Asa B Gustafsson

Summary

Affiliation: San Diego State University
Country: USA

Publications

  1. ncbi request reprint Heart mitochondria: gates of life and death
    Asa B Gustafsson
    BioScience Center San Diego State University 5500 Campanile Drive San Diego, CA 92182 4650, USA
    Cardiovasc Res 77:334-43. 2008
  2. pmc Recycle or die: the role of autophagy in cardioprotection
    Asa B Gustafsson
    BioScience Center, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4650, USA
    J Mol Cell Cardiol 44:654-61. 2008
  3. pmc Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion
    Asa B Gustafsson
    BioScience Center, San Diego State University, San Diego, California 92182 4650, USA
    Autophagy 4:416-21. 2008
  4. pmc Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism
    Melissa N Quinsay
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0748, La Jolla, CA 92093 0748, USA
    J Mol Cell Cardiol 48:1146-56. 2010
  5. pmc Autophagy in ischemic heart disease
    Asa B Gustafsson
    BioScience Center, San Diego State University, San Diego, CA 92182 4650, USA
    Circ Res 104:150-8. 2009
  6. pmc Pim-1 kinase protects mitochondrial integrity in cardiomyocytes
    Gwynngelle A Borillo
    San Diego State Heart Institute, San Diego State University, San Diego, CA 92182, USA
    Circ Res 106:1265-74. 2010
  7. pmc Sca-1 knockout impairs myocardial and cardiac progenitor cell function
    Brandi Bailey
    SDSU Heart Institute, and Department of Biology, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182, USA
    Circ Res 111:750-60. 2012
  8. pmc Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes
    Youngil Lee
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0758, USA
    Am J Physiol Heart Circ Physiol 301:H1924-31. 2011
  9. pmc Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion
    Dieter A Kubli
    BioScience Center, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 4650, USA
    Am J Physiol Heart Circ Physiol 295:H2025-31. 2008
  10. pmc Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells
    Raquel S Carreira
    BioScience Center, San Diego State University, San Diego, CA, USA
    Autophagy 6:462-72. 2010

Research Grants

  1. Role of Bnip3 in Myocardial Ischemia/Reperfusion
    Asa Gustafsson; Fiscal Year: 2007

Collaborators

  • Roberta A Gottlieb
  • Mark A Sussman
  • Xiaoxue Zhang
  • CHRISTOPHER GLEMBOTSKI
  • Mathias H Konstandin
  • Jun Sun
  • Robert M Mentzer
  • Shigeki Miyamoto
  • Wen Yu
  • Steven Barlow
  • John W Adams
  • Mirko Voelkers
  • Michael T Crow
  • J D Molkentin
  • Youngil Lee
  • Dieter A Kubli
  • Chengqun Huang
  • Shabana Din
  • Melissa N Quinsay
  • Amabel M Orogo
  • Mirko Völkers
  • Brandi Bailey
  • Hwa Youn Lee
  • Robert L Thomas
  • Roberto Alvarez
  • Natalie A Gude
  • M R Sayen
  • Shivaji Rikka
  • Raquel S Carreira
  • Gwynngelle A Borillo
  • Smadar Yitzhaki
  • M Richard Sayen
  • Joan Heller Brown
  • Jason A Wall
  • Anne Hamacher-Brady
  • Susan E Logue
  • David J Granville
  • Randa Hilal-Dandan
  • Daniel P Kelly
  • Kaitlen Samse
  • Andrew S Kraft
  • Bevan Johnson
  • Jacqueline Emathinger
  • Haruhiro Toko
  • Lucy Ormachea
  • Andrea De La Torre
  • Brett Collins
  • Jenna Fransioli
  • Xiaoxue Zhan
  • Rita A Hanna
  • Daniele Avitabile
  • Natalie Gude
  • Michael McGregor
  • Silvia Truffa
  • Matt Mason
  • Kimberlee Fischer
  • Lucy Kim
  • Jennifer M Ramil
  • Christopher Cottage
  • Matthew S Glassy
  • Ross Whittaker
  • Mariam Ghochani
  • Patricia A Thistlethwaite
  • Pearl Quijada
  • Wayne Liu
  • John E Ycaza
  • Mimi Ly
  • Steve Briggs
  • Peter Belmont
  • Joshua J Martindale
  • Paul Oeller
  • Diem Tran
  • Jing Wei
  • Wenqiong J Chen
  • Nathan R Brady
  • Afshin Samali
  • Michael R Morissette
  • Babak Tashakkor
  • Christopher K Means
  • Cindy Takeuchi
  • Paul Wentworth
  • Laurence L Brunton
  • Mark Yeager

