Research Topics
| Philip MeaseSummaryAffiliation: Seattle Rheumatology Associates Country: USA Publications
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Detail Information
Publications
Disease-modifying antirheumatic drug therapy for spondyloarthropathies: advances in treatmentPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
Curr Opin Rheumatol 15:205-12. 2003..This article reviews recent progress in disease-modifying therapy for spondyloarthropathy, including new biologic response modifiers, such as the tumor necrosis factor-alpha inhibitors etanercept and infliximab...
Quality-of-life issues in psoriasis and psoriatic arthritis: outcome measures and therapies from a dermatological perspectivePhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
J Am Acad Dermatol 54:685-704. 2006....
Fibromyalgia syndromePhilip Mease
Seattle Rhumatology Associates, Seattle, WA 98104, USA
J Rheumatol 34:1415-25. 2007..The OMERACT process has provided a framework for identification of key domains to be assessed and a path toward validation and standardization of outcome measures for clinical trials in FM...
Improved health-related quality of life for patients with active rheumatoid arthritis receiving rituximab: Results of the Dose-Ranging Assessment: International Clinical Evaluation of Rituximab in Rheumatoid Arthritis (DANCER) TrialPhilip J Mease
Seattle Rheumatology Associates, Seattle, WA 98104, USA
J Rheumatol 35:20-30. 2008....
Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercisesPhillip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
Arthritis Rheum 59:952-60. 2008....
A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexateP Mease
Division of Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, Washington, USA
Ann Rheum Dis 71:1183-9. 2012..Interleukin 6 (IL-6) plays a key role in the inflammatory cascade in rheumatoid arthritis. BMS945429 is a humanised, monoclonal antibody that potently binds IL-6...
Pharmacotherapy of fibromyalgiaPhilip J Mease
Rheumatology Research, Swedish Medical Center, Seattle, WA, USA
Best Pract Res Clin Rheumatol 25:285-97. 2011..Current therapies neither completely treat FM symptoms nor benefit all patients; thus, further research on new therapies with different mechanisms and side-effect profiles is needed...
Distinguishing inflammatory from noninflammatory arthritis, enthesitis, and dactylitis in psoriatic arthritis: a report from the GRAPPA 2010 annual meetingPhilip J Mease
Division of Rheumatology Research, Swedish Medical Center, University of Washington School of Medicine, Seattle, WA, USA
J Rheumatol 39:415-7. 2012....
Prologue: 2010 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)Philip J Mease
Swedish Medical Center and University of Washington, Seattle, Washington 98104, USA
J Rheumatol 39:391-3. 2012..Introductions to the discussions at the GRAPPA 2010 meeting are included in this prologue...
Fatigue in fibromyalgia: a conceptual model informed by patient interviewsLouise Humphrey
Mapi Values, Adelphi Mill, Bollington, Macclesfield Cheshire SK10 5JB, UK
BMC Musculoskelet Disord 11:216. 2010..The data obtained informed the development of a conceptual model of fatigue in FM...
Rapid and sustained improvements in health-related quality of life, fatigue, and other patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol plus methotrexate over 1 year: results from the RAPID 1 randomized controlledVibeke Strand
Division of Immunology Rheumatology, Stanford University School of Medicine, 306 Ramona Road, Palo Alto, CA, 94028, USA
Arthritis Res Ther 11:R170. 2009..The objective of this study was to assess the impact of certolizumab pegol (CZP) treatment on health-related quality of life (HRQoL), fatigue and other patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA)...
Risk factors for radiographic progression in psoriatic arthritis: subanalysis of the randomized controlled trial ADEPTDafna D Gladman
University of Toronto, 399 Bathurst Street, Room 1E 410B, Toronto, Ontario M5T 2S8, Canada
Arthritis Res Ther 12:R113. 2010..To identify independent predictors of radiographic progression in psoriatic arthritis (PsA) for patients treated with adalimumab or placebo in the Adalimumab Effectiveness in PsA Trial (ADEPT)...
Psoriatic arthritis: pharmacotherapy updatePhilip J Mease
Swedish Medical Center, Division of Rheumatology Research, Seattle Rheumatology Associates, University of Washington, 1101 Madison Street, Suite 1000, Seattle, WA 98104, USA
Curr Rheumatol Rep 12:272-80. 2010....
