F Mercurio

Summary

Affiliation: Signal Pharmaceuticals
Country: USA

Publications

  1. ncbi Multiple signals converging on NF-kappaB
    F Mercurio
    Signal Pharmaceuticals Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Curr Opin Cell Biol 11:226-32. 1999
  2. ncbi IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
  3. ncbi IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    F Mercurio
    Signal Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Cell Biol 19:1526-38. 1999
  4. ncbi Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    Q Li
    Salk Institute, La Jolla, CA 92037, USA Signal Pharmaceuticals, San Diego, CA 92121, USA
    Science 284:321-5. 1999
  5. ncbi Detection and purification of a multiprotein kinase complex from mammalian cells. IKK signalsome
    F Mercurio
    Signal Pharmaceuticals Inc, San Diego, CA, USA
    Methods Mol Biol 99:109-25. 2000
  6. ncbi Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer
    R Romieu-Mourez
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA
    Cancer Res 61:3810-8. 2001
  7. ncbi SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase
    A Orian
    Department of Biochemistry and the Rappaport Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel
    EMBO J 19:2580-91. 2000
  8. ncbi Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
    A Lin
    Department of Pharmacology, University of California San Diego School of Medicine, La Jolla 92093 0636, USA
    Science 268:286-90. 1995
  9. ncbi Identification of the receptor component of the IkappaBalpha-ubiquitin ligase
    A Yaron
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nature 396:590-4. 1998
  10. ncbi Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
    J Didonato
    Department of Pharmacology, Program in Biomedical Science, University of California, San Diego School of Medicine, La Jolla, USA
    Mol Cell Biol 16:1295-304. 1996

Collaborators

Detail Information

Publications12

  1. ncbi Multiple signals converging on NF-kappaB
    F Mercurio
    Signal Pharmaceuticals Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Curr Opin Cell Biol 11:226-32. 1999
    ..These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote...
  2. ncbi IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
    ..Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-kappaB signaling pathway...
  3. ncbi IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    F Mercurio
    Signal Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Cell Biol 19:1526-38. 1999
    ..IKKAP1 therefore appears to mediate an essential step of the NF-kappaB signal transduction cascade. Heterogeneity of IKK complexes in vivo may provide a mechanism for differential regulation of NF-kappaB activation...
  4. ncbi Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    Q Li
    Salk Institute, La Jolla, CA 92037, USA Signal Pharmaceuticals, San Diego, CA 92121, USA
    Science 284:321-5. 1999
    ..IKK1 associated with NF-kappaB essential modulator (IKKgamma/IKKAP1), another component of the IKK complex. These results show that IKK2 is essential for mouse development and cannot be substituted with IKK1...
  5. ncbi Detection and purification of a multiprotein kinase complex from mammalian cells. IKK signalsome
    F Mercurio
    Signal Pharmaceuticals Inc, San Diego, CA, USA
    Methods Mol Biol 99:109-25. 2000
  6. ncbi Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer
    R Romieu-Mourez
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA
    Cancer Res 61:3810-8. 2001
    ....
  7. ncbi SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase
    A Orian
    Department of Biochemistry and the Rappaport Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel
    EMBO J 19:2580-91. 2000
    ..Since p105-Delta918-934 is also conjugated and processed, it appears that p105 can be recognized under different physiological conditions by two different ligases, targeting two distinct recognition motifs...
  8. ncbi Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
    A Lin
    Department of Pharmacology, University of California San Diego School of Medicine, La Jolla 92093 0636, USA
    Science 268:286-90. 1995
    ..JNKK also activated another MAPK, p38 (Mpk2; the mammalian homolog of HOG1 from yeast), whose activity is regulated similarly to that of the JNKs...
  9. ncbi Identification of the receptor component of the IkappaBalpha-ubiquitin ligase
    A Yaron
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nature 396:590-4. 1998
    ..When these receptor components recognize their specific ligand, which is a conserved, phosphorylation-based sequence motif, they target regulatory proteins containing this motif for proteasomal degradation...
  10. ncbi Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
    J Didonato
    Department of Pharmacology, Program in Biomedical Science, University of California, San Diego School of Medicine, La Jolla, USA
    Mol Cell Biol 16:1295-304. 1996
    ..As substitution of a conserved lysine residue slows down the ubiquitination and degradation of IkappaBalpha without affecting its phosphorylation, polyubiquitination is required for inducible IkappaB degradation...
  11. ncbi Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes
    N H Purcell
    Ben May Institute for Cancer Research and the Committee on Cancer Biology, University of Chicago, 5841 South Maryland Avenue, MC6027, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 98:6668-73. 2001
    ..These findings suggest that NF-kappaB plays a critical role in the hypertrophic growth of cardiomyocytes and may serve as a potential target for the intervention of heart disease...
  12. ncbi Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes
    K R Aupperle
    Division of Rheumatology, Allergy, and Immunology, La Jolla, California 92093, USA
    Cell Immunol 214:54-9. 2001
    ..This is the first report demonstrating constitutive expression and cytokine regulation of this novel kinase in primary human synovial cells...