J P O'Reilly

Summary

Affiliation: Southeastern Louisiana University
Country: USA

Publications

  1. ncbi Time- and state-dependent effects of methanethiosulfonate ethylammonium (MTSEA) exposure differ between heart and skeletal muscle voltage-gated Na(+) channels
    JOHN P O'REILLY
    Department of Biological Sciences, Southeastern Louisana University, Hammond, LA, USA
    Biochim Biophys Acta 1818:443-7. 2012
  2. ncbi Methanethiosulfonate-modification alters local anesthetic block in rNav1.4 cysteine-substituted mutants S1276C and L1280C
    J P O'Reilly
    Department of Anesthesia Research, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Membr Biol 193:47-55. 2003
  3. ncbi Slow-inactivation induced conformational change in domain 2-segment 6 of cardiac Na+ channel
    JOHN P O'REILLY
    Department of Biological Sciences SLU 10736, Southeastern Louisiana University, Hammond, LA 70402, USA
    Biochem Biophys Res Commun 345:59-66. 2006
  4. ncbi Comparison of slow inactivation in human heart and rat skeletal muscle Na+ channel chimaeras
    J P O'Reilly
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 515:61-73. 1999
  5. ncbi Residue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels
    J P O'Reilly
    Department of Anesthesia Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biophys J 81:2100-11. 2001
  6. ncbi A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state
    J P O'Reilly
    Department of Anesthesia Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biophys J 78:773-84. 2000
  7. ncbi Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6
    Jessica Hotard Chancey
    Department of Biological Sciences, Southeastern Louisiana University, Hammond, LA 70402, USA
    Am J Physiol Cell Physiol 293:C1895-905. 2007
  8. ncbi Partial reconstitution of V(D)J rearrangement and lymphocyte development in RAG-deficient mice expressing inducible, tetracycline-regulated RAG transgenes
    Penny E Shockett
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Immunol 40:813-29. 2004

Research Grants

  1. Role of Segment 6 in Heart Na Channel Slow Inactivation
    John O Reilly; Fiscal Year: 2005

Collaborators

Detail Information

Publications8

  1. ncbi Time- and state-dependent effects of methanethiosulfonate ethylammonium (MTSEA) exposure differ between heart and skeletal muscle voltage-gated Na(+) channels
    JOHN P O'REILLY
    Department of Biological Sciences, Southeastern Louisana University, Hammond, LA, USA
    Biochim Biophys Acta 1818:443-7. 2012
    ..4, which has a native tyrosine at the homologous site C407. We conclude that differences in molecular determinants of inactivation between hNav1.4 and hNav1.5 underlie the difference in response to MTSEA exposure...
  2. ncbi Methanethiosulfonate-modification alters local anesthetic block in rNav1.4 cysteine-substituted mutants S1276C and L1280C
    J P O'Reilly
    Department of Anesthesia Research, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Membr Biol 193:47-55. 2003
    ..4 that produces an allosteric, indirect effect on bupivacaine affinity...
  3. ncbi Slow-inactivation induced conformational change in domain 2-segment 6 of cardiac Na+ channel
    JOHN P O'REILLY
    Department of Biological Sciences SLU 10736, Southeastern Louisiana University, Hammond, LA 70402, USA
    Biochem Biophys Res Commun 345:59-66. 2006
    ..We propose that D2-S6 in hNav1.5 undergoes molecular rearrangement during slow inactivation exposing the side chain of residue 930 such that it becomes accessible to modification by MTSEA...
  4. ncbi Comparison of slow inactivation in human heart and rat skeletal muscle Na+ channel chimaeras
    J P O'Reilly
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Physiol 515:61-73. 1999
    ..The results also support previous conclusions that D3 and D4 (and the D3-D4 linker) play an important role in Na+ channel fast inactivation, and that activation may require non-equivalent contributions from all four domains...
  5. ncbi Residue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels
    J P O'Reilly
    Department of Anesthesia Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biophys J 81:2100-11. 2001
    ..Our results suggest that the V787 position in Na(v)1.4 plays an important role in slow inactivation gating and that molecular rearrangement occurs at or near residue V787 in D2-S6 during NaCh slow inactivation...
  6. ncbi A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state
    J P O'Reilly
    Department of Anesthesia Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biophys J 78:773-84. 2000
    ....
  7. ncbi Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6
    Jessica Hotard Chancey
    Department of Biological Sciences, Southeastern Louisiana University, Hammond, LA 70402, USA
    Am J Physiol Cell Physiol 293:C1895-905. 2007
    ..5. We suggest that conformational change involving D2-S6 is a critical component of SI in Na(v)s, which may be differentially regulated between isoforms by other isoform-specific determinants of SI phenotype...
  8. ncbi Partial reconstitution of V(D)J rearrangement and lymphocyte development in RAG-deficient mice expressing inducible, tetracycline-regulated RAG transgenes
    Penny E Shockett
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Immunol 40:813-29. 2004
    ..These mice provide a unique system for the inducible activation of V(D)J recombination and the development of primary lymphocytes...

Research Grants2

  1. Role of Segment 6 in Heart Na Channel Slow Inactivation
    John O Reilly; Fiscal Year: 2005
    ..This information will be useful for understanding heart Nav channelopathies such as long QT and Brugada syndromes. ..