Larry Siever

Summary

Country: USA

Publications

  1. ncbi request reprint Cognitive and brain function in schizotypal personality disorder
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 54:157-67. 2002
  2. ncbi request reprint The pathophysiology of schizophrenia disorders: perspectives from the spectrum
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 161:398-413. 2004
  3. pmc Endophenotypes in the personality disorders
    Larry J Siever
    Mount Sinai School of Medicine, New York, NY, USA
    Dialogues Clin Neurosci 7:139-51. 2005
  4. ncbi request reprint Amygdala-prefrontal disconnection in borderline personality disorder
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 32:1629-40. 2007
  5. doi request reprint Recent advances in the biological study of personality disorders
    Antonia S New
    The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1217, New York, NY 10029, USA
    Psychiatr Clin North Am 31:441-61, vii. 2008
  6. pmc Frontolimbic structural changes in borderline personality disorder
    Michael J Minzenberg
    Mount Sinai School of Medicine and Bronx VA Medical Center, Bronx, NY, USA
    J Psychiatr Res 42:727-33. 2008
  7. ncbi request reprint Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, 10032, USA
    Biol Psychiatry 55:1001-6. 2004
  8. ncbi request reprint Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients
    Michael J Minzenberg
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 31:197-203. 2006
  9. ncbi request reprint Reduced anterior and posterior cingulate gray matter in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029, USA
    Biol Psychiatry 58:614-23. 2005
  10. ncbi request reprint Trauma, genes, and the neurobiology of personality disorders
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Ann N Y Acad Sci 1032:104-16. 2004

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Cognitive and brain function in schizotypal personality disorder
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 54:157-67. 2002
    ..Preliminary trials of catecholaminergic agents suggest that these agents may be able to improve these impaired cognitive functions...
  2. ncbi request reprint The pathophysiology of schizophrenia disorders: perspectives from the spectrum
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 161:398-413. 2004
    ..A pathophysiological model of the relationship between schizotypal personality disorder and schizophrenia was developed based on this data...
  3. pmc Endophenotypes in the personality disorders
    Larry J Siever
    Mount Sinai School of Medicine, New York, NY, USA
    Dialogues Clin Neurosci 7:139-51. 2005
    ..Thus, an endophenotypic approach not only provides clues to underlying candidate genes contributing to these behavioral dimensions, but may also point the way to a better understanding of pathophysiological mechanisms...
  4. ncbi request reprint Amygdala-prefrontal disconnection in borderline personality disorder
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 32:1629-40. 2007
    ..We demonstrated no significant differences in amygdala volumes or metabolism between BPD patients and controls...
  5. doi request reprint Recent advances in the biological study of personality disorders
    Antonia S New
    The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1217, New York, NY 10029, USA
    Psychiatr Clin North Am 31:441-61, vii. 2008
    ..Clearly SPD falls within the schizophrenia spectrum, but precisely the nature of what predicts full-blown schizophrenia as opposed to the milder symptoms of SPD is not yet clear...
  6. pmc Frontolimbic structural changes in borderline personality disorder
    Michael J Minzenberg
    Mount Sinai School of Medicine and Bronx VA Medical Center, Bronx, NY, USA
    J Psychiatr Res 42:727-33. 2008
    ..We tested the hypothesis that BPD patients exhibit gross structural changes that parallel the respective increases in amygdala activation and impairment of rostral/subgenual ACC activation...
  7. ncbi request reprint Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, 10032, USA
    Biol Psychiatry 55:1001-6. 2004
    ..Schizotypal personality disorder (SPD) is a schizophrenia spectrum disorder, genetically related to schizophrenia. The goal of this study was to investigate striatal DA function in patients with SPD...
  8. ncbi request reprint Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients
    Michael J Minzenberg
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 31:197-203. 2006
    ..In addition, D(2) receptor dysfunction may play a role in impulsivity, whereas 5-HT(1A) cell-body autoreceptor function may be spared in these disorders...
