Richard W Chapman

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. ncbi Effect of inhaled roflumilast on the prevention and resolution of allergen-induced late phase airflow obstruction in Brown Norway rats
    Richard W Chapman
    Schering Plough Research Institute, Pulmonary and Peripheral Neurobiology M S 1700, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States
    Eur J Pharmacol 571:215-21. 2007
  2. doi CXCR2 antagonists for the treatment of pulmonary disease
    R W Chapman
    Schering Plough Research Institute, Kenilworth, New Jersey 08844, USA
    Pharmacol Ther 121:55-68. 2009
  3. doi Canine models of asthma and COPD
    Richard W Chapman
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 0539, USA
    Pulm Pharmacol Ther 21:731-42. 2008
  4. ncbi Effect of histamine, albuterol and deep inspiration on airway and lung tissue mechanics in cynomolgus monkeys
    Richard W Chapman
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ, USA
    Pulm Pharmacol Ther 18:243-9. 2005
  5. ncbi Antitussive activity of the tachykinin NK1 receptor antagonist, CP-99994, in dogs
    Richard W Chapman
    Schering Plough Research Institute, 2015 Galloping Hill Road, MS K15 1 1650, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 485:329-32. 2004
  6. ncbi A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation
    Richard W Chapman
    Schering Plough Research Institute, Pulmonary and Peripheral Neurobiology, Kenilworth, NJ 07033, USA
    J Pharmacol Exp Ther 322:486-93. 2007
  7. ncbi A simple non-invasive method to measure the cough reflex in dogs
    R W Chapman
    Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Pharmacol Toxicol Methods 46:21-6. 2001
  8. doi Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration
    Richard W Chapman
    Department of Bone, Respiratory, Immunology and Dermatology, Merck Research Laboratories, Kenilworth, New Jersey 07033, USA
    Eur J Pharmacol 643:274-81. 2010
  9. doi Effect of mometasone furoate (MF)/formoterol fumarate (F) combination (MF/F) on late-phase responses in allergen-challenged Brown Norway rats
    Richard W Chapman
    Department of Bone, Respiratory, Immunology and Dermatology, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033 0539, USA
    Pulm Pharmacol Ther 24:67-73. 2011
  10. ncbi Differential effects of dexamethasone on the proximal and distal lung response to antigen challenge in allergic cynomolgus monkeys
    Aidan K Curran
    Schering Plough Research Institute, Kenilworth, New Jersey, USA
    J Asthma 45:377-81. 2008

