Research Topics
| James K WalshSummaryAffiliation: Sleep Medicine and Research Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Zolpidem "as needed" for the treatment of primary insomnia: a double-blind, placebo-controlled studyJames K Walsh
Sleep Medicine Research Center, St Luke's Hospital, Chesterfield, Missouri 63017, USA
Sleep Med Rev 6:S7-10; discussion S10-1, S31-3. 2002- Dose-response effects of tiagabine on the sleep of older adultsJames K Walsh
Sleep Medicine and Research Center, St John s Mercy Medical Center, St Luke s Hospital, St Louis, MO, USA
Sleep 28:673-6. 2005..To evaluate the dose- response effects of tiagabine on sleep and safety measures in healthy older adults... 
Slow wave sleep enhancement with gaboxadol reduces daytime sleepiness during sleep restrictionJames K Walsh
Sleep Medicine and Research Center, St John s Mercy Medical Center St Luke s Hospital, St Louis, MO, USA
Sleep 31:659-72. 2008..To evaluate the impact of enhanced slow wave sleep (SWS) on behavioral, psychological, and physiological changes resulting from sleep restriction...- Modafinil improves alertness, vigilance, and executive function during simulated night shiftsJames K Walsh
Sleep Medicine and Research Center, affiliated with St John s Mercy Medical Center and St Luke s Hospital, St Louis, Missouri, USA
Sleep 27:434-9. 2004..To assess the effect of 200 mg of modafinil compared to placebo on alertness, neurobehavioral performance, and executive function during 4 consecutive simulated night shifts... - Clinical and socioeconomic correlates of insomniaJames K Walsh
Sleep Medicine and Research Center at St Luke s Hospital, Chesterfield, MO, USA
J Clin Psychiatry 65:13-9. 2004..Chronic insomnia is a common problem, often associated with negative waking mood or function. As such, heightened clinical attention and clinical research appear warranted... - Tiagabine is associated with sustained attention during sleep restriction: evidence for the value of slow-wave sleep enhancement?James K Walsh
Sleep Medicine and Research Center, St John s Mercy Medical Center St Luke s Hospital, St Louis, MO, USA
Sleep 29:433-43. 2006..To evaluate the impact of enhanced slow-wave sleep (SWS) on behavioral, psychological, and physiologic changes resulting from sleep restriction.. - Laboratory and field studies of naps and caffeine as practical countermeasures for sleep-wake problems associated with night workPaula K Schweitzer
Sleep Medicine and Research Center affiliated with St John s Mercy Medical Center and St Luke s Hospital, St Louis, MO 2Pacific Sleep Medicine, La Jolla, CA 63017, USA
Sleep 29:39-50. 2006..To evaluate the effects of napping, caffeine, and napping plus caffeine on performance and alertness in both laboratory and field settings... 
Treatment of elderly primary insomnia patients with EVT 201 improves sleep initiation, sleep maintenance, and daytime sleepinessJames K Walsh
Sleep Medicine and Research Center, St Luke s Hospital, 232 S Woods Mill Road, Chesterfield, MO 63017, United States
Sleep Med 11:23-30. 2010..Two doses of EVT 201, a partial positive allosteric modulator of the GABA(A) system, were evaluated in elderly primary insomnia patients with daytime sleepiness...- Tiagabine enhances slow wave sleep and sleep maintenance in primary insomniaJames K Walsh
St John s Mercy St Luke s Hospitals, Sleep Medicine and Research Center, Chesterfield, MO 63017, and Department of Psychology, St Louis University, St Louis, MO 63130, USA
Sleep Med 7:155-61. 2006..To evaluate the effect of tiagabine on sleep and next-morning alertness and performance in adult patients with primary insomnia... - The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomniaJames K Walsh
St Johns Hospital, St Louis, MO, USA
Sleep 30:593-602. 2007..Evaluate the hypnotic efficacy of gaboxadol, a selective extrasynaptic GABAA agonist (SEGA), in a phase advance model of transient insomnia... - Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomniaJames K Walsh
Sleep Medicine and Research Center, St Johnś St Lukeś Hospitals, St Louis, MO 63017, USA
J Clin Sleep Med 2:35-41. 2006..This study evaluated dose-response effects of tiagabine on sleep in adults with primary insomnia... - A convenient expiratory positive airway pressure nasal device for the treatment of sleep apnea in patients non-adherent with continuous positive airway pressureJames K Walsh
Sleep Medicine and Research Center, St Luke s Hospital, 232 S Woods Mill Rd, Chesterfield, MO, USA
Sleep Med 12:147-52. 2011..The short-term efficacy of and adherence with a convenient expiratory positive airway pressure (EPAP) nasal device was evaluated in OSA patients non-adherent with CPAP... - Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitationsJames K Walsh
Sleep Medicine and Research Center, St John s St Luke s Hospitals and the Department of Psychology, Saint Louis University, St Louis, MO 63017, USA
