Omar Bagasra

Summary

Affiliation: South Carolina Center for Biotechnology
Country: USA

Publications

  1. pmc Computational analysis to predict functional role of hsa-miR-3065-3p as an antiviral therapeutic agent for treatment of triple infections: HCV, HIV-1, and HBV
    Ambreen Khokhar
    Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan
    Libyan J Med 7:19774. 2012
  2. doi Role of perfumes in pathogenesis of autism
    Omar Bagasra
    South Carolina Center for Biotechnology, 400 Magnolia Street, Orangeburg, SC 29115, USA
    Med Hypotheses 80:795-803. 2013
  3. doi Potential utility of GB virus type C as a preventive vaccine for HIV-1
    Omar Bagasra
    South Carolina Center for Biotechnology, Claflin University, Orangeburg, SC, USA
    Expert Rev Vaccines 11:335-47. 2012
  4. pmc hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer
    Renty B Franklin
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD, USA
    Mol Cancer 4:32. 2005
  5. ncbi Role of micro-RNAs in regulation of lentiviral latency and persistence
    Omar Bagasra
    Department of Biology, South Carolina Center for Biotechnology, Orangeburg, SC 29115, USA
    Appl Immunohistochem Mol Morphol 14:276-90. 2006
  6. ncbi RNAi as an antiviral therapy
    Omar Bagasra
    Arnold School of Public Health, Claflin University, Orangeburg, SC 29115, USA
    Expert Opin Biol Ther 5:1463-74. 2005
  7. ncbi Localization of human herpesvirus type 8 in human sperms by in situ PCR
    Omar Bagasra
    South Carolina Center for Biotechnology, Department of Biology, Claflin University, 400 Magnolia Street, Orangeburg, SC 29115, USA
    J Mol Histol 36:401-12. 2005
  8. ncbi Protocols for the in situ PCR-amplification and detection of mRNA and DNA sequences
    Omar Bagasra
    South Carolina Center for Biotechnology, Department of Biology, Claflin University, JST 215, 400 Magnolia Street, Orangeburg, South Carolina 29115, USA
    Nat Protoc 2:2782-95. 2007
  9. ncbi A unified concept of HIV latency
    Omar Bagasra
    South Carolina Center for Biotechnology, ClaflinUniversity, 400 Magnolia Street, Orangeburg, SC 29115, USA
    Expert Opin Biol Ther 6:1135-49. 2006
  10. pmc miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells
    Brittany L Mihelich
    Department of Pathology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:44503-11. 2011

Research Grants

Collaborators

  • Charles Wood
  • Larisa Nonn
  • Marek Skacel
  • R R Tubbs
  • Samina Noorali
  • Andre Kajdacsy-Balla
  • Donald Gene Pace
  • D Gene Pace
  • Krishna C Addanki
  • Joseph P Pestaner
  • Zhabiz Golkar
  • Renty B Franklin
  • Leslie C Costello
  • Ambreen Khokhar
  • Brittany L Mihelich
  • Leslie A Johnson
  • Mazhar Kanak
  • Kuha Mahalingam
  • Mayank Aggarwal
  • Shazia T Hakim
  • Pei Feng
  • Irum Rishi
  • Jamil A Abbasi
  • Ashrafe S Ewida
  • Mohammad R Khanani
  • Kuha Mahalingham
  • Muhammad Sheraz
  • Donald G Pace
  • Ekaterina A Khramtsova
  • Elena Martens-Uzunova
  • Daniel N Johnson
  • Nicole Arva
  • Angeline A Giangreco
  • Avani Vaishnav
  • Azima Kalsum
  • Prathap Balasubramanian
  • Nicholas Panasik
  • Mazhar A Kanak
  • Gene Pace
  • Mohammed Alseiari
  • Krishna Addanki
  • Cindi Lewis
  • Ioana C Rotar
  • Antonio Sison
  • Shahana U Kazmi
  • David McLean
  • Mohammad Alsayari
  • Shazia Tabassum Hakim
  • Sajid Saleem
  • David C McLean
  • B Milon
  • Ming Tan
  • Keshav K Singh
  • Mohamed M Desouki
  • Rebecca Bullard-Dillard
  • Hasna Baidouri
  • Gemma P Geslani
  • Steve A Raphael

