R A Gjerset

Summary

Affiliation: Sidney Kimmel Cancer Center
Country: USA

Publications

  1. ncbi request reprint Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification
    R A Gjerset
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cell Growth Differ 10:545-54. 1999
  2. ncbi request reprint DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer
    Ruth A Gjerset
    Sidney Kimmel Cancer Center, 10835 Road to the Cure previously Altman Row, San Diego, CA 92121, USA
    J Mol Histol 37:239-51. 2006
  3. ncbi request reprint Regulation of p14ARF through subnuclear compartmentalization
    Ruth A Gjerset
    Department of Cancer Cell Biology, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cell Cycle 5:686-90. 2006
  4. ncbi request reprint DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF
    Casey Lee
    Department of Cancer Cell Biology, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cancer Res 65:9834-42. 2005
  5. ncbi request reprint Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor
    Keya Bandyopadhyay
    Department of Cancer Cell Biology, Sidney Kimmel Cancer Center, San Diego, California, USA
    Biochemistry 46:14325-34. 2007
  6. ncbi request reprint Tumor suppression and therapy sensitization of localized and metastatic breast cancer by adenovirus p53
    S Lebedeva
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Hum Gene Ther 12:763-72. 2001
  7. ncbi request reprint Growth suppression by a p14(ARF) exon 1beta adenovirus in human tumor cell lines of varying p53 and Rb status
    Neshat Saadatmandi
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cancer Gene Ther 9:830-9. 2002
  8. ncbi request reprint Macrophage-mediated bystander effect triggered by tumor cell apoptosis
    Yinghui Huang
    Sidney Kimmel Cancer Center, San Diego, California, USA
    Mol Ther 15:524-33. 2007
  9. pmc Progressive silencing of p14ARF in oesophageal adenocarcinoma
    Yinghui Huang
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    J Cell Mol Med 13:398-409. 2009
  10. pmc Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization
    Keya Bandyopadhyay
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    Cell Cycle 8:2779-88. 2009

Collaborators

  • Keya Bandyopadhyay
  • Yinghui Huang
  • Casey Lee
  • Jean Louis Baneres
  • Joseph Parello
  • Per Borgstrom
  • Ali Haghighi
  • Neshat Saadatmandi
  • S Lebedeva
  • Christopher J Peters
  • Casimir Blonski
  • Aimée Martin
  • Rebecca C Fitzgerald
  • Brian A Smith
  • Greg Frost
  • Traci Tyler
  • X Mu
  • S Bagdasarova
  • D R Wilson
  • T Tyler

Detail Information

Publications10

  1. ncbi request reprint Inhibition of the Jun kinase pathway blocks DNA repair, enhances p53-mediated apoptosis and promotes gene amplification
    R A Gjerset
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cell Growth Differ 10:545-54. 1999
    ..These results indicate that inhibition of DNA repair leads to accumulation of DNA damage in tumor cells with unstable genomes and this, in turn, enhances p53mediated apoptosis...
  2. ncbi request reprint DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer
    Ruth A Gjerset
    Sidney Kimmel Cancer Center, 10835 Road to the Cure previously Altman Row, San Diego, CA 92121, USA
    J Mol Histol 37:239-51. 2006
    ..A better understanding of ARF's nucleolar interactions could further elucidate the regulation of the p53 pathway and suggest new therapeutic approaches to restore p53 function...
  3. ncbi request reprint Regulation of p14ARF through subnuclear compartmentalization
    Ruth A Gjerset
    Department of Cancer Cell Biology, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cell Cycle 5:686-90. 2006
    ..The results also have therapeutic implications for therapies based on exploiting p53 and other cellular stress response pathways to suppress cancer...
  4. ncbi request reprint DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF
    Casey Lee
    Department of Cancer Cell Biology, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cancer Res 65:9834-42. 2005
    ..The results implicate the nucleolus and nucleolar interactions of the ARF, including potentially novel interactions involving its COOH terminus as sites for early DNA damage and stress-mediated cellular events...
  5. ncbi request reprint Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor
    Keya Bandyopadhyay
    Department of Cancer Cell Biology, Sidney Kimmel Cancer Center, San Diego, California, USA
    Biochemistry 46:14325-34. 2007
    ..Certain cancer associated defects affecting ARF/topoisomerase I complex formation could contribute to cellular resistance to camptothecin...
  6. ncbi request reprint Tumor suppression and therapy sensitization of localized and metastatic breast cancer by adenovirus p53
    S Lebedeva
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Hum Gene Ther 12:763-72. 2001
    ..Taken together, these data indicate an additive to synergistic effect of Adp53 and doxorubicin for the treatment of primary and metastatic breast cancer...
  7. ncbi request reprint Growth suppression by a p14(ARF) exon 1beta adenovirus in human tumor cell lines of varying p53 and Rb status
    Neshat Saadatmandi
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Cancer Gene Ther 9:830-9. 2002
    ..These results point to an activity of ARF in human tumor cells that is independent of Rb or p53, and suggest that therapeutic applications based on ARF would have a broad clinical application in cancer...
  8. ncbi request reprint Macrophage-mediated bystander effect triggered by tumor cell apoptosis
    Yinghui Huang
    Sidney Kimmel Cancer Center, San Diego, California, USA
    Mol Ther 15:524-33. 2007
    ..The results suggest that pro-apoptotic therapies benefit both from the intrinsic vulnerability of cancer cells to apoptosis and from an innate immune response that amplifies the therapeutic effect...
  9. pmc Progressive silencing of p14ARF in oesophageal adenocarcinoma
    Yinghui Huang
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    J Cell Mol Med 13:398-409. 2009
    ..Silencing of ARF could provide a useful marker for increased risk of progression and poor prognosis...
  10. pmc Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization
    Keya Bandyopadhyay
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    Cell Cycle 8:2779-88. 2009
    ..These and related inhibitors of histone acetylation could therefore constitute a novel class of potent therapy sensitizers applicable to a broad range of conventional cancer treatments...