Research Topics
Species | G TrinchieriSummaryAffiliation: Schering-Plough Research Institute Country: USA Publications
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Publications
Interleukin-12 and the regulation of innate resistance and adaptive immunityGiorgio Trinchieri
Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, B P 11, 69571 Dardilly, France
Nat Rev Immunol 3:133-46. 2003....
Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+), and mature interdigitating dendritic cellsN Bendriss-Vermare
Schering-Plough, Laboratory for Immunological Research, Dardilly, France
J Clin Invest 107:835-44. 2001..The detection of Spi-B mRNA, not only upon in vitro maturation of pDCs, but also in freshly purified IDCs, suggests that in vivo pDCs may differentiate into IDCs...- Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphologyC Asselin-Paturel
Schering-Plough, Laboratory for Immunological Research, Dardilly, France
Nat Immunol 2:1144-50. 2001..Although different pathogens can selectively engage various APC subsets for IL-12 production, IFN-alpha production is restricted to mIPCs' response to viral infection... - Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responsesEstelle Merck
Laboratory for Immunological Research, Schering Plough, 27 chemin des Peupliers, BP11, 69571 Dardilly Cedex, France
Blood 105:3623-32. 2005..Altogether, these data suggest that hOSCAR may modulate the responses of both innate resistance and adaptive immunity... - Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunityChristopher E Andoniou
Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crowley 6009, Western Australia, Australia
Nat Immunol 6:1011-9. 2005..Notably, adoptive transfer of MCMV-activated CD11b(+) DCs resulted in improved control of MCMV infection, indicating that these cells participate in controlling viral replication in vivo... - Production of type I interferons: plasmacytoid dendritic cells and beyondCarine Asselin-Paturel
Laboratory for Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 202:461-5. 2005..Here we discuss recent data that begin to reveal the unique molecular mechanisms underlying the remarkably rapid and efficient type I IFN production by pDCs... - Astrocytes as antigen-presenting cells: expression of IL-12/IL-23Cris S Constantinescu
Division of Clinical Neurology, University Hospital, Queen s Medical Centre, Nottingham, UK
J Neurochem 95:331-40. 2005..Thus, astrocytes, under inflammatory conditions, express all subunits of IL-12/IL-23. Their ability to present antigen to encephalitogenic T cells can be blocked by neutralizing anti-IL-12/IL-23p40 antibodies... - Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine productionNathalie Bendriss-Vermare
Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
J Leukoc Biol 78:954-66. 2005.... - CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cellsClaudya Tenca
Department of Experimental Medicine, Human Anatomy Section, University of Genoa, Italy
J Immunol 174:6757-63. 2005..Thus, CD85j is an inhibiting receptor that is functional in human DCs... - Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejectionCristiana Guiducci
Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
Cancer Res 65:3437-46. 2005.... - Type I interferon dependence of plasmacytoid dendritic cell activation and migrationCarine Asselin-Paturel
Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly 69571, France
J Exp Med 201:1157-67. 2005..These data demonstrate that mouse pDCs differ from cDCs in the in vivo response to TLR ligands, in terms of pattern and type I IFN requirement for activation and migration... - Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88Uzma Hasan
Schering Plough Research Institute, Laboratory for Immunological Research, Dardilly, France
J Immunol 174:2942-50. 2005..However, a complete TLR10 sequence could be detected in the rat genome, indicating that a functional copy may be preserved in this species... - A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cellsGregory Gautier
Laboratory for Immunological Research, Schering Plough, 69571 Dardilly, France
J Exp Med 201:1435-46. 2005..Moreover, analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3-independent type I IFN and possibly IL-12p35 synthesis in response to TLR7/8... - Distinct and overlapping roles of interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor CD8 T-cell responsesChristophe Dercamp
Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
Cancer Res 65:8479-86. 2005..Our results point out major redundant and nonredundant roles for IL-10 and T(reg) in the inhibition of TIDC-mediated generation of antitumor CD8 T-cell response... - Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cellsFrancesca Fallarino
Department of Experimental Medicine, Section of Pharmacology, University of Perugia, 06126 Perugia, Italy
Int Immunol 17:1429-38. 2005..Therefore, although pDCs do not mediate IDO-dependent tolerance constitutively, multiple ligands and cytokines will contribute to the expression of a tolerogenic phenotype by pDCs in the mouse... - Plasmacytoid dendritic cells mediate oral toleranceAnne Goubier
INSERM, U851, 21 Avenue Tony Garnier, Lyon F 69007, France
Immunity 29:464-75. 2008..These data demonstrate that oral tolerance relies on Ag presentation by pDC to T cells and suggest that pDC could represent a key therapeutic target for intestinal and systemic inflammatory diseases... - Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cellsFranca Gerosa
Department of Pathology, Section of Immunology, University of Verona, 37134 Verona, Italy
J Exp Med 205:1447-61. 2008..Thus, the differential ability of pathogens to induce antigen-presenting cells to produce cytokines regulates the immune response to infection... - IL-10 or not IL-10: that is the questionDragana Jankovic
