S Kumar

Summary

Affiliation: SmithKline Beecham Pharmaceuticals
Country: USA

Publications

  1. ncbi request reprint Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli
    S Kumar
    Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Biochem Biophys Res Commun 235:474-8. 1997
  2. ncbi request reprint IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase
    S Kumar
    Department of Musculoskeletal Diseases, Glaxo SmithKline, King of Prussia, Pennsylvania, USA
    J Cell Physiol 187:294-303. 2001
  3. ncbi request reprint Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    Biochem Biophys Res Commun 263:825-31. 1999
  4. ncbi request reprint Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 274:17123-31. 1999
  5. ncbi request reprint Identification and initial characterization of four novel members of the interleukin-1 family
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:10308-14. 2000
  6. ncbi request reprint Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
    S Kumar
    Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    Biochem Biophys Res Commun 235:533-8. 1997
  7. ncbi request reprint Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
    P R Young
    Department of Comparative Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    J Biol Chem 272:12116-21. 1997
  8. ncbi request reprint SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes
    A M Badger
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    J Immunol 161:467-73. 1998
  9. ncbi request reprint Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures
    A M Badger
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Osteoarthritis Cartilage 8:434-43. 2000
  10. ncbi request reprint Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
    M M McLaughlin
    Department of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 271:8488-92. 1996

Detail Information

Publications80

  1. ncbi request reprint Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli
    S Kumar
    Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Biochem Biophys Res Commun 235:474-8. 1997
    ..The expression of the membrane ST2, however, remained constant. These data suggest a role for ST2 in inflammation...
  2. ncbi request reprint IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase
    S Kumar
    Department of Musculoskeletal Diseases, Glaxo SmithKline, King of Prussia, Pennsylvania, USA
    J Cell Physiol 187:294-303. 2001
    ....
  3. ncbi request reprint Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    Biochem Biophys Res Commun 263:825-31. 1999
    ..Identical results were obtained when the p38 MAPK cascade was partially reconstituted in vitro. Thus, our data clearly indicate that SB 203580 specifically inhibits the activity of p38 MAPK but not its activation by upstream MAPKK...
  4. ncbi request reprint Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 274:17123-31. 1999
    ..In addition, recombinant human CTGF-L inhibits osteocalcin production in rat osteoblast-like Ros 17/2.8 cells. Taken together, these results suggest that CTGF-L may play an important role in modulating bone turnover...
  5. ncbi request reprint Identification and initial characterization of four novel members of the interleukin-1 family
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:10308-14. 2000
    ..This suggests that IL-1H1 may be involved in pathogenesis of immune mediated disease processes. The addition of four novel IL-1 homologues suggests that the IL-1 family is significantly larger than previously thought...
  6. ncbi request reprint Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
    S Kumar
    Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    Biochem Biophys Res Commun 235:533-8. 1997
    ..These data suggest that SAPK3 and SAPK4 form a distinct subset of the p38 MAP kinases with different expression pattern, response to stimuli, substrate specificity, and inhibitor sensitivity...
  7. ncbi request reprint Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
    P R Young
    Department of Comparative Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    J Biol Chem 272:12116-21. 1997
    ....
  8. ncbi request reprint SB 203580 inhibits p38 mitogen-activated protein kinase, nitric oxide production, and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes
    A M Badger
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    J Immunol 161:467-73. 1998
    ..The iNOS mRNA levels were consistent with NO levels in 24-h cell culture supernatants of the IL-1-stimulated bovine chondrocytes used to obtain the RNA...
  9. ncbi request reprint Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures
    A M Badger
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Osteoarthritis Cartilage 8:434-43. 2000
    ..These studies indicate that there are species differences in the control of iNOS by p38 inhibitors and also that different pathways may control IL-1-induced proteoglycan breakdown and NO production...
  10. ncbi request reprint Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
    M M McLaughlin
    Department of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 271:8488-92. 1996
    ..These data suggest that MAPKAP kinase-3 is activated by stress and cytokines and is a novel substrate of CSBP both in vitro and in vivo...
  11. ncbi request reprint ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1
    S Kumar
    Department of Molecular Immunology, SmithKline Beecham Research and Development, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 270:27905-13. 1995
    ..The putative ligand was also able to stimulate CSBP/p38 MAP kinase through the ST2 receptor. These results suggest that the ST2 is not an IL-1 receptor but rather has its own cognate ligand...
