Larry J Siever

Summary

Country: USA

Publications

  1. doi request reprint The neurobiology of personality disorders: implications for psychoanalysis
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    J Am Psychoanal Assoc 57:361-98. 2009
  2. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
  3. doi request reprint Neurobiology of aggression and violence
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
    Am J Psychiatry 165:429-42. 2008
  4. pmc Potentiated amygdala response to repeated emotional pictures in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Biol Psychiatry 72:448-56. 2012
  5. ncbi request reprint Amygdala-prefrontal disconnection in borderline personality disorder
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 32:1629-40. 2007
  6. pmc Neural correlates of using distancing to regulate emotional responses to social situations
    Harold W Koenigsberg
    James J Peters VA Medical Center, Bronx, NY 10468, USA
    Neuropsychologia 48:1813-22. 2010
  7. doi request reprint Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
    Am J Psychiatry 170:521-32. 2013
  8. pmc Anterior limb of the internal capsule in schizotypal personality disorder: fiber-tract counting, volume, and anisotropy
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 141:119-27. 2012
  9. doi request reprint Proposed changes in personality and personality disorder assessment and diagnosis for DSM-5 Part II: Clinical application
    Andrew E Skodol
    Department of Psychiatry, University of Arizona, College of Medicine, Tucson, USA
    Personal Disord 2:23-40. 2011
  10. pmc Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorder
    Antonia S New
    James J Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Biol Psychiatry 66:1107-14. 2009

Collaborators

Detail Information

Publications95

  1. doi request reprint The neurobiology of personality disorders: implications for psychoanalysis
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, USA
    J Am Psychoanal Assoc 57:361-98. 2009
    ....
  2. pmc Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  3. doi request reprint Neurobiology of aggression and violence
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, NY, USA
    Am J Psychiatry 165:429-42. 2008
    ....
  4. pmc Potentiated amygdala response to repeated emotional pictures in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Biol Psychiatry 72:448-56. 2012
    ..Borderline personality disorder (BPD) is characterized by an inability to regulate emotional responses. The amygdala is important in learning about the valence (goodness and badness) of stimuli and functions abnormally in BPD...
  5. ncbi request reprint Amygdala-prefrontal disconnection in borderline personality disorder
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 32:1629-40. 2007
    ..We demonstrated no significant differences in amygdala volumes or metabolism between BPD patients and controls...
  6. pmc Neural correlates of using distancing to regulate emotional responses to social situations
    Harold W Koenigsberg
    James J Peters VA Medical Center, Bronx, NY 10468, USA
    Neuropsychologia 48:1813-22. 2010
    ..These findings demonstrate that distancing from aversive social cues modulates amygdala activity via engagement of networks implicated in social perception, perspective-taking, and attentional allocation...
  7. doi request reprint Genome-wide linkage analyses of 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, Calif, USA
    Am J Psychiatry 170:521-32. 2013
    ..The authors previously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage was evaluated...
  8. pmc Anterior limb of the internal capsule in schizotypal personality disorder: fiber-tract counting, volume, and anisotropy
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 141:119-27. 2012
    ..In contrast to prior SZ studies that report lower FA, individuals with SPD show sparing. Our findings are consistent with a pattern of milder thalamo-frontal dysconnectivity in SPD than schizophrenia...
  9. doi request reprint Proposed changes in personality and personality disorder assessment and diagnosis for DSM-5 Part II: Clinical application
    Andrew E Skodol
    Department of Psychiatry, University of Arizona, College of Medicine, Tucson, USA
    Personal Disord 2:23-40. 2011
    ....
  10. pmc Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorder
    Antonia S New
    James J Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Biol Psychiatry 66:1107-14. 2009
    ..Preclinical studies show that orbital frontal cortex (OFC) plays a role in regulating impulsive aggression. Prior work has found OFC dysfunction in BPD...
  11. pmc Pergolide treatment of cognitive deficits associated with schizotypal personality disorder: continued evidence of the importance of the dopamine system in the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education, and Clinical Center, Bronx, NY, USA
    Neuropsychopharmacology 35:1356-62. 2010
    ..These results suggest that dopamine agonists may provide benefit for the cognitive abnormalities of schizophrenia spectrum disorders...
