Kathryn A Seely

Summary

Country: USA

Publications

  1. doi request reprint Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids
    Kathryn A Seely
    Arkansas Department of Health, Public Health Laboratory, Little Rock, AR, United States
    Prog Neuropsychopharmacol Biol Psychiatry 39:234-43. 2012
  2. pmc AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies
    Kathryn A Seely
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    Neuropharmacology 63:905-15. 2012
  3. doi request reprint A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors
    Kathryn A Seely
    Public Health Laboratory, Arkansas Department of Health, Little Rock, Arkansas 72205, USA
    Chem Res Toxicol 25:825-7. 2012
  4. pmc Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands
    Krishna C Chimalakonda
    Departments of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AK 72205, USA
    Drug Metab Dispos 40:2174-84. 2012
  5. pmc Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
    Joseph H Holthoff
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Kidney Int 81:370-8. 2012
  6. pmc Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors
    Lisa K Brents
    Arkansas Biosciences Institute, Arkansas State University, AR, USA
    Xenobiotica 42:139-56. 2012
  7. doi request reprint Forensic investigation of K2, Spice, and "bath salt" commercial preparations: a three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
    Kathryn A Seely
    Arkansas Department of Health, Public Health Laboratory, Little Rock, AR 72205, United States
    Forensic Sci Int 233:416-22. 2013
  8. doi request reprint Quantitative Measurement of Acetyl Fentanyl and Acetyl Norfentanyl in Human Urine by LC-MS/MS
    Amy L Patton
    Arkansas Department of Health, Public Health Laboratory, Little Rock, Arkansas 72205, United States
    Anal Chem 86:1760-6. 2014
  9. pmc Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?
    Kathryn A Seely
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Interv 11:36-51. 2011
  10. doi request reprint Targeted metabolomic approach for assessing human synthetic cannabinoid exposure and pharmacology
    Amy L Patton
    Arkansas Department of Health, Public Health Laboratory, Little Rock, Arkansas 72205, United States
    Anal Chem 85:9390-9. 2013

Collaborators

  • Anna Radominska-Pandya
  • William E Fantegrossi
  • Neriman Gokden
  • Jeanna M Marraffa
  • Lee Ann MacMillan-Crow
  • Liana Fattore
  • Amy L Patton
  • Laura P James
  • Jeffery H Moran
  • Gregory W Endres
  • Krishna C Chimalakonda
  • Joseph H Holthoff
  • Lisa K Brents
  • Zhen Wang
  • Paul L Prather
  • Paul D Kennedy
  • Cindy L Moran
  • Stacie M Bratton
  • Philip R Mayeux
  • Jennifer L Shoemaker
  • Sharon Pulla
  • Laura D Knight
  • Nancy J Rusch
  • Matthew Trass
  • Keith R McCain
  • Art Miranda
  • Johnny P Tran
  • Paul Dobrowolski
  • Elina Pathak
  • Horace J Spencer
  • Haining Liu
  • Paul F Hollenberg
  • Fabricio Medina-Bolivar
  • Luis Nopo-Olazabal
  • Vipin Nair
  • Robert J Doerksen
  • Ronak Y Patel
  • Ronald L Reed
  • John P Crow

Detail Information

Publications13

  1. doi request reprint Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids
    Kathryn A Seely
    Arkansas Department of Health, Public Health Laboratory, Little Rock, AR, United States
    Prog Neuropsychopharmacol Biol Psychiatry 39:234-43. 2012
    ..The pharmacological and toxicological consequences of synthetic cannabinoid abuse are also reviewed to provide a future perspective on potential short- and long-term implications...
  2. pmc AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies
    Kathryn A Seely
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    Neuropharmacology 63:905-15. 2012
    ..Such CB1-independent of these antagonists effects may contribute to reported inconsistencies when CB1/MOR interactions are examined via pharmacological methods in CB1-knockout versus wild-type mice...
  3. doi request reprint A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors
    Kathryn A Seely
    Public Health Laboratory, Arkansas Department of Health, Little Rock, Arkansas 72205, USA
    Chem Res Toxicol 25:825-7. 2012
    ..The data suggests that hydroxylation by cytochrome P450s and subsequent glucuronidation by UDP-glucuronosyltransferases produces a metabolite, 018-gluc, which possesses antagonistic activity at CB1Rs...
  4. pmc Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands
    Krishna C Chimalakonda
    Departments of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AK 72205, USA
    Drug Metab Dispos 40:2174-84. 2012
    ..Results from the present study provide critical, missing data related to potential toxicological properties of "K2" parent compounds and their human metabolites, including mechanism(s) of action at cannabinoid receptors...
  5. pmc Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
    Joseph H Holthoff
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Kidney Int 81:370-8. 2012
    ..Hence, resveratrol may have a dual mechanism of action to restore the renal microcirculation and scavenge reactive nitrogen species, thus protecting the tubular epithelium even when administered after the onset of sepsis...
  6. pmc Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors
    Lisa K Brents
    Arkansas Biosciences Institute, Arkansas State University, AR, USA
    Xenobiotica 42:139-56. 2012
    ....
  7. doi request reprint Forensic investigation of K2, Spice, and "bath salt" commercial preparations: a three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds
    Kathryn A Seely
    Arkansas Department of Health, Public Health Laboratory, Little Rock, AR 72205, United States
    Forensic Sci Int 233:416-22. 2013
    ..Hallucinogenic drugs were rarely detected, but generally found on blotter paper products. Emerging designer drug products remain a significant problem and continued surveillance is needed to protect public health. ..
  8. doi request reprint Quantitative Measurement of Acetyl Fentanyl and Acetyl Norfentanyl in Human Urine by LC-MS/MS
    Amy L Patton
    Arkansas Department of Health, Public Health Laboratory, Little Rock, Arkansas 72205, United States
    Anal Chem 86:1760-6. 2014
    ..Further toxicokinetic studies are required to fully elucidate the metabolic pathways responsible for acetyl fentanyl detoxification and excretion. ..
  9. pmc Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?
    Kathryn A Seely
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Interv 11:36-51. 2011
    ..The K2/Spice "phenomenon" provides a context for considering whether marijuana-based drugs will truly provide innovative therapeutics or merely perpetuate drug abuse...
  10. doi request reprint Targeted metabolomic approach for assessing human synthetic cannabinoid exposure and pharmacology
    Amy L Patton
    Arkansas Department of Health, Public Health Laboratory, Little Rock, Arkansas 72205, United States
    Anal Chem 85:9390-9. 2013
    ..Preliminary evaluations of specific enantiomeric contributions support the use of this approach in future studies designed to understand the pharmacokinetic properties of JWH-018 and/or AM2201. ..
  11. doi request reprint The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists
    Kathryn A Seely
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    J Pharmacol Exp Ther 330:31-9. 2009
    ..Therefore, these polyphenols and their derivatives might be developed as novel, nontoxic CB1 therapeutics for obesity and/or drug dependence...
  12. pmc Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury
    Zhen Wang
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Pathol 180:505-16. 2012
    ..These data demonstrate that renal hemodynamic changes occur early after sepsis and that targeting the later oxidant generation can break the cycle of injury and enable the microcirculation and renal function to recover...
  13. pmc The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset
    Jennifer L Shoemaker
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurochem 101:87-98. 2007
    ..Therefore, CB2 agonists may slow motor neuron degeneration and preserve motor function, and represent a novel therapeutic modality for treatment of ALS...