Peng Wang

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. pmc Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor
    Peng Wang
    Allergy Department, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 1600, Kenilworth, NJ 07033, USA
    Biochem J 380:425-33. 2004
  2. doi request reprint Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration
    Richard W Chapman
    Department of Bone, Respiratory, Immunology and Dermatology, Merck Research Laboratories, Kenilworth, New Jersey 07033, USA
    Eur J Pharmacol 643:274-81. 2010
  3. ncbi request reprint Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils
    P Wang
    Allergy Department, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Immunol 160:4427-32. 1998
  4. ncbi request reprint Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils
    P Wang
    Allergy Department, Schering Plough Research Institute, Kenilworth, New Jersey, USA
    Mol Pharmacol 56:170-4. 1999
  5. ncbi request reprint Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases
    P Wang
    Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Life Sci 68:1977-87. 2001
  6. ncbi request reprint Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution
    P Wang
    Allergy Department, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 1600, Kenilworth, NJ 07033, USA
    Gene 280:183-94. 2001
  7. ncbi request reprint Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants
    Peng Wang
    Allergy Department, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 1600, Kenilworth, NJ 07033, USA
    Gene 314:15-27. 2003
  8. ncbi request reprint Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED
    Craig D Boyle
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 15:2365-9. 2005
  9. ncbi request reprint Differential inhibitor sensitivity between human recombinant and native photoreceptor cGMP-phosphodiesterases (PDE6s)
    Ji Zhang
    Allergy Department, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Biochem Pharmacol 68:867-73. 2004
  10. ncbi request reprint Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors
    Yuguang Wang
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 12:3149-52. 2002

Detail Information

Publications66

  1. pmc Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor
    Peng Wang
    Allergy Department, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 1600, Kenilworth, NJ 07033, USA
    Biochem J 380:425-33. 2004
    ..Taken together, these results suggest an important immunoregulatory role for both Neu-1 and Neu-3 in humans...
  2. doi request reprint Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration
    Richard W Chapman
    Department of Bone, Respiratory, Immunology and Dermatology, Merck Research Laboratories, Kenilworth, New Jersey 07033, USA
    Eur J Pharmacol 643:274-81. 2010
    ..These results identify COMPOUND 1 as a potent and selective inhibitor of PDE4 with properties suitable for delivery by inhalation...
  3. ncbi request reprint Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils
    P Wang
    Allergy Department, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Immunol 160:4427-32. 1998
    ..We suggest from these experiments that in human blood eosinophils, IL-5R alpha gene transcription and IL-5R alpha mRNA metabolism can be regulated by mechanisms that are distinct from those used for IL-3R alpha and GM-CSFR alpha...
  4. ncbi request reprint Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils
    P Wang
    Allergy Department, Schering Plough Research Institute, Kenilworth, New Jersey, USA
    Mol Pharmacol 56:170-4. 1999
    ..Furthermore, leukocytes are the most dominant source of PDE4B2, suggesting that PDE4B2 is a relatively specific target for discovering anti-inflammatory drugs...
  5. ncbi request reprint Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases
    P Wang
    Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Life Sci 68:1977-87. 2001
    ..This study shows that despite similar kinetics and enzymatic properties, corpus cavernosum PDE5s from different species, and corpus cavernosum and platelet PDE5s, can have differential sensitivity to pharmacological inhibitors...
  6. ncbi request reprint Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution
    P Wang
    Allergy Department, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 1600, Kenilworth, NJ 07033, USA
    Gene 280:183-94. 2001
    ..Compared to PDE8A1, PDE8As 2-5 appear to be expressed in much lower abundance. Among various tissues and organs, PDE8A1 and PDE8A2 are expressed at various levels...
  7. ncbi request reprint Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants
    Peng Wang
    Allergy Department, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 1600, Kenilworth, NJ 07033, USA
    Gene 314:15-27. 2003
    ..We speculate that the physiological role of the PDE9A diversity may be imparting cGMP-metabolizing ability to specific cellular compartments in appropriate tissues...
  8. ncbi request reprint Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED
    Craig D Boyle
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 15:2365-9. 2005
    ..In addition, purine 41 demonstrated superior overall PDE isozyme selectivity when compared to the approved PDE5 inhibitors sildenafil, vardenafil, and tadalafil, which may result in a more favorable side-effect profile...