  12. pmc Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  13. pmc Striatal activity in borderline personality disorder with comorbid intermittent explosive disorder: sex differences
    M Mercedes Perez-Rodriguez
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Psychiatr Res 46:797-804. 2012
    ..These sex differences suggest differential involvement of frontal-striatal circuits in BPD-IED, and are discussed in relation to striatal involvement in affective learning and social decision-making...
  14. ncbi request reprint Deficient attentional modulation of startle eyeblink is associated with symptom severity in the schizophrenia spectrum
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, United States
    Schizophr Res 93:288-95. 2007
    ..Among the schizophrenia-spectrum sample, more deficient PPI during the attended prepulses was associated with greater symptom severity as measured by the total 18-item Brief Psychiatric Rating Scale score...
  15. ncbi request reprint Irritable assault and variation in the COMT gene
    Janine D Flory
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Psychiatr Genet 17:344-6. 2007
    ..These findings provide limited support for a role of COMT in modulating aggressive behavior, and are extended to people with personality disorders...
  16. doi request reprint Context processing in schizotypal personality disorder: evidence of specificity of impairment to the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education and Clinical Center, Bronx, New York 10468, USA
    J Abnorm Psychol 117:342-54. 2008
    ..These findings, which are quite similar to those previously reported in patients with schizophrenia, suggest that context processing deficits are specific to the schizophrenia spectrum and are not a reflection of overall psychopathology...
  17. ncbi request reprint Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  18. doi request reprint Neural correlates of emotion processing in borderline personality disorder
    Harold W Koenigsberg
    Mount Sinai School of Medicine, New York, NY, United States
    Psychiatry Res 172:192-9. 2009
    ..The patients activate neural networks in emotion processing that are phylogeneticall older and more reflexive than those activated by HC subjects...
  19. pmc Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  20. pmc Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients
    Daniel R Rosell
    James J Peters Veterans Affairs Medical Center, Bronx, New York, NY, USA
    Biol Psychiatry 67:1154-62. 2010
    ..We have previously hypothesized that increased 5-HT(2A)R function in the OFC is a state phenomenon that promotes impulsive aggression...
  21. pmc Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder
    Kim E Goldstein
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Behav Brain Res 218:335-40. 2011
    ..05). Findings suggest spatial working memory impairments may be a core neuropsychological deficit specific to SPD patients and highlight the role of VLPFC subcomponents in normal and dysfunctional memory performance...
  22. ncbi request reprint Reduced anterior and posterior cingulate gray matter in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029, USA
    Biol Psychiatry 58:614-23. 2005
    ..We extended this investigation by examining gray and white matter volume of frontal and cingulate gyrus Brodmann areas (BAs) in a large group of patients and healthy controls...
  23. pmc Smaller superior temporal gyrus volume specificity in schizotypal personality disorder
    Kim E Goldstein
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 112:14-23. 2009
    ..This is the first morphometric study to directly compare SPD and BPD patients in temporal lobe volume...
  24. ncbi request reprint Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients
    Michael J Minzenberg
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    Neuropsychopharmacology 31:197-203. 2006
    ..In addition, D(2) receptor dysfunction may play a role in impulsivity, whereas 5-HT(1A) cell-body autoreceptor function may be spared in these disorders...
  25. pmc Frontolimbic structural changes in borderline personality disorder
    Michael J Minzenberg
    Mount Sinai School of Medicine and Bronx VA Medical Center, Bronx, NY, USA
    J Psychiatr Res 42:727-33. 2008
    ..We tested the hypothesis that BPD patients exhibit gross structural changes that parallel the respective increases in amygdala activation and impairment of rostral/subgenual ACC activation...
  26. pmc Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder
    Erin A Hazlett
    Mental Illness Research, Education and Clinical Center VISN 3, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Neuroimage 55:900-8. 2011
    ..Lower fractional anisotropy (FA), a measure of white-matter integrity within prefrontal, temporal, and cingulate regions has been reported in schizophrenia but has been little studied in SPD...
