B Stein

Summary

Affiliation: Signal Pharmaceuticals
Country: USA

Publications

  1. ncbi request reprint Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade
    B Stein
    Signal Pharmaceuticals Inc, San Diego, California 92121, USA
    J Biol Chem 271:11427-33. 1996
  2. ncbi request reprint p38-2, a novel mitogen-activated protein kinase with distinct properties
    B Stein
    Signal Pharmaceuticals Inc, San Diego, California 92121, USA
    J Biol Chem 272:19509-17. 1997
  3. pmc Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta
    B Stein
    Signal Pharmaceuticals, San Diego, California 92121, USA
    Mol Cell Biol 15:4971-9. 1995
  4. ncbi request reprint Effects of SP500263, a novel selective estrogen receptor modulator, on bone, uterus, and serum cholesterol in the ovariectomized rat
    M Kung Sutherland
    Celgene Corp, 4550 Towne Centre Court, San Diego, CA 92121, USA
    Calcif Tissue Int 72:710-6. 2003
  5. pmc 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region
    P Angel
    Mol Cell Biol 7:2256-66. 1987
  6. pmc Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia
    C J Wu
    Center for Hematologic Oncology, and Department of Biostatistical Science, Dana Farber Cancer Institute, and Department of Medicine, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 106:705-14. 2000
  7. pmc The nucleus-encoded HCF107 gene of Arabidopsis provides a link between intercistronic RNA processing and the accumulation of translation-competent psbH transcripts in chloroplasts
    S Felder
    Institut für Entwicklungs und Molekularbiologie der Pflanzen, Heinrich Heine Universitat, Universitatstrasse 1, 40225 Dusseldorf, Germany
    Plant Cell 13:2127-41. 2001
  8. ncbi request reprint The utilization of sodium taurocholate in excystation of Cryptosporidium parvum and infection of tissue culture
    D Gold
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Israel
    J Parasitol 87:997-1000. 2001
  9. pmc Metabolic activation stimulates acid secretion and expression of matrix degrading proteases in human osteoblasts
    M George
    Institute for Applied Physics and Centre for Nanoscience, Ludwig Maximilians, University Munich, Munich, Germany
    Ann Rheum Dis 63:67-70. 2004

Collaborators

  • R Janknecht
  • TONY R HUNTER
  • B W Murray
  • M George
  • M Kung Sutherland
  • D Gold
  • S Felder
  • C J Wu
  • W K Aicher
  • M Weis-Klemm
  • T Pap
  • W J Parak
  • O Muller
  • H Brady
  • N Patnaik
  • D W Anderson
  • S S Bhagwat
  • S G Lipps
  • E O'Leary
  • L M Gayo-Fung
  • J Leisten
  • J A McKie
  • A P Sane
  • H Plücken
  • P Klaff
  • K Meierhoff
  • S Tzipori
  • J Meurer
  • N Bechtold
  • C Driemel
  • P Westhoff
  • E P Alyea
  • J Ritz
  • X F Yang
  • G Dranoff
  • S McLaughlin
  • R J Soiffer
  • D Neuberg
  • C Canning
  • P Angel
  • P Herrlich
  • H Delius
  • I Baumann
  • H J Rahmsdorf

Detail Information

Publications9

  1. ncbi request reprint Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade
    B Stein
    Signal Pharmaceuticals Inc, San Diego, California 92121, USA
    J Biol Chem 271:11427-33. 1996
    ..This separates MEK6 from the ERK subgroup of protein kinases. MEK6 is only a poor substrate for MEKK, a mitogen-activated protein kinase kinase kinase that efficiently phosphorylates the related family member JNKK...
  2. ncbi request reprint p38-2, a novel mitogen-activated protein kinase with distinct properties
    B Stein
    Signal Pharmaceuticals Inc, San Diego, California 92121, USA
    J Biol Chem 272:19509-17. 1997
    ..A sequential kinetic mechanism of p38-2 is suggested by steady state kinetic analysis. In conclusion, p38-2 may be an important component of the stress response required for the homeostasis of a cell...
  3. pmc Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta
    B Stein
    Signal Pharmaceuticals, San Diego, California 92121, USA
    Mol Cell Biol 15:4971-9. 1995
    ..Therefore, drugs that separate the transactivation and transrepression functions of ER will be very helpful for treatment of osteoporosis without causing undesirable side effects...
  4. ncbi request reprint Effects of SP500263, a novel selective estrogen receptor modulator, on bone, uterus, and serum cholesterol in the ovariectomized rat
    M Kung Sutherland
    Celgene Corp, 4550 Towne Centre Court, San Diego, CA 92121, USA
    Calcif Tissue Int 72:710-6. 2003
    ..In summary, SP500263 is a new orally active SERM that acts in rats as an estrogen agonist on bone without causing uterine stimulatory effects...
  5. pmc 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region
    P Angel
    Mol Cell Biol 7:2256-66. 1987
    ..Differences in enhancer efficiency in different cell lines are interpreted to indicate differences in the activity of a trans-acting factor...
  6. pmc Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia
    C J Wu
    Center for Hematologic Oncology, and Department of Biostatistical Science, Dana Farber Cancer Institute, and Department of Medicine, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 106:705-14. 2000
    ..The characterization of B cell-defined antigens may help identify clinically relevant targets of the GVL response in vivo...
  7. pmc The nucleus-encoded HCF107 gene of Arabidopsis provides a link between intercistronic RNA processing and the accumulation of translation-competent psbH transcripts in chloroplasts
    S Felder
    Institut für Entwicklungs und Molekularbiologie der Pflanzen, Heinrich Heine Universitat, Universitatstrasse 1, 40225 Dusseldorf, Germany
    Plant Cell 13:2127-41. 2001
    ....
  8. ncbi request reprint The utilization of sodium taurocholate in excystation of Cryptosporidium parvum and infection of tissue culture
    D Gold
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Israel
    J Parasitol 87:997-1000. 2001
    ..parvum, the whole infection process can be performed in the presence of sodium taurocholate, and does not require separation and cleaning of the excysted sporozoites before their application to tissue culture cells...
  9. pmc Metabolic activation stimulates acid secretion and expression of matrix degrading proteases in human osteoblasts
    M George
    Institute for Applied Physics and Centre for Nanoscience, Ludwig Maximilians, University Munich, Munich, Germany
    Ann Rheum Dis 63:67-70. 2004
    ..Osteoblasts modulate the deposition of bone mineral components and secrete extracellular matrix proteins...