  12. ncbi request reprint Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
    R J Gum
    Department of Molecular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 273:15605-10. 1998
    ..These results indicate that these three amino acids can confer specificity and sensitivity to SB 203580 for at least two different classes of MAPKs...
  13. ncbi request reprint Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia
    F C Barone
    SmithKline Beecham Pharmaceuticals, Department of Cardiovascular Pharmacology, King of Prussia, PA 19406, USA
    Med Res Rev 21:129-45. 2001
    ....
  14. ncbi request reprint A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    J C Lee
    Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406
    Nature 372:739-46. 1994
    ..Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production...
  15. ncbi request reprint Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage
    F L Wang
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA
    Osteoarthritis Cartilage 8:161-9. 2000
    ..The purpose of this study was to identify genes that are differentially expressed in normal versus osteoarthritic human articular cartilage as either potential novel therapeutic targets or diagnostic markers of this disease...
  16. ncbi request reprint Clusterin expression in adult human normal and osteoarthritic articular cartilage
    J R Connor
    Department of Musculoskeletal Diseases, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Osteoarthritis Cartilage 9:727-37. 2001
    ..To characterize the expression pattern of clusterin in adult human normal and osteoarthritic cartilage...
  17. ncbi request reprint FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis
    I E James
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, USA
    Osteoarthritis Cartilage 8:452-63. 2000
    ..To characterize a novel secreted frizzled-related protein (SFRP) and determine its tissue distribution at the mRNA and protein level...
  18. ncbi request reprint SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia
    F C Barone
    Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Pharmacol Exp Ther 296:312-21. 2001
    ....
  19. ncbi request reprint Inhibition of p38 MAP kinase as a therapeutic strategy
    J C Lee
    SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA
    Immunopharmacology 47:185-201. 2000
    ..Treatment with p38 MAP kinase inhibitors attenuated both p38 activation and disease severity. Structurally diverse p38 MAP kinase inhibitors have been tested extensively in preclinical studies...
  20. ncbi request reprint Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction
    T M Behr
    Cardiovascular Pharmacology, GlaxoSmithKline, King of Prussia, PA, USA
    Circulation 104:1292-8. 2001
    ..CONCLUSIONS: These results demonstrate a crucial role for p38 MAPK in hypertensive cardiac hypertrophy and end-organ damage. Interrupting its function with a specific p38 MAPK inhibitor halts clinical deterioration...
  21. ncbi request reprint Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol
    T L Yue
    Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Circ Res 82:166-74. 1998
    ..The former two actions represent novel and important mechanisms that may contribute to the cardioprotective effects of carvedilol...
  22. ncbi request reprint TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease
    T L Yue
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19046, USA
    J Biol Chem 274:1479-86. 1999
    ..These findings suggest that TL1 may act as an autocrine factor to induce apoptosis in endothelial cells via activation of multiple signaling pathways, including stress protein kinases as well as certain caspases...
  23. ncbi request reprint CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues
    B J Votta
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    J Cell Physiol 183:196-207. 2000
    ..These observations suggest that CKbeta-8, and perhaps other chemokines, may play a role in the recruitment of osteoclast precursors to sites of bone resorption...
  24. ncbi request reprint Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries
    S Kumar
    Department of Musculoskeletal Diseases, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Rd, King of Prussia, Pennsylvania 19406, USA
    Osteoarthritis Cartilage 9:641-53. 2001
    ..To prepare, sequence and analyse adult human cartilage cDNA libraries to study the gene expression pattern between normal and osteoarthritic cartilage...
  25. doi request reprint Treatment with a potent cathepsin K inhibitor preserves cortical and trabecular bone mass in ovariectomized monkeys
    G B Stroup
    Department of Musculoskeletal Diseases, GlaxoSmithKline Pharmaceuticals, Collegeville, PA 19426, USA
    Calcif Tissue Int 85:344-55. 2009
    ..In cortical bone, osteonal bone formation rate was reduced by alendronate but preserved at low and medium doses of relacatib. Thus, relacatib preserved cortical and cancellous bone mass in ovariectomized monkeys...
  26. ncbi request reprint Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast
    S Kumar
    Department of Molecular Immunology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 270:29043-6. 1995
    ....
