Mandy J McGeachy

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. ncbi TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 8:1390-7. 2007
  2. ncbi T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells
    Mandy J McGeachy
    Schering Plough Biopharma, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 26:547-9. 2007
  3. doi The link between IL-23 and Th17 cell-mediated immune pathologies
    Mandy J McGeachy
    Schering Plough Biopharma Formerly DNAX Research, 901 California Avenue, Palo Alto, CA 94304, United States
    Semin Immunol 19:372-6. 2007
  4. doi Th17 cell differentiation: the long and winding road
    Mandy J McGeachy
    Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 28:445-53. 2008
  5. doi Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Immunol 185:679-87. 2010
  6. pmc The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 10:314-24. 2009
  7. doi IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells
    Caroline Diveu
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Immunol 182:5748-56. 2009
  8. doi Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23
    Christopher J Haines
    Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA
    Cell Rep 3:1378-88. 2013
  9. pmc Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 206:535-48. 2009
  10. doi Cytokines that regulate autoimmunity
    Caroline Diveu
    Discovery Research, Schering Plough Biopharma formerly DNAX Research Institute, 901 California Avenue, Palo Alto CA 94304, United States
    Curr Opin Immunol 20:663-8. 2008

Collaborators

  • Daniel J Cua
  • Cristina M Tato
  • Robert A Kastelein
  • Jason S Stumhofer
  • Ying Li
  • Ming O Li
  • JOHN J O'SHEA
  • Christopher Hunter
  • Katia Boniface
  • Yi Chen
  • Wendy M Blumenschein
  • Terrill K McClanahan
  • Caroline Diveu
  • Christopher J Haines
  • Rene de Waal Malefyt
  • Beth Basham
  • Svetlana Sadekova
  • Ricky Cheung
  • Barbara Joyce-Shaikh
  • Renu Jain
  • Stephen M Anderton
  • Katherine Porth
  • Jeanine Mattson
  • Charlie Chang
  • Fran Shen
  • Terrill McClanahan
  • Joseph H Phillips
  • Robert H Pierce
  • Ilona Gutcher
  • Kristin Hochweller
  • Günter Hämmerling
  • Paul G Heyworth
  • Robert Pierce
  • Katherine Brovont-Porth
  • Bela Desai
  • Brent S McKenzie
  • Manjiri Sathe
  • Kristian S Bak-Jensen

Detail Information

Publications14

  1. ncbi TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 8:1390-7. 2007
    ..Our findings suggest that full acquisition of pathogenic function by effector T(H)-17 cells is mediated by IL-23 rather than by TGF-beta and IL-6...
  2. ncbi T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells
    Mandy J McGeachy
    Schering Plough Biopharma, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 26:547-9. 2007
    ..In this issue of Immunity, Li et al. (2007) find that not only does T cell-produced TGF-beta regulate Th1-cell-mediated inflammation, but it is also required for the generation of Th17 cells in vivo...
  3. doi The link between IL-23 and Th17 cell-mediated immune pathologies
    Mandy J McGeachy
    Schering Plough Biopharma Formerly DNAX Research, 901 California Avenue, Palo Alto, CA 94304, United States
    Semin Immunol 19:372-6. 2007
    ..Finally, the roles of IL-23 in inflammatory diseases in relation to Th17 function will be discussed...
  4. doi Th17 cell differentiation: the long and winding road
    Mandy J McGeachy
    Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 28:445-53. 2008
    ..Unresolved controversies in this field are also discussed: For example, IL-23 is absolutely required for disease pathogenesis in many models of Th17-cell-mediated autoimmunity, yet its role in Th17 cell development is relatively unclear...
  5. doi Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Immunol 185:679-87. 2010
    ....
  6. pmc The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 10:314-24. 2009
    ..These defects were associated with less proliferation; consequently, fewer effector T(H)-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues...
  7. doi IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells
    Caroline Diveu
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Immunol 182:5748-56. 2009
    ..These results show that IL-27 acts as a negative regulator of the developing IL-17A response in vivo, suggesting a potential therapeutic role for IL-27 in autoimmune diseases...
  8. doi Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23
    Christopher J Haines
    Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA
    Cell Rep 3:1378-88. 2013
    ....
  9. pmc Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 206:535-48. 2009
    ..These findings, together with the altered IL-12/IL-23 balance induced by PGE2 in dendritic cells, further highlight the crucial role of the inflammatory microenvironment in Th17 cell development and regulation...
  10. doi Cytokines that regulate autoimmunity
    Caroline Diveu
    Discovery Research, Schering Plough Biopharma formerly DNAX Research Institute, 901 California Avenue, Palo Alto CA 94304, United States
    Curr Opin Immunol 20:663-8. 2008
    ..Unexpectedly, IL-27--another IL-12 family member--plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies...
  11. doi Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2
    Yi Chen
    Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 34:409-21. 2011
    ..Rather, regulation of IL-2 availability and resultant signaling through CD25 by Treg cells was found to play an important role...
  12. pmc Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice
    Ricky Cheung
    Discovery Research, Merck Research Laboratories, Palo Alto, California, USA
    J Clin Invest 121:4446-61. 2011
    ..Targeting the MDL-1/Syk/PI3K/Akt/eNOS pathway represents a potential new therapeutic strategy to prevent the progression of SIRS to shock...
  13. doi GM-CSF: the secret weapon in the T(H)17 arsenal
    Mandy J McGeachy
    Merck Research, Palo Alto, California, USA
    Nat Immunol 12:521-2. 2011
    ..Identification of the pathogenic cytokines that underlie the IL-23-dependent disease progression of experimental autoimmune encephalomyelitis has proven elusive. Evidence now points to GM-CSF...
  14. ncbi Cytokines in the induction and resolution of experimental autoimmune encephalomyelitis
    Mandy J McGeachy
    Institute of Immunology and Infection Research, University of Edinburgh, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Cytokine 32:81-4. 2005
    ..However, the key IL-10-producing cell within the central nervous system is a CD4+CD25+ T cell population that has regulatory function and is critical to resolution of the disease...