Ralph Axel Müller

Summary

Affiliation: San Diego State University
Country: USA

Publications

  1. ncbi request reprint Functional MRI of motor sequence acquisition: effects of learning stage and performance
    Ralph Axel Müller
    Department of Psychology, San Diego State University, MC1863, 6363 Alvarado Ct 200, San Diego, CA 92120, USA
    Brain Res Cogn Brain Res 14:277-93. 2002
  2. pmc Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders
    Ralph Axel Müller
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, USA
    Cereb Cortex 21:2233-43. 2011
  3. pmc From loci to networks and back again: anomalies in the study of autism
    Ralph Axel Müller
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120 1863, USA
    Ann N Y Acad Sci 1145:300-15. 2008
  4. pmc The study of autism as a distributed disorder
    Ralph Axel Müller
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, California 92120 1863, USA
    Ment Retard Dev Disabil Res Rev 13:85-95. 2007
  5. ncbi request reprint Abnormal activity patterns in premotor cortex during sequence learning in autistic patients
    Ralph Axel Müller
    Department of Psychology, San Diego State University, San Diego, California, USA
    Biol Psychiatry 56:323-32. 2004
  6. ncbi request reprint Are nonlinguistic functions in "Broca's area" prerequisites for language acquisition? FMRI findings from an ontogenetic viewpoint
    Ralph Axel Müller
    Department of Psychology, San Diego State University, 6363 Alvarado Ct, 225 E, San Diego, CA 92120 1863, USA
    Brain Lang 89:329-36. 2004
  7. ncbi request reprint Abnormal variability and distribution of functional maps in autism: an FMRI study of visuomotor learning
    Ralph Axel Müller
    Department of Psychology, San Diego State University, Childrens Hospital Reserch Children, La Jolla, California 92120, USA
    Am J Psychiatry 160:1847-62. 2003
  8. ncbi request reprint Linguistic theory and neuroimaging evidence: an fMRI study of Broca's area in lexical semantics
    Ralph Axel Müller
    Department of Psychology, San Diego State University, MC 1863, San Diego, CA 92120, USA
    Neuropsychologia 41:1199-207. 2003
  9. pmc Reduced functional connectivity between V1 and inferior frontal cortex associated with visuomotor performance in autism
    Michele E Villalobos
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, USA
    Neuroimage 25:916-25. 2005
  10. ncbi request reprint Partially enhanced thalamocortical functional connectivity in autism
    Akiko Mizuno
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, CA 92120, USA
    Brain Res 1104:160-74. 2006