  9. ncbi request reprint Reduced anterior and posterior cingulate gray matter in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029, USA
    Biol Psychiatry 58:614-23. 2005
    ..We extended this investigation by examining gray and white matter volume of frontal and cingulate gyrus Brodmann areas (BAs) in a large group of patients and healthy controls...
  10. ncbi request reprint Trauma, genes, and the neurobiology of personality disorders
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Ann N Y Acad Sci 1032:104-16. 2004
    ..Gene-environment interactions involving childhood maltreatment are demonstrated in recent studies on antisocial behaviors and aggressive rhesus monkeys and highlight the need for further research in this important area...
  11. doi request reprint Phenotype, endophenotype, and genotype comparisons between borderline personality disorder and major depressive disorder
    Marianne Goodman
    James J Peters VA Medical Center, Bronx, NY 10468, USA
    J Pers Disord 24:38-59. 2010
    ..Definitive clarification of what MDD and BPD have in common and in what ways they are distinct will only be derived from studies that examine both illnesses using the same study design and methodology...
  12. doi request reprint Parental viewpoints of trajectories to borderline personality disorder in female offspring
    Marianne Goodman
    Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, New York 10468, USA
    J Pers Disord 24:204-16. 2010
    ..By adolescence, difficulties with impulsivity, aggression, acting out, and self-destructive behaviors dominate the profile...
  13. ncbi request reprint 24-h Monitoring of plasma norepinephrine, MHPG, cortisol, growth hormone and prolactin in depression
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Psychiatr Res 38:503-11. 2004
    ..The present study takes advantage of frequent plasma sampling over the 24-h period and a multioscillator cosinor model to fit the 24-h rhythms...
  14. ncbi request reprint Low prolactin response to fenfluramine in impulsive aggression
    Antonia S New
    Psychiatry Service 116 A, Bronx VA Medical Center, Bronx, NY 10468, USA
    J Psychiatr Res 38:223-30. 2004
    ..This study represents a replication of previous studies, in a much larger sample, showing a blunted PRL response to fenfluramine of male patients with personality disorder in relation to impulsive aggression and to suicide attempts...
  15. ncbi request reprint Functional MRI of visuospatial working memory in schizotypal personality disorder: a region-of-interest analysis
    Harold W Koenigsberg
    Bronx Veterans Affairs Medical Center, Bronx 1046, NY, USA
    Psychol Med 35:1019-30. 2005
    ..The study of schizotypal personality disorder (SPD) provides regional analysis in unmedicated patients in the schizophrenia spectrum...
  16. pmc Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study
    Michael J Minzenberg
    Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Psychiatry Res 155:231-43. 2007
    ..The neural substrates underlying processing of anger may also be altered. These changes may represent an expression of the volumetric and serotonergic deficits observed in these brain areas in BPD...
  17. ncbi request reprint Abuse and neglect in childhood: relationship to personality disorder diagnoses
    Linda M Bierer
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:737-54. 2003
    ..Most of these findings have been generated from inpatient clinical samples...
  18. doi request reprint The neurobiology of personality disorders: implications for psychoanalysis
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    J Am Psychoanal Assoc 57:361-98. 2009
    ....
  19. ncbi request reprint Characterizing affective instability in borderline personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 159:784-8. 2002
    ..The authors also examined the subjective intensity with which moods are experienced and the association between instability and intensity of affect...
  20. ncbi request reprint Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression
    Antonia S New
    Psychiatry Service, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Arch Gen Psychiatry 59:621-9. 2002
    ..Preclinical and human studies suggest that the orbital frontal cortex and anterior cingulate cortex play an inhibitory role in the regulation of aggression...
  21. pmc Pergolide treatment of cognitive deficits associated with schizotypal personality disorder: continued evidence of the importance of the dopamine system in the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education, and Clinical Center, Bronx, NY, USA
    Neuropsychopharmacology 35:1356-62. 2010
    ..These results suggest that dopamine agonists may provide benefit for the cognitive abnormalities of schizophrenia spectrum disorders...
