hypothalamo-pituitary-adrenal axes...
  3. ncbi request reprint Prolactin in the male: 25 years later
    Andrzej Bartke
    Department of Physiology, Southern Illinois University School of Medicine, 801 N Rutledge, Springfield, IL 62794 9628, USA
    J Androl 25:661-6. 2004
  4. pmc Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity
    Michael S Bonkowski
    Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 4:e4567. 2009
    ....
  5. pmc Metabolic characteristics of long-lived mice
    Andrzej Bartke
    Division of Geriatrics Research, Department of Internal Medicine, Southern Illinois University School of Medicine Springfield, IL, USA
    Front Genet 3:288. 2012
    ..We suspect that increased oxidative metabolism combined with enhanced fatty acid oxidation contribute to the extended longevity of GHR-KO mice...
  6. pmc Decreased thyroid follicle size in dwarf mice may suggest the role of growth hormone signaling in thyroid growth regulation
    Adam Gesing
    Department of Oncological Endocrinology, Chair of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland
    Thyroid Res 5:7. 2012
    ..abstract:..
  7. pmc Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1
    Sylwia Słuczanowska-Głąbowska
    Department of Physiology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111, Szczecin, Poland
    J Ovarian Res 5:18. 2012
    ..abstract:..
  8. pmc Somatotropic signaling: trade-offs between growth, reproductive development, and longevity
    Andrzej Bartke
    Southern Illinois University School of Medicine, Department of Internal Medicine, Geriatric Research, Springfield, Illinois 62703, USA
    Physiol Rev 93:571-98. 2013
    ....
  9. pmc Links between growth hormone and aging
    Andrzej Bartke
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, United States
    Endokrynol Pol 64:46-52. 2013
    ..Many of the physiological characteristics of long-lived, GH-related mouse mutants are shared by exceptionally long-lived people and by individuals genetically predisposed to longevity...
  10. pmc Healthy aging: is smaller better? - a mini-review
    Andrzej Bartke
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, 62794 9628, USA
    Gerontology 58:337-43. 2012
    ..It is suggested that modest modifications of the diet at different ages may extend human healthspan and lifespan by reducing levels of hormones that stimulate growth...
  11. ncbi request reprint Insulin and aging
    Andrzej Bartke
    Department of Internal Medicine and Department of Physiology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9628, USA
    Cell Cycle 7:3338-43. 2008
    ..Studies of physiological characteristics and polymorphisms of insulin-related genes in exceptionally long-lived people suggest a role of insulin signaling in the control of human aging...
  12. ncbi request reprint Consequences of growth hormone (GH) overexpression and GH resistance
    A Bartke
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    Neuropeptides 36:201-8. 2002
    ..These studies also provided novel and still-disputed evidence for involvement of somatotropic axis in the control of aging and life span and in mediating the actions of longevity genes...
  13. pmc Growth hormone and aging: a challenging controversy
    Andrzej Bartke
    Department of Internal Medicine, Southern Illinois University School of Medicine, P O Box 19628, Springfield, Illinois 62794 9628, USA
    Clin Interv Aging 3:659-65. 2008
    ..Natural decline in GH levels during aging likely contributes to concomitant alterations in body composition and vigor but also may be offering important protection from cancer and other age-associated diseases...
  14. ncbi request reprint Extending the lifespan of long-lived mice
    A Bartke
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, Illinois 62901, USA
    Nature 414:412. 2001
  15. ncbi request reprint THow diet interacts with longevity genes
    Andrzej Bartke
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
    Hormones (Athens) 7:17-23. 2008
    ....
  16. doi request reprint Pleiotropic effects of growth hormone signaling in aging
    Andrzej Bartke
    Department of Internal Medicine, Southern Illinois University School of Medicine, 801 North Rutledge, PO Box 19628, Springfield, IL 62794 9628, USA
    Trends Endocrinol Metab 22:437-42. 2011
    ..This review summarizes the present understanding of the multifaceted relationship between somatotropic signaling and mammalian aging...
  17. pmc Single-gene mutations and healthy ageing in mammals
    Andrzej Bartke
    Department of Physiology, Southern Illinois University School of Medicine, 801 North Rutledge Street, Room 4389, Springfield, IL 62794 9628, USA
    Philos Trans R Soc Lond B Biol Sci 366:28-34. 2011
    ....
