Yu Sen Wang

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. ncbi Solution structure of the hypothetical protein YqgF from Escherichia coli reveals an RNAse H fold
    Dingjiang Liu
    J Biomol NMR 27:389-92. 2003
  2. doi Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors
    Yu Sen Wang
    Schering Plough Research Institute, 320 Bent Street, Cambridge, Massachusetts 02141, USA
    J Med Chem 53:942-50. 2010
  3. ncbi Competition STD NMR for the detection of high-affinity ligands and NMR-based screening
    Yu Sen Wang
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    Magn Reson Chem 42:485-9. 2004
  4. ncbi Characterization of autocatalytic conversion of precursor BACE1 by heteronuclear NMR spectroscopy
    Yu Sen Wang
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    Biochemistry 44:16594-601. 2005
  5. ncbi Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications
    Yu Sen Wang
    Structural Chemistry, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Adv Drug Deliv Rev 54:547-70. 2002
  6. doi Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation
    Zhaoning Zhu
    Department of Medicinal Chemistry, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    J Med Chem 53:951-65. 2010
  7. ncbi Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening
    Daniel F Wyss
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    J Med Chem 47:2486-98. 2004
  8. doi Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors
    Daniel F Wyss
    Merck Research Laboratories, Kenilworth, NJ 07033, USA
    Top Curr Chem 317:83-114. 2012
  9. ncbi Structure, biology, and therapeutic implications of pegylated interferon alpha-2b
    Stephen Youngster
    Schering Plough Research Institute, Structural Chemistry, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Curr Pharm Des 8:2139-57. 2002
  10. ncbi Backbone resonance assignments of the 45.3 kDa catalytic domain of human BACE1
    Dingjiang Liu
    J Biomol NMR 29:425-6. 2004

Detail Information

Publications10

  1. ncbi Solution structure of the hypothetical protein YqgF from Escherichia coli reveals an RNAse H fold
    Dingjiang Liu
    J Biomol NMR 27:389-92. 2003
  2. doi Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors
    Yu Sen Wang
    Schering Plough Research Institute, 320 Bent Street, Cambridge, Massachusetts 02141, USA
    J Med Chem 53:942-50. 2010
    ..The structure-based design of a cyclic acylguanidine lead series and its optimization into nanomolar BACE-1 inhibitors are the subject of the companion paper..
  3. ncbi Competition STD NMR for the detection of high-affinity ligands and NMR-based screening
    Yu Sen Wang
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    Magn Reson Chem 42:485-9. 2004
    ....
  4. ncbi Characterization of autocatalytic conversion of precursor BACE1 by heteronuclear NMR spectroscopy
    Yu Sen Wang
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    Biochemistry 44:16594-601. 2005
    ..The fully processed BACE1 represents a high quality well-folded protein which is highly stable over a long period of time, and is suitable for evaluation of inhibitor binding by NMR for drug intervention...
  5. ncbi Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications
    Yu Sen Wang
    Structural Chemistry, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Adv Drug Deliv Rev 54:547-70. 2002
    ..Because of the improved clinical benefits, it is anticipated that the PEG Intron plus ribavirin combination therapy will become the new standard of care for the treatment of chronic hepatitis C...
  6. doi Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation
    Zhaoning Zhu
    Department of Medicinal Chemistry, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    J Med Chem 53:951-65. 2010
    ....
  7. ncbi Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening
    Daniel F Wyss
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    J Med Chem 47:2486-98. 2004
    ....
  8. doi Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors
    Daniel F Wyss
    Merck Research Laboratories, Kenilworth, NJ 07033, USA
    Top Curr Chem 317:83-114. 2012
    ....
  9. ncbi Structure, biology, and therapeutic implications of pegylated interferon alpha-2b
    Stephen Youngster
    Schering Plough Research Institute, Structural Chemistry, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Curr Pharm Des 8:2139-57. 2002
    ....
  10. ncbi Backbone resonance assignments of the 45.3 kDa catalytic domain of human BACE1
    Dingjiang Liu
    J Biomol NMR 29:425-6. 2004