  27. ncbi request reprint Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups
    Michael J Minzenberg
    Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
    Psychiatr Genet 16:117-24. 2006
    ..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder...
  28. ncbi request reprint Exaggerated affect-modulated startle during unpleasant stimuli in borderline personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 62:250-5. 2007
    ..The affect-modulated startle response is a reliable indicator of emotional processing of stimuli. The aim of this study was to examine emotional processing in BPD patients (n = 27) and healthy control subjects (n = 21)...
  29. pmc Larger putamen size in antipsychotic-naïve individuals with schizotypal personality disorder
    Eran Chemerinski
    Mount Sinai School of Medicine, Department of Psychiatry, New York, NY, United States
    Schizophr Res 143:158-64. 2013
    ....
  30. pmc Cortical gray and white matter volume in unmedicated schizotypal and schizophrenia patients
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 101:111-23. 2008
    ..Overall, our findings suggest that increased prefrontal volume in BA10 and sparing of volume loss in temporal cortex (BAs 22 and 20) may be a protective factor in SPD which reduces vulnerability to psychosis...
  31. pmc Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 168:930-46. 2011
    ....
  32. ncbi request reprint Abuse and neglect in childhood: relationship to personality disorder diagnoses
    Linda M Bierer
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:737-54. 2003
    ..Most of these findings have been generated from inpatient clinical samples...
  33. pmc Fronto-limbic dysfunction in response to facial emotion in borderline personality disorder: an event-related fMRI study
    Michael J Minzenberg
    Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Psychiatry Res 155:231-43. 2007
    ..The neural substrates underlying processing of anger may also be altered. These changes may represent an expression of the volumetric and serotonergic deficits observed in these brain areas in BPD...
  34. pmc Frontal-striatal-thalamic mediodorsal nucleus dysfunction in schizophrenia-spectrum patients during sensorimotor gating
    Erin A Hazlett
    Department of Psychiatry, Box 1505, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroimage 42:1164-77. 2008
    ..Dysfunctional FST activation, particularly in the caudate may underlie PPI abnormalities in schizophrenia-spectrum patients...
  35. doi request reprint Genetic variations in the ADAMTS12 gene are associated with schizophrenia in Puerto Rican patients of Spanish descent
    Irina N Bespalova
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuromolecular Med 14:53-64. 2012
    ..62; 95% CI = 1.19-2.21) associated with the disorder. The association remained significant after correction for multiple testing. Our data support the hypothesis that genetic variations in ADAMTS12 influence the risk of schizophrenia...
  36. ncbi request reprint Efficacy of open-label venlafaxine in subjects with major depressive disorder: associations with neuroendocrine response to serotonergic and noradrenergic probes
    Robert Grossman
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, New York, NY 10029 6574, USA
    Psychiatry Res 128:203-6. 2004
    ..low-dose responders. Evaluation of models of "serotonergic-responsive" and norepinephrine-responsive" depression requires larger numbers of patients...
  37. pmc Deficient visual sensitivity in schizotypal personality disorder
    Brendon W Kent
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States
    Schizophr Res 127:144-50. 2011
    ....
  38. ncbi request reprint Effects of acute metabolic stress on the dopaminergic and pituitary-adrenal axis activity in patients with schizotypal personality disorder
    Vivian Mitropoulou
    Department of Psychiatry, Mt Sinai School of Medicine Clinical Reseach Center, New York, NY 10029, USA
    Schizophr Res 70:27-31. 2004
    ..We hypothesized that SPD patients would demonstrate comparable or lower DA and HPA responses after 2-DG to HV...
  39. ncbi request reprint Cingulate gyrus volume and metabolism in the schizophrenia spectrum
    M Mehmet Haznedar
    Department of Psychiatry, Mount Sinai School of Medicine, Neuroscience PET Laboratory, One Gustave L Levy Place, P O Box 1505, New York, NY 10029 6574, USA
    Schizophr Res 71:249-62. 2004
    ....