  9. ncbi request reprint Differential inhibitor sensitivity between human recombinant and native photoreceptor cGMP-phosphodiesterases (PDE6s)
    Ji Zhang
    Allergy Department, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Biochem Pharmacol 68:867-73. 2004
    ..Our data demonstrates that the recombinant and native PDE6s exhibit differential sensitivity to inhibitors, and cautions the use of recombinant catalytic subunits of PDE6 in drug discovery or in structural/functional studies...
  10. ncbi request reprint Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors
    Yuguang Wang
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 12:3149-52. 2002
    ..We have discovered potent and selective xanthine PDE5 inhibitors. Compound 25 (PDE5 IC(50)=0.6 nM, PDE6/PDE5=101) demonstrated similar functional efficacy and PK profile to Sildenafil (PDE5 IC(50)=3.5 nM, PDE6/PDE5=7)...
  11. ncbi request reprint Differential type 4 cAMP-specific phosphodiesterase (PDE4) expression and functional sensitivity to PDE4 inhibitors among rats, monkeys and humans
    Hong Bian
    Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Biochem Pharmacol 68:2229-36. 2004
    ....
  12. ncbi request reprint SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction
    Dmitri A Pissarnitski
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 14:1291-4. 2004
    ..Development of structure-activity relationship of cyclic guanines I lead us to discovery of a potent and selective series of phosphodiesterase 5 inhibitors 52-59 (IC50=1.3-11.0 nM, PDE6/5=116-600)...
  13. ncbi request reprint Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors
    Rongze Kuang
    Department of Chemical Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 17:5150-4. 2007
    ..Structure-activity relationship studies revealed that the oxazole core, with 4-carboxamide and 5-aminomethyl groups, is a novel PDE4 inhibitory pharmacophore. Selectivity profiles and in vivo biological activity are also reported...
  14. ncbi request reprint Upregulation of phosphodiesterase-4 in the lung of allergic rats
    Hui Fang Tang
    Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 1600, Kenilworth, NJ 07033, USA
    Am J Respir Crit Care Med 171:823-8. 2005
    ..Our data suggest, for the first time, that PDE4 may be upregulated in the lung and play a role in the pathogenesis of allergic asthma...
  15. pmc Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins
    Ping Wu
    Department of Inflammation and Infection, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Proc Natl Acad Sci U S A 101:17634-9. 2004
    ..However, the PDE8A1-IkappaB association did not affect NF-kappaB activation. The biological role of the PDE8A1-IkappaB association remains to be elucidated...
  16. ncbi request reprint Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor
    M Motasim Billah
    Schering Plough Research Institute, 2015 Galloping Hill Road, K15 1 1660 Kenilworth, NJ 07033, USA
    J Pharmacol Exp Ther 302:127-37. 2002
    ..Thus, SCH 351591 exhibits a promising preclinical profile as a treatment for asthma and COPD...
  17. ncbi request reprint Molecular cloning and characterization of AAAS-V2, a novel splice variant of human AAAS
    Xin Li
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People s Republic of China
    Mol Biol Rep 32:127-31. 2005
    ..3). RT-PCR analysis in our work revealed that AAAS-v2 and AAAS-v1 were ubiquitously detected in human multiple tissue cDNA (MTC) panels (CLONTECH)...
  18. ncbi request reprint Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway
    Jin H Song
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 280:12896-901. 2005
    ..Therefore, the present study suggests that IFN-gamma is not only involved in tumorigenicity but also involved in neurogenesis by regulating cell proliferation and differentiation...
  19. ncbi request reprint Molecular cloning and characterization of a novel stem-specific gene from Camptotheca acuminata
    Yan Pi
    Institute of Genetics, School of Life Sciences, Morgan Tan International Center for Life Sciences, Fudan SJTU Nottingham Plant Biotechnology R and D Center, Fudan University, Shanghai 200433, People s Republic of China
    J Biochem Mol Biol 39:68-75. 2006
    ..Northern blotting analysis revealed that CaSS expressed, in a tissuespecific manner, highly in stem and lowly in root, leaf and flower. Our study suggests that CaSS is likely to be involved in the phenylpropanoid pathway...
