Matthew E Kennedy

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. ncbi request reprint Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fluorescence
    Matthew E Kennedy
    CNS Cardiovascular Research, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Anal Biochem 319:49-55. 2003
  2. doi request reprint Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors
    Yu Sen Wang
    Schering Plough Research Institute, 320 Bent Street, Cambridge, Massachusetts 02141, USA
    J Med Chem 53:942-50. 2010
  3. doi request reprint Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor
    Jared N Cumming
    Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 22:2444-9. 2012
  4. ncbi request reprint Design and development of BACE-1 inhibitors
    Jared N Cumming
    Department of Chemical Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Curr Opin Drug Discov Devel 7:536-56. 2004
  5. doi request reprint Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation
    Zhaoning Zhu
    Department of Medicinal Chemistry, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    J Med Chem 53:951-65. 2010

Detail Information

Publications5

  1. ncbi request reprint Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fluorescence
    Matthew E Kennedy
    CNS Cardiovascular Research, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Anal Biochem 319:49-55. 2003
    ....
  2. doi request reprint Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors
    Yu Sen Wang
    Schering Plough Research Institute, 320 Bent Street, Cambridge, Massachusetts 02141, USA
    J Med Chem 53:942-50. 2010
    ..The structure-based design of a cyclic acylguanidine lead series and its optimization into nanomolar BACE-1 inhibitors are the subject of the companion paper..
  3. doi request reprint Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor
    Jared N Cumming
    Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 22:2444-9. 2012
    ..Herein we report SAR development in the S3 and F' subsites of BACE1 for this series, the synthetic approaches employed in this effort, and in vivo data for the optimized compound...
  4. ncbi request reprint Design and development of BACE-1 inhibitors
    Jared N Cumming
    Department of Chemical Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Curr Opin Drug Discov Devel 7:536-56. 2004
    ..This review provides a perspective on the recent developments in the design of BACE-1 inhibitors. An overview of early research is also included, with particular emphasis on a comprehensive survey of the patent literature...
  5. doi request reprint Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation
    Zhaoning Zhu
    Department of Medicinal Chemistry, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
    J Med Chem 53:951-65. 2010
    ....