Detail Information

Publications26

  1. pmc Computational analysis to predict functional role of hsa-miR-3065-3p as an antiviral therapeutic agent for treatment of triple infections: HCV, HIV-1, and HBV
    Ambreen Khokhar
    Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan
    Libyan J Med 7:19774. 2012
    ..These TI patients have a faster progression to AIDS, and even after antiretroviral therapy (ART) the prognosis of their disease is poor. The use of microRNA (miRNA) to silence genes holds potential applications for anti-HCV therapy...
  2. doi Role of perfumes in pathogenesis of autism
    Omar Bagasra
    South Carolina Center for Biotechnology, 400 Magnolia Street, Orangeburg, SC 29115, USA
    Med Hypotheses 80:795-803. 2013
    ....
  3. doi Potential utility of GB virus type C as a preventive vaccine for HIV-1
    Omar Bagasra
    South Carolina Center for Biotechnology, Claflin University, Orangeburg, SC, USA
    Expert Rev Vaccines 11:335-47. 2012
    ....
  4. pmc hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer
    Renty B Franklin
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD, USA
    Mol Cancer 4:32. 2005
    ..hZIP1 expression was also determined in malignant prostate cell lines...
  5. ncbi Role of micro-RNAs in regulation of lentiviral latency and persistence
    Omar Bagasra
    Department of Biology, South Carolina Center for Biotechnology, Orangeburg, SC 29115, USA
    Appl Immunohistochem Mol Morphol 14:276-90. 2006
    ..Our data suggest that triplex formation may be an important mechanism of LV latency mediated by endogenous miRNAs...
  6. ncbi RNAi as an antiviral therapy
    Omar Bagasra
    Arnold School of Public Health, Claflin University, Orangeburg, SC 29115, USA
    Expert Opin Biol Ther 5:1463-74. 2005
    ..The changing nature of HIV-1 genomes and the possible presence of microRNAs within the HIV-1 genes can suppress RNAi directed against HIV-1 gene targets. Thus, HIV-1 would be a difficult epidemic to overcome by RNAi-based therapeutics...
  7. ncbi Localization of human herpesvirus type 8 in human sperms by in situ PCR
    Omar Bagasra
    South Carolina Center for Biotechnology, Department of Biology, Claflin University, 400 Magnolia Street, Orangeburg, SC 29115, USA
    J Mol Histol 36:401-12. 2005
    ..In our studies, we sought to assess the cellular reservoirs of HHV-8 DNA in the semen of HIV-1-infected men and the potential role of HHV-8 infected spermatozoa in horizontal transmission...
  8. ncbi Protocols for the in situ PCR-amplification and detection of mRNA and DNA sequences
    Omar Bagasra
    South Carolina Center for Biotechnology, Department of Biology, Claflin University, JST 215, 400 Magnolia Street, Orangeburg, South Carolina 29115, USA
    Nat Protoc 2:2782-95. 2007
    ..An average of 48 h is required to carry out the technique...
  9. ncbi A unified concept of HIV latency
    Omar Bagasra
    South Carolina Center for Biotechnology, ClaflinUniversity, 400 Magnolia Street, Orangeburg, SC 29115, USA
    Expert Opin Biol Ther 6:1135-49. 2006
    ..This review presents various models of HIV-1 latency and forward a new unified model of lentiviral latency...
  10. pmc miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells
    Brittany L Mihelich
    Department of Pathology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:44503-11. 2011
    ..Individually or as a cluster, miR-183, -96, and -182 are overexpressed in other cancers too, implicating this miR cluster in carcinogenesis...
  11. ncbi Of lives and livers: emerging responses to the hepatitis C virus
    Samina Noorali
    Department of Biology, Claflin University Orangeburg, SC, USA
    J Infect Dev Ctries 5:1-17. 2011
    ..However, any RNAi based therapy may be years away due to off-target effects...
  12. doi Differential zinc accumulation and expression of human zinc transporter 1 (hZIP1) in prostate glands
    Leslie A Johnson
    South Carolina Center for Biotechnology, Claflin University, 400 Magniolia Street, Orangeburg, SC 29115, USA
    Methods 52:316-21. 2010
    ....
  13. ncbi Prevalence of Hepatitis B virus genotype D in females in Karachi, Pakistan
    Samina Noorali
    Department of Biology, Claflin University, 400 Magnolia Street, Orangeburg, South Carolina 29115, United States of America
    J Infect Dev Ctries 2:373-8. 2008
    ..The aim of the study was to investigate the prevalence of HBV genotypes in physically healthy females at two universities in Karachi, Sindh, Pakistan...
  14. ncbi Latest developments in in situ PCR
    Omar Bagasra
    Department of Biology, Claflin University, Orangeburg, SC, USA
    Methods Mol Biol 334:221-40. 2006
