Thomas B Kepler

Summary

Affiliation: Santa Fe Institute
Country: USA

Publications

  1. ncbi request reprint Improved inference of mutation rates: I. An integral representation for the Luria-Delbrück distribution
    T B Kepler
    Biomathematics Graduate Program, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 8203, USA
    Theor Popul Biol 59:41-8. 2001
  2. pmc Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations
    T B Kepler
    Santa Fe Institute, Santa Fe, New Mexico 87501, USA
    Biophys J 81:3116-36. 2001
  3. pmc Normalization and analysis of DNA microarray data by self-consistency and local regression
    Thomas B Kepler
    Santa Fe Institute, Santa Fe, NM 87501, USA
    Genome Biol 3:RESEARCH0037. 2002
  4. ncbi request reprint Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells
    Kevin T Morgan
    Aventis Pharmaceuticals, Raleigh, North Carolina 27604, USA
    Toxicol Pathol 30:435-51. 2002
  5. pmc Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling
    Lindsay G Cowell
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 197:207-20. 2003
  6. ncbi request reprint Statistical analysis of antigen receptor spectratype data
    Thomas B Kepler
    Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA
    Bioinformatics 21:3394-400. 2005

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Improved inference of mutation rates: I. An integral representation for the Luria-Delbrück distribution
    T B Kepler
    Biomathematics Graduate Program, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 8203, USA
    Theor Popul Biol 59:41-8. 2001
    ....
  2. pmc Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations
    T B Kepler
    Santa Fe Institute, Santa Fe, New Mexico 87501, USA
    Biophys J 81:3116-36. 2001
    ..We find stochastic bistability where the deterministic equations predict monostability and vice-versa. We derive and solve equations for the mean waiting times for spontaneous transitions between quasistable states in these switches...
  3. pmc Normalization and analysis of DNA microarray data by self-consistency and local regression
    Thomas B Kepler
    Santa Fe Institute, Santa Fe, NM 87501, USA
    Genome Biol 3:RESEARCH0037. 2002
    ..We find that these assumptions are not generally met, and that these simple methods can be improved...
  4. ncbi request reprint Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cells
    Kevin T Morgan
    Aventis Pharmaceuticals, Raleigh, North Carolina 27604, USA
    Toxicol Pathol 30:435-51. 2002
    ..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
  5. pmc Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling
    Lindsay G Cowell
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 197:207-20. 2003
    ..In scans of mouse and human genomes, these models identify a highly conserved family of repetitive DNA as an unexpected source of frequent, cryptic RS that rearrange both in extrachromosomal substrates and in their genomic context...
  6. ncbi request reprint Statistical analysis of antigen receptor spectratype data
    Thomas B Kepler
    Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27708, USA
    Bioinformatics 21:3394-400. 2005
    ..The purpose of this paper is to describe the systematic derivation and application of statistical methods for the analysis of spectratype data...