  18. doi request reprint The somatotropic axis and aging: mechanisms and persistent questions about practical implications
    Andrzej Bartke
    Department of Internal Medicine, Southern Illinois University School of Medicine, P O Box 19628, Springfield, IL 62794 9628, USA
    Exp Gerontol 44:372-4. 2009
    ..Although available clinical evidence does not support the use of recombinant GH as an anti-aging therapy, many studies suggest the potential utility of GH and GH secretagogues in the treatment of sarcopenia and frailty...
  19. pmc Growth hormone, insulin and aging: the benefits of endocrine defects
    Andrzej Bartke
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
    Exp Gerontol 46:108-11. 2011
    ..The role of GH in the control of human aging continues to be hotly debated, but recent data indicate that reduced somatotropic signaling provides protection from cancer and other age-related diseases and may promote old age survival...
  20. ncbi request reprint Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights
    A Bartke
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    Biogerontology 4:1-8. 2003
    ..We suspect that IGF-I is important in evolutionarily conserved mechanisms that link life history, including development, reproduction, and aging with availability of energy resources...
  21. ncbi request reprint Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice
    Andrzej Bartke
    Departments of Physiology and Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
    Neuroendocrinology 78:210-6. 2003
    ....
  22. ncbi request reprint Effects of Soy-derived diets on plasma and liver lipids, glucose tolerance, and longevity in normal, long-lived and short-lived mice
    A Bartke
    Department of Physiology, Southern Illinois University School of Medicine, Springfield 62794 9628, USA
    Horm Metab Res 36:550-8. 2004
    ..We conclude that dietary soy protein intake can improve plasma and hepatic lipid profiles, reduce fasting glucose, enhance capacity for glucose tolerance, and prolong life, but all of these effects are strongly genotype-dependent...
  23. ncbi request reprint Is growth hormone deficiency a beneficial adaptation to aging? Evidence from experimental animals
    Andrzej Bartke
    Geriatrics Research, Department of Medicine, Southern Illinois University School of Medicine, 801 N Rutledge, Springfield, IL 62794 9628, USA
    Trends Endocrinol Metab 14:340-4. 2003
  24. ncbi request reprint Genes that prolong life: relationships of growth hormone and growth to aging and life span
    A Bartke
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    J Gerontol A Biol Sci Med Sci 56:B340-9. 2001
    ....
  25. ncbi request reprint Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging
    Andrzej Bartke
    Department of Physiology and Internal Medicine, Southern Illinois University School of Medicine, P O Box 19628, 801 North Rutledge, Room 4389, Springfield, Illinois 62794 9628, USA
    Endocrinology 146:3718-23. 2005
    ..There is considerable evidence to suggest that the genetic and endocrine mechanisms that influence aging and longevity in mice may play a similar role in other mammalian species, including the human...
  26. ncbi request reprint New findings in transgenic, gene knockout and mutant mice
    Andrzej Bartke
    Geriatrics Research, Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, P O Box 19628, Springfield, IL 62794 9628, USA
    Exp Gerontol 41:1217-9. 2006
    ..Highlights of these recent developments will be briefly discussed in this Review...
  27. ncbi request reprint Aging: all in the head?
    Andrzej Bartke
    Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
    Cell Metab 6:153-4. 2007
    ..New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging...
  28. ncbi request reprint Effects of dietary restriction on the expression of insulin-signaling-related genes in long-lived mutant mice
    Andrzej Bartke
    Geriatrics Research, Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, PO Box 19628, Springfield, IL 62794, USA
    Interdiscip Top Gerontol 35:69-82. 2007
    ..This last category is of particular interest since genes affected in normal but not GHRKO mice may be related to mechanisms by which DR extends longevity...
  29. ncbi request reprint New findings in gene knockout, mutant and transgenic mice
    Andrzej Bartke
    Department of Internal Medicine and Physiology, Southern Illinois University School of Medicine, Springfield, IL 62794 9628, USA
    Exp Gerontol 43:11-4. 2008
    ....
