Andreas Ludwig

Summary

Affiliation: SmithKline Beecham Pharmaceuticals
Country: USA

Publications

  1. ncbi Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity
    Andreas Ludwig
    Department of Vascular Biology and Neuroscience, GlaxoSmithKline, Harlow, United Kingdom
    J Immunol 168:604-12. 2002
  2. ncbi Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules
    Andreas Ludwig
    Biochemical Institute, Christian Albrechts University, Kiel, Germany
    Comb Chem High Throughput Screen 8:161-71. 2005
  3. ncbi Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes
    Christian Hundhausen
    Institute of Biochemistry, Christian Albrechts University, Kiel, Germany
    J Immunol 178:8064-72. 2007
  4. ncbi Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin
    Felix Scholz
    Department of Dermatology, Venerology and Allergology, UKSH, Kiel, Germany
    J Invest Dermatol 127:1444-55. 2007
  5. pmc ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
    Thorsten Maretzky
    Biochemical Institute and Department of Dermatology, Christian Albrechts University Kiel, D 24098 Kiel, Germany
    Proc Natl Acad Sci U S A 102:9182-7. 2005
  6. ncbi Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells
    Andreas Ludwig
    Institute of Biochemistry, Christian Albrechts University, Kiel, Olshausenstrasse, Germany
    J Neurochem 93:1293-303. 2005
  7. pmc ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
    Karina Reiss
    Biochemical Institute, Christian Albrechts University Kiel, Kiel, Germany
    EMBO J 24:742-52. 2005
  8. ncbi Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17)
    Vadim Budagian
    Center for Cancer Drug Discovery and Development, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 279:40368-75. 2004
  9. ncbi The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10
    Soeren Abel
    Institute for Biochemistry, Christian Albrechts University, Kiel, Germany
    J Immunol 172:6362-72. 2004
  10. ncbi Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
    Vance Matthews
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    J Biol Chem 278:38829-39. 2003

Collaborators

  • Stefan Rose-John
  • Michael P Sanderson
  • Millard H Lambert
  • Hinrich P Hansen
  • C P Blobel
  • Marcus Frank
  • S Gauer
  • P C Baer
  • Christian Weber
  • K Ley
  • Janka Held Feindt
  • R Mentlein
  • Roy A Black
  • Paul Saftig
  • Karina Reiss
  • Dieter Hartmann
  • Thorsten Maretzky
  • Christian Hundhausen
  • Vadim Budagian
  • Vance Matthews
  • Beate Schulz
  • Felix Scholz
  • Peter Altevogt
  • Alexander Schulte
  • Neil Broadway
  • Karl Josef Kallen
  • Ingo Ahrens
  • David Frommhold
  • Anja Schramme
  • Lakhvir K Assi
  • Claudia Litterst
  • Elena Galkina
  • Dennis A Eichenauer
  • Paul Gutwein
  • Irit Shoval
  • Teruyuki Muraguchi
  • Brigitte Held
  • Alexander Stoeck
  • Gisela Weskamp
  • Marc Schulte
  • Bart De Strooper
  • Ernst Brandt
  • Tamer Rabie
  • Elena Bulanova
  • Zane Orinska
  • Silvia Bulfone-Paus
  • Soeren Abel
  • Agnes Bankfalvi
  • Theo A Berkhout
  • Barbara Much
  • Beate Schlierf
  • Franziska Schwartzkopff
  • Ewelina Sobkowiak
  • Eva Kiss
  • M Gabriele Bixel
  • Liliana Schäfer
  • Heinfried Radeke
  • Christoph Ellwanger
  • Nicholas Obermüller
  • Belinda K Smith
  • Jessica Pruessmeyer
  • Dietmar Vestweber
  • Hermann Josef Grone
  • Melitta Weissinger
  • Christoph Bode
  • Alma Zernecke
  • Markus Sperandio
  • Josef Pfeilschifter
  • Jamey D Marth
  • Michael Koziolek
  • Mohamed Sadek Abdel-Bakky
  • Ingeborg A Hauser
  • Lesley G Ellies
  • Karlheinz Peter
  • Bärbel Lange-Sperandio
  • Alexander Zarbock
  • Yung Chih Chen
  • Sandra Cauwenberghs
  • Irene Neudorfer
  • Nicole Bassler
  • Annette G Beck-Sickinger
  • Itamar Goren
  • Michael Sixt
  • Ritva Tikkanen
  • Inna Babushkina
  • Agatha Schwarz
  • Krzysztof Paliga
  • Elisa A Liehn
  • See Heng Wong
  • Karim Raza