  22. pmc Smaller superior temporal gyrus volume specificity in schizotypal personality disorder
    Kim E Goldstein
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 112:14-23. 2009
    ..This is the first morphometric study to directly compare SPD and BPD patients in temporal lobe volume...
  23. ncbi request reprint Cingulate gyrus volume and metabolism in the schizophrenia spectrum
    M Mehmet Haznedar
    Department of Psychiatry, Mount Sinai School of Medicine, Neuroscience PET Laboratory, One Gustave L Levy Place, P O Box 1505, New York, NY 10029 6574, USA
    Schizophr Res 71:249-62. 2004
    ....
  24. doi request reprint Neural correlates of emotion processing in borderline personality disorder
    Harold W Koenigsberg
    Mount Sinai School of Medicine, New York, NY, United States
    Psychiatry Res 172:192-9. 2009
    ..The patients activate neural networks in emotion processing that are phylogeneticall older and more reflexive than those activated by HC subjects...
  25. doi request reprint Neurobiology of aggression and violence
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
    Am J Psychiatry 165:429-42. 2008
    ....
  26. ncbi request reprint The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events
    Julia A Golier
    Department of Psychiatry, Veterans Affairs Medical Center 116 A, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Psychiatry 160:2018-24. 2003
    ..The authors examined the relationship of borderline personality disorder to posttraumatic stress disorder (PTSD) with respect to the role of trauma and its timing...
  27. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  28. ncbi request reprint Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorder
    Monte S Buchsbaum
    Neuroscience PET Laboratory, Department of Psychiatry, Mt Sinai School of Medicine, Box 1505, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 54:141-50. 2002
    ..Metabolic rates in Brodmann area 10 were distinctly higher in SPD patients than in either normal volunteers or schizophrenic patients...
  29. ncbi request reprint Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups
    Michael J Minzenberg
    Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
    Psychiatr Genet 16:117-24. 2006
    ..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder...
  30. ncbi request reprint Neuropsychological performance in schizotypal personality disorder: importance of working memory
    Vivian Mitropoulou
    Clinical Research Center, Box 1027, Mt Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Psychiatry 162:1896-903. 2005
    ....
  31. pmc Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients
    Daniel R Rosell
    James J Peters Veterans Affairs Medical Center, Bronx, New York, NY, USA
    Biol Psychiatry 67:1154-62. 2010
    ..We have previously hypothesized that increased 5-HT(2A)R function in the OFC is a state phenomenon that promotes impulsive aggression...
  32. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  33. ncbi request reprint Risperidone in the treatment of schizotypal personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Clin Psychiatry 64:628-34. 2003
    ..In addition, if SPD patients respond to an antipsychotic medication, this will provide support for the notion of a commonality in treatment response between SPD and schizophrenia...
  34. ncbi request reprint Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizotypal personality disorder
    Vivian Mitropoulou
    Department of Psychiatry, Mt Sinai School of Medicine Clinical Reseach Center, New York, NY 10029, USA
    Schizophr Res 70:27-31. 2004
    ..We hypothesized that SPD patients would demonstrate comparable or lower DA and HPA responses after 2-DG to HV...
  35. ncbi request reprint Biochemical endophenotypes in personality disorders
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Med 77:199-213. 2003
  36. ncbi request reprint Neurobiologic function and temperament in subjects with personality disorders
    Vivian Mitropoulou
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:725-30. 2003
    ....
  37. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
    ..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652...
  38. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  39. ncbi request reprint Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity
    Vivian Mitropoulou
    Mt Sinai School of Medicine, Department of Psychiatry, The Bronx Veterans Affairs Medical Center, New York, New York, USA
    Biol Psychiatry 52:1175-82. 2002
    ..We investigated the neuropsychological profile in SPD patients compared with two comparison groups: healthy volunteers (HV) and patients who met criteria for another non-schizophrenia spectrum personality disorder (NSS)...