  30. ncbi request reprint Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging
    Andrzej Bartke
    Departments of Internal Medicine and Physiology, Southern Illinois University School of Medicine, P O Box 19628, Springfield, IL 62794 9628, USA
    Trends Endocrinol Metab 17:33-5. 2006
    ..However, activation of signaling molecules downstream from IGF-1 and insulin receptors is reduced in both Klotho and dwarf mice, suggesting common mechanisms of delayed aging...
  31. doi request reprint Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings
    Andrzej Bartke
    Department of Internal Medicine, School of Medicine, Southern Illinois University, Springfield, IL 62794 9628, USA
    Aging Cell 7:285-90. 2008
    ..These important novel findings also strengthen the evidence for evolutionary conservation of mechanisms regulating lifespan in worms, insects and mammals...
  32. ncbi request reprint Pituitary and testicular function in growth hormone receptor gene knockout mice
    V Chandrashekar
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901 6512, USA
    Endocrinology 140:1082-8. 1999
    ..Thus, GH and IGF-I influence pituitary and gonadal functions in male mice...
  33. ncbi request reprint Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice
    A Bartke
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901 6512, USA
    Proc Soc Exp Biol Med 222:113-23. 1999
    ....
  34. ncbi request reprint Effects of delta-9-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combinations, on luteinizing hormone and prolactin release and on hypothalamic neurotransmitters in the male rat
    L L Murphy
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale
    Neuroendocrinology 52:316-21. 1990
    ....
  35. ncbi request reprint Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse
    S J Hauck
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 6512, USA
    Exp Biol Med (Maywood) 226:552-8. 2001
    ..Reductions in these parameters may be important to the underlying mechanisms of delayed aging in these animals...
  36. ncbi request reprint Testicular endocrine function in GH receptor gene disrupted mice
    V Chandrashekar
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 6512, USA
    Endocrinology 142:3443-50. 2001
    ..These changes are most likely due to the absence of circulating IGF-I. These findings provide evidence that systemic IGF-I plays a major modulatory role in testicular endocrine function...
  37. ncbi request reprint Life extension in the dwarf mouse
    Andrzej Bartke
    Geriatrics Research, Department of Medicine, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Curr Top Dev Biol 63:189-225. 2004
    ..An important role of IGF-1 and insulin in the control of mammalian longevity is consistent with the well-documented actions of homologous signaling pathways in invertebrates...
  38. ncbi request reprint Could a deficiency in growth hormone signaling be beneficial to the aging brain?
    B A Kinney-Forshee
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512
    Physiol Behav 80:589-94. 2004
    ..Taken together, these studies support our previous findings of delayed age-induced cognitive and behavioral decline in GH deficient/resistant mice...
  39. ncbi request reprint Influence of hypothalamus and ovary on pituitary function in transgenic mice expressing the bovine growth hormone gene and in growth hormone-deficient Ames dwarf mice
    V Chandrashekar
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901 6512, USA
    Biol Reprod 54:1002-8. 1996
    ....
  40. ncbi request reprint Antioxidative mechanisms and plasma growth hormone levels: potential relationship in the aging process
    H M Brown-Borg
    Department of Physiology, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58203 9037, USA
    Endocrine 11:41-8. 1999
    ..Animals deficient in GH (dwarf) live longer and exhibit enzyme activities and levels that may combat oxidative stress more efficiently than normal mice and those overexpressing GH...
  41. ncbi request reprint Gonadotropin secretion, synthesis, and gene expression in human growth hormone transgenic mice and in Ames dwarf mice
    K Tang
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901
    Endocrinology 132:2518-24. 1993
    ..In Ames dwarf mice, the deficiency of GH and PRL, as well as TSH, is associated with decreased LH-beta and FSH-beta gene expression which may account for the reduction in plasma gonadotropin levels...
  42. ncbi request reprint Induction of endogenous insulin-like growth factor-I secretion alters the hypothalamic-pituitary-testicular function in growth hormone-deficient adult dwarf mice
    V Chandrashekar
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901 6512
    Biol Reprod 48:544-51. 1993
    ..001) plasma LH levels. The effect of LHRH on LH secretion was increased (p < 0.001) in dwarf mice pretreated with GH, but this LH response was lower than in normal siblings that received vehicle only.(ABSTRACT TRUNCATED AT 250 WORDS)..
