Daniel J Cua

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. doi request reprint Innate IL-17-producing cells: the sentinels of the immune system
    Daniel J Cua
    Merck Research Laboratories, DNAX Discovery Research, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Rev Immunol 10:479-89. 2010
  2. doi request reprint Reconciling id, ego, and superego within interleukin-23
    Cristina M Tato
    Schering Plough Biopharma, DNAX Discovery Research, Palo Alto, CA 94304, USA
    Immunol Rev 226:103-11. 2008
  3. ncbi request reprint TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 8:1390-7. 2007
  4. doi request reprint IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells
    Caroline Diveu
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Immunol 182:5748-56. 2009
  5. pmc IL-25 regulates Th17 function in autoimmune inflammation
    Melanie A Kleinschek
    Discovery Research, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 204:161-70. 2007
  6. pmc Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 206:535-48. 2009
  7. pmc Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
    Yi Chen
    Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1317-26. 2006
  8. pmc The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 10:314-24. 2009
  9. pmc IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
  10. pmc The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production
    Cristina M Tato
    Merck Research Laboratories, Palo Alto, California, United States of America
    PLoS ONE 7:e31680. 2012

Collaborators

Detail Information

Publications33

  1. doi request reprint Innate IL-17-producing cells: the sentinels of the immune system
    Daniel J Cua
    Merck Research Laboratories, DNAX Discovery Research, 901 California Avenue, Palo Alto, CA 94304, USA
    Nat Rev Immunol 10:479-89. 2010
    ..These early sources have been shown to have a central role in the initiation of IL-17-dependent immune responses, even before the first CD4(+)T cell sees its cognate antigen and initiates the T(H)17 cell developmental programme...
  2. doi request reprint Reconciling id, ego, and superego within interleukin-23
    Cristina M Tato
    Schering Plough Biopharma, DNAX Discovery Research, Palo Alto, CA 94304, USA
    Immunol Rev 226:103-11. 2008
    ..The aim of this review is to explore the multiple characteristics of IL-23 with respect to its 'id' in autoimmunity, 'ego' in T-cell help, and 'superego' in defense against mucosal pathogens...
  3. ncbi request reprint TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 8:1390-7. 2007
    ..Our findings suggest that full acquisition of pathogenic function by effector T(H)-17 cells is mediated by IL-23 rather than by TGF-beta and IL-6...
  4. doi request reprint IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells
    Caroline Diveu
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Immunol 182:5748-56. 2009
    ..These results show that IL-27 acts as a negative regulator of the developing IL-17A response in vivo, suggesting a potential therapeutic role for IL-27 in autoimmune diseases...
  5. pmc IL-25 regulates Th17 function in autoimmune inflammation
    Melanie A Kleinschek
    Discovery Research, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 204:161-70. 2007
    ..Thus, IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity...
  6. pmc Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
    Katia Boniface
    Department of Immunology, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 206:535-48. 2009
    ..These findings, together with the altered IL-12/IL-23 balance induced by PGE2 in dendritic cells, further highlight the crucial role of the inflammatory microenvironment in Th17 cell development and regulation...
  7. pmc Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
    Yi Chen
    Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1317-26. 2006
    ..Thus, therapeutic targeting of IL-23 effectively inhibited multiple inflammatory pathways that are critical for driving CNS autoimmune inflammation...
  8. pmc The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 10:314-24. 2009
    ..These defects were associated with less proliferation; consequently, fewer effector T(H)-17 cells were produced in the lymph nodes and hence available to emigrate to the bloodstream and tissues...
  9. pmc IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 201:233-40. 2005
    ..Using passive transfer studies, we confirm that these IL-23-dependent CD4(+) T cells are highly pathogenic and essential for the establishment of organ-specific inflammation associated with central nervous system autoimmunity...
  10. pmc The myeloid receptor PILRβ mediates the balance of inflammatory responses through regulation of IL-27 production
    Cristina M Tato
    Merck Research Laboratories, Palo Alto, California, United States of America
    PLoS ONE 7:e31680. 2012
    ..Similar protection was also observed in the CNS during chronic T. gondii infection after i.p. challenge again providing evidence that PILRβ is important for regulating aberrant inflammatory responses...
  11. pmc IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    David Yen
    Department of Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    J Clin Invest 116:1310-6. 2006
    ..This pathway may be responsible for chronic intestinal inflammation as well as other chronic autoimmune inflammatory diseases...
  12. doi request reprint Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23
    Christopher J Haines
    Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA
    Cell Rep 3:1378-88. 2013
    ....
  13. doi request reprint IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells
    Jonathan P Sherlock
    Merck Research Laboratories, Palo Alto, California, USA
    Nat Med 18:1069-76. 2012
    ....
  14. pmc Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis
    Barbara Joyce-Shaikh
    Department of Discovery Research, Schering Plough Biopharma, Palo Alto, CA 94304, USA
    J Exp Med 207:579-89. 2010
    ..These findings suggest that MDL-1 receptor may be a therapeutic target for treatment of immune-mediated skeletal disorders...