  40. ncbi request reprint Refining the approaches to personality disorders
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:724. 2003
  41. doi request reprint The interpersonal dimension of borderline personality disorder: toward a neuropeptide model
    Barbara Stanley
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 167:24-39. 2010
    ....
  42. ncbi request reprint Dual-task information processing in schizotypal personality disorder: evidence of impaired processing capacity
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychology 20:453-60. 2006
    ..The authors discuss the implications of these processing capacity limitations for understanding both the signature of cognitive impairment within the schizophrenia spectrum and general abnormalities in working memory...
  43. ncbi request reprint RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York 10468, USA
    J Neurochem 87:1402-12. 2003
    ..Quantitation of 5-HT2CR and 5-HT2CR-tr mRNA variants revealed that the expression of 5-HT2CR-tr was approximately 50% of that observed for the full-length isoform...
  44. ncbi request reprint Dispositional impulsivity in normal and abnormal samples
    Janine D Flory
    Department of Psychiatry, Box 1230, One Gustave Levy Place, Mount Sinai School of Medicine, New York, NY 10029, United States
    J Psychiatr Res 40:438-47. 2006
    ..Results from these analyses also lend support to a large body of work that demonstrates that normal and abnormal personality features are related...
  45. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  46. ncbi request reprint Irritable assault and variation in the COMT gene
    Janine D Flory
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Psychiatr Genet 17:344-6. 2007
    ..These findings provide limited support for a role of COMT in modulating aggressive behavior, and are extended to people with personality disorders...
  47. ncbi request reprint The borderline diagnosis II: biology, genetics, and clinical course
    Andrew E Skodol
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, New York, USA
    Biol Psychiatry 51:951-63. 2002
    ....
  48. ncbi request reprint Reduced processing resource availability in schizotypal personality disorder: evidence from a dual-task CPT study
    Patrick J Moriarty
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    J Clin Exp Neuropsychol 25:335-47. 2003
    ....
  49. pmc Cortical gray and white matter volume in unmedicated schizotypal and schizophrenia patients
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 101:111-23. 2008
    ..Overall, our findings suggest that increased prefrontal volume in BA10 and sparing of volume loss in temporal cortex (BAs 22 and 20) may be a protective factor in SPD which reduces vulnerability to psychosis...
  50. ncbi request reprint Deficient attentional modulation of startle eyeblink is associated with symptom severity in the schizophrenia spectrum
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, United States
    Schizophr Res 93:288-95. 2007
    ..Among the schizophrenia-spectrum sample, more deficient PPI during the attended prepulses was associated with greater symptom severity as measured by the total 18-item Brief Psychiatric Rating Scale score...
  51. pmc Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia
    Pavel Katsel
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 36:1171-7. 2011
    ..These findings suggest that a subset of astrocytes localized to specific cortical layers is adversely affected in schizophrenia and raise the possibility of glutamatergic dyshomeostasis in selected neuronal populations...
  52. ncbi request reprint Dexamethasone suppression test findings in subjects with personality disorders: associations with posttraumatic stress disorder and major depression
    Robert Grossman
    Department of Psychatry Bronx VeteransAffairs medical Center, Bronx, NY, USA
    Am J Psychiatry 160:1291-8. 2003
    ..To investigate the effect of PTSD, the authors conducted a 0.5-mg DST, which is more sensitive than the 1.0-mg DST for detection of increased cortisol suppression, in a group of subjects with personality disorders...
  53. doi request reprint An attachment perspective on borderline personality disorder: advances in gene-environment considerations
    Howard Steele
    Psychology Department, New School for Social Research, Room 611, 80 Fifth Avenue, New York, NY 10011, USA
    Curr Psychiatry Rep 12:61-7. 2010
    ..This line of research may refine early risk assessment and preventive mental health services...
  54. pmc Neural correlates of the use of psychological distancing to regulate responses to negative social cues: a study of patients with borderline personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10468, USA
    Biol Psychiatry 66:854-63. 2009
    ..One possible contributing factor to emotional instability is a failure to adequately employ adaptive cognitive regulatory strategies such as psychological distancing...