Research Grants

  1. Linking Local Activity and Functional Connectivity in Autism
    RALPH AXEL MUELLER; Fiscal Year: 2009
  2. Divergence and Variability of Language Maps in Autism
    RALPH AXEL MUELLER; Fiscal Year: 2006
  3. LANGUAGE AND MOTOR PLASTICITY: FMRI IN CHILDREN
    RALPH AXEL MUELLER; Fiscal Year: 2004
  4. Linking Local Activity and Functional Connectivity in Autism
    RALPH AXEL MUELLER; Fiscal Year: 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Functional MRI of motor sequence acquisition: effects of learning stage and performance
    Ralph Axel Müller
    Department of Psychology, San Diego State University, MC1863, 6363 Alvarado Ct 200, San Diego, CA 92120, USA
    Brain Res Cogn Brain Res 14:277-93. 2002
    ....
  2. pmc Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders
    Ralph Axel Müller
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, USA
    Cereb Cortex 21:2233-43. 2011
    ..g., synaptic pruning). Both GU and NGU findings reflect important aspects of network dysfunction associated with sociocommunicative, cognitive, and sensorimotor impairments in ASD...
  3. pmc From loci to networks and back again: anomalies in the study of autism
    Ralph Axel Müller
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120 1863, USA
    Ann N Y Acad Sci 1145:300-15. 2008
    ..Here this approach is illustrated via data obtained from autism research that suggest impaired local cortical architecture and reduced long-range connectivity between cerebral regions...
  4. pmc The study of autism as a distributed disorder
    Ralph Axel Müller
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, California 92120 1863, USA
    Ment Retard Dev Disabil Res Rev 13:85-95. 2007
    ..The concepts and methodology of functional connectivity need to be refined and results need to be corroborated by anatomical studies (such as DTI tractography) before definitive conclusions can be drawn...
  5. ncbi request reprint Abnormal activity patterns in premotor cortex during sequence learning in autistic patients
    Ralph Axel Müller
    Department of Psychology, San Diego State University, San Diego, California, USA
    Biol Psychiatry 56:323-32. 2004
    ..Studies in healthy adults suggest reduced premotor and increased prefrontal activity during advanced learning stages. We examined hemodynamic changes during visuomotor learning in autistic patients...
  6. ncbi request reprint Are nonlinguistic functions in "Broca's area" prerequisites for language acquisition? FMRI findings from an ontogenetic viewpoint
    Ralph Axel Müller
    Department of Psychology, San Diego State University, 6363 Alvarado Ct, 225 E, San Diego, CA 92120 1863, USA
    Brain Lang 89:329-36. 2004
    ..We propose that Broca's area involvement in lexical semantics and syntax emerges from these nonlinguistic functions, which are prerequisites for language acquisition...
  7. ncbi request reprint Abnormal variability and distribution of functional maps in autism: an FMRI study of visuomotor learning
    Ralph Axel Müller
    Department of Psychology, San Diego State University, Childrens Hospital Reserch Children, La Jolla, California 92120, USA
    Am J Psychiatry 160:1847-62. 2003
    ..The authors examined whether such abnormalities generalize to multimodal processing (visually driven motor sequence learning)...
  8. ncbi request reprint Linguistic theory and neuroimaging evidence: an fMRI study of Broca's area in lexical semantics
    Ralph Axel Müller
    Department of Psychology, San Diego State University, MC 1863, San Diego, CA 92120, USA
    Neuropsychologia 41:1199-207. 2003
    ..Findings of lexico-semantic as well as syntactic processing in the inferior frontal lobe may be accounted for in terms of working memory demands...
  9. pmc Reduced functional connectivity between V1 and inferior frontal cortex associated with visuomotor performance in autism
    Michele E Villalobos
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, USA
    Neuroimage 25:916-25. 2005
    ..More generally, our findings suggest that dorsal stream connectivity in autism may not be fully functional...
  10. ncbi request reprint Partially enhanced thalamocortical functional connectivity in autism
    Akiko Mizuno
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, CA 92120, USA
    Brain Res 1104:160-74. 2006
    ....
  11. ncbi request reprint Activity and functional connectivity of inferior frontal cortex associated with response conflict
    Nobuko Kemmotsu
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado Ct, 225 E, San Diego, CA 92120 1863, USA
    Brain Res Cogn Brain Res 24:335-42. 2005
    ..We conclude that bilateral inferior frontal cortex is involved in response suppression associated with interference in the counting Stroop task...
  12. pmc Effects of generation mode in fMRI adaptations of semantic fluency: paced production and overt speech
    Surina Basho
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120 1863, USA
    Neuropsychologia 45:1697-706. 2007
    ..However, response pacing is associated with additional non-linguistic effects related to response inhibition, motor preparation, and sustained attention...
  13. pmc Atypical [corrected] participation of visual cortex during word processing in autism: an fMRI study of semantic decision
    Michael S Gaffrey
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, USA
    Neuropsychologia 45:1672-84. 2007
    ....
  14. ncbi request reprint Eye movement and visual search: are there elementary abnormalities in autism?
    Laurie A Brenner
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado Ct 225E, MC1863, San Diego, CA, 92120, USA
    J Autism Dev Disord 37:1289-309. 2007
    ..Oculomotor abnormalities may play a role as a sensorimotor defect at the root of impairments in later developing functional systems, ultimately resulting in sociocommunicative deficits...
  15. doi request reprint Atypical lexicosemantic function of extrastriate cortex in autism spectrum disorder: evidence from functional and effective connectivity
    Mark D Shen
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, USA