Detail Information

Publications33

  1. ncbi request reprint Heart mitochondria: gates of life and death
    Asa B Gustafsson
    BioScience Center San Diego State University 5500 Campanile Drive San Diego, CA 92182 4650, USA
    Cardiovasc Res 77:334-43. 2008
    ..In this review, we discuss the role of mitochondria in the control of cell death in cardiac myocytes...
  2. pmc Recycle or die: the role of autophagy in cardioprotection
    Asa B Gustafsson
    BioScience Center, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4650, USA
    J Mol Cell Cardiol 44:654-61. 2008
    ....
  3. pmc Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion
    Asa B Gustafsson
    BioScience Center, San Diego State University, San Diego, California 92182 4650, USA
    Autophagy 4:416-21. 2008
    ..Here, we review the evidence that autophagy can have both beneficial and detrimental roles in the myocardium, and discuss potential mechanisms by which autophagy provides protection in cells...
  4. pmc Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism
    Melissa N Quinsay
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0748, La Jolla, CA 92093 0748, USA
    J Mol Cell Cardiol 48:1146-56. 2010
    ..Thus, these studies suggest that Bnip3 mediates mitochondrial permeabilization by a novel mechanism that is different from other BH3-only proteins...
  5. pmc Autophagy in ischemic heart disease
    Asa B Gustafsson
    BioScience Center, San Diego State University, San Diego, CA 92182 4650, USA
    Circ Res 104:150-8. 2009
    ..In this review, we discuss the evidence for autophagy in the heart in response to ischemia and reperfusion, identify factors that regulate autophagy, and analyze the potential roles autophagy might play in cardiac cells...
  6. pmc Pim-1 kinase protects mitochondrial integrity in cardiomyocytes
    Gwynngelle A Borillo
    San Diego State Heart Institute, San Diego State University, San Diego, CA 92182, USA
    Circ Res 106:1265-74. 2010
    ..This study details antiapoptotic actions responsible for enhanced cell survival in cardiomyocytes with elevated Pim-1 activity...
  7. pmc Sca-1 knockout impairs myocardial and cardiac progenitor cell function
    Brandi Bailey
    SDSU Heart Institute, and Department of Biology, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182, USA
    Circ Res 111:750-60. 2012
    ..Cardiac progenitor cells are important for maintenance of myocardial structure and function, but molecular mechanisms governing these progenitor cells remain obscure and require elucidation to enhance regenerative therapeutic approaches...
  8. pmc Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes
    Youngil Lee
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0758, USA
    Am J Physiol Heart Circ Physiol 301:H1924-31. 2011
    ..Thus our data suggest that induction of autophagy in response to Bnip3 is a protective response activated by the cell that involves Drp1-mediated mitochondrial fission and recruitment of Parkin...
  9. pmc Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion
    Dieter A Kubli
    BioScience Center, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 4650, USA
    Am J Physiol Heart Circ Physiol 295:H2025-31. 2008
    ....
  10. pmc Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells
    Raquel S Carreira
    BioScience Center, San Diego State University, San Diego, CA, USA
    Autophagy 6:462-72. 2010
    ..Starvation-induced autophagy regulated by CypD and the MPT may represent a homeostatic mechanism for cellular and mitochondrial quality control...
  11. doi request reprint Role of apoptosis in cardiovascular disease
    Youngil Lee
    BioScience Center, San Diego State University, San Diego, CA 92182 4650, USA
    Apoptosis 14:536-48. 2009
    ..This review provides a current overview of the evidence of apoptosis in cardiovascular diseases and discusses the molecular pathways involved in cardiac myocyte apoptosis...
  12. pmc Mitochondrial turnover in the heart
    Roberta A Gottlieb
    BioScience Center, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4650, USA
    Biochim Biophys Acta 1813:1295-301. 2011
    ..This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
  13. pmc Mitochondria and mitophagy: the yin and yang of cell death control
    Dieter A Kubli
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Circ Res 111:1208-21. 2012
    ..Herein, we discuss the importance of mitochondria and mitophagy in cardiovascular health and disease and provide a review of our current understanding of how these processes are regulated...
  14. ncbi request reprint Bnip3-mediated defects in oxidative phosphorylation promote mitophagy
    Robert L Thomas
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA
    Autophagy 7:775-7. 2011
    ..Here, we discuss how Bnip3-mediated impairment of mitochondrial oxidative phosphorylation facilitates mitochondrial turnover via autophagy in the absence of permeabilization of the mitochondrial membrane and apoptosis...
  15. pmc Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA
    Smadar Yitzhaki
    BioScience Center, San Diego State University, San Diego, CA 92182 4650, USA
    Basic Res Cardiol 104:157-67. 2009
    ..Taken together, these results indicate that autophagy plays an important role in mediating the cardioprotective effects conferred by adenosine pretreatment...
  16. pmc Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardium
    Asa B Gustafsson
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0758, La Jolla, CA 92093 0758, USA
    Pediatr Cardiol 32:267-74. 2011
    ..Recent studies suggest that Bnip3 might have a dual function in the myocardium, where it regulates both mitochondrial turnover via autophagy and cell death and that these are two separate processes activated by Bnip3...
  17. pmc Cell death in the myocardium: my heart won't go on
    Amabel M Orogo
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    IUBMB Life 65:651-6. 2013
    ..This review focuses on the various modes of cell death in the myocardium and highlights how they contribute to loss of myocytes in response to stress...
  18. pmc Regulation of autophagy by metabolic and stress signaling pathways in the heart