Nat Immunol 8:1281-3. 2007 - TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma productionRomina S Goldszmid
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 204:2591-602. 2007.... - Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNsUzma A Hasan
Infections and Cancer Biology Group, International Agency for Research on Cancer IARC WHO, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Proc Natl Acad Sci U S A 104:8047-52. 2007..These findings reveal a previously uncharacterized function of TLR signaling in cell proliferation and survival... - Interleukin-10 production by effector T cells: Th1 cells show self controlGiorgio Trinchieri
Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
J Exp Med 204:239-43. 2007..But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens... - Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signalsAndre Boonstra
Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
J Immunol 177:7551-8. 2006.... - Ikaros is required for plasmacytoid dendritic cell differentiationDavid Allman
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
Blood 108:4025-34. 2006..These studies suggest that Ikaros controls pDC differentiation by silencing a large array of genes... - Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophilsEstelle Merck
Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
J Immunol 176:3149-56. 2006..Overall, our data demonstrate that hOSCAR is a functional receptor on monocytes and neutrophils, involved in the induction of the primary proinflammatory cascade and the initiation of downstream immune responses... - MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivoThomas Delale
Schering Plough, Laboratory for Immunological Research, Dardilly, France
J Immunol 175:6723-32. 2005.... - The reciprocal interaction of NK cells with plasmacytoid or myeloid dendritic cells profoundly affects innate resistance functionsFranca Gerosa
Department of Pathology, Section of Immunology, University of Verona, Verona, Italy
J Immunol 174:727-34. 2005..These data suggest that the reciprocal functional interaction between NK cells and either pDC or myeloid DC may play an important physiological role in the regulation of both innate resistance and adaptive immunity to infections... - Plasmacytoid dendritic cells in immunityMarco Colonna
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
Nat Immunol 5:1219-26. 2004..Here we review recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases... - Origin and filiation of human plasmacytoid dendritic cellsFrancine Briere
Laboratory for Immunological Research, Schering Plough, Dardilly, France
Hum Immunol 63:1081-93. 2002..Hopefully, novel markers will allow delineation of the relationships between dendritic cells at different stages of differentiation/maturation along the myeloid and lymphoid lineages... - IFN-gamma and IL-12 differentially regulate CC-chemokine secretion and CCR5 expression in human T lymphocytesGiuliana Losana
Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
J Leukoc Biol 72:735-42. 2002.... - Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibodyAlain P Vicari
Schering Plough Laboratory for Immunological Research, BP11, 27 chemin des Peupliers, 69571 Dardilly, France
J Exp Med 196:541-9. 2002..Subsequently, CpG plus anti-IL-10R treatment showed robust antitumor therapeutic activity exceeding by far that of CpG alone, and elicited antitumor immune memory... - Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individualsJihed Chehimi
HIV Immunopathogenesis Laboratory, Wistar Institute, Philadelphia, PA 19104, USA
J Immunol 168:4796-801. 2002..The persistent impairment of certain DC subsets may result in a sustained defect in DC-mediated innate immune functions despite an effective treatment regimen... - The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytesIrma Airoldi
Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genoa, Italy
Haematologica 87:434-42. 2002..IL-12 also activates human B-cells through the IL-12 receptor (IL-12R) complex. Here we review the expression and function of IL-12 and IL-12R in human B-cells and in their malignant counterparts... - The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factorMichel Gilliet
DNAX Research Institute, Palo Alto, CA 94304, USA
J Exp Med 195:953-8. 2002..Human IPCs and mouse IPCs display different ability to produce IL-12p70. Large numbers of mouse IPCs can now be obtained from total bone marrow culture... - Tumour escape from immune surveillance through dendritic cell inactivationAlain P Vicari
Schering Plough Research Institute, Laboratory for Immunological Research, Dardilly, France
Semin Cancer Biol 12:33-42. 2002..We will review the current knowledge of the physiopathology of DC in cancer, which paves the way for novel strategies of therapeutic intervention... - Interleukin-12 in anti-tumor immunity and immunotherapyMario P Colombo
Department of Experimental Oncology, Immunotherapy and Gene Therapy Unit, Istituto Nazionale Tumori, Via G Venezian 1, Milan 20133, Italy
Cytokine Growth Factor Rev 13:155-68. 2002..However, excessive clinical toxicity and modest clinical response observed in the clinical trials point to the necessity to plan protocols that minimize toxicity without affecting the anti-tumor effect of IL-12... - Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivoMarc Dalod
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
J Exp Med 195:517-28. 2002..They also illustrate the plasticity of cellular sources for innate cytokines in vivo and provide new insights into the roles of IFNs in shaping immune responses to viruses... - Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligationAndre Boonstra
