David V Morrissey
Affiliation: Sirna Therapeutics
- Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replicationDavid V Morrissey
Sirna Therapeutics, Inc, Boulder, CO 80301, USA
Hepatology 41:1349-56. 2005..In conclusion, these experiments establish the strong impact that siRNAs can have on the extent of HBV infection and underscore the importance of stabilization of siRNA against nuclease degradation...
- Potent and persistent in vivo anti-HBV activity of chemically modified siRNAsDavid V Morrissey
Sirna Therapeutics, Inc, 2950 Wilderness Place, Boulder, Colorado 80301, USA
Nat Biotechnol 23:1002-7. 2005..The advances demonstrated here, including persistence of in vivo activity, use of lower doses and reduced dosing frequency are important steps in making siRNA a clinically viable therapeutic approach...