    Neuroimage 62:1780-91. 2012
    ..Furthermore, our findings are inconsistent with previous reports of functional underconnectivity in ASD, probably related to removal of task effects required to isolate intrinsic low-frequency fluctuations...
  16. pmc Functional differentiation of posterior superior temporal sulcus in autism: a functional connectivity magnetic resonance imaging study
    Patricia Shih
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado Ct, SanDiego, CA 92120, USA
    Biol Psychiatry 70:270-7. 2011
    ..Abnormal development of posterior superior temporal sulcus (pSTS)--a key processing area for language, biological motion, and social context--could play a role in these deficits...
  17. pmc Brief report: eye-movement patterns during an embedded figures test in children with ASD
    Brandon Keehn
    San Diego State University, San Diego, San Diego, CA, USA
    J Autism Dev Disord 39:383-7. 2009
    ..Eye-movement results indicate that RT advantage in ASD is related to both WCC and enhanced perceptual functioning...
  18. pmc Atypical network connectivity for imitation in autism spectrum disorder
    Patricia Shih
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, United States
    Neuropsychologia 48:2931-9. 2010
    ..Our results suggest atypical connectivity of the imitation network with an enhanced role of dPFC, which may relate to behavioral impairments...
  19. doi request reprint Functional brain organization for visual search in ASD
    Brandon Keehn
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, California, USA
    J Int Neuropsychol Soc 14:990-1003. 2008
    ..These results suggest that search efficiency in ASD may be related to enhanced discrimination (reflected in occipital activation) and increased top-down modulation of visual attention (associated with frontoparietal activation)...
  20. pmc Attentional networks in children and adolescents with autism spectrum disorder
    Brandon Keehn
    Joint Doctoral Program in Language and Communicative Disorders, San Diego State University University of California San Diego, 6363 Alvarado Ct 225N, San Diego, CA 92120, USA
    J Child Psychol Psychiatry 51:1251-9. 2010
    ..The ubiquitous nature of attentional impairments in ASD has led some authors to hypothesize that atypical attentional modulation may be a factor in the development of higher-level sociocommunicative deficits...
  21. pmc Impaired thalamocortical connectivity in autism spectrum disorder: a study of functional and anatomical connectivity
    Aarti Nair
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, USA
    Brain 136:1942-55. 2013
    ....
  22. pmc An fMRI study of sentence-embedded lexical-semantic decision in children and adults
    Erin Nicole Moore-Parks
    Department of Psychology, San Diego State University, California, United States
    Brain Lang 114:90-100. 2010
    ..Unlike previous studies, age-dependent differences were not detected in posterior sensory cortices (such as extrastriate cortex), nor in middle temporal gyrus...
  23. pmc White matter compromise of callosal and subcortical fiber tracts in children with autism spectrum disorder: a diffusion tensor imaging study
    Dinesh K Shukla
    Brain Development Imaging Laboratory, San Diego State University, San Diego, USA
    J Am Acad Child Adolesc Psychiatry 49:1269-78, 1278.e1-2. 2010
    ..We used diffusion tensor imaging (DTI) to examine white matter integrity for the whole brain and for corpus callosum, internal capsule, and middle cerebellar peduncle in children with ASD and typically developing (TD) children...
  24. pmc Microstructural abnormalities of short-distance white matter tracts in autism spectrum disorder
    Dinesh K Shukla
    Department of Psychology, San Diego State University, San Diego, CA, USA
    Neuropsychologia 49:1378-82. 2011
    ..Absence of typical age-related correlations with DTI indices may reflect altered maturation of short-distance tracts in ASD. Our results are inconsistent with a notion of selective sparing of short-distance connectivity in ASD...
  25. pmc Regional homogeneity of fMRI time series in autism spectrum disorders
    Dinesh K Shukla
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, United States
    Neurosci Lett 476:46-51. 2010
    ..Our findings suggest that ReHo is a sensitive measure for detecting cortical abnormalities in autism. However, impact of methodological factors (such as spatial resolution) on ReHo require further investigation...
  26. pmc Aberrant functional connectivity in autism: evidence from low-frequency BOLD signal fluctuations
    Sarah K Noonan
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA 92120 1863, USA
    Brain Res 1262:48-63. 2009
    ..Taking into consideration methodological factors that might influence measured fcMRI effects, we suggest that ASD is associated with an inefficiency in optimizing network connections to achieve task performance...
  27. doi request reprint Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder
    Dinesh K Shukla
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, USA
    J Child Psychol Psychiatry 52:286-95. 2011
    ....
  28. pmc Category-specific activations during word generation reflect experiential sensorimotor modalities
    Kai Hwang
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, USA
    Neuroimage 48:717-25. 2009
    ....

Research Grants13

  1. Linking Local Activity and Functional Connectivity in Autism
    RALPH AXEL MUELLER; Fiscal Year: 2009
    ....
  2. Divergence and Variability of Language Maps in Autism
    RALPH AXEL MUELLER; Fiscal Year: 2006
    ..Identifying such links between brain maps and level of functioning achieved in adults will elucidate the significance of individual variation in autism in terms of different pathways of etiology and abnormal development. ..
  3. LANGUAGE AND MOTOR PLASTICITY: FMRI IN CHILDREN
    RALPH AXEL MUELLER; Fiscal Year: 2004
    ..Findings are expected to contribute to the understanding of compensatory plasticity in development. ..
  4. Linking Local Activity and Functional Connectivity in Autism
    RALPH AXEL MUELLER; Fiscal Year: 2010
    ....