AMY ARAI

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. ncbi GYKI 52466 has positive modulatory effects on AMPA receptors
    A C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 892:396-400. 2001
  2. ncbi Factors that regulate KiSS1 gene expression in the hippocampus
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 1243:10-8. 2008
  3. ncbi The role of kisspeptin and GPR54 in the hippocampus
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Peptides 30:16-25. 2009
  4. ncbi Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior
    A C Arai
    Dept of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Curr Drug Targets 8:583-602. 2007
  5. ncbi Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells
    Amy C Arai
    Department of Pharmacology, 801 N Rutledge St, P O Box 19629, Springfield, IL 62794 9629, USA
    J Neurophysiol 94:3648-52. 2005
  6. ncbi Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus
    A C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, MC 9629, 801 North Rutledge Street, Springfield, IL 62702, USA
    Neuroscience 123:1011-24. 2004
  7. ncbi Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Mol Pharmacol 62:566-77. 2002
  8. ncbi Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action
    Amy C Arai
    Department of Pharmacology, Southern Illinois University, Springfield, Illinois 62702, USA
    J Pharmacol Exp Ther 303:1075-85. 2002
  9. ncbi Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus
    Yan-Fang Xia
    Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield, IL 62794-9629, USA
    J Pharmacol Exp Ther 313:277-85. 2005
  10. ncbi C-terminal truncation affects kinetic properties of GluR1 receptors
    Erika Suzuki
    Department of Pharmacology, Southern Illinois University School of Medicine, MC 9629, 801 N Rutledge, Room 3275, Springfield, IL 62702, USA
    Mol Cell Neurosci 29:1-10. 2005