  15. ncbi request reprint Development, cytokine profile and function of human interleukin 17-producing helper T cells
    Nicholas J Wilson
    Department of Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, California 94304 1104, USA
    Nat Immunol 8:950-7. 2007
    ..Our data collectively indicate that human and mouse T(H)-17 cells require distinct factors during differentiation and that human T(H)-17 cells may regulate innate immunity in epithelial cells...
  16. ncbi request reprint Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation
    Robert A Kastelein
    Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304 1104, USA
    Annu Rev Immunol 25:221-42. 2007
    ..In this review, we aim to highlight the discoveries that have led to our current understanding of the biology of IL-23 and IL-27 in the context of their role in resistance to infection, immune-mediated inflammation, and cancer...
  17. ncbi request reprint IL-12 and IL-23: master regulators of innate and adaptive immunity
    Claire L Langrish
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    Immunol Rev 202:96-105. 2004
    ..These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression...
  18. pmc Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    Craig A Murphy
    Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
    J Exp Med 198:1951-7. 2003
    ..The data presented here indicate that IL-23 is an essential promoter of end-stage joint autoimmune inflammation, whereas IL-12 paradoxically mediates protection from autoimmune inflammation...
  19. doi request reprint Th17 cell differentiation: the long and winding road
    Mandy J McGeachy
    Schering Plough Biopharma, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 28:445-53. 2008
    ..Unresolved controversies in this field are also discussed: For example, IL-23 is absolutely required for disease pathogenesis in many models of Th17-cell-mediated autoimmunity, yet its role in Th17 cell development is relatively unclear...
  20. doi request reprint SnapShot: Cytokines IV
    Cristina M Tato
    Schering Plough Biopharma Formerly DNAX Research, Palo Alto, CA 94304, USA
    Cell 132:1062.e1-2. 2008
  21. doi request reprint The link between IL-23 and Th17 cell-mediated immune pathologies
    Mandy J McGeachy
    Schering Plough Biopharma Formerly DNAX Research, 901 California Avenue, Palo Alto, CA 94304, United States
    Semin Immunol 19:372-6. 2007
    ..Finally, the roles of IL-23 in inflammatory diseases in relation to Th17 function will be discussed...
  22. pmc Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice
    Ricky Cheung
    Discovery Research, Merck Research Laboratories, Palo Alto, California, USA
    J Clin Invest 121:4446-61. 2011
    ..Targeting the MDL-1/Syk/PI3K/Akt/eNOS pathway represents a potential new therapeutic strategy to prevent the progression of SIRS to shock...
  23. ncbi request reprint Understanding the IL-23-IL-17 immune pathway
    Brent S McKenzie
    Discovery Research, DNAX Research Inc, 901 California Ave, Palo Alto, CA 94304 1104, USA
    Trends Immunol 27:17-23. 2006
    ..By comparing the pathophysiological function of IL-12 and IL-23 in the context of host defense and autoimmune inflammation, we are beginning to understand the novel IL-23-IL-17 immune pathway...
  24. doi request reprint Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2
    Yi Chen
    Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 34:409-21. 2011
    ..Rather, regulation of IL-2 availability and resultant signaling through CD25 by Treg cells was found to play an important role...
  25. ncbi request reprint Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy
    Edward P Bowman
    Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
    Curr Opin Infect Dis 19:245-52. 2006
    ..This review discusses understanding of what distinguishes these related cytokines and the infection risks associated with targeting these cytokine pathways during treatment of inflammatory diseases...
  26. doi request reprint Th17 cell development: from the cradle to the grave
    Luis A Zuniga
    Pathway Biology, Merck Research Laboratories, Palo Alto, CA 94304 1104, USA
    Immunol Rev 252:78-88. 2013
    ....
  27. ncbi request reprint T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells
    Mandy J McGeachy
    Schering Plough Biopharma, 901 California Avenue, Palo Alto, California 94304, USA
    Immunity 26:547-9. 2007
    ..In this issue of Immunity, Li et al. (2007) find that not only does T cell-produced TGF-beta regulate Th1-cell-mediated inflammation, but it is also required for the generation of Th17 cells in vivo...
  28. doi request reprint SnapShot: cytokines II
    Cristina M Tato
    Schering Plough Biopharma, Palo Alto, CA 94304, USA
    Cell 132:500. 2008
  29. doi request reprint SnapShot: cytokines III
    Cristina M Tato
    Schering Plough Biopharma, Palo Alto, CA 94304, USA
    Cell 132:900. 2008
  30. doi request reprint SnapShot: Cytokines I
    Cristina M Tato
    Schering Plough Biopharma, Palo Alto, CA 94304, USA
    Cell 132:324, 324.e1. 2008
  31. ncbi request reprint Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    Daniel J Cua
    Department of Immunology, DNAX Research Inc, Palo Alto, California 94304 1104, USA
    Nature 421:744-8. 2003
    ..In addition, we show that IL-23, unlike IL-12, acts more broadly as an end-stage effector cytokine through direct actions on macrophages...
  32. ncbi request reprint The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS)
    Amy M Beebe
    Department of Experimental Pathology, DNAX Research Inc, 901 California Avenue, Palo Alto, CA 94304 1104, USA
    Cytokine Growth Factor Rev 13:403-12. 2002
    ..Inhibition of the immune stimulatory activities of IL-10 may provide novel approaches in the treatment of humoral autoimmune diseases, infectious diseases and cancer...
  33. ncbi request reprint Orphan cytokine reveals IL-17 family secret
    Christopher J Haines
    Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 35:498-500. 2011
    ..Chang et al. (2011), in this issue of Immunity, and two other reports (Song et al., 2011; Ramirez-Carrozzi et al., 2011) demonstrate that IL-17C has broad functions in a variety of tissues...