Greg Noel

Summary

Affiliation: Shriners Hospitals for Children
Country: USA

Publications

  1. doi request reprint Optimization and application of a flow cytometric PU.1 assay for murine immune cells
    Greg Noel
    Shriners Hospital for Children, Cincinnati, OH 45209, USA
    J Immunol Methods 382:81-92. 2012
  2. ncbi request reprint Postburn monocytes are the major producers of TNF-alpha in the heterogeneous splenic macrophage population
    Greg Noel
    Shriners Hospital for Children, Cincinnati, Ohio 45229, USA
    Shock 27:312-9. 2007
  3. ncbi request reprint Thermal injury elevates the inflammatory monocyte subpopulation in multiple compartments
    John G Noel
    Shriners Hospital for Children, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 28:684-93. 2007
  4. doi request reprint A ribonucleotide reductase inhibitor reverses burn-induced inflammatory defects
    Greg Noel
    Shriners Hospital for Children, Cincinnati, Ohio 45229, USA
    Shock 34:535-44. 2010
  5. doi request reprint Neutrophils, not monocyte/macrophages, are the major splenic source of postburn IL-10
    Greg Noel
    Department of Research, Shriners Hospital for Children and Department of Surgery, University of Cincinnati, Cincinnati, OH 45209, USA
    Shock 36:149-55. 2011
  6. doi request reprint NF-κΒ inhibition is ineffective in blocking cytokine-induced IL-8 production but P38 and STAT1 inhibitors are effective
    Quan Wang
    Department of Research, Shriners Hospital for Children, 3229 Burnet Ave, Cincinnati, OH 45229 3095, USA
    Inflamm Res 61:977-85. 2012
  7. ncbi request reprint Cytokine-induced epithelial permeability changes are regulated by the activation of the p38 mitogen-activated protein kinase pathway in cultured Caco-2 cells
    Quan Wang
    Department of Research, Shriners Hospital for Children, Cincinnati OH 45229 3095, USA
    Shock 29:531-7. 2008
  8. ncbi request reprint Heat shock stress ameliorates cytokine mixture-induced permeability by downregulating the nitric oxide and signal transducer and activator of transcription pathways in Caco-2 cells
    Quan Wang
    Department of Research, Shriners Hospital for Children, and Department of Surgery, University of Cincinnati, Cincinnati OH 45229 3229, USA
    Shock 27:179-85. 2007
  9. doi request reprint Mouse embryonic stem cells undergo charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment
    Elisia D Tichy
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA Electronic address
    Stem Cell Res 10:428-41. 2013
  10. ncbi request reprint Effect of thermal injury on splenic myelopoiesis
    John G Noel
    Research, Shriners Hospital for Children, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 23:115-22. 2005

Collaborators

  • Quan Wang
  • L P James
  • John G Noel
  • Charles C Caldwell
  • Cora K Ogle
  • Elisia D Tichy
  • Andrew Osterburg
  • Johannes Tschop
  • Xialing Guo
  • Sandy Schwemberger
  • Peter J Stambrook
  • Zachary A Stephan
  • Holly S Goetzman
  • Lisa G Choi
  • Alex B Lentsch
  • Timothy A Pritts
  • Jay A Johannigman
  • Andre Martignoni
  • Denise Byrum
  • Holly Goetzman
  • Denise Wells-Byrum