Sleep 30:959-68. 2007..To evaluate 6 months' eszopiclone treatment upon patient-reported sleep, fatigue and sleepiness, insomnia severity, quality of life, and work limitations... - Efficacy and safety of zolpidem extended release in elderly primary insomnia patientsJames K Walsh
Sleep Medicine and Research Center, St John s Mercy and St Luke s Hospitals, 232 S Woods Hill Road, Chesterfield, MO 63017, USA
Am J Geriatr Psychiatry 16:44-57. 2008..To evaluate the clinical efficacy and safety of zolpidem extended release for the treatment of primary insomnia in elderly patients... - Enhancing slow wave sleep with sodium oxybate reduces the behavioral and physiological impact of sleep lossJames K Walsh
Sleep Medicine and Research Center, St Luke s Hospital, Chesterfield, MO 63017, USA
Sleep 33:1217-25. 2010..To investigate whether enhancement of slow wave sleep (SWS) with sodium oxybate reduces the impact of sleep deprivation... - Efficacy of the selective extrasynaptic GABA A agonist, gaboxadol, in a model of transient insomnia: a randomized, controlled clinical trialJames K Walsh
St John s Hospital, St Louis, MO, USA
Sleep Med 9:393-402. 2008..The hypnotic efficacy of gaboxadol, a selective extrasynaptic GABA A agonist (SEGA), was evaluated in a phase-advance model of transient insomnia... - Efficacy and tolerability of indiplon in older adults with primary insomniaJames K Walsh
Sleep Medicine and Research Center, St John s St Luke s Hospitals, 232 S Woods Mill Road, Chesterfield, St Louis, MO 63017, USA
Sleep Med 8:753-9. 2007..To evaluate the efficacy and safety of indiplon in elderly patients with primary insomnia... - The partial positive allosteric GABA(A) receptor modulator EVT 201 is efficacious and safe in the treatment of adult primary insomnia patientsJames K Walsh
Sleep Medicine and Research Center, St Luke s Hospital, 232 S Woods Mill Road, Chesterfield, MO 63017, USA
Sleep Med 10:859-64. 2009..To evaluate polysomnographic (PSG) and self-reported measures of the efficacy and safety of EVT 201 in patients with primary insomnia... - Nighttime insomnia symptoms and perceived health in the America Insomnia Survey (AIS)James K Walsh
Sleep Medicine and Research Center, St Luke s Hospital, St Louis, MO, USA
Sleep 34:997-1011. 2011.... - Understanding GABA and its relation to insomnia and therapeuticsJames K Walsh
Sleep Medicine and Research Center, St. John K/St. Luke 's Hospitals, Department of Psychology, Saint Louis University, St. Louis, MO, USA
J Clin Sleep Med 2:S5-6. 2006 - Pharmacologic management of insomniaJames K Walsh
Sleep Medicine and Research Center, St John s Mercy and St Luke s Hospitals, Department of Psychiatry, Saint Louis University, St Louis, MO, USA
J Clin Psychiatry 65:41-5. 2004..Sedating antidepressants are also frequently prescribed to promote sleep despite inadequate data to support their efficacy for this indication and a greater potential for clinically troublesome side effects... - Pharmacologic management of insomnia: past, present, and futureDenise Troy Curry
Sleep Medicine and Research Center, St John's Mercy Medical Center and St Luke's Hospital, Chesterfield, MO 63017, USA
Psychiatr Clin North Am 29:871-93; abstract vii-viii. 2006..Improvement in managing insomnia will result from systematic research with these drugs, with drugs in development, and with novel uses, such as co-therapy... - Strategies for de-identification and anonymization of electronic health record data for use in multicenter research studiesClete A Kushida
Stanford Sleep Medicine Center, Redwood City, CA 94063 5704, USA
Med Care 50:S82-101. 2012..The use of these strategies in multicenter research studies is paramount in importance, given the need to share electronic health record data across multiple environments and institutions while safeguarding patient privacy... - Shift work sleep disorder: prevalence and consequences beyond that of symptomatic day workersChristopher L Drake
Henry Ford Hospital Sleep Disorders and Research Center, Detroit, MI 48202, USA
Sleep 27:1453-62. 2004..The present study was designed to determine the relative prevalence and negative consequences associated with shift work sleep disorder in a representative sample drawn from the working population of metropolitan Detroit... - A polysomnographic placebo-controlled evaluation of the efficacy and safety of eszopiclone relative to placebo and zolpidem in the treatment of primary insomniaMilton K Erman
Pacific Sleep Medicine Services, Inc, San Diego, CA, USA
J Clin Sleep Med 4:229-34. 2008..To evaluate the polysomnographic efficacy and the safety of a range of doses of eszopiclone relative to placebo in patients with primary insomnia. Zolpidem 10 mg was included as an active control... - Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomniaMichael L Perlis
Sleep and Neurophysiology Laboratory, Department of Psychiatry, University of Rochester, and the University of Rochester Medical Center, Neurosciences Program, Rochester, NY 14642, USA
J Clin Psychiatry 65:1128-37. 2004..The present study was designed to further evaluate this issue within a large scale, double-blind, placebo-controlled, long-term trial... - Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomniaAndrew D Krystal