Division of Immunoregulation, The National Institute for Medical Research NIMR, NW7 1AA London, United Kingdom
J Exp Med 197:101-9. 2003..Thus, the net effect of antigen dose, the state of maturation of the DCs together with the stimulation of DCs by pathogen-derived products, will determine whether a Th1 or Th2 response develops... - Reciprocal activating interaction between natural killer cells and dendritic cellsFranca Gerosa
Department of Pathology, Section of Immunology, University of Verona, 37100 Verona, Italy
J Exp Med 195:327-33. 2002..These data demonstrated for the first time a bidirectional cross talk between NK cells and DC, in which NK cells activated by IL-2 or by mature DC induce DC maturation... - Are dendritic cells afraid of commitment?Anne O'Garra
Nat Immunol 5:1206-8. 2004 - Interleukin-10 in viral diseases and cancer: exiting the labyrinth?Alain P Vicari
Schering Plough Laboratory for Immunological Research, Dardilly, France
Immunol Rev 202:223-36. 2004..In the present review, we emphasize how these multiple roles define IL-10 as an adaptive molecule, constantly tuning the host response against dangerous and resourceful pathogens... - Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagementFrancesca Fallarino
Department of Experimental Medicine, University of Perugia, Perugia, Italy
J Immunol 173:3748-54. 2004..These data prospect novel functions for both pDCs and the CD200-CD200R pair in the mouse. At the same time, these data underscore the possible unifying role of the IDO mechanism in immune tolerance... - In vivo manipulation of dendritic cell migration and activation to elicit antitumour immunityAlain P Vicari
Schering-Plough Laboratory for Immunological Research, 69571 Dardilly, France
Novartis Found Symp 256:241-54; discussion 254-69. 2004..Subsequently, CpG plus anti-IL10R treatment showed robust antitumour therapeutic activity exceeding by far that of CpG alone, and elicited antitumour immune memory... - Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibodyCarine Asselin-Paturel
Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
J Immunol 171:6466-77. 2003..The higher ability of 129Sv mice to produce IFN-alpha in vivo is related to a higher number of pDC, but also to a higher ability of pDC from 129Sv mice to produce IFN-alpha in vitro in response to viral stimulation... - The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12Béatrice Vanbervliet
Laboratory for Immunological Research, Schering Plough, 27 chemin des Peupliers, BP 11, 69571 Dardilly, France
J Exp Med 198:823-30. 2003.... - The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responsesGiorgio Trinchieri
Schering Plough Research Institute, Laboratory for Immunological Research, 69571 Dardilly, France
Immunity 19:641-4. 2003..2003; Villarino et al., 2003), indicate that they mediate complex and well-differentiated functions... - Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pHOdette de Bouteiller
Laboratory for Immunological Research, Schering Plough Research Institute, 27 chemin des Peupliers, 69571 Dardilly Cedex, France
J Biol Chem 280:38133-45. 2005..These observations demonstrate that engagement of TLR3 by poly(I-C) at an acidic pH, probably in early phagolysosomes or endosomes, induces receptor aggregation leading to signaling... - Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblastsUzma A Hasan
Schering Plough, Laboratory for Immunological Research, 27 chemin des Peupliers, B P 11, 69571 Dardilly Cedex, France
J Biol Chem 280:20620-7. 2005..These data provide evidence for a nonimmune and cell autonomous role of TLR signaling, whereby TLR stimulation provides a positive signal for cell division... - Cytokines and cytokine receptorsGiorgio Trinchieri
Schering-Plough Laboratory for Immunological Research, Dardilly, France
Immunol Rev 202:5-7. 2004 - Cooperation of Toll-like receptor signals in innate immune defenceGiorgio Trinchieri
Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Building 560, Room 31 93, Frederick, Maryland 21702 1201, USA
Nat Rev Immunol 7:179-90. 2007..This Review highlights recent advances in the newly emerging field of TLR cooperation and discusses their implications for the development of adjuvants and immunotherapies... - Effect of the V3 loop deletion of envelope glycoprotein on cellular responses and protection against challenge with recombinant vaccinia virus expressing gp160 of primary human immunodeficiency virus type 1 isolatesIrena Kiszka
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Virol 76:4222-32. 2002..The results from our studies provide insights into approaches for boosting the breadth of envelope-specific CTL responses... - Pillars of immunology: The birth of a cell typeGiorgio Trinchieri
Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 560/Room 31-93, Frederick, MD 21702, USA
J Immunol 178:3-4. 2007 - OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cellsEstelle Merck
Laboratory for Immunological Research, Schering Plough, 27 chemin des Peupliers, BP11, 69571 Dardilly Cedex, France
Blood 104:1386-95. 2004..hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response... - Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized graftsJordi C Ochando
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Nat Immunol 7:652-62. 2006..Thus, alloantigen-presenting pDCs home to the lymph nodes in tolerogenic conditions, where they mediate alloantigen-specific Treg cell development and allograft tolerance... - The choices of a natural killerGiorgio Trinchieri
Nat Immunol 4:509-10. 2003
Research Grants
- Immune EvasionGiorgio Trinchieri; Fiscal Year: 2004..We have attempted to cover many aspects of immune evasion in cancer as well as to provide examples of the importance of similar mechanisms in autoimmunity, transplantation, and pregnancy. ..