Robert A Hodgson

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. doi request reprint Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement
    Robert A Hodgson
    Departments of Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    J Pharmacol Exp Ther 330:294-303. 2009
  2. ncbi request reprint Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression
    R A Hodgson
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Pharmacol Biochem Behav 86:431-40. 2007
  3. ncbi request reprint Duration of ultrasonic vocalizations in the isolated rat pup as a behavioral measure: sensitivity to anxiolytic and antidepressant drugs
    Robert A Hodgson
    Department of Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Pharmacol Biochem Behav 88:341-8. 2008
  4. doi request reprint Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination
    Robert A Hodgson
    Department of Neurobiology, Merck Research Labs, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Pharmacol Biochem Behav 98:181-7. 2011
  5. doi request reprint The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates
    Geoffrey B Varty
    Department of Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 200:393-401. 2008
  6. doi request reprint Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders
    Robert A Hodgson
    Department of Neurobiology, Merck and Co Inc, Kenilworth, NJ 07033, USA
    Exp Neurol 225:384-90. 2010
  7. doi request reprint The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)
    Geoffrey B Varty
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Pharmacol Exp Ther 326:672-82. 2008
  8. doi request reprint The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species
    Sherry X Lu
    Department of Neurobiology, Merck and Co Inc, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 661:63-71. 2011
  9. ncbi request reprint The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors
    Guy A Higgins
    Department of Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Behav Brain Res 185:32-42. 2007
  10. ncbi request reprint The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles
    Geoffrey B Varty
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 179:207-17. 2005

Collaborators

Detail Information

Publications14

  1. doi request reprint Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement
    Robert A Hodgson
    Departments of Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    J Pharmacol Exp Ther 330:294-303. 2009
    ....
  2. ncbi request reprint Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression
    R A Hodgson
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Pharmacol Biochem Behav 86:431-40. 2007
    ..This work demonstrates the different profiles of V1b and CRF1 receptor antagonists and supports both approaches in the treatment of affective disorders...
  3. ncbi request reprint Duration of ultrasonic vocalizations in the isolated rat pup as a behavioral measure: sensitivity to anxiolytic and antidepressant drugs
    Robert A Hodgson
    Department of Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Pharmacol Biochem Behav 88:341-8. 2008
    ..These data support USV duration as a more sensitive and useful measure than USV number in the isolated rat pup model...
  4. doi request reprint Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination
    Robert A Hodgson
    Department of Neurobiology, Merck Research Labs, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Pharmacol Biochem Behav 98:181-7. 2011
    ..Pharmacological inhibition of the mGluR1 receptor has a modest effect on motor function but blocks motor learning and may reduce motivation to perform simple behaviors...
  5. doi request reprint The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates
    Geoffrey B Varty
    Department of Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 200:393-401. 2008
    ..Preclinical studies in the rat have demonstrated that adenosine A2A receptor antagonists can attenuate behaviors reflecting reduced dopamine activity, such as haloperidol-induced catalepsy and hypoactivity...
  6. doi request reprint Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders
    Robert A Hodgson
    Department of Neurobiology, Merck and Co Inc, Kenilworth, NJ 07033, USA
    Exp Neurol 225:384-90. 2010
    ..3-3.0 mg/kg; PO) delayed the onset of EPS symptoms evoked by an acute haloperidol challenge. Collectively, these data support the use of preladenant for the treatment of PD and antipsychotic-induced movement disorders...
  7. doi request reprint The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)
    Geoffrey B Varty
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Pharmacol Exp Ther 326:672-82. 2008
    ..Collectively, these data suggest that NOP agonists such as SCH 221510 may have an anxiolytic-like profile similar to benzodiazepines, with a reduced side-effect liability...
  8. doi request reprint The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species
    Sherry X Lu
    Department of Neurobiology, Merck and Co Inc, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 661:63-71. 2011
    ..Taken together, SCH 655842 may represent a NOP receptor agonist with improved tolerability compared to other members of this class although further studies are necessary to establish whether this extends to higher species...
  9. ncbi request reprint The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors
    Guy A Higgins
    Department of Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Behav Brain Res 185:32-42. 2007
    ..Furthermore, the improvement in response control in amphetamine-treated rats following CGS-21680 pretreatment supports the view that A(2A) agonists have potential as novel antipsychotics...
  10. ncbi request reprint The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles
    Geoffrey B Varty
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 179:207-17. 2005
    ..Modulation of metabotropic glutamate receptor (mGluR) subtypes represents a novel approach for the treatment of neurological and psychiatric disorders...
  11. doi request reprint Characterization of the V1a antagonist, JNJ-17308616, in rodent models of anxiety-like behavior
    C J Bleickardt
    Department of Neurobiology, K 15 2600, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 202:711-8. 2009
    ..Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was identified as a V1a antagonist...
  12. ncbi request reprint Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species
    G B Varty
    Department of Neurobiology, K 15 2600, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 182:132-43. 2005
    ..Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist, Ro64-6198...
  13. doi request reprint Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists
    Jack D Scott
    Department of Chemical Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 19:6018-22. 2009
    ..Further optimization of the right hand portion afforded potent V1b antagonists that possessed moderate to high selectivity over other receptors...
  14. pmc Adenosine A(2A) Receptor Antagonists Do Not Disrupt Rodent Prepulse Inhibition: An Improved Side Effect Profile in the Treatment of Parkinson's Disease
    Carina J Bleickardt
    Department of In Vivo Pharmacology, Neuroscience, Merck Research Laboratories, 2015 Galloping Hill Road, K 15 1600, Kenilworth, NJ 07033, USA
    Parkinsons Dis 2012:591094. 2012
    ..1-1 mg/kg) marginally disrupted mouse but not rat PPI. These results suggest that A(2A) antagonists, unlike dopamine agonists, have an improved neuropsychiatric side effect profile...