F Mercurio

Summary

Affiliation: Signal Pharmaceuticals
Country: USA

Publications

  1. request reprint
    Mercurio F, Zhu H, Murray B, Shevchenko A, Bennett B, Li J, et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science. 1997;278:860-6 pubmed
    ..Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-kappaB signaling pathway. ..
  2. Mercurio F, Murray B, Shevchenko A, Bennett B, Young D, Li J, et al. IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol Cell Biol. 1999;19:1526-38 pubmed
    ..IKKAP1 therefore appears to mediate an essential step of the NF-kappaB signal transduction cascade. Heterogeneity of IKK complexes in vivo may provide a mechanism for differential regulation of NF-kappaB activation. ..
  3. request reprint
    Mercurio F, Manning A. Multiple signals converging on NF-kappaB. Curr Opin Cell Biol. 1999;11:226-32 pubmed
    ..These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote. ..

Detail Information

Publications3

  1. request reprint
    Mercurio F, Zhu H, Murray B, Shevchenko A, Bennett B, Li J, et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science. 1997;278:860-6 pubmed
    ..Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-kappaB signaling pathway. ..
  2. Mercurio F, Murray B, Shevchenko A, Bennett B, Young D, Li J, et al. IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol Cell Biol. 1999;19:1526-38 pubmed
    ..IKKAP1 therefore appears to mediate an essential step of the NF-kappaB signal transduction cascade. Heterogeneity of IKK complexes in vivo may provide a mechanism for differential regulation of NF-kappaB activation. ..
  3. request reprint
    Mercurio F, Manning A. Multiple signals converging on NF-kappaB. Curr Opin Cell Biol. 1999;11:226-32 pubmed
    ..These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote. ..