Linda M Bradley

Summary

Affiliation: Sidney Kimmel Cancer Center
Country: USA

Publications

  1. ncbi Interleukin 7 regulates the survival and generation of memory CD4 cells
    Robyn M Kondrack
    Department of Immunology, The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    J Exp Med 198:1797-806. 2003
  2. ncbi Availability of antigen-presenting cells can determine the extent of CD4 effector expansion and priming for secretion of Th2 cytokines in vivo
    Linda M Bradley
    The Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Eur J Immunol 32:2338-46. 2002
  3. ncbi Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo
    Phyllis Jean Linton
    The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    J Exp Med 197:875-83. 2003
  4. ncbi CD4+ cell memory: the enigma of Th1 cells
    Linda M Bradley
    Division of Immunology, The Sidney Kimmel Cancer Center, 10 835 Altman Row, San Diego, CA 92121, USA
    Trends Mol Med 9:186-8. 2003
  5. ncbi Migration and T-lymphocyte effector function
    Linda M Bradley
    Division of Immunology, The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Curr Opin Immunol 15:343-8. 2003
  6. ncbi Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo
    Sarah E Weber
    Department of Immunology, Sidney Kimmel Cancer Center, San Diego, CA 92131, USA
    J Immunol 176:4730-9. 2006
  7. ncbi IL-7: maintaining T-cell memory and achieving homeostasis
    Linda M Bradley
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Trends Immunol 26:172-6. 2005
  8. ncbi Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infection
    Timothy J Chapman
    Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, NY 14642, USA
    Virology 340:296-306. 2005
  9. ncbi Withdrawal of stimulation may initiate the transition of effector to memory CD4 cells
    Judith Harbertson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 168:1095-102. 2002
  10. ncbi Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells
    Elana Godebu
    School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 181:1798-805. 2008

Research Grants

  1. REGULATION OF HELPER T CELL MEMORY
    Linda Bradley; Fiscal Year: 2002

Collaborators

Detail Information

Publications10

  1. ncbi Interleukin 7 regulates the survival and generation of memory CD4 cells
    Robyn M Kondrack
    Department of Immunology, The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    J Exp Med 198:1797-806. 2003
    ..The results demonstrate that IL-7 can have previously unrecognized roles in the maintenance of memory in the CD4 cell population and in the survival of CD4 cells with a capacity to become memory cells...
  2. ncbi Availability of antigen-presenting cells can determine the extent of CD4 effector expansion and priming for secretion of Th2 cytokines in vivo
    Linda M Bradley
    The Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Eur J Immunol 32:2338-46. 2002
    ..The results suggest that the level of APC engagement can not only determine the extent of effector expansion, but also the overall Th1/Th2 cytokine balance...
  3. ncbi Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo
    Phyllis Jean Linton
    The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    J Exp Med 197:875-83. 2003
    ..The results suggest that without engagement of OX40L on B cells, CD4 cell responses to many protein Ag would be dominated by Th1 cytokines. These data have important implications for strategies to achieve optimal priming of CD4 subsets...
  4. ncbi CD4+ cell memory: the enigma of Th1 cells
    Linda M Bradley
    Division of Immunology, The Sidney Kimmel Cancer Center, 10 835 Altman Row, San Diego, CA 92121, USA
    Trends Mol Med 9:186-8. 2003
    ..These studies support a new paradigm, in which memory T cells are heterogeneous in terms of their stage of maturation and function as well as mechanisms of homeostatic control...
  5. ncbi Migration and T-lymphocyte effector function
    Linda M Bradley
    Division of Immunology, The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Curr Opin Immunol 15:343-8. 2003
    ..There are many unanswered questions about the developmental relationships and roles in protective immunity of antigen-experienced T cells that partition in different tissues...
  6. ncbi Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo
    Sarah E Weber
    Department of Immunology, Sidney Kimmel Cancer Center, San Diego, CA 92131, USA
    J Immunol 176:4730-9. 2006
    ....
  7. ncbi IL-7: maintaining T-cell memory and achieving homeostasis
    Linda M Bradley
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Trends Immunol 26:172-6. 2005
    ..In this Review, we discuss the role of IL-7 in the survival and homeostasis of naive and memory T cells and how that role is regulated by other factors...
  8. ncbi Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infection
    Timothy J Chapman
    Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, NY 14642, USA
    Virology 340:296-306. 2005
    ..These data show that, when primed, CD4(+) T cells may traffic to the lung in the absence of antigen, but do not proliferate. These results also document a useful tool for the study of CD4 T cells in influenza infection...
  9. ncbi Withdrawal of stimulation may initiate the transition of effector to memory CD4 cells
    Judith Harbertson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 168:1095-102. 2002
    ....
  10. ncbi Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells
    Elana Godebu
    School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 181:1798-805. 2008
    ....

Research Grants1

  1. REGULATION OF HELPER T CELL MEMORY
    Linda Bradley; Fiscal Year: 2002
    ..The proposed studies represents an integrated investigation of factors that will provide essential, basic information about the regulation of CD4 memory. ..