  43. ncbi request reprint Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters
    B A Kinney
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, 62901 6512, USA
    Horm Behav 39:277-84. 2001
    ..In fact, the Ames dwarf mouse may provide a model for studies of delayed mental as well as physical aging...
  44. ncbi request reprint Prolonged longevity of hypopituitary dwarf mice
    A Bartke
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    Exp Gerontol 36:21-8. 2001
    ..In this review, we will describe the key phenotypic characteristics of these animals, the evidence that they exhibit delayed aging, and the mechanisms that are suspected to account for their prolonged longevity...
  45. ncbi request reprint Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice
    Zhihui Wang
    Division of Diabetes, Endocrinology, and Metabolism, School of Medicine, Vanderbilt University, 2220 Pierce Avenue, Nashville, TN 37232 6303, USA
    Endocrinology 148:2845-53. 2007
    ..An increase in plasma adiponectin and decrease in plasma IL-6, triglycerides, and cholesterol levels in response to CR may improve insulin sensitivity...
  46. ncbi request reprint Testicular function after local injection of 6-hydroxydopamine or norepinephrine in the golden hamster (Mesocricetus auratus)
    A Mayerhofer
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901 6512
    J Androl 11:301-11. 1990
    ..To examine this possibility, the authors have tested the effects of intratesticular NE injections. This treatment caused decrease of LH-R at 24 h followed by an increase at 72 h.(ABSTRACT TRUNCATED AT 400 WORDS)..
  47. ncbi request reprint Role of growth hormone and prolactin in the control of reproduction: what are we learning from transgenic and knock-out animals?
    A Bartke
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901 6512, USA
    Steroids 64:598-604. 1999
    ..Studies in GH transgenics should allow the identification of mechanisms that mediate the effects of chronic overexposure to GH on reproduction...
  48. ncbi request reprint Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice
    S J Hauck
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 6512, USA
    Horm Metab Res 34:481-6. 2002
    ....
  49. ncbi request reprint Transgenic mice overexpressing the growth-hormone-releasing hormone gene have high concentrations of tachykinins in the anterior pituitary gland
    L Debeljuk
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Ill, USA
    Neuroendocrinology 70:107-16. 1999
    ..The GHRH transgenic mice may be an interesting model to study the regulation of tachykinin stores in the anterior pituitary gland...
  50. ncbi request reprint Free radical defenses in the liver and kidney of human growth hormone transgenic mice: possible mechanisms of early mortality
    S J Hauck
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, 62901-6512, USA
    J Gerontol A Biol Sci Med Sci 56:B153-62. 2001
    ....
  51. ncbi request reprint Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase
    S J Hauck
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    Free Radic Biol Med 28:970-8. 2000
    ....
  52. ncbi request reprint Effects of psychoactive and nonpsychoactive cannabinoids on the hypothalamic-pituitary axis of the adult male rat
    R W Steger
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901 6512
    Pharmacol Biochem Behav 37:299-302. 1990
    ..These results suggest that the decrease in LH secretion in THC- or CBN-treated rats is due to reductions in NE stimulation of LHRH release rather than to changes in LHRH synthesis or pituitary LHRH response...
  53. ncbi request reprint Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice
    Liou Y Sun
    Geriatrics Research, Department of Internal Medicine, Southern Illinois University School of Medicine, Room 4389, 801 North Rutledge, Springfield, Illinois 62794 9628, USA
    Endocrinology 146:1138-44. 2005
    ....
  54. pmc Effects of growth hormone and thyroxine replacement therapy on insulin signaling in Ames dwarf mice
    Audreen Louis
    Department of Internal Medicine, Division of Geriatric Research, School of Medicine, Southern Illinois University, 801 N Rutledge, Room 4389, PO Box 19628, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 65:344-52. 2010
    ..These results indicate that GH and T4 treatment has differential impact on insulin signaling during development and adulthood...
  55. ncbi request reprint Immune function in transgenic mice overexpressing growth hormone (GH) releasing hormone, GH or GH antagonist
    E Dialynas
    Department of Physiology, Southern Illinois University, Carbondale, Illinois 62901 6512, USA
    Proc Soc Exp Biol Med 221:178-83. 1999
    ....
  56. ncbi request reprint Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice
    B A Kinney
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    Physiol Behav 72:653-60. 2001
    ..Thus, it was concluded that inhibitory avoidance performance was not affected by differences of locomotor activity or emotionality, and that the absence of GH signaling may be associated with improved long-term memory in aging mice...