  20. ncbi request reprint Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development
    Christine M Eischen
    Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Oncogene 23:8931-40. 2004
    ..Collectively, these results support a model whereby the stoichiometry of Mdm2 and ARF controls apoptosis and tumor development, which should have significant implications in the treatment of malignancies that have inactivated ARF...
  21. ncbi request reprint [Progress on Chlorella in the area of molecular biology]
    Yi Qin Wang
    Institute of Genetics and Developmental Biology, CAS, Beijing 100 101, China
    Yi Chuan 26:399-402. 2004
    ..This review reports the research progress in these aspects...
  22. ncbi request reprint Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site
    Jing De Zhu
    Laboratory of Cancer Epigenetics and Gene Therapy, The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, China
    Cell Res 16:780-96. 2006
    ..Our observations provide insight into the mechanistic aspects of HCCS1 transcription regulation...
  23. ncbi request reprint Expression, purification, and characterization of recombinant human keratinocyte growth factor-2 in Pichia pastoris
    Yanchun Wang
    Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing 100071, China
    J Biotechnol 132:44-8. 2007
    ..A preliminary biochemical characterization of purified rhKGF-2 was performed both by Western blot analysis and biological activity analysis, and the result demonstrated that the recombinant KGF-2 was expressed successfully...
  24. ncbi request reprint Cloning and characterization of a novel alpha-galactosidase from Bifidobacterium breve 203 capable of synthesizing Gal-alpha-1,4 linkage
    Han Zhao
    State Key Lab of Microbial Technology, Shandong University, Jinan, China
    FEMS Microbiol Lett 285:278-83. 2008
    ..In the presence of pNPG as a donor, Aga2 was able to catalyze glycosyl transfer to various acceptors including monosaccharides, disaccharides and sugar alcohols...
  25. ncbi request reprint Cloning and functional analysis of a cDNA encoding Ginkgo biloba farnesyl diphosphate synthase
    Peng Wang
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan SJTU Nottingham Plant Biotechnology R and D Center, Morgan Tan International Center for Life Sciences, Fudan University, Shanghai 20433, China
    Mol Cells 18:150-6. 2004
    ..biloba. Expression analysis indicated that GbFPS expression was high in roots and leaves, and low in stems. Functional complementation of GbFPS in an FPS-deficient strain confirmed that GbFPS mediates farnesyl diphosphate biosynthesis...
  26. pmc Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response
    Ramon Arens
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 180:6472-6. 2008
    ..In total, this study reveals that the MCMV-specific CD4 T cell response is complex and functionally diverse, highlighting its important role in controlling this persistent pathogen...
  27. ncbi request reprint [Characteristics and in vitro imaging study of matrix metalloproteinase-2 targeting activable cell-penetrating peptide]
    Min Liu
    Imaging Center, The 2nd Affiliated Hospital of Medical School, Xi an Jiao Tong University, Xi an 710004, China
    Zhonghua Yi Xue Za Zhi 87:233-9. 2007
    ..To study invasively imaging MMP2-positive tumor cell by paramagnetic Gadolinium or fluorescein carried by a activable cell penetrating peptides...
  28. ncbi request reprint [MDR-reversing effect of short peptide binding specifically to multidrug-resistant gastric cancer cells]
    Peng Wang
    State Key Laboratory of Biology and PLA Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Zhonghua Zhong Liu Za Zhi 29:258-61. 2007
    ..To investigate the binding effect of the short peptide SY1 to the multidrug-resistant gastric cancer cell line SGC7901/VCR cells and its reversing effect on those cancer cells...
  29. pmc The C. elegans Twist target gene, arg-1, is regulated by distinct E box promoter elements
    Jie Zhao
    Department of Biology, The Catholic University of America, Washington, DC 20064, USA
    Mech Dev 124:377-89. 2007
    ..On the basis of these results, we propose a model of CeTwist gene regulation in which expression is controlled by tissue-specific binding of distinct sets of E boxes...
  30. ncbi request reprint Evolutionary and biomedical insights from the rhesus macaque genome
    Richard A Gibbs
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
    Science 316:222-34. 2007
    ..The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species...
  31. ncbi request reprint Activation of ASK1 during reperfusion of ischemic spinal cord
    Peng Wang
    Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China
    Neurosci Lett 415:248-52. 2007
    ..These results indicate that activation of ASK1 may play an important role in the apoptotic signaling mechanisms that occur in reperfused spinal cord injuries...
