Affiliation: Schering-Plough Research Institute
- Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor betaJohn Dulos
Schering Plough Research Institute, PO Box 20, 5340 BH Oss, The Netherlands
Arthritis Res Ther 12:R101. 2010..Estrogens bind both estrogen receptor (ER)alpha and beta. The contribution of ERalpha and ERbeta to ER-mediated immune modulation was studied in delayed type hypersensitivity (DTH) and in experimental arthritis..
- Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2Dorien M de Groot
Schering Plough Research Institute, Oss, The Netherlands
J Immunol 183:4127-34. 2009..The pharmacokinetic profile of the 1B2 Ab illustrates the complexity of Ab elimination from an organism and stresses the importance of understanding Ag-Ab interactions when developing therapeutic mAbs...