  27. ncbi request reprint Intracellular signaling pathways as a target for the treatment of rheumatoid arthritis
    S Kumar
    Musculoskeletal Diseases, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pa 19406 0939, USA
    Curr Opin Pharmacol 1:307-13. 2001
    ..In particular the mitogen-activated protein kinase pathway, the nuclear factor kappaB pathway and the cross-talk between these offer several potential therapeutic opportunities for rheumatoid arthritis...
  28. ncbi request reprint A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys
    S Kumar
    Department of Musculoskeletal Diseases, GlaxoSmithKline, Collegeville, PA 19426, USA
    Bone 40:122-31. 2007
    ..These studies also demonstrate the therapeutic potential of relacatib in the treatment of postmenopausal osteoporosis and serves to model the planned clinical trials in human subjects...
  29. ncbi request reprint Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments
    M A Pratta
    Department of Musculoskeletal Diseases, GlaxoSmithKline Pharmaceutical Company, Collegeville, PA 19426 0989, USA
    Osteoarthritis Cartilage 14:702-13. 2006
    ..To develop an enzyme linked immunosorbent assay (ELISA) to quantify the levels of specific aggrecan fragments generated by aggrecanase-mediated cleavage at the 373Glu-374 Ala bond within the aggrecan interglobular domain...
  30. ncbi request reprint Vascular gene transfer driven by endoglin and ICAM-2 endothelial-specific promoters
    B Velasco
    , CSIC, Madrid, Spain
    Gene Ther 8:897-904. 2001
    ....
  31. ncbi request reprint The biochemical mechanism of caspase-2 activation
    B C Baliga
    Hanson Institute, IMVS, Frome Road, Adelaide 5000, Australia
    Cell Death Differ 11:1234-41. 2004
    ..As caspase-2 does not require cleavage for its initial activation, our findings confirm caspase-2 to be a bona fide initiator caspase...
  32. ncbi request reprint Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes
    H H Zhang
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom B15 2TT
    J Clin Endocrinol Metab 86:2817-25. 2001
    ..In obesity, glucocorticoids may reduce TNF alpha actions in adipose tissue by inhibiting TNF alpha-induced apoptosis, IL-1 beta release, and TNF alpha expression...
  33. ncbi request reprint Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population
    G Kaur
    Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Tissue Antigens 69:113-20. 2007
    ..The data can be used for anthropological comparisons, as well as for association studies with different diseases and for use in transplant situations involving acute and chronic rejection...
  34. ncbi request reprint Interaction of PAH-related compounds with the alpha and beta isoforms of the estrogen receptor
    K C Fertuck
    Department of Biochemistry and Molecular Biology, National Food Safety and Toxicology Center, Michigan State University, Wilson Road, East Lansing, MI 48824-1319, USA
    Toxicol Lett 121:167-77. 2001
    ....
  35. ncbi request reprint ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells
    M P Kline
    Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 21:1549-60. 2007
    ..These data indicate that therapies targeting apoptotic pathways may be effective in MM treatment and warrant clinical evaluation of ABT-737 and similar drugs alone or in combination with other agents in the setting of MM...
  36. ncbi request reprint A biochemical analysis of the activation of the Drosophila caspase DRONC
    L Dorstyn
    Department of Haematology, Hanson Institute, IMVS, Adelaide, SA, Australia
    Cell Death Differ 15:461-70. 2008
    ..These results suggest that, similar to mammalian caspase-2 and caspase-9, the initial cleavage of DRONC is not essential for its activation and suggest a mechanism of ARK-mediated DRONC activation different from that proposed previously...
  37. ncbi request reprint Identification and implantation stage-specific expression of an interferon-alpha-regulated gene in human and rat endometrium
    Q Li
    The Population Council and Rockefeller University, New York, NY 10021, USA
    Endocrinology 142:2390-400. 2001
    ..More importantly, our studies reveal that a complex interplay between the steroid hormone and IFN pathways regulates the expression of these genes in the endometrium at the time of implantation...
  38. ncbi request reprint A new nomenclature for IL-1-family genes
    J E Sims
    Trends Immunol 22:536-7. 2001
  39. ncbi request reprint Design, synthesis, and evaluation of alpha-ketoheterocycles as class C beta-lactamase inhibitors
    S Kumar
    Department of Chemistry, Wesleyan University, Middletown, CT 06459, USA
    Bioorg Med Chem 9:2035-44. 2001
    ..Interpretation of the results was aided by computational models of the tetrahedral adducts. Most of the compounds also inhibited alpha-chymotrypsin but not porcine pancreatic elastase...
