MICHAL FRIED FRIED

Summary

Affiliation: Seattle Biomedical Research Institute
Country: USA

Publications

  1. pmc Plasma levels of apolipoprotein A1 in malaria-exposed primigravidae are associated with severe anemia
    David C Simpson
    Seattle Biomedical Research Institute, Seattle, Washington, United States of America
    PLoS ONE 5:e8822. 2010
  2. pmc Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria
    Edward R Kabyemela
    Mother Offspring Malaria Studies MOMS Project, Seattle Biomedical Research Institute, Seattle WA 98109, USA
    Malar J 7:26. 2008
  3. ncbi request reprint The distinct proteome of placental malaria parasites
    Michal Fried
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Mol Biochem Parasitol 155:57-65. 2007
  4. ncbi request reprint Plasmodium falciparum: chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta
    Michal Fried
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Exp Parasitol 113:36-42. 2006
  5. ncbi request reprint VAR2CSA domains expressed in Escherichia coli induce cross-reactive antibodies to native protein
    Andrew V Oleinikov
    Seattle Biomedical Research Institute, University of Washington, Seattle, USA
    J Infect Dis 197:1119-23. 2008
  6. pmc Six genes are preferentially transcribed by the circulating and sequestered forms of Plasmodium falciparum parasites that infect pregnant women
    Susan E Francis
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Seattle, WA 98109 5219, USA
    Infect Immun 75:4838-50. 2007
  7. ncbi request reprint Analysis of CSA-binding parasites and antiadhesion antibodies
    Michal Fried
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Methods Mol Med 72:555-60. 2002
  8. pmc Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes
    Marion Avril
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
    Infect Immun 78:2248-56. 2010
  9. ncbi request reprint Two DBLgamma subtypes are commonly expressed by placental isolates of Plasmodium falciparum
    Michal Fried
    Seattle Biomedical Research Institute, 4 Nickerson Street, WA 98109, USA
    Mol Biochem Parasitol 122:201-10. 2002
  10. pmc Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA
    Marion Avril
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
    Infect Immun 76:1791-800. 2008