    ..This protocol should serve as a primer for the investigators, and each researcher must use his or her variation according to their needs...
  15. doi Triplex-forming MicroRNAs form stable complexes with HIV-1 provirus and inhibit its replication
    Mazhar Kanak
    Department of Biology, South Carolina Center for Biotechnology, Claflin University, 400 Magnolia Street, Orangeburg, SC 29115, USA
    Appl Immunohistochem Mol Morphol 18:532-45. 2010
    ..We have explored TF complexes between human miRNAs (hsa-miR) that are complementary to human immunodeficiency virus (HIV)-1 and their antiviral potential as therapeutic agents...
  16. doi Role of HERV-W syncytin-1 in placentation and maintenance of human pregnancy
    Samina Noorali
    South Carolina Center for Biotechnology, Claflin University, Orangeburg, SC 29115, USA
    Appl Immunohistochem Mol Morphol 17:319-28. 2009
    ..In conclusion, our findings suggest that expression of syncytin-1 (HERV-W env) in utero is expressed exclusively in the syncytiotrophoblast layer and is upregulated by progesterone...
  17. ncbi Prostate cancer in African American men is associated with downregulation of zinc transporters
    Irum Rishi
    University of South Carolina Cancer Research Center, Columbia, SC, USA
    Appl Immunohistochem Mol Morphol 11:253-60. 2003
    ..Because dietary zinc supplements are relatively nontoxic, any efficacy trial would be low-risk...
  18. ncbi In situ PCR protocols
    Omar Bagasra
    Department of Biology, Claflin University, Orangeburg, SC, USA
    Methods Mol Biol 334:61-78. 2006
    ..We have declined to devote detailed discussions on in situ hybridization because there are several excellent articles and books available on this subject...
  19. doi In situ polymerase chain reaction and hybridization to detect low-abundance nucleic acid targets
    Omar Bagasra
    South Carolina Center for Biotechnology, Claflin University, Orangeburg, South Carolina, USA
    Curr Protoc Mol Biol . 2008
    ..It includes all essential components of the techniques, including variations suitable for different kinds of tissue and cell preparations. Planning, controls, and critical parameters for the amplification steps are discussed...
  20. doi Bacteriophage therapy: a potential solution for the antibiotic resistance crisis
    Zhabiz Golkar
    South Carolina Center for Biotechnology, Claflin University, Orangeburg, United States
    J Infect Dev Ctries 8:129-36. 2014
    ..We discuss the advantages and disadvantages of bacteriophages as therapeutic agents in this regard. ..
  21. ncbi RNA interference: the molecular immune system
    Omar Bagasra
    South Carolina Center for Biotechnology, Claflin University, Orangeburg, SC 29115, USA
    J Mol Histol 35:545-53. 2004
    ..The potential for therapeutic application of RBGS technology in treating viral infections such as HIV is also discussed...
  22. ncbi A practice for all seasons: male circumcision and the prevention of HIV transmission
    Krishna C Addanki
    South Carolina Center for Biotechnology, Claflin University, Orangeburg, South Carolina 29115, USA
    J Infect Dev Ctries 2:328-34. 2008
    ..Moreover, many nations have initiated adult circumcision as a public health measure...
  23. ncbi Evaluation of Th-1 and Th-2 immune responses in the skin lesions of patients with Blau syndrome
    Ashrafe S Ewida
    Department of Biology, Lincoln University, Oxford, PA, USA
    Appl Immunohistochem Mol Morphol 10:171-7. 2002
    ..Further studies would be necessary to confirm the presence of other cytokines and to establish the regulatory roles of Th-1 and Th-2 lymphocytes in the pathogenesis of Blau syndrome...
  24. ncbi A large number of the human microRNAs target lentiviruses, retroviruses, and endogenous retroviruses
    Shazia T Hakim
    Department of Microbiology, Jinnah University for Women, Karachi 74600, Pakistan
    Biochem Biophys Res Commun 369:357-62. 2008
    ..e. HERV-K). Implications of these observations in RE disease and therapy are discussed...
  25. doi NACO and the World Bank are correct in their crackdowns
    D Gene Pace
    Nat Med 14:588. 2008
  26. ncbi Zinc and prostate cancer: a critical scientific, medical, and public interest issue (United States)
    Leslie C Costello
    Department of Biomedical Sciences, Dental School, University of Maryland, 666 W Baltimore St, Baltimore, MD 21201, USA
    Cancer Causes Control 16:901-15. 2005
    ....

Research Grants1

  1. Training of Claflin Minorities at the USC Cancer Center
    Omar Bagasra; Fiscal Year: 2005
    ..The PIs of these projects will be Dr. Omar Bagasra of Claflin University, and Dr. Kim E. Creek of the SCCC.