Matilda H C Sheng

Summary

Country: USA

Publications

  1. doi request reprint Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity
    Matilda H C Sheng
    Musculoskeletal Disease Center 151, Jerry L Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA
    FEBS Lett 582:1451-8. 2008
  2. ncbi request reprint Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice
    Xiao S Zhang
    Department of Medicine, Loma Linda University, and Gene Therapy Division, Musculoskeletal Disease Center 151, VA Loma Linda Healthcare Network, Loma Linda, CA 92357, USA
    J Gene Med 6:4-15. 2004
  3. ncbi request reprint In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4
    Charles H Rundle
    Departments of Medicine and Biochemistry, Loma Linda University, and the Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Bone 32:591-601. 2003
  4. ncbi request reprint A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2
    Mehran Amoui
    The Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Arch Biochem Biophys 463:47-59. 2007
  5. ncbi request reprint In vivo and in vitro evidence that the high osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is intrinsic to bone cells
    Matilda H C Sheng
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Medical Center, Loma Linda, CA 92357, USA
    Bone 35:711-9. 2004
  6. ncbi request reprint Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density
    Jon E Wergedal
    Musculoskeletal Disease Center, J L Pettis Memorial V A Medical Center and Department of Medicine, Loma Linda University, Loma Linda, CA 92357, USA
    Bone 36:111-22. 2005
  7. ncbi request reprint An osteoclastic protein-tyrosine phosphatase is a potential positive regulator of the c-Src protein-tyrosine kinase activity: a mediator of osteoclast activity
    K H William Lau
    Department of Medicine and Biochemistry, Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California 92357, USA
    J Cell Biochem 97:940-55. 2006
  8. ncbi request reprint Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat
    Charles H Rundle
    Department of Medicine, Loma Linda University, Loma Linda, CA, USA
    J Gene Med 10:229-41. 2008
  9. doi request reprint Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity
    K H William Lau
    Division of Regenerative Medicine, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Endocrinol Metab 305:E271-81. 2013
  10. doi request reprint Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice
    Matilda H C Sheng
    Division of Regenerative Medicine, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Bone 52:133-44. 2013

Collaborators

Detail Information

Publications14

  1. doi request reprint Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity
    Matilda H C Sheng
    Musculoskeletal Disease Center 151, Jerry L Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA
    FEBS Lett 582:1451-8. 2008
    ..These findings indicate that OA is a novel osteoclastic protein and plays a role in osteoclast differentiation and/or activity...
  2. ncbi request reprint Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice
    Xiao S Zhang
    Department of Medicine, Loma Linda University, and Gene Therapy Division, Musculoskeletal Disease Center 151, VA Loma Linda Healthcare Network, Loma Linda, CA 92357, USA
    J Gene Med 6:4-15. 2004
    ....
  3. ncbi request reprint In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4
    Charles H Rundle
    Departments of Medicine and Biochemistry, Loma Linda University, and the Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Bone 32:591-601. 2003
    ....
  4. ncbi request reprint A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2
    Mehran Amoui
    The Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Arch Biochem Biophys 463:47-59. 2007
    ..In conclusion, PTP-oc activates osteoclast activity in part by promoting osteoclast survival through the PTP-oc-mediated c-Src-dependent activation of NFkappaB and JNK2...
  5. ncbi request reprint In vivo and in vitro evidence that the high osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is intrinsic to bone cells
    Matilda H C Sheng
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Medical Center, Loma Linda, CA 92357, USA
    Bone 35:711-9. 2004
    ....
  6. ncbi request reprint Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density
    Jon E Wergedal
    Musculoskeletal Disease Center, J L Pettis Memorial V A Medical Center and Department of Medicine, Loma Linda University, Loma Linda, CA 92357, USA
    Bone 36:111-22. 2005
    ..These studies identify inbred mouse strains suitable for future studies identifying genes regulating bone geometry and mechanical properties...
  7. ncbi request reprint An osteoclastic protein-tyrosine phosphatase is a potential positive regulator of the c-Src protein-tyrosine kinase activity: a mediator of osteoclast activity
    K H William Lau
    Department of Medicine and Biochemistry, Musculoskeletal Disease Center, Jerry L Pettis Memorial VA Medical Center, Loma Linda, California 92357, USA
    J Cell Biochem 97:940-55. 2006
    ..These findings are consistent with the hypothesis that PTP-oc is a positive regulator of c-Src in osteoclasts...
  8. ncbi request reprint Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat
    Charles H Rundle
    Department of Medicine, Loma Linda University, Loma Linda, CA, USA
    J Gene Med 10:229-41. 2008
    ..An in vivo gene therapy strategy was developed to accelerate bone fracture repair...
  9. doi request reprint Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity
    K H William Lau
    Division of Regenerative Medicine, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Am J Physiol Endocrinol Metab 305:E271-81. 2013
    ..In conclusion, osteocyte-derived IGF-I plays a key determining role in bone mechanosensitivity...
  10. doi request reprint Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice
    Matilda H C Sheng
    Division of Regenerative Medicine, Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Bone 52:133-44. 2013
    ..In summary, this study shows for the first time that osteocyte-derived IGF-1 plays an essential role in regulating bone turnover during developmental bone growth...
  11. ncbi request reprint Sca-1(+) hematopoietic cell-based gene therapy with a modified FGF-2 increased endosteal/trabecular bone formation in mice
    Susan L Hall
    Musculoskeletal Disease Center, Jerry L Pettis Memorial V A Medical Center, Loma Linda, California 92357, USA
    Mol Ther 15:1881-9. 2007
    ..In conclusion, this study provided compelling test-of-principle evidence for the feasibility of using an Sca-1(+) cell-based ex vivo systemic FGF-2 gene therapy strategy to promote endosteal bone formation...
  12. doi request reprint Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis
    Charles H Rundle
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Administration Medical Center 151, 11201 Benton Street, Loma Linda, CA 92357, USA
    Bone 43:880-8. 2008
    ..The unexpected effect of Bax deficiency on chondrocyte proliferation implicates a novel regulatory function for Bax on chondrocyte proliferation during fracture repair...
  13. ncbi request reprint Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry
    Jon E Wergedal
    Musculoskeletal Disease Center, J L Pettis Memorial VA Medical Center, Loma Linda, CA 92357, USA
    J Bone Miner Res 21:1256-66. 2006
    ..Genetic analysis of an NZB/B1NJ x RF/J cross has identified QTLs for femur mechanical, geometric, and densitometric phenotypes. Most mechanical QTLs were associated with geometric QTLs, strongly suggesting common genetic regulation...
  14. pmc Targeted transgenic expression of an osteoclastic transmembrane protein-tyrosine phosphatase in cells of osteoclastic lineage increases bone resorption and bone loss in male young adult mice
    Matilda H C Sheng
    Musculoskeletal Disease Center, Jerry L Pettis Memorial Veterans Affairs Medical Center, Loma Linda, California 92357, USA
    J Biol Chem 284:11531-45. 2009
    ..In summary, this study provides compelling in vivo evidence that PTP-oc is a positive regulator of osteoclasts...