  57. ncbi request reprint Neuroendocrine function in adult female transgenic mice expressing the human growth hormone gene
    V Chandrashekar
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901 6512
    Endocrinology 130:1802-8. 1992
    ..Yet due to PRL-like activity of hGH, the gonadotropin secretion is altered. Thus, endogenously secreted hGH modulates the hypothalamic-pituitary function of adult female transgenic mice bearing the hGH gene...
  58. ncbi request reprint Age-related alterations in pituitary and testicular functions in long-lived growth hormone receptor gene-disrupted mice
    Varadaraj Chandrashekar
    Department Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Endocrinology 148:6019-25. 2007
    ....
  59. pmc Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?
    Jacob A Panici
    Department of Internal Medicine, Geriatrics Research, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 64:1126-33. 2009
    ....
  60. ncbi request reprint Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction
    Khalid A Al-Regaiey
    Department of Physiology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9628, USA
    Endocrinology 146:851-60. 2005
    ..These results also add to the evidence that targeted disruption of the GH receptor/GH-binding protein gene and CR act via overlapping, but distinct, mechanisms...
  61. ncbi request reprint Low body temperature in long-lived Ames dwarf mice at rest and during stress
    W S Hunter
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901, USA
    Physiol Behav 67:433-7. 1999
    ..However, whether low Tco per se is related to the increased longevity of the dwarf mice remains an interesting possibility to be investigated...
  62. ncbi request reprint Deficits in female reproductive function in GH-R-KO mice; role of IGF-I
    N Danilovich
    Department of Physiology, Southern Illinois University, Carbondale 62901 6512, USA
    Endocrinology 140:2637-40. 1999
    ..We conclude that GH resistance and consequent reduction in peripheral IGF-I levels is associated with delay of female puberty, alterations in fetal and placental growth, delay of parturition, and reduced litter size...
  63. pmc Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 295:H1882-94. 2008
    ..Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress...
  64. ncbi request reprint Human placental growth hormone causes severe insulin resistance in transgenic mice
    Linda A Barbour
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Am J Obstet Gynecol 186:512-7. 2002
    ..Our aim was to evaluate the effect of placental growth hormone on insulin sensitivity in vivo using transgenic mice that overexpress the human placental growth hormone gene...
  65. pmc Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
    Michael S Bonkowski
    Department of Internal Medicine Geriatrics Research, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Proc Natl Acad Sci U S A 103:7901-5. 2006
    ..The present findings also support the notion that enhanced sensitivity to insulin plays a prominent role in the actions of CR and GH resistance on longevity...
  66. ncbi request reprint Effect of progesterone on tachykinin concentrations in the hypothalamus and anterior pituitary of female siberian hamsters
    L Debeljuk
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901, USA
    Peptides 20:353-60. 1999
    ..These results suggest that progesterone may modulate tachykinin stores in the anterior pituitary gland of Siberian hamsters...
  67. ncbi request reprint Thymostimulin effects on lymphoid organs in Ames dwarf mice
    M A Villanua
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901
    Acta Endocrinol (Copenh) 128:74-80. 1993
    ..Plasma prolactin (PRL) and growth hormone (GH) levels of pituitary-grafted dwarf mice were not changed after TP-1 administration.(ABSTRACT TRUNCATED AT 250 WORDS)..
  68. ncbi request reprint Genetic determination of coat color affects testicular steroidogenesis in the Mustela vison
    A G Amador
    Department of Obstetrics and Gynecology, SIU School of Medicine, Springfield, IL 62794 1315, USA
    Rev Esp Fisiol 52:83-8. 1996
    ..Since the genotype of the opaline mink differs from the other mink studied, only in their combination at the pastel (b) and moyle (m) loci, their bb mm genotype could be assumed to be responsible for the increase in testicular steroids...
  69. ncbi request reprint Assessment of the primary adrenal cortical and pancreatic hormone basal levels in relation to plasma glucose and age in the unstressed Ames dwarf mouse
    K E Borg
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901 6512, USA
    Proc Soc Exp Biol Med 210:126-33. 1995
    ..These results provide new insights into the roles GH may play in glucose metabolism and perhaps also in adiposity which is a common characteristic of Df/- aged females from this line of mice...
