Hongwei Zhang

Summary

Affiliation: South Dakota State University
Country: USA

Publications

  1. pmc Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system
    Hongwei Zhang
    Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Mol Ther 19:1440-8. 2011
  2. pmc MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression
    Jun Xie
    Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Ther 19:526-35. 2011
  3. pmc Long-term, efficient inhibition of microRNA function in mice using rAAV vectors
    Jun Xie
    Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Methods 9:403-9. 2012
  4. pmc Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10
    Bin Yang
    1 Department of Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, Massachusetts, USA 2 Division of Biology, California Institute of Technology, Pasadena, California, USA
    Mol Ther 22:1299-309. 2014
  5. pmc A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in canavan mice
    Seemin Seher Ahmed
    1 Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA 2 Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Mol Ther 21:2136-47. 2013
  6. doi request reprint Adenovirus-adeno-associated virus hybrid for large-scale recombinant adeno-associated virus production
    Hongwei Zhang
    Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hum Gene Ther 20:922-9. 2009

Collaborators

Detail Information

Publications6

  1. pmc Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system
    Hongwei Zhang
    Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Mol Ther 19:1440-8. 2011
    ....
  2. pmc MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression
    Jun Xie
    Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Ther 19:526-35. 2011
    ..Our findings promise to facilitate the development of miRNA-regulated rAAV for CNS-targeted gene delivery and other applications...
  3. pmc Long-term, efficient inhibition of microRNA function in mice using rAAV vectors
    Jun Xie
    Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Methods 9:403-9. 2012
    ..rAAV-mediated miRNA inhibition thus provides a simple way to study miRNA function in adult mammals and a potential therapy for dyslipidemia and other diseases caused by miRNA deregulation...
  4. pmc Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10
    Bin Yang
    1 Department of Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, Massachusetts, USA 2 Division of Biology, California Institute of Technology, Pasadena, California, USA
    Mol Ther 22:1299-309. 2014
    ..Additionally, systemically delivered rAAVrh.10 can transduce the CNS efficiently, and its transgene expression can be limited in the periphery by endogenous miRNAs in adult marmosets. ..
  5. pmc A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in canavan mice
    Seemin Seher Ahmed
    1 Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA 2 Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Mol Ther 21:2136-47. 2013
    ..We demonstrate that systemically delivered and CNS-restricted rAAVs can serve as efficacious and sustained gene therapeutics in a model of a severe neurodegenerative disorder even when administered as late as P20...
  6. doi request reprint Adenovirus-adeno-associated virus hybrid for large-scale recombinant adeno-associated virus production
    Hongwei Zhang
    Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hum Gene Ther 20:922-9. 2009
    ..This minireview provides an overview of this scaleable rAAV production platform, describing its basic components and biological mechanisms and process...