  40. ncbi request reprint Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY
    J Doumanis
    Hanson Institute, IMVS, Frome Road, Adelaide, Australia
    Cell Death Differ 14:907-15. 2007
    ..Interestingly, a functional nuclear localization signal was identified in the N-terminal region of BUFFY and in the absence of the MA, BUFFY accumulated in the nucleus. The functional implications of these findings are discussed...
  41. ncbi request reprint Expression of VEGF and its receptors by myeloma cells
    S Kumar
    Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 17:2025-31. 2003
    ..Demonstration of the presence of VEGFR2 in our study provides a potential biological explanation for the preclinical activity observed with VEGFR2 inhibitors...
  42. ncbi request reprint Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc
    T J Daish
    Hanson Institute, IMVS, Adelaide 5000, Australia
    Cell Death Differ 10:1348-56. 2003
    ..Our data suggest that the dronc promoter is regulated in a highly complex manner, and provides an ideal system to explore the temporal and spatial regulation of gene expression driven by nuclear hormone receptors...
  43. ncbi request reprint Immunodetection and molecular forms of plasma vascular endothelial growth factor-C
    S E Duff
    Laboratory Medicine Academic Group, Department of Experimental Pathology, Stopford Building, University of Manchester, Manchester M13 9PT, UK
    Int J Oncol 22:339-43. 2003
    ..The measurement of plasma VEGF-C offers opportunities to explore clinical applications in the management of malignancy, in particular in the prediction of lymphatic spread and in other lymphangiogenesis-related diseases...
  44. ncbi request reprint Hypothyroidism alters the expression of Bcl-2 family genes to induce enhanced apoptosis in the developing cerebellum
    R Singh
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India
    J Endocrinol 176:39-46. 2003
    ....
  45. ncbi request reprint A set of cattle microsatellite DNA markers for genome analysis of riverine buffalo (Bubalus bubalis)
    N Navani
    National Bureau of Animal Genetic Resources, Karnal, India
    Anim Genet 33:149-54. 2002
    ..20, and the mean heterozygosity per polymorphic marker was 0.66 +/- 0.02. Successful genotyping of buffaloes using cattle specific primers suggests that the latter can be a valuable resource for genome analysis in bubaline species...
  46. ncbi request reprint Protein disulfide isomerase assisted protein folding in malaria parasites
    B Mahajan
    Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20895, USA
    Int J Parasitol 36:1037-48. 2006
    ..These studies open the avenues to understand the process of protein folding and secretory pathway in malaria parasites that in turn might aid in the production of superior recombinant vaccines and provide novel drug targets...
  47. ncbi request reprint Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells
    N Raje
    Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA 02114, USA
    Br J Haematol 135:52-61. 2006
    ..7 as determined by the Chou-Talalay method. These studies therefore provide the preclinical rationale for evaluation of Didox, alone and in combination with DNA-damaging agents, to improve patient outcome in MM...
  48. ncbi request reprint The cooperative transforming effects of PAX3-FKHR and IGF-II on mouse myoblasts
    W Wang
    Department of Biological Sciences, Manchester Metropolitan University, Manchester M1 5GD, UK
    Int J Oncol 27:1087-96. 2005
    ..Our results suggest that high expression of PAX3-FKHR and IGF-II in ARMS synergistically play a key role in oncogenesis and tumour progression of ARMS...
  49. ncbi request reprint Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis
    P Chaturvedi
    Microbial, Musculoskeletal, and Proliferative Diseases, GlaxoSmithKline, Collegeville, Pennsylvania 19426, USA
    Arthritis Rheum 54:3513-22. 2006
    ..To evaluate the expression and function of the orphan nuclear receptor Rev-ErbAalpha in articular cartilage and to investigate its role in osteoarthritis (OA)...
  50. ncbi request reprint STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2
    J Doumanis
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5000, Australia
    Cell Death Differ 8:387-94. 2001
    ..Interestingly, unlike other fly caspases, STRICA showed physical association with DIAP2, in cotransfection experiments. These results suggest that STRICA may have a unique cellular function...
  51. ncbi request reprint Characterization of the Drosophila caspase, DAMM
    N L Harvey
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia
    J Biol Chem 276:25342-50. 2001
    ....