Research Grants

  1. DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORS
    AMY ARAI; Fiscal Year: 2004
  2. Differential effects of TARPs on AMPA receptor subunits
    AMY ARAI; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. ncbi GYKI 52466 has positive modulatory effects on AMPA receptors
    A C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 892:396-400. 2001
    ..The results indicate that GYKI 52466 modulates AMPA receptor-mediated currents in a complex manner, perhaps by acting through more than one binding site...
  2. ncbi Factors that regulate KiSS1 gene expression in the hippocampus
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 1243:10-8. 2008
    ..In additional experiments, KiSS1 mRNA was found to be increased after orchidectomy and thus expression may be regulated also by gonadal hormones...
  3. ncbi The role of kisspeptin and GPR54 in the hippocampus
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, P O Box 19629, Springfield, IL 62794 9629, USA
    Peptides 30:16-25. 2009
    ..This novel peptide system may play a role in cognition and in the pathogenesis of epilepsy...
  4. ncbi Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior
    A C Arai
    Dept of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Curr Drug Targets 8:583-602. 2007
    ..Type II drugs like CX516 in particular appear to be inherently safe since their ability to prolong responses is kinetically limited...
  5. ncbi Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells
    Amy C Arai
    Department of Pharmacology, 801 N Rutledge St, P O Box 19629, Springfield, IL 62794 9629, USA
    J Neurophysiol 94:3648-52. 2005
    ..Metastin is thus a novel endogenous factor that modulates synaptic excitability in the dentate gyrus through mechanisms involving MAP kinases, which in turn may be controlled upstream by calcium-activated kinases and tyrosine kinases...
  6. ncbi Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus
    A C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, MC 9629, 801 North Rutledge Street, Springfield, IL 62702, USA
    Neuroscience 123:1011-24. 2004
    ....
  7. ncbi Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses
    Amy C Arai
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    Mol Pharmacol 62:566-77. 2002
    ..The large gain in potency conferred by alkyl substitution suggests that the 5' substituent is in intimate contact with the receptor, with the size of the substituent determining the way in which receptor kinetics is changed...
  8. ncbi Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action
    Amy C Arai
    Department of Pharmacology, Southern Illinois University, Springfield, Illinois 62702, USA
    J Pharmacol Exp Ther 303:1075-85. 2002
    ..Of these, CX516-type drugs may have the greater therapeutic utility because of their limited efficacy in prolonging synaptic responses and in attenuating receptor desensitization...
  9. ncbi Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus
    Yan-Fang Xia
    Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield, IL 62794-9629, USA
    J Pharmacol Exp Ther 313:277-85. 2005
    ..Although regional preferences of the ampakines were modest in their extent, they may be sufficient to be of relevance when considering future therapeutic applications of such compounds...
  10. ncbi C-terminal truncation affects kinetic properties of GluR1 receptors
    Erika Suzuki
    Department of Pharmacology, Southern Illinois University School of Medicine, MC 9629, 801 N Rutledge, Room 3275, Springfield, IL 62702, USA
    Mol Cell Neurosci 29:1-10. 2005
    ..The lowered affinity and faster inactivation of these receptors suggests that their presence does not represent a risk for neuronal viability...
  11. ncbi Modulation of agonist binding to AMPA receptors by 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine (CX546): differential effects across brain regions and GluA1-4/transmembrane AMPA receptor regulatory protein combinations
    Kyle E Montgomery
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
    J Pharmacol Exp Ther 331:965-74. 2009
    ....
  12. ncbi Spontaneous activity in Purkinje cells: multi-electrode recording from organotypic cerebellar slice cultures
    Markus Kessler
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Brain Res 1218:54-69. 2008
    ....
  13. ncbi Physiological significance of high- and low-affinity agonist binding to neuronal and recombinant AMPA receptors
    Markus Kessler
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Neurochem Int 52:1383-93. 2008
    ....
  14. ncbi Factors affecting guanine nucleotide binding to rat AMPA receptors
    Kyle Montgomery
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Brain Res 1177:1-8. 2007
    ..Thus new approaches, including crystallography, may be called for to identify residues uniquely involved in nucleotide binding...
  15. ncbi Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators
    Markus Kessler
    Department of Pharmacology, Southern Illinois University School of Medicine, 801 N Rutledge, PO Box 19629, Springfield, IL 62794 9629, USA
    Brain Res 1076:25-41. 2006
    ..Lastly, data are shown which highlight the importance of optimizing experimental conditions in filtration assays, for instance by always including thiocyanate in wash buffers...
  16. ncbi The fast kinetics of AMPA GluR3 receptors is selectively modulated by the TARPs gamma 4 and gamma 8
    Erika Suzuki
    Department of Pharmacology, Southern Illinois University School of Medicine, 801 North Rutledge Street, PO Box 19629, Springfield, Illinois 62794 9629, USA
    Mol Cell Neurosci 38:117-23. 2008
    ..The differential TARP effects on deactivation time constants of the GluR3 subunit are likely to have a significant impact on synaptic responses across different neurons in the brain...
  17. ncbi Divergent effects of the purinoceptor antagonists suramin and pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) (PPNDS) on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors
    Erika Suzuki
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62702, USA
    Mol Pharmacol 66:1738-47. 2004
    ..By extension, suramin is proposed to stabilize the unbound state and thereby to reduce affinity for agonists. These drugs thus act through a novel type of noncompetitive antagonism...
  18. ncbi Integrins regulate NMDA receptor-mediated synaptic currents
    Bin Lin
    Department of Psychiatry and Human Behavior, University of California, Irvine 92612 1695, USA
    J Neurophysiol 89:2874-8. 2003
    ..Integrins regulate Src kinases that are known to phosphorylate NMDA receptors. It is concluded that integrins act through this route to exert potent modulatory effects on the operation of NMDA receptors...
  19. ncbi 5'-alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity
    Dean Phillips
    Department of Chemistry, University of California, Irvine, CA 92697, USA
    Bioorg Med Chem 10:1229-48. 2002
    ..The structure--activity relationships reported here thus offer to provide new insights how receptor kinetics is linked to particular aspects of receptor--drug interactions...
  20. ncbi A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor
    Eniko A Kramar
    Department of Psychiatry and Human Behavior, University of California, Irvine, California 92612 1695, USA
    J Neurosci 24:5151-61. 2004
    ..It is likely that this mechanism, acting with other factors, promotes the formation and increases the magnitude of LTP...
  21. ncbi Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans
    Ye Wu
    Institute of Genetic Medicine and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:18163-8. 2007
    ..Our study provides the genetic and functional evidence that mutant iGluR3 with altered kinetic properties is associated with moderate cognitive impairment in humans...

Research Grants6

  1. DIFFERENCES IN SYNAPTIC VS NONSYNAPTIC AMPA RECEPTORS
    AMY ARAI; Fiscal Year: 2004
    ..Determining which cellular factor stabilizes the low-affinity receptors will constitute the Fifth Aim of this application. ..
  2. Differential effects of TARPs on AMPA receptor subunits
    AMY ARAI; Fiscal Year: 2007
    ....