Kelly A Frazer

Summary

Affiliation: Scripps Clinic
Country: USA

Publications

  1. ncbi request reprint A sequence-based variation map of 8.27 million SNPs in inbred mouse strains
    Kelly A Frazer
    Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
    Nature 448:1050-3. 2007
  2. ncbi request reprint Whole-genome patterns of common DNA variation in three human populations
    David A Hinds
    Perlegen Sciences Inc, 2021 Stierlin Court, Mountain View, CA 94043, USA
    Science 307:1072-9. 2005
  3. pmc Segmental phylogenetic relationships of inbred mouse strains revealed by fine-scale analysis of sequence variation across 4.6 mb of mouse genome
    Kelly A Frazer
    Perlegen Sciences, Mountain View, California 94043, USA
    Genome Res 14:1493-500. 2004
  4. pmc Analysis of allelic differential expression in human white blood cells
    P V Krishna Pant
    Perlegen Sciences, Mountain View, California 94043, USA
    Genome Res 16:331-9. 2006
  5. pmc Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels
    David A Hinds
    Perlegen Sciences, 2021 Stierlin Court, Mountain View, CA 94043, USA
    Hum Genomics 1:421-34. 2004
  6. pmc Allele-specific KRT1 expression is a complex trait
    Heng Tao
    Perlegen Sciences, Mountain View, California, USA
    PLoS Genet 2:e93. 2006
  7. ncbi request reprint Common deletions and SNPs are in linkage disequilibrium in the human genome
    David A Hinds
    Perlegen Sciences, Inc, 2021 Stierlin Court, Mountain View, California 94043, USA
    Nat Genet 38:82-5. 2006
  8. pmc In vitro human keratinocyte migration rates are associated with SNPs in the KRT1 interval
    Heng Tao
    Perlegen Sciences, Mountain View, California, United States of America
    PLoS ONE 2:e697. 2007
  9. pmc Noncoding sequences conserved in a limited number of mammals in the SIM2 interval are frequently functional
    Kelly A Frazer
    Perlegen Sciences, Mountain View, California 95051, USA
    Genome Res 14:367-72. 2004
  10. pmc VISTA: computational tools for comparative genomics
    Kelly A Frazer
    Perlegen Sciences, Inc, 2021 Stierlin Court, Mountain View, CA 94043, USA
    Nucleic Acids Res 32:W273-9. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint A sequence-based variation map of 8.27 million SNPs in inbred mouse strains
    Kelly A Frazer
    Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA
    Nature 448:1050-3. 2007
    ..The considerable regional redundancy of the SNP data will facilitate imputation of the majority of these genotypes in less-densely typed classical inbred strains to provide a complete view of variation in additional strains...
  2. ncbi request reprint Whole-genome patterns of common DNA variation in three human populations
    David A Hinds
    Perlegen Sciences Inc, 2021 Stierlin Court, Mountain View, CA 94043, USA
    Science 307:1072-9. 2005
    ..Our data provide a tool for exploring many questions that remain regarding the causal role of common human DNA variation in complex human traits and for investigating the nature of genetic variation within and between human populations...
  3. pmc Segmental phylogenetic relationships of inbred mouse strains revealed by fine-scale analysis of sequence variation across 4.6 mb of mouse genome
    Kelly A Frazer
    Perlegen Sciences, Mountain View, California 94043, USA
    Genome Res 14:1493-500. 2004
    ....
  4. pmc Analysis of allelic differential expression in human white blood cells
    P V Krishna Pant
    Perlegen Sciences, Mountain View, California 94043, USA
    Genome Res 16:331-9. 2006
    ....
  5. pmc Application of pooled genotyping to scan candidate regions for association with HDL cholesterol levels
    David A Hinds
    Perlegen Sciences, 2021 Stierlin Court, Mountain View, CA 94043, USA
    Hum Genomics 1:421-34. 2004
    ..Our study is among the first to demonstrate the application of pooled genotyping followed by confirmation with individual genotyping to identify genetic determinants of a complex trait...
  6. pmc Allele-specific KRT1 expression is a complex trait
    Heng Tao
    Perlegen Sciences, Mountain View, California, USA
    PLoS Genet 2:e93. 2006
    ....
  7. ncbi request reprint Common deletions and SNPs are in linkage disequilibrium in the human genome
    David A Hinds
    Perlegen Sciences, Inc, 2021 Stierlin Court, Mountain View, California 94043, USA
    Nat Genet 38:82-5. 2006
    ....
  8. pmc In vitro human keratinocyte migration rates are associated with SNPs in the KRT1 interval
