Russell B Williams

Summary

Affiliation: Sequoia Sciences
Country: USA

Publications

  1. doi request reprint Isolation of apoptosis-inducing stilbenoids from four members of the Orchidaceae family
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, St Louis, Missouri, USA
    Planta Med 78:160-5. 2012
  2. pmc Cytotoxic and antibacterial beilschmiedic acids from a Gabonese species of Beilschmiedia
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, USA
    J Nat Prod 75:1319-25. 2012
  3. ncbi request reprint Antibiotic indole sesquiterpene alkaloid from Greenwayodendron suaveolens with a new natural product framework
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, USA
    J Nat Prod 73:1008-11. 2010
  4. pmc Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, St Louis, MO 63114, United States
    Phytochemistry 74:185-9. 2012
  5. doi request reprint Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Phytochemistry 71:104-9. 2010
  6. doi request reprint Acetylated dammarane-type bisdesmosides from Combretum inflatum
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, United States
    J Nat Prod 76:1592-7. 2013
  7. pmc Phenylpropanoids from Phragmipedium calurum and their antiproliferative activity
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, United States
    Phytochemistry 82:172-5. 2012
  8. doi request reprint Dammarane-type triterpene glycosides from Oncoba manii active against methicillin-resistant Staphylococcus aureus
    Eliane Garo
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, Saint Louis, Missouri 63114, USA
    Planta Med 75:541-3. 2009
  9. doi request reprint Antibacterial chromene and chromane stilbenoids from Hymenocardia acida
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, United States Electronic address
    Phytochemistry 98:216-22. 2014
  10. pmc Novel pentadecenyl tetrazole enhances susceptibility of methicillin-resistant Staphylococcus aureus biofilms to gentamicin
    Krista M Olson
    Sequoia Sciences, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Antimicrob Agents Chemother 55:3691-5. 2011

Detail Information

Publications11

  1. doi request reprint Isolation of apoptosis-inducing stilbenoids from four members of the Orchidaceae family
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, St Louis, Missouri, USA
    Planta Med 78:160-5. 2012
    ..Based on these results, a portion of the extract from a commercially available Oncidium sp. was chemically modified in an attempt to obtain additional phenanthraquinones...
  2. pmc Cytotoxic and antibacterial beilschmiedic acids from a Gabonese species of Beilschmiedia
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, USA
    J Nat Prod 75:1319-25. 2012
    ..This is the first report of cytotoxic activity for the endiandric/beilschmiedic acid class of compounds...
  3. ncbi request reprint Antibiotic indole sesquiterpene alkaloid from Greenwayodendron suaveolens with a new natural product framework
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, USA
    J Nat Prod 73:1008-11. 2010
    ..Pentacyclindole (1) and polyalthenol (4) showed activity against clinical isolates of Staphylococcus aureus with polyalthenol (4) demonstrating a MIC(90) of 4 microg/mL...
  4. pmc Polyoxygenated cyclohexene derivatives from Monanthotaxis congoensis
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, St Louis, MO 63114, United States
    Phytochemistry 74:185-9. 2012
    ..Structures were determined using NMR, MS, and optical rotation analyses. One compound displayed moderate antiproliferative activity against NCI-H460 and M14 cancer cells...
  5. doi request reprint Antibacterial clerodane diterpenes from Goldenrod (Solidago virgaurea)
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Phytochemistry 71:104-9. 2010
    ..The structures were determined by NMR spectroscopic analysis. Several displayed moderate antibacterial activity against Staphylococcus aureus...
  6. doi request reprint Acetylated dammarane-type bisdesmosides from Combretum inflatum
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, United States
    J Nat Prod 76:1592-7. 2013
    ..Compounds 3-7 reduced the growth of MRSA at 16 μg/mL by 71-45%, and compound 7 had an IC₅₀ value of 3.9 μM in NCI-H460...
  7. pmc Phenylpropanoids from Phragmipedium calurum and their antiproliferative activity
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, United States
    Phytochemistry 82:172-5. 2012
    ..They were evaluated for antiproliferative activity against multiple human cancer cell lines, and two displayed moderate activity against several cell lines...
  8. doi request reprint Dammarane-type triterpene glycosides from Oncoba manii active against methicillin-resistant Staphylococcus aureus
    Eliane Garo
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, Saint Louis, Missouri 63114, USA
    Planta Med 75:541-3. 2009
    ..Compounds 1 and 2 inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA)...
  9. doi request reprint Antibacterial chromene and chromane stilbenoids from Hymenocardia acida
    Courtney M Starks
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, United States Electronic address
    Phytochemistry 98:216-22. 2014
    ..None had IC50 values <20 μM in antiproliferation assays against several human cancer cell lines...
  10. pmc Novel pentadecenyl tetrazole enhances susceptibility of methicillin-resistant Staphylococcus aureus biofilms to gentamicin
    Krista M Olson
    Sequoia Sciences, 1912 Innerbelt Business Center Drive, St Louis, MO 63114, USA
    Antimicrob Agents Chemother 55:3691-5. 2011
    ..This novel combination also exhibits synergistic effects on MRSA planktonic cells. This plant-derived compound reveals promise for its effectiveness and warrants further lead optimization as an antibiotic and aminoglycoside potentiator...
  11. ncbi request reprint Diterpenes from the Endangered Goldenrod Solidago shortii
    Russell B Williams
    Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, St Louis, Missouri 63114, United States
    J Nat Prod 77:1438-44. 2014
    ....