Research Grants

  1. Plasma Proteome During Pregnancy Malaria
    Michal Fried; Fiscal Year: 2007
  2. Pathways of Maternal Anemia
    Michal Fried; Fiscal Year: 2009
  3. Pathways of Maternal Anemia
    MICHAL FRIED FRIED; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. pmc Plasma levels of apolipoprotein A1 in malaria-exposed primigravidae are associated with severe anemia
    David C Simpson
    Seattle Biomedical Research Institute, Seattle, Washington, United States of America
    PLoS ONE 5:e8822. 2010
    ..Here we aimed to identify additional changes in the plasma proteome associated with pregnancy malaria that may contribute to the development of malaria-related maternal anemia...
  2. pmc Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malaria
    Edward R Kabyemela
    Mother Offspring Malaria Studies MOMS Project, Seattle Biomedical Research Institute, Seattle WA 98109, USA
    Malar J 7:26. 2008
    ..Diagnosis is difficult because PM is often asymptomatic, peripheral blood smear examination detects parasitemia as few as half of PM cases, and no peripheral markers have been validated for placental inflammation...
  3. ncbi request reprint The distinct proteome of placental malaria parasites
    Michal Fried
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Mol Biochem Parasitol 155:57-65. 2007
    ..One of these hypothetical proteins, PFI1785w, is a 42kDa molecule detected by Western blot in parasites infecting pregnant women but not those infecting children...
  4. ncbi request reprint Plasmodium falciparum: chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta
    Michal Fried
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Exp Parasitol 113:36-42. 2006
    ..P. falciparum adhesion in the placenta appears to be a non-redundant process that requires CSA as a receptor. Vaccines that elicit functional antibodies against CSA-binding parasites may confer resistance to pregnancy malaria...
  5. ncbi request reprint VAR2CSA domains expressed in Escherichia coli induce cross-reactive antibodies to native protein
    Andrew V Oleinikov
    Seattle Biomedical Research Institute, University of Washington, Seattle, USA
    J Infect Dis 197:1119-23. 2008
    ..This is the first report that E. coli-expressed VAR2CSA domains induce antibody to native VAR2CSA...
  6. pmc Six genes are preferentially transcribed by the circulating and sequestered forms of Plasmodium falciparum parasites that infect pregnant women
    Susan E Francis
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Seattle, WA 98109 5219, USA
    Infect Immun 75:4838-50. 2007
    ..These findings suggest that a suite of genes may be important for the genesis of the placental binding phenotype of P. falciparum and may provide novel targets for therapeutic intervention...
  7. ncbi request reprint Analysis of CSA-binding parasites and antiadhesion antibodies
    Michal Fried
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Methods Mol Med 72:555-60. 2002
  8. pmc Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes
    Marion Avril
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
    Infect Immun 78:2248-56. 2010
    ..These findings demonstrate that the major PfEMP1 variant expressed by placental isolates exposes strain-transcendent epitopes that can be targeted by vaccination and may have application for pregnancy malaria vaccine development...
  9. ncbi request reprint Two DBLgamma subtypes are commonly expressed by placental isolates of Plasmodium falciparum
    Michal Fried
    Seattle Biomedical Research Institute, 4 Nickerson Street, WA 98109, USA
    Mol Biochem Parasitol 122:201-10. 2002
    ..The findings are consistent with earlier serologic evidence that surface antigens of placental parasites have conserved features, and suggest that vaccines based on DBLgamma may only need to target a limited number of variants...
  10. pmc Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA
    Marion Avril
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
    Infect Immun 76:1791-800. 2008
    ..This study demonstrates that VAR2CSA contains common polymorphic epitopes that are shared between geographically diverse CSA-binding lines...
  11. pmc High throughput functional assays of the variant antigen PfEMP1 reveal a single domain in the 3D7 Plasmodium falciparum genome that binds ICAM1 with high affinity and is targeted by naturally acquired neutralizing antibodies
    Andrew V Oleinikov
    Seattle Biomedical Research Institute, Seattle, Washington, USA
    PLoS Pathog 5:e1000386. 2009
    ..Our high throughput approach will significantly accelerate studies of PfEMP1 binding domains and protective antibody responses...
  12. pmc A novel histological grading scheme for placental malaria applied in areas of high and low malaria transmission
    Atis Muehlenbachs
    Seattle Biomedical Research Institute, University of Washington, Seattle, USA
    J Infect Dis 202:1608-16. 2010
    ..Histologic measurements during placental malaria might provide surrogate end points for interventional trials, but existing histologic schemes capture limited complexity and are not consistently used among study sites...
  13. ncbi request reprint Effects of sex, parity, and sequence variation on seroreactivity to candidate pregnancy malaria vaccine antigens
    Andrew V Oleinikov
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    J Infect Dis 196:155-64. 2007
    ..Two IE surface molecules, VAR1CSA and VAR2CSA, bind CSA in vitro and are potential vaccine candidates...
  14. ncbi request reprint Malaria vaccines: using models of immunity and functional genomics tools to accelerate the development of vaccines against Plasmodium falciparum