  55. ncbi request reprint The borderline diagnosis I: psychopathology, comorbidity, and personality structure
    Andrew E Skodol
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 51:936-50. 2002
    ..Although there are a number of competing models of personality structure, they have remarkable convergence on a set of three to five basic personality dimensions...
  56. pmc Frontal-striatal-thalamic mediodorsal nucleus dysfunction in schizophrenia-spectrum patients during sensorimotor gating
    Erin A Hazlett
    Department of Psychiatry, Box 1505, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroimage 42:1164-77. 2008
    ..Dysfunctional FST activation, particularly in the caudate may underlie PPI abnormalities in schizophrenia-spectrum patients...
  57. ncbi request reprint Deficient attentional modulation of the startle response in patients with schizotypal personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029, USA
    Am J Psychiatry 160:1621-6. 2003
    ..The purpose of this study was to examine automatic sensorimotor gating and controlled attentional modulation of the startle eye blink response in unmedicated subjects with schizotypal personality disorder...
  58. ncbi request reprint The role of childhood trauma in differences in affective instability in those with personality disorders
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:763-70. 2003
    ..This study examined the relationship of self-reported histories of childhood trauma to measures of affective instability in a sample of unmedicated outpatients with various personality disorders (n=174)...
  59. ncbi request reprint Efficacy of open-label venlafaxine in subjects with major depressive disorder: associations with neuroendocrine response to serotonergic and noradrenergic probes
    Robert Grossman
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, New York, NY 10029 6574, USA
    Psychiatry Res 128:203-6. 2004
    ..low-dose responders. Evaluation of models of "serotonergic-responsive" and norepinephrine-responsive" depression requires larger numbers of patients...
  60. ncbi request reprint The borderline diagnosis III: identifying endophenotypes for genetic studies
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 51:964-8. 2002
    ..The use of laboratory paradigms for measures of aggression and affective instability are discussed in the context of such endophenotypic approaches...
  61. ncbi request reprint Exaggerated affect-modulated startle during unpleasant stimuli in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 62:250-5. 2007
    ..The affect-modulated startle response is a reliable indicator of emotional processing of stimuli. The aim of this study was to examine emotional processing in BPD patients (n = 27) and healthy control subjects (n = 21)...
  62. ncbi request reprint Fine mapping of the 5p13 locus linked to schizophrenia and schizotypal personality disorder in a Puerto Rican family
    Irina N Bespalova
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatr Genet 15:205-10. 2005
    ....
  63. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  64. ncbi request reprint Growth hormone response to guanfacine in boys with attention deficit hyperactivity disorder: a preliminary study
    Jeffrey M Halperin
    Department of Psychology, Queens College of the City University of New York, New York, New York 11367, USA
    J Child Adolesc Psychopharmacol 13:283-94. 2003
    ....
  65. ncbi request reprint Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction
    Patricia S Goldman-Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Psychopharmacology (Berl) 174:3-16. 2004
    ....
  66. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  67. ncbi request reprint Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression
    Antonia S New
    Psychiatry Service Mount Sinai School of Medicine and the Bronx VA Medical Center, 130 West Kingsbridge Road, PO Box 1168, Bronx, NY 10468, USA
    Psychopharmacology (Berl) 176:451-8. 2004
    ..In addition, patients with impulsive aggression have an attenuation of symptoms with selective serotonin reuptake inhibitor (SSRI) treatment...
  68. ncbi request reprint The effects of guanfacine on context processing abnormalities in schizotypal personality disorder
    Margaret M McClure
    VA VISN3 Mental Illness Research, Education, and Clinical Center, Bronx, New York 10468, USA
    Biol Psychiatry 61:1157-60. 2007
    ..This study examined the potential of guanfacine for improving context processing, a feature of working memory, in SPD...