Patient-reported outcomes in a randomized trial of etanercept in psoriatic arthritisPhilip J Mease
Seattle Rheumatology Associates and Swedish Medical Center, 1101 Madison Street, Seattle, WA 98104, USA
J Rheumatol 37:1221-7. 2010..To evaluate the effects of etanercept treatment on patient-reported outcomes (PRO) in patients with psoriatic arthritis (PsA)...
Efficacy and safety of retreatment in patients with rheumatoid arthritis with previous inadequate response to tumor necrosis factor inhibitors: results from the SUNRISE trialPhilip J Mease
Seattle Rheumatology Associates, Swedish Medical Center, Seattle, WA 98104, USA
J Rheumatol 37:917-27. 2010..To assess the efficacy and safety of 1 versus 2 courses of rituximab over 48 weeks in patients with rheumatoid arthritis (RA)...
Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a phase 1/2 StudyPhilip J Mease
Seattle Rheumatology Associates, Swedish Medical Center, Seattle, Wahington 98104, USA
J Rheumatol 37:692-703. 2010....
Further strategies for treating fibromyalgia: the role of serotonin and norepinephrine reuptake inhibitorsPhilip J Mease
Seattle Rheumatology Associates, Swedish Medical Center, Seattle, Washington, USA
Am J Med 122:S44-55. 2009..Pharmacologic agents that specifically target serotonin and norepinephrine reuptake may prove to be valuable tools in the treatment of fibromyalgia...
Spondyloarthritis update: new insights regarding classifcation, pathophysiology, and managementPhilip J Mease
University of Washington School of Medicine, Seattle, Washington, USA
Bull NYU Hosp Jt Dis 66:203-9. 2008..International treatment recommendations have been or are being developed based on the evidence base from clinical trials...
Psoriatic arthritis assessment and treatment updatePhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington, USA
Curr Opin Rheumatol 21:348-55. 2009..To review the current state of knowledge about assessment and management of psoriatic arthritis (PsA)...
Alefacept with methotrexate for treatment of psoriatic arthritis: open-label extension of a randomized, double-blind, placebo-controlled studyPhilip J Mease
Seattle Rheumatology Associates, Division of Rheumatology Research, Swedish Medical Center, Seattle, Washington, USA
J Am Acad Dermatol 60:402-11. 2009..A single course of alefacept intramuscularly in combination with methotrexate (MTX) was effective in treating both psoriasis and psoriatic arthritis (PsA)...
Abatacept in the treatment of patients with psoriatic arthritis: Results of a six-month, multicenter, randomized, double-blind, placebo-controlled, phase II trialPhilip Mease
Swedish Medical Center and University of Washington, Seattle, Washington
Arthritis Rheum 63:939-48. 2011..To assess the safety and efficacy of abatacept, a selective T cell costimulation modulator, in patients with psoriatic arthritis (PsA)...
Improving the routine management of rheumatoid arthritis: the value of tight controlPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
J Rheumatol 37:1570-8. 2010..A case study clearly demonstrates the benefits of the tight control approach in routine clinical practice...
Minimally important difference of Health Assessment Questionnaire in psoriatic arthritis: relating thresholds of improvement in functional ability to patient-rated importance and satisfactionPhilip J Mease
Swedish Medical Center and University of Washington, Seattle, WA 98104, USA
J Rheumatol 38:2461-5. 2011..To evaluate changes in function as measured by Health Assessment Questionnaire Disability Index (HAQ-DI) and the meaningfulness of the changes, in importance and satisfaction, in patients with psoriatic arthritis (PsA)...
Toward development of a fibromyalgia responder index and disease activity score: OMERACT module updatePhilip J Mease
Division of Rheumatology Research, Swedish Medical Center, University of Washington, Seattle, Washington, USA
J Rheumatol 38:1487-95. 2011..Final results of this work will be published in a separate report pending completion of analyses...
The potential roles for novel biomarkers in rheumatoid arthritis assessmentP J Mease
Rheumatology Research, Swedish Medical Center, Seattle, WA 98104, USA
Clin Exp Rheumatol 29:567-74. 2011..This article reviews the current management strategies for monitoring RA and the potential impact that multi-biomarker assays may have on RA assessment, which may further improve clinical outcomes...
Pain mechanisms in osteoarthritis: understanding the role of central pain and current approaches to its treatmentPhilip J Mease
Seattle Rheumatology Associates, Seattle, WA 98104, USA
J Rheumatol 38:1546-51. 2011..Evidence is presented for the efficacy of centrally acting analgesics for OA pain (opioids, antiepileptics, tricyclic antidepressants, and serotonin/norepinephrine receptor inhibitors)...
