Research Topics
| John M LuceSummaryAffiliation: San Francisco General Hospital Country: USA Publications
| Collaborators
|
Detail Information
Publications
The pressure to withhold or withdraw life-sustaining therapy from critically ill patients in the United StatesJohn M Luce
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, 1001 Potrero Avenue, Room 5 K1, San Francisco, CA 94110, USA
Am J Respir Crit Care Med 175:1104-8. 2007..The pressure also may damage communications and cause resentment. If communications cannot be improved, and if the pressure cannot be relieved, a due process approach to conflict resolution that involves other parties may be required...- A history of ethics and law in the intensive care unitJohn M Luce
Department of Medicine, University of California, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Crit Care Clin 25:221-37, x. 2009..Advancement of the ethical principle of respect for patient autonomy in ICUs increasingly is in conflict with physicians' concern about their own prerogatives and with the just distribution of medical resources... 
Research ethics and consent in the intensive care unitJohn M Luce
Medical and Surgical Intensive Care Units, San Francisco General Hospital, University of California, San Francisco, California 94110, USA
Curr Opin Crit Care 9:540-4. 2003..The subject of research ethics and informed consent in the ICU has recently received unprecedented attention during the past year, the reasons for which are reviewed herein...
Medical malpractice and the chest physicianJohn M Luce
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
Chest 134:1044-50. 2008..And by stressing individual accountability, it conflicts with a systems-oriented approach to reducing medical errors...- Informed consent for clinical research involving patients with chest disease in the United StatesJohn M Luce
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Chest 135:1061-8. 2009..Consent can be deferred or waived for emergency research only rarely in the United States, in contrast to other countries... - Hope, truth, and preparing for death: perspectives of surrogate decision makersLatifat Apatira
University of California, San Francisco, and San Francisco General Hospital, San Francisco, California 94143, USA
Ann Intern Med 149:861-8. 2008..Although many physicians worry that openly discussing a poor prognosis will cause patients and families to lose hope, surrogate decision makers' perspectives on this topic are largely unknown... - A history of resolving conflicts over end-of-life care in intensive care units in the United StatesJohn M Luce
Department of Medicine and Anesthesia, University of California, San Francisco, and San Francisco General Hospital, San Francisco, CA, USA
Crit Care Med 38:1623-9. 2010..To present a case of conflict over end-of-life care in the intensive care unit (ICU) and to describe how such conflicts have been resolved in the United States since the inception of ICUs... - Life support for patients without a surrogate decision maker: who decides?Douglas B White
University of California, San Francisco, and San Francisco General Hospital, San Francisco, California 94143 0903, USA
Ann Intern Med 147:34-40. 2007..Physicians in intensive care units have withdrawn life support in incapacitated patients who lack surrogate decision makers and advance directives, yet little is known about how often this occurs or under what circumstances... - End-of-life decision making in the intensive care unitJohn M Luce
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, 1001 Potrero Avenue, Room 5K1, San Francisco, CA 94110, USA
Am J Respir Crit Care Med 182:6-11. 2010..Ethics committees actually are allowed to make such decisions in one state when disagreements cannot be resolved otherwise... - Decisions to limit life-sustaining treatment for critically ill patients who lack both decision-making capacity and surrogate decision-makersDouglas B White
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA
Crit Care Med 34:2053-9. 2006..Decisions to limit life support were generally made by physicians without judicial or institutional review. Further research and debate are needed to develop optimal decision-making strategies for these difficult cases... - Are physicians' recommendations to limit life support beneficial or burdensome? Bringing empirical data to the debateDouglas B White
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
Am J Respir Crit Care Med 180:320-5. 2009..Although there is a growing belief that physicians should routinely provide a recommendation to surrogates during deliberations about withdrawing life support, there is a paucity of empirical data on surrogates' perspectives on this topic... - Surrogate decision-makers' perspectives on discussing prognosis in the face of uncertaintyLeah R Evans
