Research Topics
| MICHAL FRIED FRIEDSummaryAffiliation: Seattle Biomedical Research Institute Country: USA Publications
Research Grants
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Detail Information
Publications
Maternal peripheral blood level of IL-10 as a marker for inflammatory placental malariaEdward R Kabyemela
Mother Offspring Malaria Studies MOMS Project, Seattle Biomedical Research Institute, Seattle WA 98109, USA
Malar J 7:26. 2008..Diagnosis is difficult because PM is often asymptomatic, peripheral blood smear examination detects parasitemia as few as half of PM cases, and no peripheral markers have been validated for placental inflammation...
The distinct proteome of placental malaria parasitesMichal Fried
Seattle Biomedical Research Institute, Seattle, WA 98109, USA
Mol Biochem Parasitol 155:57-65. 2007..One of these hypothetical proteins, PFI1785w, is a 42kDa molecule detected by Western blot in parasites infecting pregnant women but not those infecting children...- Plasmodium falciparum: chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placentaMichal Fried
Seattle Biomedical Research Institute, Seattle, WA, USA
Exp Parasitol 113:36-42. 2006..P. falciparum adhesion in the placenta appears to be a non-redundant process that requires CSA as a receptor. Vaccines that elicit functional antibodies against CSA-binding parasites may confer resistance to pregnancy malaria... 
VAR2CSA domains expressed in Escherichia coli induce cross-reactive antibodies to native proteinAndrew V Oleinikov
Seattle Biomedical Research Institute, University of Washington, Seattle, USA
J Infect Dis 197:1119-23. 2008..This is the first report that E. coli-expressed VAR2CSA domains induce antibody to native VAR2CSA...- Six genes are preferentially transcribed by the circulating and sequestered forms of Plasmodium falciparum parasites that infect pregnant womenSusan E Francis
Seattle Biomedical Research Institute, 307 Westlake Ave N, Seattle, WA 98109 5219, USA
Infect Immun 75:4838-50. 2007..These findings suggest that a suite of genes may be important for the genesis of the placental binding phenotype of P. falciparum and may provide novel targets for therapeutic intervention... - Analysis of CSA-binding parasites and antiadhesion antibodiesMichal Fried
Seattle Biomedical Research Institute, Seattle, WA, USA
Methods Mol Med 72:555-60. 2002 - Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytesMarion Avril
Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
Infect Immun 78:2248-56. 2010..These findings demonstrate that the major PfEMP1 variant expressed by placental isolates exposes strain-transcendent epitopes that can be targeted by vaccination and may have application for pregnancy malaria vaccine development... - A novel histological grading scheme for placental malaria applied in areas of high and low malaria transmissionAtis Muehlenbachs
Seattle Biomedical Research Institute, University of Washington, Seattle, USA
J Infect Dis 202:1608-16. 2010..Histologic measurements during placental malaria might provide surrogate end points for interventional trials, but existing histologic schemes capture limited complexity and are not consistently used among study sites... - Two DBLgamma subtypes are commonly expressed by placental isolates of Plasmodium falciparumMichal Fried
Seattle Biomedical Research Institute, 4 Nickerson Street, WA 98109, USA
Mol Biochem Parasitol 122:201-10. 2002..The findings are consistent with earlier serologic evidence that surface antigens of placental parasites have conserved features, and suggest that vaccines based on DBLgamma may only need to target a limited number of variants... - Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSAMarion Avril
Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
Infect Immun 76:1791-800. 2008..This study demonstrates that VAR2CSA contains common polymorphic epitopes that are shared between geographically diverse CSA-binding lines... - High throughput functional assays of the variant antigen PfEMP1 reveal a single domain in the 3D7 Plasmodium falciparum genome that binds ICAM1 with high affinity and is targeted by naturally acquired neutralizing antibodiesAndrew V Oleinikov
Seattle Biomedical Research Institute, Seattle, Washington, USA
PLoS Pathog 5:e1000386. 2009..Our high throughput approach will significantly accelerate studies of PfEMP1 binding domains and protective antibody responses... - Effects of sex, parity, and sequence variation on seroreactivity to candidate pregnancy malaria vaccine antigensAndrew V Oleinikov
Seattle Biomedical Research Institute, Seattle, WA 98109, USA
J Infect Dis 196:155-64. 2007..Two IE surface molecules, VAR1CSA and VAR2CSA, bind CSA in vitro and are potential vaccine candidates... - Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein-1 variants expressed by placental malaria parasitesMichal Fried
Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
Proteomics 4:1086-93. 2004..These novel PfEMP1 variants require further study to confirm whether they play a role in placental malaria... - Red blood cells that do and red blood cells that don't: how to resist a persistent parasitePatrick E Duffy
Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA
Trends Parasitol 22:99-101. 2006..HbC-containing red blood cells have modified displays of malaria surface proteins that reduce parasite adhesiveness and could reduce the risk of severe disease... - Plasmodium falciparum adhesion in the placentaPatrick E Duffy
Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, 4 Nickerson ST STE 200, Seattle, WA 98109 1651, USA
Curr Opin Microbiol 6:371-6. 2003..Adhesins and other surface proteins of placental parasites are targets of naturally occurring antibodies associated with protection and therefore could be used to develop vaccines that prevent malaria in pregnancy... - Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newbornsPatrick E Duffy
Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
Infect Immun 71:6620-3. 2003..019) and 2 weeks more mature (P = 0.002) than babies delivered to secundigravidas without antiadhesion activity. Our findings support the development of antiadhesion vaccines to prevent poor fetal outcomes due to pregnancy malaria... - Malaria vaccines: using models of immunity and functional genomics tools to accelerate the development of vaccines against Plasmodium falciparumPatrick E Duffy
Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA
Vaccine 23:2235-42. 2005..These candidate antigens are then subjected to detailed studies according to criteria established by the understanding of pathogenesis and protective immunity, to identify the optimal antigens for inclusion in subunit vaccines... - Hypertension and maternal-fetal conflict during placental malariaAtis Muehlenbachs
MOMS Project, Seattle Biomedical Research Institute, Seattle, Washington, United States of America
PLoS Med 3:e446. 2006..Because placental inflammation causes poor fetal outcomes, we hypothesize that fetal mechanisms that promote sVEGFR1 expression may be under selective pressure during first pregnancies in malaria-endemic areas... - Natural selection of FLT1 alleles and their association with malaria resistance in uteroAtis Muehlenbachs
Mother Offspring Malaria Studies Project, Seattle Biomedical Research Institute, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 105:14488-91. 2008..This indicates that FLT1 is under natural selection in a malaria endemic area and that human exposure to malaria can influence the evolutionary genetics of the maternal-fetal relationship... - Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiencyEdward R Kabyemela
Mother Offspring Malaria Studies Project, Seattle Biomedical Research Institute, Seattle, Washington 98109, USA
J Infect Dis 198:163-6. 2008..Interventional trials of iron and folate supplementation during pregnancy in malaria-endemic regions in Africa are urgently needed to ascertain the benefits and risks of this intervention... - Plasma levels of apolipoprotein A1 in malaria-exposed primigravidae are associated with severe anemiaDavid C Simpson
Seattle Biomedical Research Institute, Seattle, Washington, United States of America
PLoS ONE 5:e8822. 2010..Here we aimed to identify additional changes in the plasma proteome associated with pregnancy malaria that may contribute to the development of malaria-related maternal anemia... - An unusual presentation of placental malaria: a single persisting nidus of sequestered parasitesAtis Muehlenbachs
Mother Offspring Malaria Studies Project, Seattle Biomedical Research Institute, Seattle WA 98109, USA
Hum Pathol 38:520-3. 2007..This finding suggests ring stage-infected erythrocytes sequester in vivo, or P falciparum can persist as a dormant blood stage form... - Fetal responses during placental malaria modify the risk of low birth weightEdward R Kabyemela
MOMS Project, Seattle Biomedical Research Institute, Seattle, WA 98109, USA
Infect Immun 76:1527-34. 2008..Because fetal cells are a source of placental IFN-gamma and cord ferritin, the fetal response to PM may modify the risk of LBW... - Maternal malaria and gravidity interact to modify infant susceptibility to malariaTheonest K Mutabingwa
Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington, USA
PLoS Med 2:e407. 2005.... - Genome-wide expression analysis of placental malaria reveals features of lymphoid neogenesis during chronic infectionAtis Muehlenbachs
Mother Offspring Malaria Study MOMS Project, Seattle Biomedical Research Institute, 307 Westlake Avenue North, Seattle, WA 98109, USA
J Immunol 179:557-65. 2007..We propose a model where the production of Ig during chronic malaria may enhance inflammation by attracting and activating macrophages that, in turn, recruit B cells to further produce Ig in the intervillous spaces... - Malaria: new diagnostics for an old problemPatrick Duffy
Am J Trop Med Hyg 73:482-3. 2005
Research Grants
- Plasma Proteome During Pregnancy MalariaMichal Fried; Fiscal Year: 2007....
- Pathways of Maternal AnemiaMICHAL FRIED FRIED; Fiscal Year: 2010..This study will identify potential immunological and transcriptional pathways and mediators that are pivotal in the pathogenesis of malaria associated maternal anemia. ..