Inflammatory musculoskeletal disease: identification and assessmentPhilip J Mease
Swedish Medical Center and University of Washington, Seattle, WA 98104, USA
J Rheumatol 38:557-61. 2011..Features that assist identification and assessment of PsA are reviewed in this article...
Prologue: 2009 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)Philip J Mease
University of Washington, Seattle, WA 98104, USA
J Rheumatol 38:522-5. 2011..Other topics for discussion at the GRAPPA meeting included presentations on genetic associations with PsA and on comorbidities in patients with PsA. Current and future research projects also were outlined...
Psoriatic arthritis: update on pathophysiology, assessment and managementPhilip J Mease
Seattle Rheumatology Associates, 1101 Madison St Ste 1000, Seattle, WA 98104, USA
Ann Rheum Dis 70:i77-84. 2011..Although there is considerable overlap with RA, there are some differences in pathophysiology and approach to assessment and management that are important to consider. This paper reviews these subjects, with an emphasis on recent data...
Abatacept in the treatment of patients with psoriatic arthritis: results of a six-month, multicenter, randomized, double-blind, placebo-controlled, phase II trialPhilip Mease
University of Washington, Seattle, WA, USA
Arthritis Rheum 63:939-48. 2011..To assess the safety and efficacy of abatacept, a selective T cell costimulation modulator, in patients with psoriatic arthritis (PsA)...
Psoriatic arthritis - update on pathophysiology, assessment, and managementPhilip J Mease
University of Washington School of Medicine, Seattle, Washington 98104, USA
Bull NYU Hosp Jt Dis 68:191-8. 2010..A number of advances in assessment and treatment have occurred in the last few years, which are highlighted in this update. This article reviews assessment and treatment of PsA, with an emphasis on recent data...
Certolizumab pegol in the treatment of rheumatoid arthritis: a comprehensive review of its clinical efficacy and safetyPhilip J Mease
Seattle Rheumatology Associates, Seattle, WA 98104, USA
Rheumatology (Oxford) 50:261-70. 2011..CZP was generally well tolerated when used either as monotherapy or added to MTX; most adverse events were mild or moderate. Taken together, the results of these trials suggest that CZP is an effective new option for the treatment of RA...
Adalimumab for long-term treatment of psoriatic arthritis: 2-year data from the Adalimumab Effectiveness in Psoriatic Arthritis Trial (ADEPT)P J Mease
Swedish Medical Center and University of Washington, Seattle, Washington, USA
Ann Rheum Dis 68:702-9. 2009..To evaluate the long-term effectiveness and tolerability of adalimumab in the treatment of psoriatic arthritis (PsA)...
Alefacept in combination with methotrexate for the treatment of psoriatic arthritis: results of a randomized, double-blind, placebo-controlled studyPhilip J Mease
Swedish Medical Center, Seattle, Washington, USA
Arthritis Rheum 54:1638-45. 2006..To evaluate the efficacy and safety of alefacept in combination with methotrexate (MTX) for the treatment of psoriatic arthritis (PsA)...
Continued inhibition of radiographic progression in patients with psoriatic arthritis following 2 years of treatment with etanerceptPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
J Rheumatol 33:712-21. 2006..Clinical and radiographic responses were evaluated in patients with psoriatic arthritis (PsA) treated for up to 2 years with etanercept...
Fibromyalgia syndromePhilip J Mease
Swedish Medical Center, The University of Washington School of Medicine, Seattle, WA, USA
J Rheumatol 32:2270-7. 2005..A prioritized list of domains of FM to be investigated was thus developed, key issues and controversies in the field were debated, and consensus on a research agenda on outcome measure development was reached...
Adalimumab: an anti-TNF agent for the treatment of psoriatic arthritisPhilip J Mease
Seattle Rheumatology Associates, Seattle, WA 98104, USA
Expert Opin Biol Ther 5:1491-504. 2005..In addition, structural changes were inhibited, and statistically and clinically significant improvements in measures of disability and quality of life were observed. Adalimumab was generally safe and well tolerated...
Adalimumab for the treatment of patients with moderately to severely active psoriatic arthritis: results of a double-blind, randomized, placebo-controlled trialPhilip J Mease
Seattle Rheumatology Associates, Swedish Medical Center, Seattle, Washington 98104, USA
Arthritis Rheum 52:3279-89. 2005..Adalimumab, a fully human, anti-tumor necrosis factor monoclonal antibody, was evaluated for its safety and efficacy compared with placebo in the treatment of active psoriatic arthritis (PsA)...
Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatmentPhilip Mease
Seattle Rheumatology Associates, Washington 98104, USA
J Rheumatol Suppl 75:6-21. 2005..The multifaceted nature of FM suggests that multimodal individualized treatment programs may be necessary to achieve optimal outcomes in patients with this syndrome...
Psoriatic arthritis therapy advancesPhilip J Mease
Seattle Rheumatology Associates, Swedish Medical Center, Rheumatology Research Division, and University of Washington School of Medicine Seattle, Washington 98104, USA
Curr Opin Rheumatol 17:426-32. 2005..This paper will review the data published in 2004 on the treatment of psoriatic arthritis, which arthritis affects 6 to 39% of all patients with psoriasis...
Psoriatic arthritis treatment: biological response modifiersP J Mease
Seattle Rheumatology Associates, 1101 Madison St, 10th Floor, Seattle, WA 98104, USA
Ann Rheum Dis 64:ii78-82. 2005..Also, it will be useful to learn more about the effects of combining traditional disease modifying drugs and the newer biologicals...
Psoriatic arthritis assessment tools in clinical trialsP J Mease
Seattle Rheumatology Associates and Swedish Medical Center Rhematology Research Division, University of Washington School of Medicine, Seattle, WA 98104, USA
Ann Rheum Dis 64:ii49-54. 2005..This report reviews the current state of the art of assessment in PsA and points toward future directions of development of this field...
Diagnosis and treatment of psoriatic arthritisPhilip Mease
Seattle Rheumatology Associates, Swedish Hospital Medical Center, Division of Clinical Research, WA 98104, USA
J Am Acad Dermatol 52:1-19. 2005....
Etanercept treatment of psoriatic arthritis: safety, efficacy, and effect on disease progressionPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
Arthritis Rheum 50:2264-72. 2004..In this study, we further evaluated the safety, efficacy, and effect on radiographic progression of etanercept in patients with PsA...
Pneumococcal vaccine response in psoriatic arthritis patients during treatment with etanerceptPhillip J Mease
Seattle Rheumatology Associates, 1101 Madison, Suite 230, Seattle, WA 98104, USA
J Rheumatol 31:1356-61. 2004..Immune system function can be assessed by evaluating response to vaccination. We assessed the ability of patients with PsA treated with etanercept to produce antibodies in response to pneumococcal antigen challenge...
TNFalpha therapy in psoriatic arthritis and psoriasisP Mease
Seattle Rheumatology Associates, Seattle, WA 98104, USA
Ann Rheum Dis 63:755-8. 2004
Current treatment of psoriatic arthritisPhilip J Mease
Seattle Rheumatology Associates, Division of Clinical Research, Swedish Hospital Medical Center, University of Washington School of Medicine, Seattle, WA, USA
Rheum Dis Clin North Am 29:495-511. 2003....
Management of psoriatic arthritis: the therapeutic interface between rheumatology and dermatologyPhilip Mease
Seattle Rheumatology Associates, Division of Rheumatology Research, Swedish Medical Center, University of Washington School of Medicine, 1101 Madison Street, Suite 1000, Seattle, WA 98104, USA
Curr Rheumatol Rep 8:348-54. 2006....
Assessing the impact of psoriatic arthritis on patient function and quality of life: lessons learned from other rheumatologic conditionsPhilip J Mease
Seattle Rheumatology Associates, Rheumatology Clinical Research, Swedish Medical Center, University of Washington School of Medicine, Seattle, WA, USA
Semin Arthritis Rheum 38:320-35. 2009..To identify and describe measures that can be used to assess the impact of psoriatic arthritis (PsA) on patient functioning and health-related quality of life (HRQOL)...
A randomized, double-blind, placebo-controlled, phase III trial of pregabalin in the treatment of patients with fibromyalgiaPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
J Rheumatol 35:502-14. 2008..To evaluate the efficacy and safety of pregabalin for symptomatic relief of pain associated with fibromyalgia (FM) and for management of FM...
B cell-targeted therapy in autoimmune disease: rationale, mechanisms, and clinical applicationPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
J Rheumatol 35:1245-55. 2008..In this review we explore the rationale behind B cell-targeted therapy, highlight the results of clinical trials with rituximab in RA and other autoimmune diseases, and describe other emerging therapies directed at B cells...
