W F Reynolds

Summary

Affiliation: Sidney Kimmel Cancer Center
Country: USA

Publications

  1. ncbi Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease
    W F Reynolds
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California, 92121, USA
    Exp Neurol 155:31-41. 1999
  2. ncbi -463 G/A myeloperoxidase promoter polymorphism is associated with clinical manifestations and the course of disease in MPO-ANCA-associated vasculitis
    Wanda F Reynolds
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Clin Immunol 103:154-60. 2002
  3. ncbi Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism
    Alan P Kumar
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 279:8300-15. 2004
  4. ncbi MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Neurology 55:1284-90. 2000
  5. pmc The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands
    Wanda F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Biochem Biophys Res Commun 349:846-54. 2006
  6. ncbi A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Genes Immun 3:345-9. 2002
  7. pmc Myeloperoxidase promoter polymorphism -463G is associated with more severe clinical expression of cystic fibrosis pulmonary disease
    Wanda F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Mediators Inflamm 2006:36735. 2006
  8. ncbi Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males
    Lawrence W Castellani
    Department of Medicine, University of California Los Angeles, 90095, USA
    J Lipid Res 47:1366-77. 2006
  9. ncbi Statins downregulate myeloperoxidase gene expression in macrophages
    Alan P Kumar
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Biochem Biophys Res Commun 331:442-51. 2005
  10. ncbi Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease
    Folkert W Asselbergs
    Am J Med 116:429-30. 2004

Research Grants

  1. Involvement of Myeloperoxidase in Atherosclerosis
    Wanda Reynolds; Fiscal Year: 2006

Collaborators

Detail Information

Publications13

  1. ncbi Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease
    W F Reynolds
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, California, 92121, USA
    Exp Neurol 155:31-41. 1999
    ..006). These findings suggest that the MPO polymorphism is a gender-specific risk factor for Alzheimer's disease...
  2. ncbi -463 G/A myeloperoxidase promoter polymorphism is associated with clinical manifestations and the course of disease in MPO-ANCA-associated vasculitis
    Wanda F Reynolds
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Clin Immunol 103:154-60. 2002
    ..These findings suggest that MPO expression levels influence the disease course of MPO-ANCA-associated vasculitis and further support the view that genetic factors are involved in the pathophysiology of this autoimmune disease...
  3. ncbi Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism
    Alan P Kumar
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 279:8300-15. 2004
    ....
  4. ncbi MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Neurology 55:1284-90. 2000
    ..MPO in plaques is highest in APOE epsilon4 carriers, suggesting a functional interaction. An MPO promoter polymorphism (-463G/A) linked to increased MPO expression has been associated with increased risk of AD...
  5. pmc The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands
    Wanda F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Biochem Biophys Res Commun 349:846-54. 2006
    ..These findings identify human MPO as a novel LXR and PPARalpha target gene, consistent with the role of these receptors in regulation of proinflammatory genes in macrophages...
  6. ncbi A genotypic association implicates myeloperoxidase in the progression of hepatic fibrosis in chronic hepatitis C virus infection
    W F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Genes Immun 3:345-9. 2002
    ..05). The mechanism(s) by which MPO contributes to fibrosis progression remains to be determined...
  7. pmc Myeloperoxidase promoter polymorphism -463G is associated with more severe clinical expression of cystic fibrosis pulmonary disease
    Wanda F Reynolds
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Mediators Inflamm 2006:36735. 2006
    ..Our findings indicate that the level of MPO gene expression influences the CF pathogenesis, presumably reflecting cellular damage by MPO-generated oxidants or other activity of MPO in airway inflammation...
  8. ncbi Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males
    Lawrence W Castellani
    Department of Medicine, University of California Los Angeles, 90095, USA
    J Lipid Res 47:1366-77. 2006
    ..The human MPO transgenic model will facilitate studies of MPO involvement in atherosclerosis and lipid homeostasis...
  9. ncbi Statins downregulate myeloperoxidase gene expression in macrophages
    Alan P Kumar
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Biochem Biophys Res Commun 331:442-51. 2005
    ..These findings suggest that the pleiotropic protections afforded by statins may be due in part to suppression of MPO expression...
  10. ncbi Myeloperoxidase polymorphism related to cardiovascular events in coronary artery disease
    Folkert W Asselbergs
    Am J Med 116:429-30. 2004
  11. ncbi A myeloperoxidase polymorphism associated with reduced risk of lung cancer
    Matthew B Schabath
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Box 189, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Lung Cancer 37:35-40. 2002
    ..This report provides further support for the hypothesis that a single nucleotide polymorphism in the MPO gene is a protective factor in lung cancer carcinogenesis...
  12. ncbi Protein carbamylation links inflammation, smoking, uremia and atherogenesis
    Zeneng Wang
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Nat Med 13:1176-84. 2007
    ..We propose that protein carbamylation is a mechanism linking inflammation, smoking, uremia and coronary artery disease pathogenesis...
  13. ncbi Inducible nitric oxide synthase expression is inhibited by myeloperoxidase
    Alan P Kumar
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Nitric Oxide 13:42-53. 2005
    ..The combined signaling of IFNgamma/LPS overrides the gatekeeper function by suppressing MPO gene expression...

Research Grants2

  1. Involvement of Myeloperoxidase in Atherosclerosis
    Wanda Reynolds; Fiscal Year: 2006
    ..These studies will reveal if MPO-generated oxidants promote atherosclerosis in mouse models, thereby humanizing existing mouse models, and enabling investigations of the role of MPO-mediated oxidation in atherosclerosis. ..