Division of Pulmonary and Critical Care Medicine, University of California School of Medicine, San Francisco, California 94143 0903, USA
Am J Respir Crit Care Med 179:48-53. 2009..Many physicians are reluctant to discuss a patient's prognosis when there is significant prognostic uncertainty... - Doubt and belief in physicians' ability to prognosticate during critical illness: the perspective of surrogate decision makersLucas S Zier
UC Berkeley UC San Francisco Joint Medical Program, School of Public Health, University of California, Berkeley, CA, USA
Crit Care Med 36:2341-7. 2008..We sought to determine: 1) surrogates' beliefs about whether physicians can accurately prognosticate for critically ill patients; and 2) how individuals use prognostic information in their role as surrogate decision-makers... - Palliative care in the intensive care unit: barriers, advances, and unmet needsDouglas B White
Division of Pulmonary and Critical Care Medicine and Program in Medical Ethics, University of California, 521 Parnassus Avenue, Suite C 126, San Francisco, CA 94143 0903, USA
Crit Care Clin 20:329-43, vii. 2004..As ongoing research efforts yield new insights, our ability to practice evidence-based palliative care in the ICU will grow, and new avenues for improvement will become evident... - Who should receive life support during a public health emergency? Using ethical principles to improve allocation decisionsDouglas B White
Program in Medical Ethics, School of Medicine, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0903, USA
Ann Intern Med 150:132-8. 2009..We discuss strategies to engage the public in setting the priorities that will guide allocation of scarce life-sustaining treatments during a public health emergency... - Is the concept of informed consent applicable to clinical research involving critically ill patients?John M Luce
San Francisco General Hospital, CA, USA
Crit Care Med 31:S153-60. 2003..Stronger research oversight may be as important as informed consent in protecting patient welfare... - Can health care costs be reduced by limiting intensive care at the end of life?John M Luce
Department of Medicine, University of California, San Francisco, San Francisco, California, USA
Am J Respir Crit Care Med 165:750-4. 2002 - Clinical implementation of the ARDS network protocol is associated with reduced hospital mortality compared with historical controlsRichard H Kallet
Department of Anesthesia, University of California, San Francisco at San Francisco General Hospital, California, USA
Crit Care Med 33:925-9. 2005..CONCLUSION: Adoption of the ARDS Network protocol for routine ventilator management of acute lung injury/acute respiratory distress syndrome patients was associated with a lower mortality compared with recent historical controls... - Protecting subjects with decisional impairment in research: the need for a multifaceted approachHenry J Silverman
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Am J Respir Crit Care Med 169:10-4. 2004 - Intrinsic positive end-expiratory pressure in Acute Respiratory Distress Syndrome (ARDS) Network subjectsCatherine Lee Hough
Division of Pulmonary and Critical Care Medicine, Department of Medicine at the University of Washington, Seattle, WA, USA
Crit Care Med 33:527-32. 2005..It is unlikely that the difference in intrinsic PEEP between the study groups was clinically important in the ARDS Network study of low tidal volume ventilation... - Corticosteroids in ARDS. An evidence-based reviewJohn M Luce
Department of Medicine and Anesthesia, University of California, Medical Surgical Intensive Care Unit, San Francisco General Hospital, San Francisco, California, USA
Crit Care Clin 18:79-89, vii. 2002.... - Three patients who asked that life support be withheld or withdrawn in the surgical intensive care unitJohn M Luce
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, USA
Crit Care Med 30:775-80. 2002..CONCLUSIONS: Patients' wishes change and are difficult to know, and even when they are known, physicians may have difficulty honoring them. Nevertheless, patient autonomy should be respected whenever possible in the intensive care unit... - Intensive care of human immunodeficiency virus-infected patients during the era of highly active antiretroviral therapyAlison Morris
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
Am J Respir Crit Care Med 166:262-7. 2002..These patients may have an improved survival because of effects of therapy on variables such as likelihood of non-AIDS-associated admission diagnoses and serum albumin levels... - Update in critical careJohn M Luce
University of California, San Francisco, and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, California 94110, USA
Ann Intern Med 139:748-52. 2003 - Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injuryCarolyn S Calfee
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143 0111, USA
