Jingsong Zhao

Summary

Affiliation: Section of Hematology and Coagulation Medicine
Country: USA

Publications

  1. ncbi Oral RDP58 allows CPT-11 dose intensification for enhanced tumor response by decreasing gastrointestinal toxicity
    Jingsong Zhao
    Department of Discovery Research, SangStat Medical Corporation, Fremont, California 94555, USA
    Clin Cancer Res 10:2851-9. 2004
  2. ncbi Mitogenic influence of human R-spondin1 on the intestinal epithelium
    Kyung Ah Kim
    Nuvelo, Inc, 675 Almanor Avenue, Sunnyvale, CA 94085, USA
    Science 309:1256-9. 2005
  3. ncbi R-Spondin proteins: a novel link to beta-catenin activation
    Kyung Ah Kim
    Nuvelo Inc, San Carlos, California, USA
    Cell Cycle 5:23-6. 2006
  4. ncbi R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice
    Jingsong Zhao
    Department of Research, Nuvelo, Inc, San Carlos, California, USA
    Gastroenterology 132:1331-43. 2007
  5. doi rNAPc2 inhibits colorectal cancer in mice through tissue factor
    Jingsong Zhao
    Department of Research, Nuvelo, Inc, San Carlos, California 94070, USA
    Clin Cancer Res 15:208-16. 2009
  6. pmc R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway
    Jingsong Zhao
    Department of Research, Nuvelo, Inc, 201 Industrial Road, Suite 310, San Carlos, CA 94070, USA
    Proc Natl Acad Sci U S A 106:2331-6. 2009
  7. ncbi The lymphoid cell surface receptor NTB-A: a novel monoclonal antibody target for leukaemia and lymphoma therapeutics
    Wouter Korver
    Nuvelo, Inc, San Carlos, CA, USA
    Br J Haematol 137:307-18. 2007
  8. ncbi Tipping the balance: modulating the Wnt pathway for tissue repair
    Jingsong Zhao
    Nuvelo, Inc, 201 Industrial Road, Suit 310, San Carlos, CA 94070 6211, USA
    Trends Biotechnol 27:131-6. 2009
  9. ncbi Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins
    Wei Shi
    Developmental Biology Program, Department of Surgery, Children s Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 286:L293-300. 2004
  10. ncbi Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse
    Michael J Leinwand
    Division of Pediatric Surgery and Developmental Biology Program, Childrens Hospital Los Angeles Research Institute, Los Angeles, CA, USA
    J Pediatr Surg 37:1263-8. 2002

Collaborators

Detail Information

Publications10

  1. ncbi Oral RDP58 allows CPT-11 dose intensification for enhanced tumor response by decreasing gastrointestinal toxicity
    Jingsong Zhao
    Department of Discovery Research, SangStat Medical Corporation, Fremont, California 94555, USA
    Clin Cancer Res 10:2851-9. 2004
    ..Our results suggest that RDP58 may have clinical utility in cancer therapy by preventing treatment-associated GI toxicity and potentially increasing the effectiveness of chemotherapy...
  2. ncbi Mitogenic influence of human R-spondin1 on the intestinal epithelium
    Kyung Ah Kim
    Nuvelo, Inc, 675 Almanor Avenue, Sunnyvale, CA 94085, USA
    Science 309:1256-9. 2005
    ..The protein also displayed efficacy in a model of chemotherapy-induced intestinal mucositis and may have therapeutic application in gastrointestinal diseases...
  3. ncbi R-Spondin proteins: a novel link to beta-catenin activation
    Kyung Ah Kim
    Nuvelo Inc, San Carlos, California, USA
    Cell Cycle 5:23-6. 2006
    ....
  4. ncbi R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice
    Jingsong Zhao
    Department of Research, Nuvelo, Inc, San Carlos, California, USA
    Gastroenterology 132:1331-43. 2007
    ..R-spondin 1 (Rspo1) is a novel epithelial mitogen that stimulates the growth of mucosa in both the small and large intestine...
  5. doi rNAPc2 inhibits colorectal cancer in mice through tissue factor
    Jingsong Zhao
    Department of Research, Nuvelo, Inc, San Carlos, California 94070, USA
    Clin Cancer Res 15:208-16. 2009
    ..TF is highly expressed in human colorectal tumors, and levels are positively correlated with disease progression...
  6. pmc R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway
    Jingsong Zhao
    Department of Research, Nuvelo, Inc, 201 Industrial Road, Suite 310, San Carlos, CA 94070, USA
    Proc Natl Acad Sci U S A 106:2331-6. 2009
    ..In conclusion, our results demonstrate RSpo1 to be a potent therapeutic agent for oral mucositis by enhancing basal layer epithelial regeneration and accelerating mucosal repair through up-regulation of Wnt/beta-catenin pathway...
  7. ncbi The lymphoid cell surface receptor NTB-A: a novel monoclonal antibody target for leukaemia and lymphoma therapeutics
    Wouter Korver
    Nuvelo, Inc, San Carlos, CA, USA
    Br J Haematol 137:307-18. 2007
    ..Taken together, these results demonstrate NTB-A as a potential new target for immunotherapy of leukaemia and lymphomas...
  8. ncbi Tipping the balance: modulating the Wnt pathway for tissue repair
    Jingsong Zhao
    Nuvelo, Inc, 201 Industrial Road, Suit 310, San Carlos, CA 94070 6211, USA
    Trends Biotechnol 27:131-6. 2009
    ..As physiological Wnt response is essential for the regeneration of damaged tissues, modulation of the Wnt pathway might be beneficial for the treatment of multiple human diseases...
  9. ncbi Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins
    Wei Shi
    Developmental Biology Program, Department of Surgery, Children s Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 286:L293-300. 2004
    ..Thus overexpression of Smurf1 specifically promotes Smad1 and Smad5 ubiquitination and degradation in embryonic lung epithelium, thereby modulating the effects of BMP4 on embryonic lung growth...
  10. ncbi Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse
    Michael J Leinwand
    Division of Pediatric Surgery and Developmental Biology Program, Childrens Hospital Los Angeles Research Institute, Los Angeles, CA, USA
    J Pediatr Surg 37:1263-8. 2002
    ..Using the murine nitrofen-induced model of CDH, the authors evaluated lung growth and development before diaphragm closure or herniation...