  40. ncbi request reprint The effects of guanfacine on context processing abnormalities in schizotypal personality disorder
    Margaret M McClure
    VA VISN3 Mental Illness Research, Education, and Clinical Center, Bronx, New York 10468, USA
    Biol Psychiatry 61:1157-60. 2007
    ..This study examined the potential of guanfacine for improving context processing, a feature of working memory, in SPD...
  41. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
    ..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652...
  42. pmc Functional outcomes, functional capacity, and cognitive impairment in schizotypal personality disorder
    Margaret M McClure
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY, United States
    Schizophr Res 144:146-50. 2013
    ....
  43. doi request reprint Sex differences in familiality effects on neurocognitive performance in schizophrenia
    Monica E Calkins
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Biol Psychiatry 73:976-84. 2013
    ..In view of these findings, the current investigation tested the hypothesis that neurocognitive performance of schizophrenia probands can predict the neurocognitive performance of their unaffected family members...
  44. pmc Anterior and posterior cingulate cortex volume in healthy adults: effects of aging and gender differences
    Sarah L Mann
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Brain Res 1401:18-29. 2011
    ..The Brodmann area-based approach also facilitates comparisons across studies that aim to draw inferences between age- and gender-related structural differences in the cingulate gyrus and corresponding differences in cingulate function...
  45. ncbi request reprint Functional MRI of visuospatial working memory in schizotypal personality disorder: a region-of-interest analysis
    Harold W Koenigsberg
    Bronx Veterans Affairs Medical Center, Bronx 1046, NY, USA
    Psychol Med 35:1019-30. 2005
    ..The study of schizotypal personality disorder (SPD) provides regional analysis in unmedicated patients in the schizophrenia spectrum...
  46. ncbi request reprint Dispositional impulsivity in normal and abnormal samples
    Janine D Flory
    Department of Psychiatry, Box 1230, One Gustave Levy Place, Mount Sinai School of Medicine, New York, NY 10029, United States
    J Psychiatr Res 40:438-47. 2006
    ..Results from these analyses also lend support to a large body of work that demonstrates that normal and abnormal personality features are related...
  47. doi request reprint Eye tracking performance and the boundaries of the schizophrenia spectrum
    Vivian Mitropoulou
    Mount Sinai School of Medicine Dept of Psychiatry, The James J Peters Veterans Affairs Medical Center, and VISN 3 MIRECC, NY, USA
    Psychiatry Res 186:18-22. 2011
    ..Indeed, SPD subjects comprise the only group not statistically different from schizophrenic patients in quantitative or qualitative ratings...
  48. pmc Neural correlates of the use of psychological distancing to regulate responses to negative social cues: a study of patients with borderline personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10468, USA
    Biol Psychiatry 66:854-63. 2009
    ..One possible contributing factor to emotional instability is a failure to adequately employ adaptive cognitive regulatory strategies such as psychological distancing...
  49. pmc Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls
    M Mercedes Perez-Rodriguez
    Department of Psychiatry, Mount Sinai School of Medicine, Psychiatry Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    J Psychiatr Res 44:1075-81. 2010
    ..Only one study has analyzed the association between the tryptophan-hydroxylase 2 (TPH2) gene and BPD. A TPH2 "risk" haplotype has been described that is associated with anxiety, depression and suicidal behavior...
  50. ncbi request reprint Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide
    Anissa Abi-Dargham
    Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, 10032, USA
    Biol Psychiatry 55:1001-6. 2004
    ..Schizotypal personality disorder (SPD) is a schizophrenia spectrum disorder, genetically related to schizophrenia. The goal of this study was to investigate striatal DA function in patients with SPD...
  51. doi request reprint Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients
    Harold W Koenigsberg
    Mount Sinai School of Medicine, Department of Psychiatry, New York, NY, USA
    Psychiatry Res 199:92-7. 2012
    ..These findings are consistent with altered PKC and BDNF activity in a range of neuropsychiatric conditions including bipolar disorder, depression and suicide...
  52. pmc Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia
    Panos Roussos
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA
    Neuropsychopharmacology 38:533-9. 2013
    ..These findings implicate abnormalities of the NF-κB signaling pathway in SZ and provide evidence for an additional possible mechanism affecting the translocation of NF-κB signaling to the nucleus...
