E Hu

Summary

Affiliation: SmithKline Beecham Pharmaceuticals
Country: USA

Publications

  1. ncbi Molecular cloning and characterization of profilin-3: a novel cytoskeleton-associated gene expressed in rat kidney and testes
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Exp Nephrol 9:265-74. 2001
  2. ncbi Rapid isolation of tissue-specific genes from rat kidney
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Exp Nephrol 9:156-64. 2001
  3. ncbi Identification of a novel kidney-specific gene downregulated in acute ischemic renal failure
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19403, USA
    Am J Physiol Renal Physiol 279:F426-39. 2000
  4. ncbi Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19403, USA
    J Biol Chem 275:15254-64. 2000
  5. ncbi Tissue restricted expression of two human Frzbs in preadipocytes and pancreas
    E Hu
    Department of Renal Pharmacology, Department of Bio Pharmacology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania, 19406, USA
    Biochem Biophys Res Commun 247:287-93. 1998
  6. pmc DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines
    F J King
    Department of Cancer Biology, The Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Cell Biol 19:2330-7. 1999
  7. ncbi Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
    E Hu
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 274:2100-3. 1996
  8. pmc Regulation of PPAR gamma gene expression by nutrition and obesity in rodents
    A Vidal-Puig
    Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    J Clin Invest 97:2553-61. 1996
  9. ncbi AdipoQ is a novel adipose-specific gene dysregulated in obesity
    E Hu
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 271:10697-703. 1996
  10. ncbi mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer
    P Tontonoz
    Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1224-34. 1994

Collaborators

Detail Information

Publications13

  1. ncbi Molecular cloning and characterization of profilin-3: a novel cytoskeleton-associated gene expressed in rat kidney and testes
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Exp Nephrol 9:265-74. 2001
    ....
  2. ncbi Rapid isolation of tissue-specific genes from rat kidney
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Exp Nephrol 9:156-64. 2001
    ..Our results suggested that tissue-specific genes can be rapidly isolated and characterized using PCR-select techniques and this methodology may be generally applicable to isolate specific genes from a variety of tissues...
  3. ncbi Identification of a novel kidney-specific gene downregulated in acute ischemic renal failure
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19403, USA
    Am J Physiol Renal Physiol 279:F426-39. 2000
    ..Both KSP32 mRNA levels as well as renal function recovered 14 days after injury. Administration of an endothelin receptor antagonist (SB-209670), known to restore renal function, significantly increased KSP32 expression...
  4. ncbi Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor
    E Hu
    Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19403, USA
    J Biol Chem 275:15254-64. 2000
    ..These results indicate that HDAC8 is a novel member of the histone deacetylase family, which may play a role in the development of a broad range of tissues and potentially in the etiology of cancer...
  5. ncbi Tissue restricted expression of two human Frzbs in preadipocytes and pancreas
    E Hu
    Department of Renal Pharmacology, Department of Bio Pharmacology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania, 19406, USA
    Biochem Biophys Res Commun 247:287-93. 1998
    ..Molecular cloning and expression of these Frzbs will allow detailed molecular and biochemical analysis of Wnt-Frzb interaction and their impact on Wnt-Frizzled receptor signal transduction...
  6. pmc DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines
    F J King
    Department of Cancer Biology, The Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Cell Biol 19:2330-7. 1999
    ..These results suggest that DEF-1 is an important component of a signal transduction process that is involved in the differentiation of fibroblasts and possibly of other types of cells...
  7. ncbi Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
    E Hu
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 274:2100-3. 1996
    ..These results indicate that covalent modification of PPARgamma by serum and growth factors is a major regulator of the balance between cell growth and differentiation in the adipose cell lineage...
  8. pmc Regulation of PPAR gamma gene expression by nutrition and obesity in rodents
    A Vidal-Puig
    Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    J Clin Invest 97:2553-61. 1996
    ..These findings demonstrate in vivo modulation of PPAR gamma mRNA levels over a fourfold range and provide an additional level of regulation for the control of adipocyte development and function...
  9. ncbi AdipoQ is a novel adipose-specific gene dysregulated in obesity
    E Hu
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 271:10697-703. 1996
    ..Whereas the biological function of this polypeptide is presently unknown, the tissue-specific expression of a putative secreted protein suggests that this factor may function as a novel signaling molecule for adipose tissue...
  10. ncbi mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer
    P Tontonoz
    Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1224-34. 1994
    ....
  11. pmc Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes
    E Hu
    Dana Farber Cancer Institute, Boston, MA 02115
    EMBO J 13:3094-103. 1994
    ..These results also imply that c-fos may play an important regulatory role in the invasive behavior of malignant tumors, independent of any role this proto-oncogene might play in cell growth per se...
  12. ncbi Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    P Tontonoz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    Cell 79:1147-56. 1994
    ....
  13. pmc Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha
    E Hu
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 92:9856-60. 1995
    ..These factors have an ability to inhibit myogenesis that is temporally and functionally separate from their ability to stimulate adipogenesis...