F Mercurio

Summary

Affiliation: Signal Pharmaceuticals
Country: USA

Publications

  1. ncbi request reprint Multiple signals converging on NF-kappaB
    F Mercurio
    Signal Pharmaceuticals Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Curr Opin Cell Biol 11:226-32. 1999
  2. ncbi request reprint IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
  3. pmc IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    F Mercurio
    Signal Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Cell Biol 19:1526-38. 1999
  4. ncbi request reprint Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    Q Li
    Salk Institute, La Jolla, CA 92037, USA Signal Pharmaceuticals, San Diego, CA 92121, USA
    Science 284:321-5. 1999
  5. ncbi request reprint Detection and purification of a multiprotein kinase complex from mammalian cells. IKK signalsome
    F Mercurio
    Signal Pharmaceuticals Inc, San Diego, CA, USA
    Methods Mol Biol 99:109-25. 2000
  6. ncbi request reprint Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer
    R Romieu-Mourez
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA
    Cancer Res 61:3810-8. 2001
  7. pmc SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase
    A Orian
    Department of Biochemistry and the Rappaport Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel
    EMBO J 19:2580-91. 2000
  8. ncbi request reprint Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
    A Lin
    Department of Pharmacology, University of California San Diego School of Medicine, La Jolla 92093 0636, USA
    Science 268:286-90. 1995
  9. ncbi request reprint Identification of the receptor component of the IkappaBalpha-ubiquitin ligase
    A Yaron
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nature 396:590-4. 1998
  10. pmc Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
    J Didonato
    Department of Pharmacology, Program in Biomedical Science, University of California, San Diego School of Medicine, La Jolla, USA
    Mol Cell Biol 16:1295-304. 1996

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Multiple signals converging on NF-kappaB
    F Mercurio
    Signal Pharmaceuticals Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Curr Opin Cell Biol 11:226-32. 1999
    ..These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote...
  2. ncbi request reprint IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
    ..Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-kappaB signaling pathway...
  3. pmc IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    F Mercurio
    Signal Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Cell Biol 19:1526-38. 1999
    ..IKKAP1 therefore appears to mediate an essential step of the NF-kappaB signal transduction cascade. Heterogeneity of IKK complexes in vivo may provide a mechanism for differential regulation of NF-kappaB activation...
  4. ncbi request reprint Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    Q Li
    Salk Institute, La Jolla, CA 92037, USA Signal Pharmaceuticals, San Diego, CA 92121, USA
    Science 284:321-5. 1999
    ..IKK1 associated with NF-kappaB essential modulator (IKKgamma/IKKAP1), another component of the IKK complex. These results show that IKK2 is essential for mouse development and cannot be substituted with IKK1...
  5. ncbi request reprint Detection and purification of a multiprotein kinase complex from mammalian cells. IKK signalsome
    F Mercurio
    Signal Pharmaceuticals Inc, San Diego, CA, USA
    Methods Mol Biol 99:109-25. 2000
  6. ncbi request reprint Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer
    R Romieu-Mourez
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA
    Cancer Res 61:3810-8. 2001
    ....
  7. pmc SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase
    A Orian
    Department of Biochemistry and the Rappaport Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel
    EMBO J 19:2580-91. 2000
    ..Since p105-Delta918-934 is also conjugated and processed, it appears that p105 can be recognized under different physiological conditions by two different ligases, targeting two distinct recognition motifs...
  8. ncbi request reprint Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
    A Lin
    Department of Pharmacology, University of California San Diego School of Medicine, La Jolla 92093 0636, USA
    Science 268:286-90. 1995
    ..JNKK also activated another MAPK, p38 (Mpk2; the mammalian homolog of HOG1 from yeast), whose activity is regulated similarly to that of the JNKs...
  9. ncbi request reprint Identification of the receptor component of the IkappaBalpha-ubiquitin ligase
    A Yaron
    The Lautenberg Center for Immunology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nature 396:590-4. 1998
    ..When these receptor components recognize their specific ligand, which is a conserved, phosphorylation-based sequence motif, they target regulatory proteins containing this motif for proteasomal degradation...
  10. pmc Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
    J Didonato
    Department of Pharmacology, Program in Biomedical Science, University of California, San Diego School of Medicine, La Jolla, USA
    Mol Cell Biol 16:1295-304. 1996
    ..As substitution of a conserved lysine residue slows down the ubiquitination and degradation of IkappaBalpha without affecting its phosphorylation, polyubiquitination is required for inducible IkappaB degradation...
  11. pmc Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes
    N H Purcell
    Ben May Institute for Cancer Research and the Committee on Cancer Biology, University of Chicago, 5841 South Maryland Avenue, MC6027, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 98:6668-73. 2001
    ..These findings suggest that NF-kappaB plays a critical role in the hypertrophic growth of cardiomyocytes and may serve as a potential target for the intervention of heart disease...
  12. ncbi request reprint Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes
    K R Aupperle
    Division of Rheumatology, Allergy, and Immunology, La Jolla, California 92093, USA
    Cell Immunol 214:54-9. 2001
    ..This is the first report demonstrating constitutive expression and cytokine regulation of this novel kinase in primary human synovial cells...