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Sleep 26:793-9. 2003..To determine the long-term efficacy of eszopiclone in patients with chronic insomnia... - Drugs used to treat insomnia in 2002: regulatory-based rather than evidence-based medicineJames K Walsh
Sleep 27:1441-2. 2004 - Modafinil for excessive sleepiness associated with shift-work sleep disorderCharles A Czeisler
Division of Sleep Medicine, Harvard Medical School, and Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 353:476-86. 2005..Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder... - Ramelteon (TAK-375), a selective MT1/MT2-receptor agonist, reduces latency to persistent sleep in a model of transient insomnia related to a novel sleep environmentThomas Roth
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI 48202, USA
Sleep 28:303-7. 2005..Evaluate the efficacy of ramelteon, an MT/1MT2-receptor agonist, for the treatment of transient insomnia in healthy adults... - Efficacy and safety of zolpidem-MR: a double-blind, placebo-controlled study in adults with primary insomniaThomas Roth
Henri Ford Hospital, Detroit, MI 48202, USA
Sleep Med 7:397-406. 2006..To evaluate the clinical efficacy and safety of modified-release zolpidem (zolpidem-MR 12.5mg) for the treatment of primary insomnia in adults... - The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsyJohn R Harsh
The University of Southern Mississippi, Hattiesburg, MS 39406, USA
Curr Med Res Opin 22:761-74. 2006..This study assessed the efficacy and safety of armodafinil, the longer half-life enantiomer of modafinil, for the treatment of excessive sleepiness in patients with narcolepsy... - Frequent napping is associated with excessive daytime sleepiness, depression, pain, and nocturia in older adults: findings from the National Sleep Foundation '2003 Sleep in America' PollDaniel J Foley
Center for Mental Health Services DJF, Substance Abuse and Mental Health Services Administration, Department of Health and Human Services, Rockville, MD 20857, USA
Am J Geriatr Psychiatry 15:344-50. 2007..The objective of this study was to describe the prevalence and correlates of regular napping among older adults... - The direct and indirect costs of untreated insomnia in adults in the United StatesRonald J Ozminkowski
Institute for Health and Productivity Studies, Cornell University, Washington, D C, USA
Sleep 30:263-73. 2007..To estimate the direct and indirect cost burden of untreated insomnia among younger adults (age 18-64), and to estimate the direct costs of untreated insomnia for elderly patients (age 65 and over)... - Insights into the public health burden of insomniaJames K Walsh
Sleep 29:142-3. 2006 - An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomniaThomas Roth
Henry Ford Hospital Sleep Center, 2799 West Grand Blvd, CFP 3, Detroit, MI 48202, USA
Sleep Med 6:487-95. 2005..A double-blind placebo-controlled study of eszopiclone found significant, sustained improvement in sleep and daytime function. The 6-month open-label extension phase is described herein... - The Apnea Positive Pressure Long-term Efficacy Study (APPLES): rationale, design, methods, and proceduresClete A Kushida
Stanford Universit y, Stanfbrd, CA, USA
J Clin Sleep Med 2:288-300. 2006..To assess the size, time course, and durability of the effects of long-term continuous positive airway pressure (CPAP) therapy on neurocognitive function, mood, sleepiness, and quality of life in patients with obstructive sleep apnea... - Efficacy and tolerability of modified-release indiplon in elderly patients with chronic insomnia: results of a 2-week double-blind, placebo-controlled trialR Bruce Lydiard
Department of Neuropsychiatny and Behavioral Science University of South Carolina, Columbia, SC, USA
J Clin Sleep Med 2:309-15. 2006..The aim of the present study was to evaluate the efficacy and safety of a 15-mg nightly dose of modified-release indiplon tablets in elderly patients with primary insomnia characterized by sleep-maintenance difficulties... - Panel discussion: changing how we think about insomniaSonia Ancoli-Israel
J Clin Psychiatry 65:44-6. 2004 - The treatment of chronic insomnia: drug indications, chronic use and abuse liability. Summary of a 2001 New Clinical Drug Evaluation Unit meeting symposiumWallace B Mendelson
Sleep Med Rev 8:7-17. 2004..All currently available agents, while effective and safe, do not achieve this ideal. The next few years are likely to see the appearance of a variety of agents with new and promising mechanisms of action... - Tiredness versus sleepiness: semantics or a target for public education?William C Dement
Sleep Research Center and Department of Psychiatry, Stanford University, Palo Alto, CA, USA
Sleep 26:485-6. 2003 - History of the development of sleep medicine in the United StatesJohn W Shepard
Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Clin Sleep Med 1:61-82. 2005....