Intensive Care Med 35:248-57. 2009.... - Detection of patient-ventilator asynchrony during low tidal volume ventilation, using ventilator waveform graphicsRichard H Kallet
National Heart, Lung, and Blood Institute's ARDS Network, University of California, San Francisco General Hospital, 94110, USA
Respir Care 47:183-5. 2002 - Quality indicators for end-of-life care in the intensive care unitEllen B Clarke
Center for Applied Ethics and Professional Practice, University of Washington, Seattle, USA
Crit Care Med 31:2255-62. 2003..Once validated, these indicators might be used to improve the quality of EOLC by serving as the components of an internal or external audit evaluating EOLC continuous quality improvement efforts in intensive care unit settings... - A content analysis of forms, guidelines, and other materials documenting end-of-life care in intensive care unitsEllen B Clarke
Department of Critical Care Medicine, Brown University, Rhode Island Hospital, Providence, RI, USA
J Crit Care 19:108-17. 2004..A second purpose was to determine how these materials might be modified to include more EOLC content and used to trigger clinical behaviors that might improve the quality of EOLC... - The ethical conduct of clinical research involving critically ill patients in the United States and Canada: principles and recommendationsJohn M Luce
Am J Respir Crit Care Med 170:1375-84. 2004 - Development of an e-mail database of US intensive care physiciansScott D Halpern
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Crit Care 22:28-31. 2007..We sought to develop an e-mail database for all intensivists associated with US training programs in critical care medicine (academic intensivists) and to determine the feasibility of using this database to survey intensivists... - Ethics consultation in the intensive care unitDouglas B White
JAMA 290:3191; author reply 3191-2. 2003 - Rationing critical care beds: a systematic reviewTasnim Sinuff
Crit Care Med 32:1588-97. 2004..Critical care bed rationing requires further investigation... - Rationing in the intensive care unitRobert D Truog
Professor of Medical Ethics and Anesthesia (Pediatrics, Harvard Medical School, Senior Associate in Critical Care Medicine, Children's Hospital, Boston, MA, USA
Crit Care Med 34:958-63; quiz 971. 2006..Additional work is needed to elucidate how both empirical evidence and ethical analysis can further inform the rationing decisions that arise in the taxonomy described here... - Recommendations for informed consent forms for critical care clinical trialsHenry J Silverman
University of Maryland School of Medicine, Baltimore, MD, USA
Crit Care Med 33:867-82. 2005..Prospective evaluation is needed to determine whether our recommendations enhance the informed consent process... - International differences in end-of-life attitudes in the intensive care unit: results of a surveyArino Yaguchi
Department of Intensive Care Medicine, Erasme Hospital, Free University of Brussels, Brussels, Belgium
Arch Intern Med 165:1970-5. 2005..Substantial work remains if an international consensus on these issues is to be reached... - Reasons for nonenrollment in a clinical trial of acute lung injuryAndrea E Glassberg
The Permanente Medical Group, 39400 Paseo Padre Parkway, Fremont, CA 94538, USA
Chest 134:719-23. 2008..We examined the reasons for nonenrollment and the impact of the availability of a surrogate decision maker on critical care clinical trials enrollment... - The imperfect diagnosis of acute respiratory distress syndromeJohn M Luce
Crit Care Med 33:2419-20. 2005 - Recommendations for end-of-life care in the intensive care unit: a consensus statement by the American College [corrected] of Critical Care MedicineRobert D Truog
Harvard Medical School and Children s Hospital, Boston, MA, USA
Crit Care Med 36:953-63. 2008..S. perspective. They do not use an evidence grading system because most of the recommendations are based on ethical and legal principles that are not derived from empirically based evidence... - Nonconsented human immunodeficiency virus testing among critically ill patients: intensivists' practices and the influence of state lawsScott D Halpern
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 423 Guardian Dr, 711 Blockley Hall, Philadelphia, PA 19104 6021, USA
Arch Intern Med 167:2323-8. 2007..Human immunodeficiency virus (HIV) testing can improve care for many critically ill patients, but state laws and institutional policies may impede such testing when patients cannot provide consent... - Acknowledging our mistakesJohn M Luce
Crit Care Med 34:1575-6. 2006 - A legally sanctioned process for resolving conflicts about treatment considered medically inappropriateJohn M Luce
Crit Care Med 35:1419-20. 2007 - California's new law allowing surrogate consent for clinical research involving subjects with impaired decision-making capacityJohn M Luce
Intensive Care Med 29:1024-5. 2003