  53. ncbi request reprint 24-h Monitoring of plasma norepinephrine, MHPG, cortisol, growth hormone and prolactin in depression
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Psychiatr Res 38:503-11. 2004
    ..The present study takes advantage of frequent plasma sampling over the 24-h period and a multioscillator cosinor model to fit the 24-h rhythms...
  54. ncbi request reprint Dual-task information processing in schizotypal personality disorder: evidence of impaired processing capacity
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychology 20:453-60. 2006
    ..The authors discuss the implications of these processing capacity limitations for understanding both the signature of cognitive impairment within the schizophrenia spectrum and general abnormalities in working memory...
  55. ncbi request reprint Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression
    Antonia S New
    Psychiatry Service Mount Sinai School of Medicine and the Bronx VA Medical Center, 130 West Kingsbridge Road, PO Box 1168, Bronx, NY 10468, USA
    Psychopharmacology (Berl) 176:451-8. 2004
    ..In addition, patients with impulsive aggression have an attenuation of symptoms with selective serotonin reuptake inhibitor (SSRI) treatment...
  56. doi request reprint The neurobiology of empathy in borderline personality disorder
    Luis H Ripoll
    Department of Psychiatry One Gustave L Levy Place, Mount Sinai School of Medicine, Box 1230, New York, NY 10029, USA
    Curr Psychiatry Rep 15:344. 2013
    ..Future avenues for BPD research will include developmental assessment of attachment and neurobiological functioning under varying conditions...
  57. doi request reprint Proposed changes in personality and personality disorder assessment and diagnosis for DSM-5 Part I: Description and rationale
    Andrew E Skodol
    Department of Psychiatry, University of Arizona, College of Medicine, Tucson, USA
    Personal Disord 2:4-22. 2011
    ..In Part II, we will illustrate the clinical application of the model with vignettes of patients with varying degrees of personality psychopathology, to show how assessments might be conducted and diagnoses reached...
  58. doi request reprint No link of serotonin 2C receptor editing to serotonin transporter genotype
    Rebecca Lyddon
    James J Peters Veterans Affairs Medical Center, Bronx, New York, USA
    Neuroreport 21:1080-4. 2010
    ..Our findings argue against the hypothesis that 5-HT2cR editing efficiency is regulated by extracellular serotonin levels...
  59. ncbi request reprint The role of childhood trauma in differences in affective instability in those with personality disorders
    Marianne Goodman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:763-70. 2003
    ..This study examined the relationship of self-reported histories of childhood trauma to measures of affective instability in a sample of unmedicated outpatients with various personality disorders (n=174)...
  60. ncbi request reprint Low prolactin response to fenfluramine in impulsive aggression
    Antonia S New
    Psychiatry Service 116 A, Bronx VA Medical Center, Bronx, NY 10468, USA
    J Psychiatr Res 38:223-30. 2004
    ..This study represents a replication of previous studies, in a much larger sample, showing a blunted PRL response to fenfluramine of male patients with personality disorder in relation to impulsive aggression and to suicide attempts...
  61. ncbi request reprint Neurobiologic function and temperament in subjects with personality disorders
    Vivian Mitropoulou
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:725-30. 2003
    ....
  62. pmc The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  63. ncbi request reprint Cognitive and brain function in schizotypal personality disorder
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 54:157-67. 2002
    ..Preliminary trials of catecholaminergic agents suggest that these agents may be able to improve these impaired cognitive functions...
  64. ncbi request reprint Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression
    Antonia S New
    Psychiatry Service, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Arch Gen Psychiatry 59:621-9. 2002
    ..Preclinical and human studies suggest that the orbital frontal cortex and anterior cingulate cortex play an inhibitory role in the regulation of aggression...
  65. ncbi request reprint Characterizing affective instability in borderline personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 159:784-8. 2002
    ..The authors also examined the subjective intensity with which moods are experienced and the association between instability and intensity of affect...