  52. pmc Protein folding and function: the N-terminal fragment in adenylate kinase
    S Kumar
    Laboratory of Experimental and Computational Biology, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Biophys J 80:2439-54. 2001
    ..Furthermore, this element is critically important for the function of the enzyme, coupling folding, and function...
  53. ncbi request reprint Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase
    M Liedtke
    Cancer Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Oncogene 17:1889-92. 1998
    ..Importantly, SHPTP1 also decreases Bcr-Abl-dependent transformation of fibroblasts. These findings indicate that SHPTP1 functions as a tumor suppressor in cells transformed by Bcr-Abl...
  54. ncbi request reprint Expression of DRG during murine embryonic development
    T Sazuka
    Laboratory of Molecular Oncology, RIKEN, Tsukuba Life Science Center, Ibaraki, Japan
    Biochem Biophys Res Commun 189:371-7. 1992
    ..The expression of drg mRNA is greatly reduced in newborn animals. At cellular level, DRG protein can be detected in the cytoplasm. These observations suggest that DRG may play multiple roles in development and normal cell metabolism...
  55. ncbi request reprint Evolution of functional diversification of the paired box (Pax) DNA-binding domains
    K A Balczarek
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Mol Biol Evol 14:829-42. 1997
    ..Implications of such fixed amino acid differences in potentially generating sequence recognition specificities are discussed in the context of some recent experimental findings...
  56. ncbi request reprint Characterization of a mammalian cell death gene Nedd2
    S Kumar
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Japan
    Leukemia 11:385-6. 1997
    ..elegans) cell death gene ced-3. Our data suggest that Nedd2 is an important component of the mammalian programmed cell death machinery...
  57. ncbi request reprint Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures
    M Kinoshita
    Department of Molecular Oncology, Graduate School of Medicine, Kyoto University, Japan
    Genes Dev 11:1535-47. 1997
    ....
  58. ncbi request reprint Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity
    S Kumar
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:13548-54. 1997
    ....
  59. ncbi request reprint Effects of Mg2+ and denaturants on the unfolding pattern of DNA-T--a replication protein of E. coli
    T Antony
    Centre for Biochemical Technology, Delhi, India
    Int J Biol Macromol 19:91-7. 1996
    ..The results suggest that the pathways of unfolding of thermal- and urea-induced transitions are different. MgCl2, which affects the conformation of the protein and stabilises the secondary structure, also affects the unfolding pattern...
  60. ncbi request reprint Molecular cloning and biological activity of a novel developmentally regulated gene encoding a protein with beta-transducin-like structure
    S Kumar
    Cancer Institute, Japanese Foundation for Cancer Research, Tokyo
    J Biol Chem 269:11318-26. 1994
    ..The strongest effects were evident in differentiation-competent neuroblastoma-derived cell lines. Our results suggest that the Nedd1 gene may play a role in the differentiation-coupled growth arrest in neuronal cells...
  61. ncbi request reprint Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme
    S Kumar
    Department of Viral Oncology, Japanese Foundation for Cancer Research, Tokyo
    Genes Dev 8:1613-26. 1994
    ..Our data suggest that Nedd2 is an important component of the mammalian programmed cell death machinery...
  62. ncbi request reprint Uromodulin (Tamm-Horsfall glycoprotein): a renal ligand for lymphokines
    C Hession
    Science 237:1479-84. 1987
    ..Thus, uromodulin (Tamm-Horsfall glycoprotein) may function as a unique renal regulatory glycoprotein that specifically binds to and regulates the circulating activity of a number of potent cytokines, including IL-1 and TNF...
  63. ncbi request reprint Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase
    A M Dizhoor
    Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, USSR
    Science 251:915-8. 1991
    ..A comparison of recoverin with other calcium binding proteins reveals that it may represent, along with the protein visinin, a family of proteins that are regulated by submicromolar calcium concentrations...
  64. pmc Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts
    S Kumar
    Department of Biological Sciences, State University of New York, Albany 12222
    Proc Natl Acad Sci U S A 89:4683-7. 1992
    ..The mechanism for this constitutive production of IL-1 is explored in this paper...
  65. ncbi request reprint p300/MDM2 complexes participate in MDM2-mediated p53 degradation
    S R Grossman
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:405-15. 1998
    ..Taken together, the data indicate that specific interactions between p300/CBP C/H1, p53, and MDM2 are intimately involved in the MDM2-mediated control of p53 abundance...
