Scott W Altmann

Summary

Affiliation: Schering-Plough Research Institute
Country: USA

Publications

  1. ncbi Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis
    Harry R Davis
    Department of Cardiovascular Metabolic Disease and Department of Discovery Technologies, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 279:33586-92. 2004
  2. ncbi The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption
    Scott W Altmann
    Department of CNS and Cardiovascular Research, Schering Plough Research Institute, Kenilworth, NJ 07033 0539, USA
    Biochim Biophys Acta 1580:77-93. 2002
  3. ncbi Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    Scott W Altmann
    Department of Cardiovascular Endocrine Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033 0539, USA
    Science 303:1201-4. 2004
  4. ncbi Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice
    Harry R Davis
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, K15 2 2600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Arterioscler Thromb Vasc Biol 27:841-9. 2007
  5. ncbi In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs
    Brian E Hawes
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, Kenilworth, New Jersey, USA
    Mol Pharmacol 71:19-29. 2007
  6. doi Cholesterol homeostasis by the intestine: lessons from Niemann-Pick C1 Like 1 [NPC1L1)
    Harry R Davis
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, K15 2 2600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Atheroscler Suppl 9:77-81. 2008
  7. ncbi Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1 (NPC1L1) protein
    Sai Prasad N Iyer
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, 2015 Galloping Hill Rd, K15 3 3600, Kenilworth, NJ 07033, USA
    Biochim Biophys Acta 1722:282-92. 2005
  8. doi Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter
    Harry R Davis
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Biochim Biophys Acta 1791:679-83. 2009
  9. ncbi Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors
    Duane A Burnett
    Schering Plough Research Institute, 2015 Galloping Hill Road MS 2800, Kenilworth, NJ 07033 0539, USA
    Bioorg Med Chem Lett 12:315-8. 2002
  10. ncbi mRNA and 18S-RNA coapplication-reverse transcription for quantitative gene expression analysis
    Li ji Zhu
    Department of Cardiovascular Metabolic Disease Research, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Anal Biochem 345:102-9. 2005

Collaborators

Detail Information

Publications11

  1. ncbi Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis
    Harry R Davis
    Department of Cardiovascular Metabolic Disease and Department of Discovery Technologies, Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 279:33586-92. 2004
    ..NPC1L1 is required for intestinal uptake of both cholesterol and phytosterols and plays a major role in cholesterol homeostasis. Thus, NPC1L1 may be a useful drug target for the treatment of hypercholesterolemia and sitosterolemia...
  2. ncbi The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption
    Scott W Altmann
    Department of CNS and Cardiovascular Research, Schering Plough Research Institute, Kenilworth, NJ 07033 0539, USA
    Biochim Biophys Acta 1580:77-93. 2002
    ..In contrast studies with SR-B1 knockout mice suggest that SR-B1 is not essential for intestinal cholesterol absorption or the activity of ezetimibe...
  3. ncbi Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    Scott W Altmann
    Department of Cardiovascular Endocrine Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033 0539, USA
    Science 303:1201-4. 2004
    ..Ezetimibe, a drug that inhibits cholesterol absorption, had no effect in NPC1L1 knockout mice, suggesting that NPC1L1 resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption...
  4. ncbi Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice
    Harry R Davis
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, K15 2 2600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Arterioscler Thromb Vasc Biol 27:841-9. 2007
    ..The objective of this study was to determine whether the deficiency of Niemann-Pick C1 Like 1 (Npc1l1) prevents atherosclerosis in apoE null mice...
  5. ncbi In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs
    Brian E Hawes
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, Kenilworth, New Jersey, USA
    Mol Pharmacol 71:19-29. 2007
    ..The results demonstrate that the ability of compounds to bind to NPC1L1 is the major determinant of in vivo responsiveness...
  6. doi Cholesterol homeostasis by the intestine: lessons from Niemann-Pick C1 Like 1 [NPC1L1)
    Harry R Davis
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, K15 2 2600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Atheroscler Suppl 9:77-81. 2008
    ..Therefore, NPC1L1 is the critical intestinal sterol transporter which influences whole body cholesterol homeostasis, and is the molecular target of ezetimibe...
  7. ncbi Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1 (NPC1L1) protein
    Sai Prasad N Iyer
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, 2015 Galloping Hill Rd, K15 3 3600, Kenilworth, NJ 07033, USA
    Biochim Biophys Acta 1722:282-92. 2005
    ..These biochemical data indicate that NPC1L1 exists as a predominantly cell surface membrane expressed protein, consistent with its proposed role as the putative intestinal sterol transporter...
  8. doi Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter
    Harry R Davis
    Department of Cardiovascular Metabolic Disease, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Biochim Biophys Acta 1791:679-83. 2009
    ..Therefore, NPC1L1 is a critical intestinal sterol uptake transporter which influences whole body cholesterol homeostasis...
  9. ncbi Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors
    Duane A Burnett
    Schering Plough Research Institute, 2015 Galloping Hill Road MS 2800, Kenilworth, NJ 07033 0539, USA
    Bioorg Med Chem Lett 12:315-8. 2002
    ..Biological testing reveals that they are potent CAIs and are suitable tools for the investigation of the azetidinone CAI mechanism of action (MOA)...
  10. ncbi mRNA and 18S-RNA coapplication-reverse transcription for quantitative gene expression analysis
    Li ji Zhu
    Department of Cardiovascular Metabolic Disease Research, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Anal Biochem 345:102-9. 2005
    ..Co-RT provides increased sensitivity and higher accuracy than do the standard random primed RT methods...
  11. pmc The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
    Margarita Garcia-Calvo
    Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 102:8132-7. 2005
    ..These results unequivocally establish NPC1L1 as the direct target of ezetimibe and should facilitate efforts to identify the molecular mechanism of cholesterol transport...