Ralph McGinnis

Summary

Affiliation: SmithKline Beecham Pharmaceuticals
Country: USA

Publications

  1. pmc General equations for Pt, Ps, and the power of the TDT and the affected-sib-pair test
    R McGinnis
    SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AW, United Kingdom
    Am J Hum Genet 67:1340-7. 2000
  2. ncbi request reprint Power and efficiency of the TDT and case-control design for association scans
    Ralph McGinnis
    GlaxoSmithKline Pharmaceuticals, Harlow, Essex, United Kingdom
    Behav Genet 32:135-44. 2002
  3. pmc Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    Heribert Schunkert
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:1675-84. 2008
  4. pmc Newly identified genetic risk variants for celiac disease related to the immune response
    Karen A Hunt
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Nat Genet 40:395-402. 2008
  5. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
  6. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
  7. pmc A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    David A van Heel
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK
    Nat Genet 39:827-9. 2007
  8. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
  9. pmc Association of warfarin dose with genes involved in its action and metabolism
    Mia Wadelius
    Department of Medical Sciences, Clinical Pharmacology, University Hospital, 751 85 Uppsala, Sweden
    Hum Genet 121:23-34. 2007
  10. ncbi request reprint Treasure hunting in a new era: genotyping of single nucleotide polymorphisms and the search for complex disease genes by association scans
    Ralph McGinnis
    Psychiatr Genet 12:63-6. 2002

Collaborators

Detail Information

Publications11

  1. pmc General equations for Pt, Ps, and the power of the TDT and the affected-sib-pair test
    R McGinnis
    SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AW, United Kingdom
    Am J Hum Genet 67:1340-7. 2000
    ....
  2. ncbi request reprint Power and efficiency of the TDT and case-control design for association scans
    Ralph McGinnis
    GlaxoSmithKline Pharmaceuticals, Harlow, Essex, United Kingdom
    Behav Genet 32:135-44. 2002
    ..Nevertheless, possible population stratification needs to be addressed when the case-control design is applied...
  3. pmc Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    Heribert Schunkert
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:1675-84. 2008
    ..3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis...
  4. pmc Newly identified genetic risk variants for celiac disease related to the immune response
    Karen A Hunt
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Nat Genet 40:395-402. 2008
    ..Type 1 diabetes and celiac disease share HLA-DQ, IL2-IL21, CCR3 and SH2B3 risk regions. Thus, this extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways...
  5. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  6. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  7. pmc A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    David A van Heel
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK
    Nat Genet 39:827-9. 2007
    ..3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease...
  8. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  9. pmc Association of warfarin dose with genes involved in its action and metabolism
    Mia Wadelius
    Department of Medical Sciences, Clinical Pharmacology, University Hospital, 751 85 Uppsala, Sweden
    Hum Genet 121:23-34. 2007
    ..Translation of this knowledge into clinical guidelines for warfarin prescription will be likely to have a major impact on the safety and efficacy of warfarin...
  10. ncbi request reprint Treasure hunting in a new era: genotyping of single nucleotide polymorphisms and the search for complex disease genes by association scans
    Ralph McGinnis
    Psychiatr Genet 12:63-6. 2002
    ..In this article, I sketch empirical results and statistical theory that together form the scientific rationale for anticipating enhanced success in gene mapping in the new era that is now approaching...
  11. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....