Affiliation: South Dakota State University
Teleb M, Rizk O, Zhang F, Fronczek F, Zamponi G, Fahmy H. Design, synthesis and pharmacological evaluation of some substituted dihydropyrimidines with L-/T-type calcium channel blocking activities. Bioorg Chem. 2018;83:354-366 pubmed publisher
..2. Their drug-likeness has been assessed using Molinspiration and Molsoft softwares. Their physicochemical properties and pharmacokinetic profiles recommend that they can be considered as drug-like candidates. ..
Kuppast B, Fahmy H. Thiazolo[4,5-d]pyrimidines as a privileged scaffold in drug discovery. Eur J Med Chem. 2016;113:198-213 pubmed publisher
Teleb M, Zhang F, Huang J, Gadotti V, Farghaly A, AboulWafa O, et al
. Synthesis and biological evaluation of novel N3-substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain. Bioorg Med Chem. 2017;25:1926-1938 pubmed publisher
..Based on selectivity and efficiency, two compounds were selected for in vivo evaluation in mouse models of inflammatory pain. Results showed effective attenuation of nociception and mechanical hypersensitivity. ..
Teleb M, Zhang F, Farghaly A, Aboul Wafa O, Fronczek F, Zamponi G, et al
. Synthesis of new N3-substituted dihydropyrimidine derivatives as L-/T- type calcium channel blockers. Eur J Med Chem. 2017;134:52-61 pubmed publisher
..Structure requirements for selectivity against Cav1.2 as well against Cav3.2 are described. ..
Teleb M, Kuppast B, Spyridaki K, Liapakis G, Fahmy H. Synthesis of 2-imino and 2-hydrazono thiazolo[4,5-d]pyrimidines as corticotropin releasing factor (CRF) antagonists. Eur J Med Chem. 2017;138:900-908 pubmed publisher
..A lead compound was identified and further evaluated by measuring its effect on the inhibition of the agonist-stimulated accumulation of second messengers. ..
Chilampalli C, Guillermo R, Zhang X, Kaushik R, Young A, Zeman D, et al
. Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action. BMC Cancer. 2011;11:456 pubmed publisher
..Magnolol could be a potentially safe and potent anticarcinogenic agent against skin cancer. ..