  32. ncbi request reprint Shewanella psychrophila sp. nov. and Shewanella piezotolerans sp. nov., isolated from west Pacific deep-sea sediment
    Xiang Xiao
    Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, P R China
    Int J Syst Evol Microbiol 57:60-5. 2007
    ..The names Shewanella psychrophila sp. nov. (type strain WP2(T)=JCM 13876(T)=CGMCC 1.6159(T)) and Shewanella piezotolerans (type strain WP3(T)=JCM 13877(T)=CGMCC 1.6160(T)) are proposed...
  33. ncbi request reprint The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC
    Michael D Horwich
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 17:1265-72. 2007
    ..2'-O-methylation of siRNAs may be the final step in assembly of the RNAi-enzyme complex, RISC, occurring after an Argonaute-bound siRNA duplex is converted to single-stranded RNA...
  34. doi request reprint Experimental study on the treatment of intracerebral glioma xenograft with human cytokine-induced killer cells
    Peng Wang
    Department of Neurosurgery and Neuro Oncology, Key Laboratory of Cancer Prevention and Therapy, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China
    Cell Immunol 253:59-65. 2008
    ..Local injection of CIKs does not produce severe damage to normal brain tissue and is likely to be used in clinical adoptive immunotherapy of intracerebral glioma...
  35. ncbi request reprint Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells
    Peng Wang
    Department of Laboratory Medicine and Pathology and Surgery, University of Alberta, Edmonton, Alberta, Canada
    Cell Signal 19:2237-46. 2007
    ..These studies therefore suggest that combination treatment with chemotherapy can overcome TRAIL resistance and enhance TRAIL therapeutic efficacy in treating pancreatic cancers...
  36. ncbi request reprint Deconstruction-reconstruction strategy for accessing valuable polyketides. Preparation of the C15-C24 stereopentad of discodermolide
    Kathlyn A Parker
    Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Org Lett 9:4793-6. 2007
    ..This synthesis illustrates a new strategy, "deconstruction-reconstruction", for accessing stereochemically complex polyketide building blocks...
  37. pmc Nitric oxide destabilizes Pias3 and regulates sumoylation
    Jing Qu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Beijing, China
    PLoS ONE 2:e1085. 2007
    ..This study reveals a novel crosstalk between S-nitrosation, ubiquitination, and sumoylation, which may be crucial for NO-related physiological and pathological processes...
  38. ncbi request reprint Immunotherapy of human neuroblastoma using umbilical cord blood-derived effector cells
    Avadhut D Joshi
    Department of Genetics, Cell Biology and Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198 6395, USA
    J Neuroimmune Pharmacol 2:202-12. 2007
    ..01) inhibition of tumor growth and increased overall survival. Thus, these results demonstrate the potential of UCB-derived effector cells against human neuroblastoma and warrant further preclinical studies...
  39. doi request reprint Apoptosis induced by ardipusilloside III through BAD dephosphorylation and cleavage in human glioblastoma U251MG cells
    Hong Lin
    Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, No127 Changle Western Road, Xi an 710032, PR China
    Apoptosis 13:247-57. 2008
    ..These data suggest that ardipusilloside III is a reliable candidate for chemotherapeutic treatment of human glioblastomas, and should be investigated further...
  40. doi request reprint Exopolysaccharide biosynthesis is important for Mesorhizobium tianshanense: plant host interaction
    Peng Wang
    Department of Microbiology, MOA Key Lab of Microbiological Engineering of Agricultural Environment, Nanjing Agricultural University, Nanjing, China
    Arch Microbiol 189:525-30. 2008
    ..EPS mutants formed significantly less biofilm and displayed severely reduced nodulation capacity than wild type bacteria, suggesting that EPS synthesis can play important roles in the symbiosis process...
  41. doi request reprint Isolation, characterization and gene modification of fetal neural stem/progenitor cells from cynomolgus monkey
    Peng Wang
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangdong, PR China
    Neuroreport 19:419-24. 2008
    ....
  42. doi request reprint Differential gene expression in murine large cell B-cell lymphoma metastatic variants
    Shantaram S Joshi
    Department of Genetics, University of Nebraska Medical Center, Omaha, Nebraska 68198 6395, USA
    Int Immunopharmacol 8:1257-63. 2008
    ....