  66. ncbi request reprint Calpain activation is upstream of caspases in radiation-induced apoptosis
    N J Waterhouse
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Cell Death Differ 5:1051-61. 1998
    ..These results support a role for calpain in the early phases of the radiation-induced apoptosis pathway, upstream of the caspases...
  67. ncbi request reprint Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis
    P A Colussi
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
    Immunol Cell Biol 77:58-63. 1999
    ..The present review discusses these recent findings and elaborates on how these mutant mouse models have helped the understanding of the mechanisms that govern programmed cell death in the immune and other systems...
  68. ncbi request reprint Chimeric caspase molecules with potent cell killing activity in apoptosis-resistant cells
    L Shearwin-Whyatt
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia, 5000, Australia
    Biochem Biophys Res Commun 282:1114-9. 2001
    ..Here we show that these chimeric caspase molecules possess potent, rapid cell-killing activity in cell lines which display a range of defects resulting in apoptosis resistance...
  69. ncbi request reprint The fly caspases
    S Kumar
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5000, Australia
    Cell Death Differ 7:1039-44. 2000
    ..The presence of multiple caspases in Drosophila indicates that apoptotic pathways in insects are likely to be as complex as in vertebrates...
  70. ncbi request reprint The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome
    M F Kleijnen
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 6:409-19. 2000
    ..Our findings raise the possibility that the hPLIC proteins, and possibly related ubiquitin-like family members, may functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation...
  71. ncbi request reprint Cloning of a cDNA which encodes a novel ubiquitin-like protein
    S Kumar
    Department of Viral Oncology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo
    Biochem Biophys Res Commun 195:393-9. 1993
    ..These data suggest that like ubiquitin, the product of this gene may play some essential role in eukaryotic cellular metabolism...
  72. ncbi request reprint Expansion and molecular evolution of the interferon-induced 2'-5' oligoadenylate synthetase gene family
    S Kumar
    Department of Biology and Molecular and Cellular Biology Program, Arizona State University, Tempe 85287 1501, USA
    Mol Biol Evol 17:738-50. 2000
    ..Evolutionary analyses show that the 2'-5'OAS genes in rodents underwent gene duplications as recently as 11 MYA and predict the existence of additional undiscovered OAS genes in mammals...
  73. ncbi request reprint Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD
    L M Shearwin-Whyatt
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Frome Road, Adelaide, Australia
    Cell Death Differ 7:155-65. 2000
    ..We also present evidence that RAIDD-CARD oligomerization may be regulated by intramolecular folding of the RAIDD molecule...
  74. pmc Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery
    P A Colussi
    The Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    J Cell Biol 148:703-14. 2000
    ..RNA interference studies indicate that Debcl is required for developmental apoptosis in Drosophila embryos. These results suggest that the main components of the mammalian apoptosis machinery are conserved in insects...
  75. ncbi request reprint DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7
    L Dorstyn
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia
    J Biol Chem 274:30778-83. 1999
    ....
  76. ncbi request reprint Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase SHPTP1
    S Kumar
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:30657-63. 1999
    ..Taken together, these findings suggest that SHPTP1 plays a negative role in PYK2/RAFTK signaling by dephosphorylating RAFTK...
  77. pmc Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase
    C D Novina
    Department of Pathology and Program in Immunology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 19:5014-24. 1999
    ..Thus, mutations impairing the physical and/or functional association between TFII-I and Btk may result in diminished TFII-I-dependent transcription and contribute to defective B-cell development and/or function...
  78. ncbi request reprint All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+
    K F Harvey
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia
    J Biol Chem 274:12525-30. 1999
    ..We propose that Nedd4-mediated down-regulation of Na+ channels involves the binding of WW domains 2 and 3 to the Na+ channel and of WW domain 1 to an unknown associated protein...
  79. pmc DRONC, an ecdysone-inducible Drosophila caspase
    L Dorstyn
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5000, Australia
    Proc Natl Acad Sci U S A 96:4307-12. 1999
    ..These results suggest that DRONC is an effector of steroid-mediated apoptosis during insect metamorphosis...
  80. ncbi request reprint Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein
    T Sazuka
    Laboratory of Molecular Oncology, Tsukuba Life Science Center, Japan
    Biochim Biophys Acta 1132:240-8. 1992
    ....