  70. ncbi request reprint Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle
    Khalid A Al-Regaiey
    Departments of Internal Medicine, Southern Illinois University, School of Medicine, Springfield, USA
    J Gerontol A Biol Sci Med Sci 62:18-26. 2007
    ..These changes may be related to mechanisms of improving insulin sensitivity and life expectancy...
  71. ncbi request reprint Tachykinins in the pineal gland: effect of castration and ganglionectomy
    L Debeljuk
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901, USA
    Peptides 19:1073-8. 1998
    ..These results indicate that NKA and other tachykinins are present in the pineal gland of the male rat, and they seem to be regulated by gonadal hormones and the innervation originated from the superior cervical ganglia...
  72. ncbi request reprint The impact of altered insulin-like growth factor-I secretion on the neuroendocrine and testicular functions
    V Chandrashekar
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    Minerva Ginecol 57:87-97. 2005
    ....
  73. ncbi request reprint Effect of a non-peptide NK-2 tachykinin receptor antagonist on LH, FSH, and prolactin release by rat hemipituitaries in vitro
    L Debeljuk
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, USA
    J Physiol Pharmacol 48:461-78. 1997
    ..Therefore, the results observed with the use of some of these antagonists should be interpreted with great caution...
  74. ncbi request reprint Puberty is delayed in male growth hormone receptor gene-disrupted mice
    David E Keene
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 6512, USA
    J Androl 23:661-8. 2002
    ..These results suggest that the absence of IGF-I secretion delays the normal course of sexual maturation in male GHR-KO mice, indicating that IGF-I plays an important role in the initiation of puberty in male mice...
  75. ncbi request reprint Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice
    Liou Y Sun
    Geriatrics Research, Department of Medicine, Southern Illinois University, Springfield, IL 62794, USA
    Neurobiol Aging 26:929-37. 2005
    ....
  76. pmc Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice
    Jacob A Panici
    Department of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    FASEB J 24:5073-9. 2010
    ..We conclude that the remarkable life-span extension of Ames dwarf mice, and the stress resistance of cells from these mice, depends on low levels of GH exposure in juvenile and very young adult mice...
  77. pmc Glucose homeostasis and insulin sensitivity in growth hormone-transgenic mice: a cross-sectional analysis
    Ravneet K Boparai
    Department of Internal Medicine, Division of Geriatrics Research, School of Medicine, Southern Illinois University, 801 N Rutledge, Room 4389, P O Box 19628, Springfield, IL 62794 9628, USA
    Biol Chem 391:1149-55. 2010
    ..In addition, they pose intriguing queries about the relationships between GH, endocrine control of metabolism, and aging...
  78. pmc The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet
    Oge Arum
    Department of Internal Medicine, Southern Illinois University School of Medicine, 801 N Rutledge St, Springfield, IL 62794, USA
    Aging Cell 8:756-60. 2009
    ..Insulin sensitivity may be a mechanism and/or a marker of the lifespan extending potential of an intervention...
  79. pmc Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice
    Reyhan Westbrook
    Department of Internal Medicine, Division of Geriatric Research, Southern Illinois University School of Medicine, 801 North Rutledge Street, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 64:443-51. 2009
    ....
  80. ncbi request reprint Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics
    Michael S Bonkowski
    Department of Physiology and Internal Medicine Geriatrics Research, Southern Illinois University School of Medicine, Springfield IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 61:562-7. 2006
    ..These parameters also continued to increase with age. Our results indicate that GH resistance alters body composition, bone growth, and bone maintenance during aging in GHR-KO mice...
  81. ncbi request reprint Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice
    Zhihui Wang
    Geriatrics Research, Department of Physiology and Internal Medicine, School of Medicine, Southern Illinois University, 801 N Rutledge, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 61:323-31. 2006
    ..However, CR may reduce rather than enhance some of the insulin effects in the highly insulin-sensitive dwarf mice...
  82. ncbi request reprint Soy isoflavones modify liver free radical scavenger systems and liver parameters in Sprague-Dawley rats
    William Banz
    Departments of Animal Science, Food and Nutrition and Physiology, Southern Illinois University, Carbondale, IL 62901, USA
    J Med Food 7:477-81. 2004
    ....
