Payal R Sheth

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. doi request reprint Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein
    Payal R Sheth
    Protein Science Department, Schering Plough Research Institute, 320 Bent Street, Cambridge, Massachusetts 02141, USA
    Biochemistry 48:11045-55. 2009
  2. doi request reprint Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli
    Payal R Sheth
    Protein Science Department, Cambridge, MA 02141, USA
    Arch Biochem Biophys 503:191-201. 2010
  3. doi request reprint Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain
    Payal R Sheth
    Protein Science Department, Merck Research Laboratories, 320 Bent Street, Cambridge, Massachusetts 02141, USA
    Biochemistry 49:8350-8. 2010
  4. doi request reprint Affinity characterization-mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution
    Lev Z Vilenchik
    Protein Science, Merck Research Laboratories, Cambridge, MA 02141, USA
    Anal Biochem 418:10-8. 2011
  5. doi request reprint Fully activated MEK1 exhibits compromised affinity for binding of allosteric inhibitors U0126 and PD0325901
    Payal R Sheth
    Protein Science Department, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    Biochemistry 50:7964-76. 2011
  6. doi request reprint SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics
    Andrea D Basso
    Department of Oncology, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07093, USA
    Mol Cancer Ther 9:2993-3002. 2010
  7. doi request reprint Purification and characterization of truncated human AMPK alpha 2 beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells
    Lata Ramanathan
    Protein Science Department, Schering Plough Research Institute, 320 Bent St, Cambridge, MA 02141, USA
    Protein Expr Purif 70:13-22. 2010

Detail Information

Publications7

  1. doi request reprint Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein
    Payal R Sheth
    Protein Science Department, Schering Plough Research Institute, 320 Bent Street, Cambridge, Massachusetts 02141, USA
    Biochemistry 48:11045-55. 2009
    ..The resulting overall information formed a strong basis for future structure-based design of inhibitors of KSP and related motor enzymes...
  2. doi request reprint Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli
    Payal R Sheth
    Protein Science Department, Cambridge, MA 02141, USA
    Arch Biochem Biophys 503:191-201. 2010
    ..The direct binding results support the hypothesis that the purified human AurB(69-333) fragment is a good surrogate for its full-length counterpart for biophysical and structural analyses...
  3. doi request reprint Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain
    Payal R Sheth
    Protein Science Department, Merck Research Laboratories, 320 Bent Street, Cambridge, Massachusetts 02141, USA
    Biochemistry 49:8350-8. 2010
    ....
  4. doi request reprint Affinity characterization-mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution
    Lev Z Vilenchik
    Protein Science, Merck Research Laboratories, Cambridge, MA 02141, USA
    Anal Biochem 418:10-8. 2011
    ..It was established as a valuable resource for counter screen and structure-activity relationship studies in drug discovery, especially when other classical techniques could only provide ambiguous results...
  5. doi request reprint Fully activated MEK1 exhibits compromised affinity for binding of allosteric inhibitors U0126 and PD0325901
    Payal R Sheth
    Protein Science Department, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    Biochemistry 50:7964-76. 2011
    ..The differences in inhibitor binding affinity provide direct evidence that unphosphorylated and RAF1-phosphorylated MEK1 form distinct inhibitor sites...
  6. doi request reprint SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics
    Andrea D Basso
    Department of Oncology, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07093, USA
    Mol Cancer Ther 9:2993-3002. 2010
    ..SCH 2047069 showed antitumor activity in a variety of preclinical models as a single agent and in combination with paclitaxel, gemcitabine, or vincristine...
  7. doi request reprint Purification and characterization of truncated human AMPK alpha 2 beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells
    Lata Ramanathan
    Protein Science Department, Schering Plough Research Institute, 320 Bent St, Cambridge, MA 02141, USA
    Protein Expr Purif 70:13-22. 2010
    ..The gamma 1 and gamma 3 isoforms showed comparable nucleotide binding affinities and solution behavior properties...