    Heng Tao
    Perlegen Sciences, Mountain View, California, United States of America
    PLoS ONE 2:e697. 2007
    ..Furthermore we show that in vitro cell assays can successfully be used to deconstruct complex traits into simple biological model systems for genetic association studies...
  9. pmc Noncoding sequences conserved in a limited number of mammals in the SIM2 interval are frequently functional
    Kelly A Frazer
    Perlegen Sciences, Mountain View, California 95051, USA
    Genome Res 14:367-72. 2004
    ..These findings suggest that functional conserved noncoding human sequences can be missing in other mammals, even closely related primate species...
  10. pmc VISTA: computational tools for comparative genomics
    Kelly A Frazer
    Perlegen Sciences, Inc, 2021 Stierlin Court, Mountain View, CA 94043, USA
    Nucleic Acids Res 32:W273-9. 2004
    ..We illustrate capabilities of the VISTA site by the analysis of a 180 kb interval on human chromosome 5 that encodes for the kinesin family member 3A (KIF3A) protein...
  11. pmc Genomic DNA insertions and deletions occur frequently between humans and nonhuman primates
    Kelly A Frazer
    Perlegen Sciences, Mountain View, California 94043, USA
    Genome Res 13:341-6. 2003
    ..These DNA rearrangements are commonly found in genic intervals, and thus provide natural starting points for focused investigations of qualitative and quantitative gene expression differences between humans and other primates...
  12. ncbi request reprint Evaluation of the SNP tagging approach in an independent population sample--array-based SNP discovery in Sami
    Asa Johansson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
    Hum Genet 122:141-50. 2007
    ..These results point to serious limitations in the transferability of common tagSNPs to capture random sequence variation, even between closely related populations, such as CEU and Sami...
  13. pmc Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy
    Joseph Donfack
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Respir Res 6:145. 2005
    ..Evolutionarily conserved sequences likely have biological function...
  14. pmc Genome-wide detection and characterization of positive selection in human populations
    Pardis C Sabeti
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nature 449:913-8. 2007
    ....
  15. pmc A second generation human haplotype map of over 3.1 million SNPs
    Kelly A Frazer
    The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA
    Nature 449:851-61. 2007
    ..Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations...
  16. pmc The nature, pattern and function of human sequence variation
    Evan E Eichler
    Department of Genetics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Genome Biol 5:318. 2004
  17. ncbi request reprint Fine-scale recombination patterns differ between chimpanzees and humans
    Susan E Ptak
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6 04103, Leipzig, Germany
    Nat Genet 37:429-34. 2005
    ..Therefore, the recombination landscape has changed markedly between the two species...
  18. ncbi request reprint Common sequence polymorphisms shaping genetic diversity in Arabidopsis thaliana
    Richard M Clark
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Science 317:338-42. 2007
    ..Analyzing the polymorphisms we describe in larger sets of accessions will enable a detailed understanding of forces shaping population-wide sequence variation in A. thaliana...
  19. ncbi request reprint The genomics gold rush
    Eric J Topol
    Scripps Genomic Medicine, Scripps Health, and The Scripps Research Institute, La Jolla, California 92037, USA
    JAMA 298:218-21. 2007
  20. ncbi request reprint The resequencing imperative
    Eric J Topol
    Nat Genet 39:439-40. 2007
  21. pmc High-resolution whole-genome association study of Parkinson disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Am J Hum Genet 77:685-93. 2005
    ..07 x 10(-6); P=2.96 x 10(-5)) tagged the PARK10 late-onset PD susceptibility locus. Independent replication across populations will clarify the role of the genomic loci tagged by these SNPs in conferring PD susceptibility...
  22. doi request reprint Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
    ..4 x 10(-10)). MLXIPL coordinates transcriptional regulation of enzymes that channel glycolytic end-products into lipogenesis and energy storage, making MLXIPL a plausible 'thrifty gene'...