Current treatment for psoriatic arthritis and other spondyloarthritidesPhilip Mease
Division of Rheumatology Research, Swedish Medical Center
Rheum Dis Clin North Am 32:11-20. 2006
Assessment tools in psoriatic arthritisPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
J Rheumatol 35:1426-30. 2008..We present a review of those discussions...
Fibromyalgia syndrome module at OMERACT 9: domain constructPhilip Mease
Seattle Rheumatology Associates and Division of Rheumatology Research, Swedish Medical Center, Seattle, WA 98104, USA
J Rheumatol 36:2318-29. 2009..In conclusion, a multidimensional symptom core set is proposed for evaluation of FM in clinical trials. Research on improved measures of single domains and composite measures is ongoing...
Single-joint outcome measures: preliminary validation of patient-reported outcomes and physical examinationAlison E Heald
Targeted Genetics Corporation, Seattle, Washington, USA
J Rheumatol 37:1042-8. 2010..To assess the validity, responsiveness, and reliability of single-joint outcome measures for determining target joint (TJ) response in patients with inflammatory arthritis...
Long-term safety, tolerability, and efficacy of duloxetine in the treatment of fibromyalgiaPhilip J Mease
Seattle Rheumatology Associates, Seattle, WA, USA
Semin Arthritis Rheum 39:454-64. 2010..To assess the long-term safety, tolerability, and efficacy of duloxetine in patients with fibromyalgia...
Impact of adalimumab on symptoms of psoriatic arthritis in patients with moderate to severe psoriasis: a pooled analysis of randomized clinical trialsPhilip J Mease
Seattle Rheumatology Associates, Seattle, WA 98104, USA pmease nwlink com
Dermatology 220:1-7. 2010..Psoriatic arthritis often affects patients with psoriasis...
The efficacy and safety of milnacipran for treatment of fibromyalgia. a randomized, double-blind, placebo-controlled trialPhilip J Mease
Seattle Rheumatology Associates, 1101 Madison Street, Suite 1000, Seattle, WA 98104, USA
J Rheumatol 36:398-409. 2009..To evaluate the safety and efficacy of milnacipran, a dual norepinephrine and serotonin reuptake inhibitor, in the treatment of fibromyalgia (FM)...
Pharmacotherapy of fibromyalgiaPhilip J Mease
Seattle Rheumatology Associates, Swedish Medical Center, Seattle, WA 98104
Rheum Dis Clin North Am 35:359-72. 2009....
Recent advances in the management of psoriatic arthritisPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
Curr Opin Rheumatol 16:366-70. 2004..Newer trials in psoriatic arthritis therapy demonstrate ongoing ability to control disease symptoms and signs and the progression of the disease significantly...
Fibromyalgia: should the treatment paradigm be monotherapy or combination pharmacotherapy?Philip J Mease
Seattle Rheumatology Associates, Swedish Medical Center, Seattle, WA 98104, USA
Curr Pain Headache Rep 12:399-405. 2008..Trials are currently being developed to assess the potential additive or synergistic effects of combined central pharmacotherapy and to assess the safety and tolerability of this approach...
Psoriatic arthritis updatePhilip Mease
Seattle Rheumatology Associates, Swedish Medical Center, University of Washington School of Medicine, Seattle, Washington, USA
Bull NYU Hosp Jt Dis 64:25-31. 2006..Adverse effects with these agents can be significant but are usually manageable. Cost is also significant, but cost-effectiveness analysis is demonstrating reasonable trade-off between cost and benefit...
Nursing considerations for infusion therapy in rheumatoid arthritis versus malignancyNicole Furfaro
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
J Infus Nurs 31:350-60. 2008..This article focuses on the specific pathophysiology of the RA disease state and patient characteristics that may affect infusion therapy, illustrated by a case study...
Effects of prasterone on bone mineral density in women with systemic lupus erythematosus receiving chronic glucocorticoid therapyPhilip J Mease
Seattle Rheumatology Associates, Seattle, Washington, USA
J Rheumatol 32:616-21. 2005..CONCLUSION: Prasterone treatment prevented BMD loss and significantly increased BMD at both the lumbar spine and total hip in female patients with SLE receiving exogenous glucocorticoids...
Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trialMario H Cardiel
Hospital General Dr Miguel Silva, Morelia, Michoacan, Mexico
Arthritis Rheum 58:2470-80. 2008....