  83. ncbi request reprint Divergent effects of caloric restriction on gene expression in normal and long-lived mice
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University, School of Medicine, Springfield 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 59:784-8. 2004
    ..Moreover, effects of dwarfism on the expression of the examined genes differed from the effects of CR, thus adding to the evidence that these long-lived mutants are not CR mimetics...
  84. ncbi request reprint Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice
    Michal M Masternak
    Departments of Internal Medicine and Physiology, Geriatrics Research, Southern Illinois University, School of Medicine, Springfield, IL 62794, USA
    Exp Gerontol 40:491-7. 2005
    ..The results indicate that EOD produces some changes in the insulin and IGF1 signaling pathways, and that these changes are consistent with EOD increasing insulin sensitivity...
  85. ncbi request reprint The role of insulin-like growth factor-I in neuroendocrine function and the consequent effects on sexual maturation: inferences from animal models
    Varadaraj Chandrashekar
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 6512, USA
    Reprod Biol 3:7-28. 2003
    ..Therefore, the concentrations of IGF binding proteins and the ratio of these binding proteins and IGF-I within the body might play a pivotal role in modulating IGF-I effects on the neuroendocrine-gonadal system...
  86. pmc Insulin sensitivity as a key mediator of growth hormone actions on longevity
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    J Gerontol A Biol Sci Med Sci 64:516-21. 2009
    ..We also report that the effects of GH treatment on insulin sensitivity may be limited to the period of GH administration...
  87. ncbi request reprint Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice
    Michal M Masternak
    Departments of Internal Medicine and Physiology, Geriatrics Research, Southern Illinois University, School of Medicine, P O Box 19628, Springfield, IL 62794 9628, USA
    Exp Gerontol 40:679-84. 2005
    ..The results also show that improved insulin sensitivity in response to CR is not due to increased mRNA expression of the above genes in either normal or GHR-KO animals...
  88. ncbi request reprint Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice
    Denise Zaczek
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901 6512, USA
    Biol Reprod 67:1115-24. 2002
    ..Although GHR-KO female mice are fertile, they exhibit quantitative deficits in various parameters of reproductive function...
  89. ncbi request reprint Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice
    Michal M Masternak
    Department of Internal Medicine, Geriatrics Research, Southern Illnois University School of Medicine, Springfield, 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 60:1238-45. 2005
    ..This suggested metabolic change clearly does not affect whole-body insulin action. These findings suggest that whole-animal insulin sensitivity is not regulated through skeletal muscle insulin action...
  90. pmc Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart
    Michal M Masternak
    Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Exp Gerontol 41:417-29. 2006
    ....
  91. ncbi request reprint Effects of caloric restriction and growth hormone resistance on the expression level of peroxisome proliferator-activated receptors superfamily in liver of normal and long-lived growth hormone receptor/binding protein knockout mice
    Michal M Masternak
    Southern Illinois University, School of Medicine, Geriatrics Research, Department of Internal Medicine, 801 N Rutledge St, Room 4389, P O Box 19628, Springfield, IL 62794 9628, USA
    J Gerontol A Biol Sci Med Sci 60:1394-8. 2005
    ..The results also indicate that CR may increase insulin sensitivity through a different mechanism...
  92. ncbi request reprint Effects of soy protein and soy phytochemicals on mammary tumor development in female transgenic mice overexpressing human pituitary growth hormone
    Jennifer Hickey
    Departments of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL 62901 4317, USA
    J Med Food 8:556-9. 2005
    ..Furthermore, some bioactive compounds in the HIS diet appeared to confound the soy protein-induced beneficial effects...
  93. ncbi request reprint Insulin-like growth factor 1 and mammalian aging
    Andrzej Bartke
    Department of Physiology in the School of Medicine at Southern Illinois University, Carbondale, IL 62901, USA
    Sci Aging Knowledge Environ 2002:vp4. 2002
  94. ncbi request reprint Developmental aspects of prolactin receptor gene expression in fetal and neonatal mice
    H M Brown-Borg
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6512, USA
    Eur J Endocrinol 134:751-7. 1996
    ..These data are the first to show the presence of PRL-R gene expression in various organ systems in fetal mice and suggest that PRL is among several factors necessary to coordinate developmental activities...