Detail Information

Publications11

  1. doi request reprint Optimization and application of a flow cytometric PU.1 assay for murine immune cells
    Greg Noel
    Shriners Hospital for Children, Cincinnati, OH 45209, USA
    J Immunol Methods 382:81-92. 2012
    ..1 than did unburned, but proliferating cells from burn or sham mice showed no difference in their levels of PU.1. This assay should be a useful addition to the tools used to study the function of PU.1 in health and disease...
  2. ncbi request reprint Postburn monocytes are the major producers of TNF-alpha in the heterogeneous splenic macrophage population
    Greg Noel
    Shriners Hospital for Children, Cincinnati, Ohio 45229, USA
    Shock 27:312-9. 2007
    ..These data suggest that the monocyte is a major source of inflammatory cytokines in the postburn spleen...
  3. ncbi request reprint Thermal injury elevates the inflammatory monocyte subpopulation in multiple compartments
    John G Noel
    Shriners Hospital for Children, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 28:684-93. 2007
    ..We conclude that in this model, IMs are a significant source of in vivo TNF-alpha...
  4. doi request reprint A ribonucleotide reductase inhibitor reverses burn-induced inflammatory defects
    Greg Noel
    Shriners Hospital for Children, Cincinnati, Ohio 45229, USA
    Shock 34:535-44. 2010
    ..aeruginosa infection. Our report shows that proliferative cells are major drivers of postburn immune changes and provides evidence that implicates immature myeloid cells in these processes...
  5. doi request reprint Neutrophils, not monocyte/macrophages, are the major splenic source of postburn IL-10
    Greg Noel
    Department of Research, Shriners Hospital for Children and Department of Surgery, University of Cincinnati, Cincinnati, OH 45209, USA
    Shock 36:149-55. 2011
    ..Finally, LPS-induced mortality of burn mice was made worse by anti-Gr-1 depletion of all PMNs and 66% of iMos from burn mice. This suggests that PMNs play a primarily anti-inflammatory role in vitro and in vivo...
  6. doi request reprint NF-κΒ inhibition is ineffective in blocking cytokine-induced IL-8 production but P38 and STAT1 inhibitors are effective
    Quan Wang
    Department of Research, Shriners Hospital for Children, 3229 Burnet Ave, Cincinnati, OH 45229 3095, USA
    Inflamm Res 61:977-85. 2012
    ..We hypothesized that the failure of in vitro experiments to predict in vivo outcome was due to the use of short time periods of observation and the use of single cytokines to stimulate NF-κB...
  7. ncbi request reprint Cytokine-induced epithelial permeability changes are regulated by the activation of the p38 mitogen-activated protein kinase pathway in cultured Caco-2 cells
    Quan Wang
    Department of Research, Shriners Hospital for Children, Cincinnati OH 45229 3095, USA
    Shock 29:531-7. 2008
    ..SB203580 also prevented the CytoMix-induced permeability increase and reduced NO, IL-6, and IL-8 levels. The results suggest that p38 MAPK plays an important role in regulating epithelial barrier function during inflammation...
  8. ncbi request reprint Heat shock stress ameliorates cytokine mixture-induced permeability by downregulating the nitric oxide and signal transducer and activator of transcription pathways in Caco-2 cells
    Quan Wang
    Department of Research, Shriners Hospital for Children, and Department of Surgery, University of Cincinnati, Cincinnati OH 45229 3229, USA
    Shock 27:179-85. 2007
    ..The SA treatment ameliorated cytomix-induced permeability, possibly through the downregulation of the NO and Janus kinase/STAT pathways...
  9. doi request reprint Mouse embryonic stem cells undergo charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment
    Elisia D Tichy
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA Electronic address
    Stem Cell Res 10:428-41. 2013
    ..We coined the term charontosis after Charon, the ferryman of the dead in Greek mythology, to refer to the PCD signaling events induced by ETO in mESCs...
  10. ncbi request reprint Effect of thermal injury on splenic myelopoiesis
    John G Noel
    Research, Shriners Hospital for Children, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
    Shock 23:115-22. 2005
    ..Our work clearly shows that the increased myelopoiesis observed postinjury leads to the production of mature myeloid cells. However, the effects of thermal injury on progenitors in the spleen and marrow are not equivalent...
  11. pmc Gammadelta T cells mitigate the organ injury and mortality of sepsis
    Johannes Tschop
    The Laboratory of Trauma, Sepsis and Inflammation Research, Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0558, USA
    J Leukoc Biol 83:581-8. 2008
    ..Collectively, our data suggest that gammadelta T cells modulate the response to sepsis and may be a potential therapeutic target...