B L Bennett

Summary

Affiliation: Signal Pharmaceuticals
Country: USA

Publications

  1. pmc SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    B L Bennett
    Signal Research Division, Celgene Corporation, 5555 Oberlin Drive, San Diego, CA 92121 USA
    Proc Natl Acad Sci U S A 98:13681-6. 2001
  2. ncbi request reprint Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide]
    M S Palanki
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, California 92121, USA
    J Med Chem 43:3995-4004. 2000
  3. ncbi request reprint IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
  4. pmc IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    F Mercurio
    Signal Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Cell Biol 19:1526-38. 1999
  5. ncbi request reprint Isolation of cDNAs and tissue specific expression of ovine glucose transporters
    B L Bennett
    Dairy Science Group, AgResearch, Ruakura Research Centre, Hamilton, New Zealand
    Biochem Mol Biol Int 37:9-16. 1995
  6. pmc Activation of c-Jun N-terminal kinase (JNK) signalling in experimentally induced gastric lesions in rats
    K Mitsuyama
    Second Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Clin Exp Immunol 143:24-9. 2006
  7. ncbi request reprint Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes
    K R Aupperle
    Division of Rheumatology, Allergy, and Immunology, La Jolla, California 92093, USA
    Cell Immunol 214:54-9. 2001
  8. ncbi request reprint TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells
    B Schnabl
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hepatology 34:953-63. 2001
  9. ncbi request reprint Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation
    P P Tak
    University of California (San Diego) School of Medicine, La Jolla, USA
    Arthritis Rheum 44:1897-907. 2001
  10. ncbi request reprint NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis
    E Hatano
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 120:1251-62. 2001

Collaborators

  • M S Palanki
  • F Mercurio
  • Paul Peter Tak
  • Matthias Mann
  • B W Murray
  • R S Flanc
  • K Mitsuyama
  • B Schnabl
  • A M Manning
  • K R Aupperle
  • E Hatano
  • D A Brenner
  • D J Nikolic-Paterson
  • R C Atkins
  • G C Friedman
  • Y Han
  • F Y Ma
  • G H Tesch
  • J H Fan
  • K Harada
  • O Tsuruta
  • N Tomiyasu
  • J Masuda
  • M Sata
  • A Suzuki
  • K Handa
  • A Toyonaga
  • K Takaki
  • Y Matsui
  • Y Satoh
  • G S Firestein
  • D L Boyle
  • B Stefanovic
  • C A Bradham
  • T Qian
  • Y Yamanishi
  • J J Lemasters

Detail Information

Publications11

  1. pmc SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    B L Bennett
    Signal Research Division, Celgene Corporation, 5555 Oberlin Drive, San Diego, CA 92121 USA
    Proc Natl Acad Sci U S A 98:13681-6. 2001
    ..Our study supports targeting JNK as an important strategy in inflammatory disease, apoptotic cell death, and cancer...
  2. ncbi request reprint Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide]
    M S Palanki
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, California 92121, USA
    J Med Chem 43:3995-4004. 2000
    ..If it was moved to the 6-position, the activity was lost. The 2-methyl analogue of 1 (81) showed comparable in vitro activity and improved Caco-2 permeability compared to 1...
  3. ncbi request reprint IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
    ..Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-kappaB signaling pathway...
  4. pmc IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    F Mercurio
    Signal Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Cell Biol 19:1526-38. 1999
    ..IKKAP1 therefore appears to mediate an essential step of the NF-kappaB signal transduction cascade. Heterogeneity of IKK complexes in vivo may provide a mechanism for differential regulation of NF-kappaB activation...
  5. ncbi request reprint Isolation of cDNAs and tissue specific expression of ovine glucose transporters
    B L Bennett
    Dairy Science Group, AgResearch, Ruakura Research Centre, Hamilton, New Zealand
    Biochem Mol Biol Int 37:9-16. 1995
    ..This method has been used to isolate the corresponding ovine subclones...
  6. pmc Activation of c-Jun N-terminal kinase (JNK) signalling in experimentally induced gastric lesions in rats
    K Mitsuyama
    Second Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Clin Exp Immunol 143:24-9. 2006
    ..These findings indicate that experimental gastric injury is associated with activation of the JNK signalling pathway, and also suggest that JNK inhibitors may play a role in the treatment of gastric injury in humans...
  7. ncbi request reprint Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes
    K R Aupperle
    Division of Rheumatology, Allergy, and Immunology, La Jolla, California 92093, USA
    Cell Immunol 214:54-9. 2001
    ..This is the first report demonstrating constitutive expression and cytokine regulation of this novel kinase in primary human synovial cells...
  8. ncbi request reprint TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells
    B Schnabl
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hepatology 34:953-63. 2001
    ..These results show novel roles for the TAK1/JNK pathway and p38 during HSC activation in culture. Despite similar activators of TAK1/JNK and p38, their functions in HSCs are distinct and opposed...
  9. ncbi request reprint Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation
    P P Tak
    University of California (San Diego) School of Medicine, La Jolla, USA
    Arthritis Rheum 44:1897-907. 2001
    ..IKKbeta-dn-treated animals. CONCLUSION: IKKbeta plays a key role in rodent synovial inflammation. Intraarticular gene therapy to inhibit IKKbeta activity represents an attractive strategy for the treatment of chronic arthritis...
  10. ncbi request reprint NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis
    E Hatano
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Gastroenterology 120:1251-62. 2001
    ..CONCLUSIONS: NO protects hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Endogenous iNOS, which is activated by NF-kappaB via IKKbeta, provides partial protection from apoptosis...
  11. ncbi request reprint A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis
    R S Flanc
    Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia
    Kidney Int 72:698-708. 2007
    ..These studies suggest that JNK signaling promotes renal injury in acute and progressive rat anti-GBM disease. JNK inhibitors may be a novel therapeutic approach for the treatment of human glomerulonephritis...