  43. ncbi request reprint Total synthesis of cleistetroside-2, partially acetylated dodecanyl tetrarhamnoside derivative isolated from Cleistopholis patens and Cleistopholis glauca
    Zaihong Zhang
    Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Pharmacy, Ocean University of China, Qingdao 266003, China
    Carbohydr Res 342:1159-68. 2007
    ....
  44. ncbi request reprint Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells
    Tong Liu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Carcinogenesis 28:488-96. 2007
    ....
  45. ncbi request reprint [Separation and purification of skeletal muscle satellite cells for tissue engineering applications by Percoll]
    Yu shi Hang
    Department of Urology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:182-5. 2006
    ..To investigate separation and purification of skeletal muscle satellite cells with improved incontinuous density Percoll gradient centrifugation technique...
  46. ncbi request reprint [Study on making pneumoconiosis model and method of lung lavage in rabbit]
    Dong Xu
    Department of Occupational Health and Toxicology, Zhengzhou University, Zhengzhou, 450052, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 20:131-3. 2002
    ..To provide an intact rabbit pneumoconiosis model and a method of lung lavage for studying the pathogenesis and treatment of pneumoconiosis...
  47. ncbi request reprint The site-directed mutagenesis of gastrodia anti-fungal protein mannose-binding sites and its expression in Escherichia coli
    Peng Wang
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, PR China
    Protein Pept Lett 10:599-606. 2003
    ..The double and triplicate amino acids mutated GAFPs have very low inhibitory activity. For the first time it was proved that GAFP mannose-binding sites play key role in anti-fungi process...
  48. ncbi request reprint [Co-expression of CFA/I and CS6 of Enterotoxigenic Escherichia coli ( ETEC ) in Shigella flexneri 2a T32 Derivative Strain FWL01]
    Ji Ping Zheng
    Beijing Institute of Biotechnology, Beijing 100071, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:1005-10. 2003
    ..Those observations show the feasibility of a multivalent vaccine expressing different fimbrial antigens in attenuated Shigella flexneri...
  49. ncbi request reprint Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease
    Shao Bo Su
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 171:2314-9. 2003
    ..Our results suggest that PT-B is largely responsible for the disease-enhancing properties of PT...
  50. ncbi request reprint Characteristics and mechanisms of isolated rubella virus, strain JR23: infection of the central nervous system of BALB/c mice
    Zhiyu Wang
    Department of Virology, School of Public Health, Shandong University, Jinan, People s Republic of China
    Intervirology 46:79-85. 2003
    ..To investigate the correlation between rubella virus (RuV) antigen in peripheral lymphocytes, the immune status and RuV infection in the central nervous system (CNS)...
  51. ncbi request reprint Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer
    Xiao Lin Guo
    Cancer Institute, The First Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
    World J Gastroenterol 9:246-9. 2003
    ....
  52. ncbi request reprint Methimazole protects from experimental autoimmune uveitis (EAU) by inhibiting antigen presenting cell function and reducing antigen priming
    Peng Wang
    Laboratory of Immunology, NEI NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Leukoc Biol 73:57-64. 2003
    ..We suggest that MMI inhibits EAU at least in part by preventing the recruitment and/or maturation of APC, resulting in reduced generation of Ag-specific T cells...
  53. ncbi request reprint Study on the screening of molecular structure parameter in QSAR model
    Da Wen Gao
    Department of Environmental Science and Engineering, Harbin Institute of Technology, China
    J Environ Sci Health A Tox Hazard Subst Environ Eng 37:601-9. 2002
    ..The method established the foundation for further study in the mechanism research of the bio-toxicity of organic chemicals...
  54. ncbi request reprint Screening combinatorial libraries by mass spectrometry. 2. Identification of optimal substrates of protein tyrosine phosphatase SHP-1
    Peng Wang
    Department of Chemistry and Ohio State Biochemistry Program, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
    Biochemistry 41:6202-10. 2002
    ..These results demonstrate that ECLIPSE is a viable method for studying the substrate specificity of PTPs...
