Research Topics
Genomes and Genes | Marissa VignaliSummaryAffiliation: Seattle Biomedical Research Institute Country: USA Publications
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Detail Information
Publications
Interaction of an atypical Plasmodium falciparum ETRAMP with human apolipoproteinsMarissa Vignali
Department of Genome Sciences, University of Washington, Box 355065, Seattle, WA 98195, USA
Malar J 7:211. 2008..To better understand this aspect of malaria pathogenesis, a study was conducted with the goal of identifying interactions between proteins of the parasite and those of its human host...
Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinaseChristopher L Brett
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
J Cell Biol 182:1141-51. 2008..We propose that signal propagation through the Ypt7 pathway is controlled by integrated feedback and feed-forward loops. In this model, Yck3 enforces a requirement for the activated Rab in docking and fusion...
A protein interaction network of the malaria parasite Plasmodium falciparumDouglas J LaCount
Howard Hughes Medical Institute, University of Washington, Box 357730, Seattle, Washington 98195, USA
Nature 438:103-7. 2005..These data constitute the first extensive description of the protein interaction network for this important human pathogen...
Intrinsic tethering activity of endosomal Rab proteinsSheng Ying Lo
Department of Biochemistry, University of Washington School of Medicine, Seattle, Washington, USA
Nat Struct Mol Biol 19:40-7. 2012..In our working model, the intrinsic tethering capacity Vps21 operates in concert with conventional effectors and SNAREs to drive efficient docking and fusion...
Malaria sporozoite proteome leaves a trailMarissa Vignali
Malaria Program, Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
Genome Biol 10:216. 2009..The malaria parasite sporozoite proteome changes during maturation, revealing proteins specifically expressed in the stage that infects the human host...
Structural genomics of pathogenic protozoa: an overviewErkang Fan
Department of Biochemistry, University of Washington, Seattle, WA, USA
Methods Mol Biol 426:497-513. 2008..quot;Fragment cocktail crystallography" for medical structural genomics is also described...
NSR-seq transcriptional profiling enables identification of a gene signature of Plasmodium falciparum parasites infecting childrenMarissa Vignali
Seattle Biomedical Research Institute, Seattle, Washington, USA
J Clin Invest 121:1119-29. 2011..Our study provides proof of principle that NSR-seq represents an approach that can be used to study clinical isolates of parasites causing severe malaria syndromes as well other blood-borne pathogens and blood-related diseases...
