SUBRAMANIAM C ANANTHAN

Summary

Affiliation: Southern Research Institute
Country: USA

Publications

  1. ncbi request reprint Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety
    S Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama 35255, USA
    J Med Chem 41:2872-81. 1998
  2. ncbi request reprint Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans
    S Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama 35255, USA
    J Med Chem 42:3527-38. 1999
  3. ncbi request reprint Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, AL 35255, USA
    Bioorg Med Chem Lett 12:2225-8. 2002
  4. ncbi request reprint Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, AL 35255, USA
    Bioorg Med Chem Lett 13:529-32. 2003
  5. ncbi request reprint Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, AL 35255, USA
    Bioorg Med Chem 11:4143-54. 2003
  6. ncbi request reprint Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama 35255, USA
    J Med Chem 47:1400-12. 2004
  7. pmc Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, AL, USA
    AAPS J 8:E118-25. 2006
  8. pmc Recent advances in structure-based virtual screening of G-protein coupled receptors
    Subramaniam Ananthan
    Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA
    AAPS J 11:178-85. 2009
  9. doi request reprint Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function
    N Schormann
    Department of Pharmaceutical Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Proteins 73:889-901. 2008

Research Grants

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety
    S Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama 35255, USA
    J Med Chem 41:2872-81. 1998
    ..The results of the present study suggest that morphinan derivatives related to 16 and 14 may provide useful leads for the development of potent nonpeptide ligands possessing delta agonist or mixed delta antagonist/mu agonist activities...
  2. ncbi request reprint Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans
    S Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama 35255, USA
    J Med Chem 42:3527-38. 1999
    ..The potent delta antagonist component of this mixed mu agonist/delta antagonist may be responsible for the diminished propensity to produce tolerance that this compound displays...
  3. ncbi request reprint Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, AL 35255, USA
    Bioorg Med Chem Lett 12:2225-8. 2002
    ..Among the compounds studied, 4-[(diphenylmethyl)amino]-2-phenylquinazoline (4 g) was identified as a novel partial inhibitor of [(125)I]RTI-55 binding to the dopamine transporter and a partial inhibitor of [(3)H]dopamine uptake...
  4. ncbi request reprint Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, AL 35255, USA
    Bioorg Med Chem Lett 13:529-32. 2003
    ....
  5. ncbi request reprint Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, AL 35255, USA
    Bioorg Med Chem 11:4143-54. 2003
    ..The in vitro delta antagonist profile of this pyridomorphinan 10c resembles that of the widely used delta selective antagonist ligand naltrindole...
  6. ncbi request reprint Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama 35255, USA
    J Med Chem 47:1400-12. 2004
    ....
  7. pmc Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics
    Subramaniam Ananthan
    Organic Chemistry Department, Southern Research Institute, Birmingham, AL, USA
    AAPS J 8:E118-25. 2006
    ..A brief overview of mu-delta interactions and recent developments in identification of ligands possessing mixed mu agonist/delta agonist and mu agonist/delta antagonist activities is provided in this report...
  8. pmc Recent advances in structure-based virtual screening of G-protein coupled receptors
    Subramaniam Ananthan
    Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA
    AAPS J 11:178-85. 2009
    ..Recent examples of such virtual screening against GPCRs are discussed in this review...
  9. doi request reprint Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function
    N Schormann
    Department of Pharmaceutical Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Proteins 73:889-901. 2008
    ..Further refinement of the models through integration of additional activity data and optimization of reliable docking poses is expected to lead to an improved predictive ability...

Research Grants13

  1. NOVEL NONPEPTIDE LIGANDS FOR THE OPIOID RECEPTORS
    Subramaniam Ananthan; Fiscal Year: 2007
    ....
  2. NOVEL NONPEPTIDE LIGANDS FOR THE OPIOID RECEPTORS
    Subramaniam Ananthan; Fiscal Year: 2002
    ..This comprehensive approach should lead to the identification and development of drugs that could provide new approaches to the treatment of chronic pain and for the teatrnent of problems associated with drugs of abuse. ..
  3. Development of Dopamine D3 Ligands as Medications for Psychostimulant Addiction
    Subramaniam Ananthan; Fiscal Year: 2010
    ....