    Youngil Lee
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0758, La Jolla, CA 92093 0758, USA
    J Cardiovasc Pharmacol 60:118-24. 2012
    ..In this review, we will discuss how this diverse cast of characters regulates the important autophagic process in the myocardium...
  19. pmc Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice
    Chengqun Huang
    San Diego State University, BioScience Center and Department of Biology, CA, USA
    Circulation 121:675-83. 2010
    ..To date, very little is known about the mechanism of this late-onset cardiotoxicity...
  20. ncbi request reprint Metabolic dysfunction consistent with premature aging results from deletion of pim kinases
    Shabana Din
    From the Department of Biology, San Diego State Heart Institute, San Diego State University, CA S D, M H K, B J, J E, M V, H T, B C, L O, K S, A D L T, M A S Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla D A K, A B G and Department of Medicine, Medical University of South Carolina Hollings Cancer Center, Charleston A S K, and Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL D P K
    Circ Res 115:376-87. 2014
    ..Study of the pathological effects resulting from genetic deletion of all Pim kinase family members could provide important insight about cardiac mitochondrial biology and the aging phenotype...
  21. ncbi request reprint Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6
    Jason A Wall
    SDSU Heart Institute and the Dept of Biology, San Diego State Univ, San Diego, CA 92182, USA
    Am J Physiol Heart Circ Physiol 291:H2462-72. 2006
    ....
  22. ncbi request reprint Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho
    Randa Hilal-Dandan
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    J Mol Cell Cardiol 36:481-93. 2004
    ....
  23. ncbi request reprint Mechanisms of apoptosis in the heart
    Asa B Gustafsson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Immunol 23:447-59. 2003
    ..This review is focused on the basic cellular mechanisms of apoptosis, as well as our current understanding of this process in the heart...
  24. ncbi request reprint Bcl-2 family members and apoptosis, taken to heart
    Asa B Gustafsson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Am J Physiol Cell Physiol 292:C45-51. 2007
    ..This review summarizes the current understanding of the role of Bcl-2 proteins in the heart...
  25. ncbi request reprint TAT-mediated protein transduction: delivering biologically active proteins to the heart
    Asa B Gustafsson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Methods Mol Med 112:81-90. 2005
    ..The present chapter outlines the methodology pertaining to the preparation of TAT-fusion proteins and how to efficiently transduce these proteins into cultured cells or isolated rat hearts perfused in Langendorff mode...
  26. ncbi request reprint Ischemia/reperfusion injury at the intersection with cell death
    Susan E Logue
    National University of Ireland, Galway, Ireland
    J Mol Cell Cardiol 38:21-33. 2005
    ..The intersection of ischemic preconditioning and cell death can provide illumination to both signal transduction pathways...
  27. ncbi request reprint Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production
    M R Sayen
    The Scripps Research Institute, La Jolla, California 92037, USA
    Am J Physiol Cell Physiol 284:C562-70. 2003
    ..Taken together, these data indicate that calcineurin signaling affects mitochondrial energetics and superoxide production. The excessive production of superoxide may contribute to the development of cardiac failure...
  28. ncbi request reprint Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation
    Asa B Gustafsson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 279:21233-8. 2004
    ..This suggests that ARC can protect against cell death by interfering with activation of the mitochondrial death pathway through the interaction with Bax, preventing mitochondrial dysfunction and release of pro-apoptotic factors...
  29. pmc Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors
    David J Granville
    Departments of Molecular and Experimental Medicine, Cell Biology, Chemistry, and Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:1321-6. 2004
    ..We also showed that chloramphenicol reduced infarct size in an open chest rabbit model of regional ischemia. Taken together, these findings implicate CYPs in myocardial ischemia/reperfusion injury...
  30. ncbi request reprint TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective
    Asa B Gustafsson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif 92037, USA
    Circulation 106:735-9. 2002
    ..Linkage of the 11-amino-acid transduction domain of HIV TAT to a heterologous protein allows the protein to be transduced readily into cells...
  31. ncbi request reprint Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heart
    Anne Hamacher-Brady
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Autophagy 2:307-9. 2006
    ..Here we present additional evidence that enhanced autophagic activity functions as a cytoprotective pathway to oppose ischemia/reperfusion-related apoptosis...
  32. pmc Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak
    Dieter A Kubli
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biochem J 405:407-15. 2007
    ..These results suggest that Bnip3 mediates mitochondrial dysfunction through activation of Bax or Bak which is independent of mPTP opening...
  33. ncbi request reprint Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2
    Asa B Gustafsson
    Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093, USA
    Am J Physiol Cell Physiol 283:C463-71. 2002
    ..Although NO reportedly acts by reducing AC activity in some cells, in cardiac fibroblasts NO production decreases cAMP accumulation largely by the cGMP-mediated activation of PDE2...

Research Grants1

  1. Role of Bnip3 in Myocardial Ischemia/Reperfusion
    Asa Gustafsson; Fiscal Year: 2007
    ..Further understanding of how BnipS functions in the heart has the potential to identify new therapeutic targets to treat or prevent heart disease. ..