Detail Information

Publications34

  1. ncbi Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity
    Andreas Ludwig
    Department of Vascular Biology and Neuroscience, GlaxoSmithKline, Harlow, United Kingdom
    J Immunol 168:604-12. 2002
    ....
  2. ncbi Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules
    Andreas Ludwig
    Biochemical Institute, Christian Albrechts University, Kiel, Germany
    Comb Chem High Throughput Screen 8:161-71. 2005
    ..Thus, GI254023X may by of use as a preferential inhibitor of constitutive shedding events without effecting the inducible shedding in response to agonists acting similar to PMA...
  3. ncbi Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes
    Christian Hundhausen
    Institute of Biochemistry, Christian Albrechts University, Kiel, Germany
    J Immunol 178:8064-72. 2007
    ..These data provide evidence for an inducible release mechanism via ADAM10 potentially important for leukocyte diapedesis...
  4. ncbi Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin
    Felix Scholz
    Department of Dermatology, Venerology and Allergology, UKSH, Kiel, Germany
    J Invest Dermatol 127:1444-55. 2007
    ..Thus, CXCL16 is constitutively expressed on the surface of human epidermal keratinocytes, released upon cell activation or photodamage and may then target CXCR6-expressing T cells in the dermis...
  5. pmc ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
    Thorsten Maretzky
    Biochemical Institute and Department of Dermatology, Christian Albrechts University Kiel, D 24098 Kiel, Germany
    Proc Natl Acad Sci U S A 102:9182-7. 2005
    ..Our data strongly suggest that this protease constitutes a major regulatory element for the multiple functions of E-cadherin under physiological as well as pathological conditions...
  6. ncbi Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells
    Andreas Ludwig
    Institute of Biochemistry, Christian Albrechts University, Kiel, Olshausenstrasse, Germany
    J Neurochem 93:1293-303. 2005
    ..Thus, the transmembrane chemokine CXCL16 is expressed in the brain by malignant and inflamed astroglial cells, shed to a soluble form and targets not only activated T cells but also glial cells themselves...
  7. pmc ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
    Karina Reiss
    Biochemical Institute, Christian Albrechts University Kiel, Kiel, Germany
    EMBO J 24:742-52. 2005
    ....
  8. ncbi Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17)
    Vadim Budagian
    Center for Cancer Drug Discovery and Development, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 279:40368-75. 2004
    ..The existence of natural sIL-15Ralpha offers novel insights into the complex biology of IL-15 and envisages a new level for therapeutic intervention...
  9. ncbi The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10
    Soeren Abel
    Institute for Biochemistry, Christian Albrechts University, Kiel, Germany
    J Immunol 172:6362-72. 2004
    ..Hence, during inflammation in the vasculature, ADAM10 may act as a CXCL16 sheddase and thereby finely control the expression and function of CXCL16 in the inflamed tissue...
  10. ncbi Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
    Vance Matthews
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    J Biol Chem 278:38829-39. 2003
    ..For decades, high cholesterol levels have been considered harmful. This study indicates that low cholesterol levels may play a role in shedding of the membrane-bound IL-6R and thereby in the immunopathogenesis of human diseases...
  11. ncbi The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
    Christian Hundhausen
    Institute for Biochemistry, Christian Albrechts University, Kiel, Germany
    Blood 102:1186-95. 2003
    ..Our data demonstrate that ADAM10 is involved in the constitutive cleavage of CX3CL1 and thereby may regulate the recruitment of monocytic cells to CX3CL1-expressing cell layers...
  12. ncbi CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall
    Elena Galkina
    Department of Biomedical Engineering and Robert M Berne Cardiovascular Research Center, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    Circulation 116:1801-11. 2007
    ....
  13. doi Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney
    Anja Schramme
    1pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Kidney Int 74:328-38. 2008
    ..Our results suggest that CXCL16 and ADAM10 are involved in the recruitment of T cells to the kidney and play an important role in inflammatory kidney diseases...
  14. ncbi Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor
    Claudia Litterst
    Department of Psychiatry and Neuroscience, Mount Sinai School of Medicine New York University, New York, NY 10029, USA, and Institute for Molecular Cardiovascular Research, University Hospital Reinisch West Faelische Technische Hochschule, Aachen, Germany
    J Biol Chem 282:16155-63. 2007
    ..Our data identify novel cleavages and modifications of EphB2 receptor and indicate that specific conditions determine the proteolytic systems and subcellular sites involved in the processing of this receptor...
  15. ncbi Transmembrane chemokines: versatile 'special agents' in vascular inflammation
    Andreas Ludwig
    Institute of Molecular Cardiovascular Research IMCAR, University Hospital, RWTH Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Thromb Haemost 97:694-703. 2007
    ..Small molecules that block either the receptors or the shedding enzymes of transmembrane chemokines need to be tested in animal models of vascular inflammation...
  16. pmc Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint
    Lakhvir K Assi
    Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Arthritis Rheum 56:1776-86. 2007
    ..This study was undertaken to investigate the expression of BLyS and regulation of BLyS release from the surface of neutrophils infiltrating the rheumatoid joint...
  17. pmc ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin
    Beate Schulz
    Biochemical Institute, Christian Albrecht University Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Circ Res 102:1192-201. 2008
    ....