  66. pmc Joint Effect of Childhood Abuse and Family History of Major Depressive Disorder on Rates of PTSD in People with Personality Disorders
    Janine D Flory
    Department of Psychiatry, Mount Sinai School of Medicine MSSM, One Gustave L Levy Place, NY 10029, USA
    Depress Res Treat 2012:350461. 2012
    ....
  67. doi request reprint Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia
    Panos Roussos
    Department of Psychiatry, The Mount Sinai School of Medicine, Bronx, NY 10468, USA
    Arch Gen Psychiatry 69:7-15. 2012
    ....
  68. doi request reprint The interpersonal dimension of borderline personality disorder: toward a neuropeptide model
    Barbara Stanley
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 167:24-39. 2010
    ....
  69. ncbi request reprint Fine mapping of the 5p13 locus linked to schizophrenia and schizotypal personality disorder in a Puerto Rican family
    Irina N Bespalova
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatr Genet 15:205-10. 2005
    ....
  70. pmc Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions
    Winnie W Leung
    Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center MIRECC, Bronx, NY, USA
    Neuropsychiatr Dis Treat 3:925-34. 2007
    ..No differences were found on processing speed or verbal working memory. Both context processing and working memory appear related to COMT genotype and the AX-CPT and N-back may be most sensitive to the effects of COMT variation...
  71. ncbi request reprint Refining the approaches to personality disorders
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:724. 2003
  72. ncbi request reprint Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorder
    Monte S Buchsbaum
    Neuroscience PET Laboratory, Department of Psychiatry, Mt Sinai School of Medicine, Box 1505, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 54:141-50. 2002
    ..Metabolic rates in Brodmann area 10 were distinctly higher in SPD patients than in either normal volunteers or schizophrenic patients...
  73. ncbi request reprint Risperidone in the treatment of schizotypal personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Clin Psychiatry 64:628-34. 2003
    ..In addition, if SPD patients respond to an antipsychotic medication, this will provide support for the notion of a commonality in treatment response between SPD and schizophrenia...
  74. ncbi request reprint Biochemical endophenotypes in personality disorders
    Antonia S New
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Med 77:199-213. 2003
  75. doi request reprint Evidence-based pharmacotherapy for personality disorders
    Luis H Ripoll
    Mental Illness Research Education and Clinical Center, James J Peters VA Medical Center, Bronx, NY 10468, USA
    Int J Neuropsychopharmacol 14:1257-88. 2011
    ..Increasing efforts to translate personality theory and social cognitive neuroscience into increasingly specific neurobiological substrates may provide more effective targets for pharmacotherapy...
  76. ncbi request reprint The pathophysiology of schizophrenia disorders: perspectives from the spectrum
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 161:398-413. 2004
    ..A pathophysiological model of the relationship between schizotypal personality disorder and schizophrenia was developed based on this data...
  77. ncbi request reprint The borderline diagnosis II: biology, genetics, and clinical course
    Andrew E Skodol
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, New York, USA
    Biol Psychiatry 51:951-63. 2002
    ....
  78. ncbi request reprint Reduced processing resource availability in schizotypal personality disorder: evidence from a dual-task CPT study
    Patrick J Moriarty
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    J Clin Exp Neuropsychol 25:335-47. 2003
    ....
  79. ncbi request reprint Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity
    Vivian Mitropoulou
    Mt Sinai School of Medicine, Department of Psychiatry, The Bronx Veterans Affairs Medical Center, New York, New York, USA
    Biol Psychiatry 52:1175-82. 2002
    ..We investigated the neuropsychological profile in SPD patients compared with two comparison groups: healthy volunteers (HV) and patients who met criteria for another non-schizophrenia spectrum personality disorder (NSS)...
  80. ncbi request reprint The relationship of borderline personality disorder to posttraumatic stress disorder and traumatic events
    Julia A Golier
    Department of Psychiatry, Veterans Affairs Medical Center 116 A, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Psychiatry 160:2018-24. 2003
    ..The authors examined the relationship of borderline personality disorder to posttraumatic stress disorder (PTSD) with respect to the role of trauma and its timing...