  95. ncbi request reprint Sertoli cells in testes containing or lacking germ cells: a comparative study of paracrine effects using the W (c-kit) gene mutant mouse model
    L R De Franca
    Laboratory of Structural Biology, Southern Illinois University, School of Medicine, Carbondale
    Anat Rec 240:225-32. 1994
    ..Paracrine effects of germ cells on Sertoli cell structure were examined in a mouse model with the W locus (dominant white spotting) mutation in which animals with the W/Wv genotype (referred to as mutants) lack virtually all germ cells...
  96. ncbi request reprint The consequences of altered somatotropic system on reproduction
    Varadaraj Chandrashekar
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    Biol Reprod 71:17-27. 2004
    ..These data suggest that, in addition to GnRH and gonadotropins, GH/IGF-I influences the pituitary and gonadal functions in animals and humans...
  97. ncbi request reprint In vitro effects of psychoactive and non-psychoactive cannabinoids on immature rat Sertoli cell function
    S C Newton
    Department of Physiology, Southern Illinois University, School of Medicine, Carbondale 62901
    Life Sci 53:1429-37. 1993
    ..These results add to the growing evidence that cannabinoids can exert direct effects on Sertoli cell function and modulate their responses to physiological stimuli...
  98. ncbi request reprint Tachykinins and their possible modulatory role on testicular function: a review
    Luciano Debeljuk
    Department of Health Care Professions, Southern Illinois University, Carbondale, IL 62901, USA
    Int J Androl 26:202-10. 2003
    ..These findings suggest that tachykinins may have a physiological function in the testes as modulators of the functions of the different cell types contained in these organs...
  99. ncbi request reprint Diet and aging
    Matthew D W Piper
    UCL Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK
    Cell Metab 8:99-104. 2008
    ..Here we discuss examples of diet/genotype interactions that show a more complex mechanistic view is required and that mild dietary modifications can dramatically change the interpretation of model organism aging studies...
  100. ncbi request reprint Adult neurogenesis in the hippocampus of long-lived mice during aging
    Liou Y Sun
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 62:117-25. 2007
    ....
  101. ncbi request reprint Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity
    Yuji Ikeno
    Research Service, Audie Murphy VA Hospital STVHCS, San Antonio, Texas 78229, USA
    J Gerontol A Biol Sci Med Sci 58:291-6. 2003
    ....

Research Grants15

  1. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2010
    ....
  2. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2001
    ..In future studies, we will verify involvement of these mechanisms in the control of normal and delayed aging and examine their potential in designing interventions that prolong health span. ..
  3. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2009
    ..abstract_text> ..
  4. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2009
    ....
  5. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2007
    ..abstract_text> ..
  6. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2007
    ....
  7. Eighth & Ninth International Symposia on Neurobiology & Neuroendocrinology Aging
    Andrzej Bartke; Fiscal Year: 2007
    ..We are also seeking partial support for the expenses of invited speakers from the United States. ..
  8. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2006
    ....
  9. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2005
    ..In future studies, we will verify involvement of these mechanisms in the control of normal and delayed aging and examine their potential in designing interventions that prolong health span. ..
  10. Aging:Mechanisms & Prevention:34th Annual Meeting of AGE
    Andrzej Bartke; Fiscal Year: 2005
    ..Financial assistance will be provided to those in training to encourage their participation in the meeting. ..
  11. 7th Intl Symposium-Neurobiology/Neuroendocrinology/Aging
    Andrzej Bartke; Fiscal Year: 2004
    ..We are also seeking support for the presenters of the Special Lecture and the Keynote Lecture who will be traveling to Bregenz from the United States. ..
  12. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2004
    ..In future studies, we will verify involvement of these mechanisms in the control of normal and delayed aging and examine their potential in designing interventions that prolong health span. ..
  13. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2003
    ..In future studies, we will verify involvement of these mechanisms in the control of normal and delayed aging and examine their potential in designing interventions that prolong health span. ..
  14. Interaction of Caloric Restriction with Longevity Genes
    Andrzej Bartke; Fiscal Year: 2002
    ..In future studies, we will verify involvement of these mechanisms in the control of normal and delayed aging and examine their potential in designing interventions that prolong health span. ..