  69. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  70. ncbi request reprint Visual-spatial learning and memory in schizotypal personality disorder: continued evidence for the importance of working memory in the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education, and Clinical Center, Bronx, NY 10468, United States
    Arch Clin Neuropsychol 22:109-16. 2007
    ..These findings suggest that it is possible to detect both auditory and visual processing episodic memory abnormalities in the spectrum and that these deficits are uniformly a function of verbal working memory impairments...
  71. doi request reprint Context processing in schizotypal personality disorder: evidence of specificity of impairment to the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education and Clinical Center, Bronx, New York 10468, USA
    J Abnorm Psychol 117:342-54. 2008
    ..These findings, which are quite similar to those previously reported in patients with schizophrenia, suggest that context processing deficits are specific to the schizophrenia spectrum and are not a reflection of overall psychopathology...
  72. doi request reprint Affective lability and affect intensity as core dimensions of bipolar disorders during euthymic period
    Chantal Henry
    Departement de psychiatrie adulte, B√Ętiment Lescure, CHS Charles Perrens, 121 rue de la Bechade, 33076 Bordeaux Cedex, France
    Psychiatry Res 159:1-6. 2008
    ..Both dimensions could account for the stress reactivity of bipolar patients that may lead to relapses...
  73. ncbi request reprint "Late-onset" borderline personality disorder: a life unraveling
    Matthew E Bernstein
    McLean Hospital, Belmont, Mass 02478, USA
    Harv Rev Psychiatry 10:292-301. 2002
  74. ncbi request reprint Context-processing deficits in schizotypal personality disorder
    Deanna M Barch
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    J Abnorm Psychol 113:556-68. 2004
    ..Context processing was strongly associated with working memory and selective attention performance in the SPD individuals...

Research Grants31

  1. PHARMACOLOGY OF COGNITION IN SCHIZOTYPAL PERSONALITY
    Larry Siever; Fiscal Year: 2006
    ..abstract_text> ..
  2. Imaging 5-HT2A Receptors in Patients with Impulsive Aggression and Controls with
    Larry Siever; Fiscal Year: 2005
    ..The proposed study will enable a better understanding of the character of serotonergic dysfunction in impulsive/aggression. ..
  3. The Genetics of Endophenotypes and Schizophrenia
    Larry Siever; Fiscal Year: 2007
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
  4. Pharmacology of Cognition in Schizotypal Personality Disorder
    Larry Siever; Fiscal Year: 2007
    ..These studies will help to clarify the exact nature of this memory problem and investigate how it can be improved by medication treatment. ..
  5. 5HTT and 5-HT2A Receptors in Impulsive Aggression and Effects of Fluoxetine
    Larry J Siever; Fiscal Year: 2010
    ..These studies will help our understanding of an important brain chemical, serotonin, which is related to aggression, and how it is affected by antidepressants that increase serotonin. ..
  6. Pharmacology of Cognition in Schizotypal Personality Disorder
    Larry J Siever; Fiscal Year: 2010
    ..These studies will help to clarify the exact nature of this memory problem and investigate how it can be improved by medication treatment. ..
  7. Imaging 5-HT2A Receptors in Impulsive Aggression
    Larry Siever; Fiscal Year: 2004
    ....
  8. M-CPP/PET IN IMPULSIVE PERSONALITY DISORDERS
    Larry Siever; Fiscal Year: 2001
    ....
  9. PHARMACOLOGY OF COGNITION IN SCHIZOTYPAL PERSONALITY
    Larry Siever; Fiscal Year: 2001
    ....
  10. PHARMACOLOGY OF COGNITION IN SCHIZOTYPAL PERSONALITY
    Larry Siever; Fiscal Year: 2003
    ....
  11. 2/6 The Genetics of Endophenotypes and Schizophrenia
    Larry J Siever; Fiscal Year: 2010
    ..Once we understand the genetic architecture of these abnormalities, new medications that aim to improve the functioning and quality of life of schizophrenia patients can be developed. ..