  81. pmc Endophenotypes in the personality disorders
    Larry J Siever
    Mount Sinai School of Medicine, New York, NY, USA
    Dialogues Clin Neurosci 7:139-51. 2005
    ..Thus, an endophenotypic approach not only provides clues to underlying candidate genes contributing to these behavioral dimensions, but may also point the way to a better understanding of pathophysiological mechanisms...
  82. ncbi request reprint RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine and Bronx Veterans Affairs Medical Center, New York 10468, USA
    J Neurochem 87:1402-12. 2003
    ..Quantitation of 5-HT2CR and 5-HT2CR-tr mRNA variants revealed that the expression of 5-HT2CR-tr was approximately 50% of that observed for the full-length isoform...
  83. ncbi request reprint The borderline diagnosis I: psychopathology, comorbidity, and personality structure
    Andrew E Skodol
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 51:936-50. 2002
    ..Although there are a number of competing models of personality structure, they have remarkable convergence on a set of three to five basic personality dimensions...
  84. ncbi request reprint The borderline diagnosis III: identifying endophenotypes for genetic studies
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 51:964-8. 2002
    ..The use of laboratory paradigms for measures of aggression and affective instability are discussed in the context of such endophenotypic approaches...
  85. ncbi request reprint Deficient attentional modulation of the startle response in patients with schizotypal personality disorder
    Erin A Hazlett
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1505, New York, NY 10029, USA
    Am J Psychiatry 160:1621-6. 2003
    ..The purpose of this study was to examine automatic sensorimotor gating and controlled attentional modulation of the startle eye blink response in unmedicated subjects with schizotypal personality disorder...
  86. ncbi request reprint Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction
    Patricia S Goldman-Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Psychopharmacology (Berl) 174:3-16. 2004
    ....
  87. ncbi request reprint Neuropsychological performance in schizotypal personality disorder: importance of working memory
    Vivian Mitropoulou
    Clinical Research Center, Box 1027, Mt Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Psychiatry 162:1896-903. 2005
    ....
  88. ncbi request reprint Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  89. ncbi request reprint Visual-spatial learning and memory in schizotypal personality disorder: continued evidence for the importance of working memory in the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education, and Clinical Center, Bronx, NY 10468, United States
    Arch Clin Neuropsychol 22:109-16. 2007
    ..These findings suggest that it is possible to detect both auditory and visual processing episodic memory abnormalities in the spectrum and that these deficits are uniformly a function of verbal working memory impairments...
  90. doi request reprint Affective lability and affect intensity as core dimensions of bipolar disorders during euthymic period
    Chantal Henry
    Departement de psychiatrie adulte, Bâtiment Lescure, CHS Charles Perrens, 121 rue de la Bechade, 33076 Bordeaux Cedex, France
    Psychiatry Res 159:1-6. 2008
    ..Both dimensions could account for the stress reactivity of bipolar patients that may lead to relapses...
  91. pmc Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  92. doi request reprint Recent advances in the biological study of personality disorders
    Antonia S New
    The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1217, New York, NY 10029, USA
    Psychiatr Clin North Am 31:441-61, vii. 2008
    ..Clearly SPD falls within the schizophrenia spectrum, but precisely the nature of what predicts full-blown schizophrenia as opposed to the milder symptoms of SPD is not yet clear...
  93. ncbi request reprint Context-processing deficits in schizotypal personality disorder
    Deanna M Barch
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    J Abnorm Psychol 113:556-68. 2004
    ..Context processing was strongly associated with working memory and selective attention performance in the SPD individuals...
  94. ncbi request reprint Growth hormone response to guanfacine in boys with attention deficit hyperactivity disorder: a preliminary study
    Jeffrey M Halperin
    Department of Psychology, Queens College of the City University of New York, New York, New York 11367, USA
    J Child Adolesc Psychopharmacol 13:283-94. 2003
    ....
  95. ncbi request reprint "Late-onset" borderline personality disorder: a life unraveling
    Matthew E Bernstein
    McLean Hospital, Belmont, Mass 02478, USA
    Harv Rev Psychiatry 10:292-301. 2002