Collaborators

Detail Information

Publications23

  1. ncbi Effect of inhaled roflumilast on the prevention and resolution of allergen-induced late phase airflow obstruction in Brown Norway rats
    Richard W Chapman
    Schering Plough Research Institute, Pulmonary and Peripheral Neurobiology M S 1700, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States
    Eur J Pharmacol 571:215-21. 2007
    ..These results support the development of inhaled PDE4 inhibitors for the treatment of asthma and COPD, particularly for the improvement of lung function...
  2. doi CXCR2 antagonists for the treatment of pulmonary disease
    R W Chapman
    Schering Plough Research Institute, Kenilworth, New Jersey 08844, USA
    Pharmacol Ther 121:55-68. 2009
    ..Clinical trials evaluating small molecule CXCR2 antagonists in COPD, asthma and cystic fibrosis are currently underway. These studies hold considerable promise for identifying novel and efficacious treatments of pulmonary disorders...
  3. doi Canine models of asthma and COPD
    Richard W Chapman
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 0539, USA
    Pulm Pharmacol Ther 21:731-42. 2008
    ..This review highlights some of the important features of these canine models and how they have increased our understanding of the pathology, pathophysiology and control of human asthma and COPD...
  4. ncbi Effect of histamine, albuterol and deep inspiration on airway and lung tissue mechanics in cynomolgus monkeys
    Richard W Chapman
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ, USA
    Pulm Pharmacol Ther 18:243-9. 2005
    ....
  5. ncbi Antitussive activity of the tachykinin NK1 receptor antagonist, CP-99994, in dogs
    Richard W Chapman
    Schering Plough Research Institute, 2015 Galloping Hill Road, MS K15 1 1650, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 485:329-32. 2004
    ..Plasma levels of CP-99994 were highest at 2 h (75+/-26 ng/ml) and fell to 22+/-6 ng/ml at 6 h. These results demonstrate antitussive activity of CP-99994 in dogs at a dose proven to antagonize tachykinin NK(1) receptors in this species...
  6. ncbi A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation
    Richard W Chapman
    Schering Plough Research Institute, Pulmonary and Peripheral Neurobiology, Kenilworth, NJ 07033, USA
    J Pharmacol Exp Ther 322:486-93. 2007
    ..3 mg/kg). Therefore, Sch527123 may offer benefit for the treatment of inflammatory lung disorders in which pulmonary neutrophilia and mucus hypersecretion are important components of the underlying disease pathology...
  7. ncbi A simple non-invasive method to measure the cough reflex in dogs
    R W Chapman
    Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Pharmacol Toxicol Methods 46:21-6. 2001
    ..This study describes a method to measure the cough reflex in dogs that is simple to perform, requires no surgical intervention and can be used to profile efficacy and side-effect liabilities of antitussive drugs...
  8. doi Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration
    Richard W Chapman
    Department of Bone, Respiratory, Immunology and Dermatology, Merck Research Laboratories, Kenilworth, New Jersey 07033, USA
    Eur J Pharmacol 643:274-81. 2010
    ..These results identify COMPOUND 1 as a potent and selective inhibitor of PDE4 with properties suitable for delivery by inhalation...
  9. doi Effect of mometasone furoate (MF)/formoterol fumarate (F) combination (MF/F) on late-phase responses in allergen-challenged Brown Norway rats
    Richard W Chapman
    Department of Bone, Respiratory, Immunology and Dermatology, Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033 0539, USA
    Pulm Pharmacol Ther 24:67-73. 2011
    ....
  10. ncbi Differential effects of dexamethasone on the proximal and distal lung response to antigen challenge in allergic cynomolgus monkeys
    Aidan K Curran
    Schering Plough Research Institute, Kenilworth, New Jersey, USA
    J Asthma 45:377-81. 2008
    ..These data may help to provide a mechanism for evaluation of novel therapies for small airway dysfunction...
  11. ncbi Temporal profile of forced expiratory lung function in allergen-challenged Brown-Norway rats
    Chander S Celly
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 540:147-54. 2006
    ....
  12. ncbi Cough reflex in allergic dogs
    Aileen House
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 492:251-8. 2004
    ..In conclusion, both antigen and histamine bronchoprovocation changed the characteristics of the mechanically induced cough in dogs to a response of increased cough number but reduced mean expiratory cough amplitude...
  13. ncbi Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist
    Pauline C Ting
    The Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 12:2125-8. 2002
    ..Compound 10R is a potent dual NK(1)/NK(2) antagonist and demonstrates excellent in vivo activity and good oral plasma levels in the dog...
  14. ncbi An enzyme-linked immunosorbent assay (ELISA) for the determination of mucin levels in bronchoalveolar lavage fluid
    Jonathan E Phillips
    Pulmonary and Peripheral Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road M S 1700, Kenilworth, NJ 07033, USA
    J Pharmacol Toxicol Methods 53:160-7. 2006
    ..Mucins are the major macromolecular components of mucus. In the airways, mucus is the first line of defense against inhaled microorganisms (infection) and particulates (irritation)...
  15. ncbi Airway closure after antigen challenge in cynomolgus monkeys: effect of the histamine H1 receptor antagonist, chlorpheniramine maleate
    Susan Skeans
    Schering Plough Research Institute, Kenilworth, NJ 07033 0539, USA
    Int Arch Allergy Immunol 137:37-44. 2005
    ..In this study, an allergic cynomolgus monkey model was used to characterize the condition of airway closure and assess the contribution of histamine H1 receptors to this response...
  16. ncbi SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist
    John C Anthes
    Department of Allergy, Schering Plough Research Institute, K15 1 1600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 450:191-202. 2002
    ..This compound may have beneficial effects in diseases thought to be mediated by tachykinins, such as cough, asthma, and chronic obstructive pulmonary disease...
  17. ncbi Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor
    M Motasim Billah
    Schering Plough Research Institute, 2015 Galloping Hill Road, K15 1 1660 Kenilworth, NJ 07033, USA
    J Pharmacol Exp Ther 302:127-37. 2002
    ..Thus, SCH 351591 exhibits a promising preclinical profile as a treatment for asthma and COPD...
  18. ncbi Role of cholinergic reflexes on the bronchoconstrictor reactivity to neurokinin a in allergic dogs
    Aileen House
    Allergy, Schering Plough Research Institute, Kenilworth, NJ, USA
    Pulm Pharmacol Ther 15:169-73. 2002
    ..It is speculated that heightened activity of cholinergic reflexes contributes to the bronchial hyperresponsiveness seen in allergic dogs...
  19. ncbi Development and potential utility of dual and triple NK receptor antagonists
    Charles A Rizzo
    Allergy, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033 USA
    Curr Top Med Chem 3:1410-22. 2003
    ..Whether such agents will fulfill researchers' expectations must await further clinical trials...
  20. doi Role of α2-adrenoceptors in electrical field stimulation-induced contraction of pig nasal mucosa and pharmacologic characterization of a novel α2C-adrenoceptor agonist
    Michel R Corboz
    In vivo Pharmacology Department, Merck Research Laboratory, Kenilworth, New Jersey, USA
    Am J Rhinol Allergy 27:84-90. 2013
    ....
  21. pmc Three-dimensional analysis of rodent paranasal sinus cavities from X-ray computed tomography (CT) scans
    Jonathan E Phillips
    Pulmonary and Peripheral Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Can J Vet Res 73:205-11. 2009
    ..This represents a potentially useful endpoint for developing and testing drugs in a small animal model of sinusitis...
  22. doi Pharmacological characterization of the late phase reduction in lung functions and correlations with microvascular leakage and lung edema in allergen-challenged Brown Norway rats
    Peter J Mauser
    Merck Research Laboratories, 2015, Galloping Hill Road, Kenilworth, NJ 07033 0539, USA Electronic address
    Pulm Pharmacol Ther 26:677-84. 2013
    ....
  23. ncbi New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25
    Stephen D Hurst
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 169:443-53. 2002
    ..Further, these data demonstrate the heterogeneity of function within the IL-17 cytokine family and suggest that IL-25 may be an important mediator of allergic disease via production of IL-4, IL-5, IL-13, and eotaxin...