L A Hyde

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. ncbi request reprint Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse
    Lynn A Hyde
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Pharmacol Exp Ther 319:1133-43. 2006
  2. ncbi request reprint Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease
    L A Hyde
    Department of Pediatrics, University of Colorado School of Medicine, USA
    Behav Neurosci 115:1239-46. 2001
  3. ncbi request reprint Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice
    Lynn A Hyde
    Schering Plough Research Institute, NJ 07033, Kenilworth, USA
    Behav Brain Res 160:344-55. 2005
  4. ncbi request reprint Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease
    Lynn A Hyde
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Brain Res 945:26-30. 2002
  5. ncbi request reprint Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease
    Theodros Asberom
    Department of Chemical Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 17:511-6. 2007
  6. ncbi request reprint Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function
    L A Hyde
    Department of Pediatrics, University of Colorado, School of Medicine, 4200 East Ninth Avenue Box C233, Denver, CO 80262, USA
    Behav Brain Res 118:53-60. 2001
  7. ncbi request reprint Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein
    Martha F McCool
    CNS Biological Research, Schering Plough Research Institute, K15 2 2600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Brain Res 994:99-106. 2003
  8. ncbi request reprint Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species
    G B Varty
    Department of Neurobiology, K 15 2600, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 182:132-43. 2005
  9. ncbi request reprint Increased seizure threshold and severity in young transgenic CRND8 mice
    Robert A Del Vecchio
    CNS Biological Research, K 15 2600, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Neurosci Lett 367:164-7. 2004
  10. ncbi request reprint Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation
    Tatiana M Kazdoba
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Behav Pharmacol 18:89-102. 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Studies to investigate the in vivo therapeutic window of the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY411,575) in the CRND8 mouse
    Lynn A Hyde
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Pharmacol Exp Ther 319:1133-43. 2006
    ....
  2. ncbi request reprint Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease
    L A Hyde
    Department of Pediatrics, University of Colorado School of Medicine, USA
    Behav Neurosci 115:1239-46. 2001
    ..Therefore, Ts65Dn mice have an age-related learning impairment that coincides with their age-related neuroanatomical abnormalities and, consequently, may be a useful model of AD...
  3. ncbi request reprint Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice
    Lynn A Hyde
    Schering Plough Research Institute, NJ 07033, Kenilworth, USA
    Behav Brain Res 160:344-55. 2005
    ..Therefore compared to their Non-Tg littermates, Tg CRND8 mice demonstrate cognitive impairments that progressed with age and seemed to coincide with the onset of beta-amyloid plaque deposition...
  4. ncbi request reprint Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease
    Lynn A Hyde
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
    Brain Res 945:26-30. 2002
    ..One may be related to recent studies that suggest that only rats with neonatal, but not adult, basal forebrain cholinergic 192 IgG-saporin lesions are impaired in reacting to spatial novelty...
  5. ncbi request reprint Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease
    Theodros Asberom
    Department of Chemical Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 17:511-6. 2007
    ..Strategies for subsequent improvement of the in vivo pharmacokinetic profile of the series are discussed. Resulting compounds significantly reduce Abeta levels in TgCRND8 mice after a single PO dosing at 30 mpk...
  6. ncbi request reprint Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function
    L A Hyde
    Department of Pediatrics, University of Colorado, School of Medicine, 4200 East Ninth Avenue Box C233, Denver, CO 80262, USA
    Behav Brain Res 118:53-60. 2001
    ..Therefore, Ts65Dn mice have learning deficits in a hippocampal dependent task that may be related to the loss of cholinergic input to the hippocampus, which occurs after 6 months of age...
  7. ncbi request reprint Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein
    Martha F McCool
    CNS Biological Research, Schering Plough Research Institute, K15 2 2600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Brain Res 994:99-106. 2003
    ..These PPI deficits were present at pre- and post-plaque time points and did not appear to intensify with age; thus, they do not seem to correlate with the known neuropathology of TgCRND8 mice...
  8. ncbi request reprint Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species
    G B Varty
    Department of Neurobiology, K 15 2600, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 182:132-43. 2005
    ..Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist, Ro64-6198...
  9. ncbi request reprint Increased seizure threshold and severity in young transgenic CRND8 mice
    Robert A Del Vecchio
    CNS Biological Research, K 15 2600, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Neurosci Lett 367:164-7. 2004
    ..Thus, the TgCRND8 mice are not only a model for Abeta production and plaque deposition, but may also be useful for AD associated seizure...
  10. ncbi request reprint Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation
    Tatiana M Kazdoba
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Behav Pharmacol 18:89-102. 2007
    ..Overall, these results demonstrate that our automated method is a quick and simple way to accurately assess potential foot shock sensitivity differences owing to strain, genotype or drug treatments...
  11. ncbi request reprint Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors
    Hubert Josien
    Department of Chemical Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07302, USA
    Bioorg Med Chem Lett 17:5330-5. 2007
    ..Compounds active orally in lowering Abeta levels in Tg CRND8 mice were identified as potential treatments for Alzheimer's disease...
  12. ncbi request reprint Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors
    Mark D McBriar
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 18:215-9. 2008
    ..In several cases, amides lessened CYP liabilities in this class of gamma-secretase inhibitors. Selected compounds showed significant reduction of Abeta levels upon oral dosing in a transgenic murine model of Alzheimer's disease...
  13. doi request reprint Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability
    Hubert Josien
    Department of CV and CNS Medicinal Chemistry, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 19:6032-7. 2009
    ..This resulted in compounds with improved CYP 3A4 profiles. Several analogs that were active at lowering Abeta levels in Tg CRND8 mice upon oral administration were identified...
  14. ncbi request reprint Motor learning in Ts65Dn mice, a model for Down syndrome
    L A Hyde
    Departments of Pediatrics and Psychiatry, University of Colorado, School of Medicine, 4200 East Ninth Street, Denver, CO 80262, USA
    Dev Psychobiol 38:33-45. 2001
    ..These data indicate that Ts65Dn mice are not impaired in motor learning...
  15. ncbi request reprint Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice
    T J Kowalski
    Department of CV Metabolic Diseases, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Endocrinol 185:151-64. 2005
    ..Despite the increased weight gain with high-fat feeding, glucose tolerance was significantly improved in the transgenic mice. These findings support the hypothesized role of NmU as an endogenous anorexigenic peptide...
  16. ncbi request reprint Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome
    Ann Charlotte E Granholm
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Physiol Behav 77:371-85. 2002
    ..The findings also indicate that estrogen may act, at least partially, via endogenous growth factors. Collectively, the data suggest that ERT may be a viable therapeutic approach for women with DS coupled with dementia...
  17. ncbi request reprint Differential learning strategies in spatial and nonspatial versions of the Morris water maze in the C57BL/6J inbred mouse strain
    Amy Jo Stavnezer
    Biobehavioral Sciences Graduate Degree Program, U 154, University of Connecticut, 3107 Horsebarn Hill Road, Storrs 06269 4154, USA
    Behav Brain Res 133:261-70. 2002
    ..Overall, C57 mice can learn both the spatial and nonspatial versions of the Morris maze presented here; however, the nonspatial version is more difficult and is solved using an egocentric strategy...
  18. ncbi request reprint Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex
    Lynn A Hyde
    Biobehavioral Sciences Graduate Degree Program, University of Connecticut, U 154, 3107 Horsebarn Hill Road, Storrs 06269 4154, USA
    Behav Brain Res 133:247-59. 2002
    ..Thus, the presence of one or more ectopias in the prefrontal region of cortex disrupted one of the normal functions of the prefrontal cortex...