  55. ncbi request reprint Cytotoxicity of cord blood derived Her2/neu-specific cytotoxic T lymphocytes against human breast cancer in vitro and in vivo
    Peng Wang
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 6395, USA
    Breast Cancer Res Treat 83:15-23. 2004
    ..These results demonstrate that human umbilical cord blood mononuclear cells are a good source for generating Her2/neu-specific CTLs against human breast cancer both in vitro and in vivo...
  56. ncbi request reprint [Effects of a novel recombinant polypeptide from the sea anemone Anthopleura sp. on left ventricular function in New Zealand rabbits with chronic congestive heart failure]
    Yan bo Liu
    Department of Cardiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:269-72. 2004
    ..To observe the effects of recombinant hk2a, a novel neurotoxin from the sea anemone Anthopleura sp. on the left ventricular function in New Zealand rabbits with chronic congestive heart failure(CCHF)...
  57. ncbi request reprint PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells
    Lihua Ming
    Department of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 281:16034-42. 2006
    ..Together, these results indicate that PUMA initiates apoptosis in part by dissociating Bax and Bcl-X(L), thereby promoting Bax multimerization and mitochondrial translocation...
  58. ncbi request reprint [Enteropathy T-cell lymphoma]
    Peng Wang
    Zhonghua Bing Li Xue Za Zhi 34:542-3. 2005
  59. ncbi request reprint Immortalized rat astrocyte strain genetically modified by rat preprogalanin gene
    Ke An
    Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:144-6, 197. 2005
    ..01), but no significant differences were found between the IAST and IAST/Neo (P>0.05). It was concluded that IAST/GAL strain was constructed successfully and it might provide a basis for the further study of pain therapy...
  60. ncbi request reprint Construction of a novel Shigella live-vector strain co-expressing CS3 and LTB/STm of enterotoxigenic E.coli
    Ji Ping Zheng
    Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing 100071, China
    World J Gastroenterol 11:3411-8. 2005
    ..To construct and evaluate a polyvalent recombinant vaccine strain Shigella flexneri 2a T32 against enterotoxigenic E.coli (ETEC)...
  61. ncbi request reprint Determination of roxithromycin in rat lung tissue by liquid chromatography-mass spectrometry
    Peng Wang
    Shenyang Pharmtech Institute of Pharmaceuticals, Shenyang 110016, China
    J Pharm Biomed Anal 39:618-23. 2005
    ..The present study demonstrates that the concentration of roxithromycin in rat lung tissues can be significantly increased by ambroxol when they are formulated in combination...
  62. ncbi request reprint Endomorphin 1[psi] and endomorphin 2[psi], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception
    Qian Yu Zhao
    Department of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China
    Life Sci 77:1155-65. 2005
    ..However, the increased conformational flexibility induced by the reduced (CH2NH) bond made less influence on their antinociception...
  63. ncbi request reprint Stereoselective kinetic study of hexaconazole enantiomers in the rabbit
    Qiu Xia Wang
    Department of Applied Chemistry, China Agricultural University, Beijing 100094, China
    Chirality 17:186-92. 2005
    ..Other pharmacokinetic parameters of the enantiomers were also different. These results indicate substantial stereoselectivity in the kinetics of hexaconazole enantiomers in rabbits...
  64. ncbi request reprint A novel protein-DNA interaction involved with the CpG dinucleotide at -30 upstream is linked to the DNA methylation mediated transcription silencing of the MAGE-A1 gene
    Jie Zhang
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, LN 2200 25, Xietu Road, Shanghai 200032, China
    Cell Res 14:283-94. 2004
    ....
  65. ncbi request reprint Isolation of extremophiles with the detection and retrieval of Shewanella strains in deep-sea sediments from the west Pacific
    Fengping Wang
    Key Laboratory of Marine Biogenetic Resources, State Oceanic Administration, Xiamen, PR China
    Extremophiles 8:165-8. 2004
    ..Combined phenotypic analysis, 16S rDNA sequences, and DNA-DNA hybridization results suggest that WP2 and WP3 are two new deep-sea Shewanella species...
  66. ncbi request reprint Reactive coupling of poly(ethylene glycol) on electroactive polyaniline films for reduction in protein adsorption and platelet adhesion
    Fu Zhang
    Department of Chemical Engineering, National University of Singapore, Singapore
    Biomaterials 23:787-95. 2002
    ..The mPEG-c-PANI surface with a high concentration of coupled mPEG also exhibited good resistance towards platelet adhesion...