C E Muller-Sieburg

Summary

Affiliation: Sidney Kimmel Cancer Center
Country: USA

Publications

  1. ncbi Genetic control of hematopoietic stem cell frequency in mice is mostly cell autonomous
    C E Muller-Sieburg
    Sidney Kimmel Cancer Center, Department of Mathematics, University of California, San Diego, USA
    Blood 95:2446-8. 2000
  2. ncbi Tissue- and epitope-specific mechanisms account for the diverse effects of anti-CD44 antibodies on the maintenance of primitive hematopoietic progenitors in vitro
    C E Muller-Sieburg
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Blood Cells Mol Dis 26:291-302. 2000
  3. ncbi Deterministic regulation of hematopoietic stem cell self-renewal and differentiation
    Christa E Muller-Sieburg
    Sidney Kimmel Cancer Center and Department of Mathematics, University of California at San Diego, CA 92121, USA
    Blood 100:1302-9. 2002
  4. ncbi Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness
    Christa E Muller-Sieburg
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Blood 103:4111-8. 2004
  5. pmc The GOD of hematopoietic stem cells: a clonal diversity model of the stem cell compartment
    C E Muller-Sieburg
    Sidney Kimmel Cancer Center, San Diego, California 92112, USA
    Cell Cycle 5:394-8. 2006
  6. pmc Stem cell aging: survival of the laziest?
    Christa Muller-Sieburg
    Sidney Kimmel Cancer Center, San Diego, California 92112, USA
    Cell Cycle 7:3798-804. 2008

Research Grants

  1. Epigenetic control of hematopoietic stem cells
    Christa Muller Sieburg; Fiscal Year: 2007

Collaborators

Detail Information

Publications6

  1. ncbi Genetic control of hematopoietic stem cell frequency in mice is mostly cell autonomous
    C E Muller-Sieburg
    Sidney Kimmel Cancer Center, Department of Mathematics, University of California, San Diego, USA
    Blood 95:2446-8. 2000
    ..For each chimera, individual LTC-IC were genotyped on the clonal levels by analyzing their progeny. We found that most of the difference that regulates the size of the stem cell compartment was intrinsic...
  2. ncbi Tissue- and epitope-specific mechanisms account for the diverse effects of anti-CD44 antibodies on the maintenance of primitive hematopoietic progenitors in vitro
    C E Muller-Sieburg
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Blood Cells Mol Dis 26:291-302. 2000
    ..U. Thus, the CD44 epitopes defined by the mAbs bind distinct ligands and the ligands provide a potential physiological counterpart for the regulatory actions of the mAbs...
  3. ncbi Deterministic regulation of hematopoietic stem cell self-renewal and differentiation
    Christa E Muller-Sieburg
    Sidney Kimmel Cancer Center and Department of Mathematics, University of California at San Diego, CA 92121, USA
    Blood 100:1302-9. 2002
    ..By extension, this suggests that the self-renewal and differentiation behavior of HSCs in adult bone marrow is more predetermined than previously thought...
  4. ncbi Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness
    Christa E Muller-Sieburg
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Blood 103:4111-8. 2004
    ..The data demonstrate that epigenetic regulation on the level of the HSCs can directly affect the number, composition, and function of the mature progeny...
  5. pmc The GOD of hematopoietic stem cells: a clonal diversity model of the stem cell compartment
    C E Muller-Sieburg
    Sidney Kimmel Cancer Center, San Diego, California 92112, USA
    Cell Cycle 5:394-8. 2006
    ..Selection for the appropriate subsets of HSC, rather than attempts to force HSC to adjust, should improve their utility in transplantation and gene transfer applications...
  6. pmc Stem cell aging: survival of the laziest?
    Christa Muller-Sieburg
    Sidney Kimmel Cancer Center, San Diego, California 92112, USA
    Cell Cycle 7:3798-804. 2008
    ..We propose that such slow, "lazy" HSC are less likely to be transformed and therefore may safely sustain hematopoiesis for a long time...

Research Grants1

  1. Epigenetic control of hematopoietic stem cells
    Christa Muller Sieburg; Fiscal Year: 2007
    ..Relevance: Data from the proposed studies may provide better ways to treat leukopenia and may help in the design of approaches to selectively eradicate leukemic stem cells. ..