    Patrick E Duffy
    Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA
    Vaccine 23:2235-42. 2005
    ..These candidate antigens are then subjected to detailed studies according to criteria established by the understanding of pathogenesis and protective immunity, to identify the optimal antigens for inclusion in subunit vaccines...
  15. ncbi request reprint Red blood cells that do and red blood cells that don't: how to resist a persistent parasite
    Patrick E Duffy
    Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA
    Trends Parasitol 22:99-101. 2006
    ..HbC-containing red blood cells have modified displays of malaria surface proteins that reduce parasite adhesiveness and could reduce the risk of severe disease...
  16. ncbi request reprint Plasmodium falciparum adhesion in the placenta
    Patrick E Duffy
    Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, 4 Nickerson ST STE 200, Seattle, WA 98109 1651, USA
    Curr Opin Microbiol 6:371-6. 2003
    ..Adhesins and other surface proteins of placental parasites are targets of naturally occurring antibodies associated with protection and therefore could be used to develop vaccines that prevent malaria in pregnancy...
  17. pmc Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns
    Patrick E Duffy
    Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    Infect Immun 71:6620-3. 2003
    ..019) and 2 weeks more mature (P = 0.002) than babies delivered to secundigravidas without antiadhesion activity. Our findings support the development of antiadhesion vaccines to prevent poor fetal outcomes due to pregnancy malaria...
  18. ncbi request reprint Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein-1 variants expressed by placental malaria parasites
    Michal Fried
    Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    Proteomics 4:1086-93. 2004
    ..These novel PfEMP1 variants require further study to confirm whether they play a role in placental malaria...
  19. pmc Hypertension and maternal-fetal conflict during placental malaria
    Atis Muehlenbachs
    MOMS Project, Seattle Biomedical Research Institute, Seattle, Washington, United States of America
    PLoS Med 3:e446. 2006
    ..Malaria and hypertension are major causes of maternal mortality in tropical countries, especially during first pregnancies, but evidence for a relationship between these syndromes is contradictory...
  20. pmc Natural selection of FLT1 alleles and their association with malaria resistance in utero
    Atis Muehlenbachs
    Mother Offspring Malaria Studies Project, Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 105:14488-91. 2008
    ..This indicates that FLT1 is under natural selection in a malaria endemic area and that human exposure to malaria can influence the evolutionary genetics of the maternal-fetal relationship...
  21. doi request reprint Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiency
    Edward R Kabyemela
    Mother Offspring Malaria Studies Project, Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
    J Infect Dis 198:163-6. 2008
    ..Interventional trials of iron and folate supplementation during pregnancy in malaria-endemic regions in Africa are urgently needed to ascertain the benefits and risks of this intervention...
  22. ncbi request reprint An unusual presentation of placental malaria: a single persisting nidus of sequestered parasites
    Atis Muehlenbachs
    Mother Offspring Malaria Studies Project, Seattle Biomedical Research Institute, Seattle WA 98109, USA
    Hum Pathol 38:520-3. 2007
    ..This finding suggests ring stage-infected erythrocytes sequester in vivo, or P falciparum can persist as a dormant blood stage form...
  23. pmc Maternal malaria and gravidity interact to modify infant susceptibility to malaria
    Theonest K Mutabingwa
    Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington, USA
    PLoS Med 2:e407. 2005
    ..Placental malaria may increase the susceptibility of infants to malaria parasitemia, but evidence for this effect is inconclusive...
  24. pmc Fetal responses during placental malaria modify the risk of low birth weight
    Edward R Kabyemela
    MOMS Project, Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Infect Immun 76:1527-34. 2008
    ..Because fetal cells are a source of placental IFN-gamma and cord ferritin, the fetal response to PM may modify the risk of LBW...
  25. ncbi request reprint Genome-wide expression analysis of placental malaria reveals features of lymphoid neogenesis during chronic infection
    Atis Muehlenbachs
    Mother Offspring Malaria Study MOMS Project, Seattle Biomedical Research Institute, 307 Westlake Avenue North, Seattle, WA 98109, USA
    J Immunol 179:557-65. 2007
    ..We propose a model where the production of Ig during chronic malaria may enhance inflammation by attracting and activating macrophages that, in turn, recruit B cells to further produce Ig in the intervillous spaces...
  26. ncbi request reprint Malaria: new diagnostics for an old problem
    Patrick Duffy
    Am J Trop Med Hyg 73:482-3. 2005

Research Grants3

  1. Plasma Proteome During Pregnancy Malaria
    Michal Fried; Fiscal Year: 2007
    ....
  2. Pathways of Maternal Anemia
    Michal Fried; Fiscal Year: 2009
    ..This study will identify potential immunological and transcriptional pathways and mediators that are pivotal in the pathogenesis of malaria associated maternal anemia. ..
  3. Pathways of Maternal Anemia
    MICHAL FRIED FRIED; Fiscal Year: 2010
    ..This study will identify potential immunological and transcriptional pathways and mediators that are pivotal in the pathogenesis of malaria associated maternal anemia. ..