  18. ncbi RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity
    Teruyuki Muraguchi
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Nat Neurosci 10:838-45. 2007
    ..These findings indicate that RECK is a physiological inhibitor of ADAM10, an upstream regulator of Notch signaling and a critical modulator of brain development...
  19. doi Selenium supplementation induces metalloproteinase-dependent L-selectin shedding from monocytes
    Ingo Ahrens
    Department of Cardiology and Angiology, University Hospital of Freiburg, Freiburg, Germany
    J Leukoc Biol 83:1388-95. 2008
    ..The impairment of monocyte adhesion by selenium supplementation may represent an important, underlying mechanism for the modulation of inflammatory reactions in patients with severe sepsis...
  20. ncbi Ca2+ channel currents and contraction in CaVbeta3-deficient ileum smooth muscle from mouse
    Brigitte Held
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultat, Universitat des Saarlandes, D 66421 Homburg, Germany
    Cell Calcium 42:477-87. 2007
    ....
  21. ncbi ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro
    Dennis A Eichenauer
    Department of Internal Medicine I and Center for Molecular Medicine, University Hospital Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Cancer Res 67:332-8. 2007
    ....
  22. ncbi Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination
    Irit Shoval
    Department of Anatomy and Cell Biology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Development 134:491-501. 2007
    ..Hence, by promoting its cleavage, BMP4 converts N-cadherin inhibition into an activity that is likely to participate, along with canonical Wnt signaling, in the stimulation of neural crest emigration...
  23. ncbi The CXC chemokine NAP-2 mediates differential heterologous desensitization of neutrophil effector functions elicited by platelet-activating factor
    Franziska Schwartzkopff
    Department of Immunology and Cell Biology, Research Center Borstel, D 23845 Borstel, Germany
    J Interferon Cytokine Res 22:257-67. 2002
    ..Thus, a role for NAP-2 may be to limit PAF-dependent vascular tissue damage by preventing degranulation of neutrophils without affecting their migration into the inflamed tissue...
  24. pmc Cooperative binding of Sox10 to DNA: requirements and consequences
    Beate Schlierf
    Institut fur Biochemie, Fahrstrasse 17, 91054 Erlangen, Germany
    Nucleic Acids Res 30:5509-16. 2002
    ....
  25. ncbi Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels
    Barbara Much
    Department Pharmazie Pharmakologie für Naturwissenschaften, Ludwig Maximilians Universitat Munchen, Butenandtstrasse 7, 81377 Munchen, Germany
    J Biol Chem 278:43781-6. 2003
    ..Taken together our results indicate that subunit heteromerization and glycosylation are important determinants of the formation of native HCN channels...
  26. ncbi Different proliferative activity of the glandular and myoepithelial lineages in benign proliferative and early malignant breast diseases
    Agnes Bankfalvi
    Institute of Pathology, Munster University Hospital, Munster, Germany
    Mod Pathol 17:1051-61. 2004
    ..Our results provide cell kinetic support to the functional progenitor cell hypothesis, and we propose this concept as an operative model for understanding benign proliferative and malignant breast diseases...
  27. ncbi Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V
    Tamer Rabie
    Vascular Biology, Rudolf Virchow Center, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
    J Biol Chem 280:14462-8. 2005
    ..These results demonstrate that GPV is cleaved upon agonist-induced platelet activation and show that ADAM17 is the major enzyme mediating this process...
  28. pmc L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth
    Thorsten Maretzky
    Biochemical Institute, Christian Albrechts University Kiel, Germany
    Mol Cell Biol 25:9040-53. 2005
    ..Thus, our data identify ADAM10 and ADAM17 as differentially regulated L1 membrane sheddases, both critically affecting the physiological functions of this adhesion protein...
  29. pmc Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum
    Vadim Budagian
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Mol Cell Biol 25:9324-39. 2005
    ..Upon immobilization, sAxl promoted cell migration and induced the phosphorylation of Axl and phosphatidylinositol 3-kinase. Thus, ADAM10-mediated generation of sAxl might play an important role in diverse biological processes...
  30. pmc A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44
    Alexander Stoeck
    Tumor Immunology Programme, D010, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochem J 393:609-18. 2006
    ..Our findings open up the possibility that exosomes serve as a platform for ectodomain shedding and as a vehicle for the cellular export of soluble molecules...
  31. ncbi Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion
    Karina Reiss
    Biochemical Institute, Christian Albrecht University Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Pharmacol Ther 111:985-1006. 2006
    ..Moreover, metalloproteases of the ADAM family are emerging as promising targets for new therapeutic options...
  32. ncbi Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion
    Karina Reiss
    Biochemical Institute, Christian Albrecht University Kiel, D 24098 Kiel, Germany
    J Biol Chem 281:21735-44. 2006
    ..The identification of ADAM10 as the protease responsible for constitutive and regulated Pcdh gamma shedding may therefore provide new insight into the regulation of Pcdh gamma functions...
  33. ncbi ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23
    Gisela Weskamp
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery and Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Immunol 7:1293-8. 2006
    ..Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies...
  34. pmc Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
    David Frommhold
    Children s Hospital, University of Heidelberg, 69120 Heidelberg, Germany
    J Exp Med 205:1435-46. 2008
    ..Collectively, we provide substantial evidence that sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo...