H J Meadows

Summary

Affiliation: SmithKline Beecham Pharmaceuticals
Country: USA

Publications

  1. ncbi Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel
    H J Meadows
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Pflugers Arch 439:714-22. 2000
  2. ncbi The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK
    H J Meadows
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Brain Res 892:94-101. 2001
  3. ncbi Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel
    H J Meadows
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex CM19 5AW, UK
    Neuropharmacology 40:551-9. 2001
  4. ncbi Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel
    C G Chapman
    Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Essex CM19 5AW, Harlow, UK
    Brain Res Mol Brain Res 82:74-83. 2000
  5. ncbi Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
    P Hayes
    Department of Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow CM19 5AW, UK
    Pain 88:205-15. 2000
  6. ncbi Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS
    G J Hervieu
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, Third Avenue, Essex CM19 5AW, Harlow, UK
    Neuroscience 103:899-919. 2001
  7. ncbi Recombinant hTASK1 is an O(2)-sensitive K(+) channel
    A Lewis
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
    Biochem Biophys Res Commun 285:1290-4. 2001
  8. pmc Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K+ channels in central neuroprotection
    P Miller
    School of Biomedical Sciences, University of Leeds, UK
    J Physiol 548:31-7. 2003

Collaborators

Detail Information

Publications8

  1. ncbi Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel
    H J Meadows
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Pflugers Arch 439:714-22. 2000
    ..Only low levels of expression were seen in the majority of peripheral regions. Thus, hTREK-1, although functionally and pharmacologically similar to mouse TREK-1, appears to have a more CNS-specific distribution...
  2. ncbi The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK
    H J Meadows
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Brain Res 892:94-101. 2001
    ..The related compound lamotrigine, which is a better anticonvulsant but weaker neuroprotective agent than sipatrigine, was a far less effective antagonist of both channels, producing <10% inhibition at a concentration of 10 microM...
  3. ncbi Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel
    H J Meadows
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex CM19 5AW, UK
    Neuropharmacology 40:551-9. 2001
    ..4. Furthermore, the activity of TASK-3 was potentiated by the volatile anaesthetic halothane but inhibited by the local anaesthetic bupivacaine...
  4. ncbi Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel
    C G Chapman
    Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Essex CM19 5AW, Harlow, UK
    Brain Res Mol Brain Res 82:74-83. 2000
    ..TASK-3 is inhibited by extracellular acidosis with a mid-point of inhibition around pH 6. 5, supporting the predictions from the sequence data that this is a third human TASK (TWIK-related acid sensitive K(+) channel) gene...
  5. ncbi Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
    P Hayes
    Department of Biotechnology and Genetics, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow CM19 5AW, UK
    Pain 88:205-15. 2000
    ..Together the sequence homology, similar expression profile and functional properties confirm that the cloned cDNA represents the human orthologue of rat VR1...
  6. ncbi Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS
    G J Hervieu
    Neuroscience Research, SmithKline Beecham Pharmaceuticals, Third Avenue, Essex CM19 5AW, Harlow, UK
    Neuroscience 103:899-919. 2001
    ..These studies indicate a widespread distribution of TREK-1 potassium channels throughout the rat brain and spinal cord, with expression in a number of areas being demonstrated to be present on GABA-containing neurones...
  7. ncbi Recombinant hTASK1 is an O(2)-sensitive K(+) channel
    A Lewis
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom
    Biochem Biophys Res Commun 285:1290-4. 2001
    ..These data represent the first direct verification that hTASK1 is O(2)-sensitive and reinforce the idea that this K(+) channel is key to O(2) sensing in chemoreceptors...
  8. pmc Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K+ channels in central neuroprotection
    P Miller
    School of Biomedical Sciences, University of Leeds, UK
    J Physiol 548:31-7. 2003
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