Research Topics
Genomes and Genes | Asa B GustafssonSummaryAffiliation: San Diego State University Country: USA Publications
Research Grants
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Detail Information
Publications
Heart mitochondria: gates of life and deathAsa B Gustafsson
BioScience Center San Diego State University 5500 Campanile Drive San Diego, CA 92182 4650, USA
Cardiovasc Res 77:334-43. 2008..In this review, we discuss the role of mitochondria in the control of cell death in cardiac myocytes...
Recycle or die: the role of autophagy in cardioprotectionAsa B Gustafsson
BioScience Center, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4650, USA
J Mol Cell Cardiol 44:654-61. 2008....- Eat your heart out: Role of autophagy in myocardial ischemia/reperfusionAsa B Gustafsson
BioScience Center, San Diego State University, San Diego, California 92182 4650, USA
Autophagy 4:416-21. 2008..Here, we review the evidence that autophagy can have both beneficial and detrimental roles in the myocardium, and discuss potential mechanisms by which autophagy provides protection in cells... - Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanismMelissa N Quinsay
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0748, La Jolla, CA 92093 0748, USA
J Mol Cell Cardiol 48:1146-56. 2010..Thus, these studies suggest that Bnip3 mediates mitochondrial permeabilization by a novel mechanism that is different from other BH3-only proteins... - Pim-1 kinase protects mitochondrial integrity in cardiomyocytesGwynngelle A Borillo
San Diego State Heart Institute, San Diego State University, San Diego, CA 92182, USA
Circ Res 106:1265-74. 2010..This study details antiapoptotic actions responsible for enhanced cell survival in cardiomyocytes with elevated Pim-1 activity... - Autophagy in ischemic heart diseaseAsa B Gustafsson
BioScience Center, San Diego State University, San Diego, CA 92182 4650, USA
Circ Res 104:150-8. 2009..In this review, we discuss the evidence for autophagy in the heart in response to ischemia and reperfusion, identify factors that regulate autophagy, and analyze the potential roles autophagy might play in cardiac cells... - Sca-1 knockout impairs myocardial and cardiac progenitor cell functionBrandi Bailey
SDSU Heart Institute, and Department of Biology, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182, USA
Circ Res 111:750-60. 2012..Cardiac progenitor cells are important for maintenance of myocardial structure and function, but molecular mechanisms governing these progenitor cells remain obscure and require elucidation to enhance regenerative therapeutic approaches... - Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytesYoungil Lee
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093 0758, USA
Am J Physiol Heart Circ Physiol 301:H1924-31. 2011..Thus our data suggest that induction of autophagy in response to Bnip3 is a protective response activated by the cell that involves Drp1-mediated mitochondrial fission and recruitment of Parkin... - Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusionDieter A Kubli
BioScience Center, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 4650, USA
Am J Physiol Heart Circ Physiol 295:H2025-31. 2008.... - Mitochondrial turnover in the heartRoberta A Gottlieb
BioScience Center, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4650, USA
Biochim Biophys Acta 1813:1295-301. 2011..This article is part of a Special Issue entitled: Mitochondria and Cardioprotection... 
Role of apoptosis in cardiovascular diseaseYoungil Lee
BioScience Center, San Diego State University, San Diego, CA 92182 4650, USA
Apoptosis 14:536-48. 2009..This review provides a current overview of the evidence of apoptosis in cardiovascular diseases and discusses the molecular pathways involved in cardiac myocyte apoptosis...- Mitochondria and mitophagy: the yin and yang of cell death controlDieter A Kubli
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Circ Res 111:1208-21. 2012..Herein, we discuss the importance of mitochondria and mitophagy in cardiovascular health and disease and provide a review of our current understanding of how these processes are regulated... - Bnip3-mediated defects in oxidative phosphorylation promote mitophagyRobert L Thomas
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA
Autophagy 7:775-7. 2011..Here, we discuss how Bnip3-mediated impairment of mitochondrial oxidative phosphorylation facilitates mitochondrial turnover via autophagy in the absence of permeabilization of the mitochondrial membrane and apoptosis... - Bnip3 as a dual regulator of mitochondrial turnover and cell death in the myocardiumAsa B Gustafsson
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0758, La Jolla, CA 92093 0758, USA
Pediatr Cardiol 32:267-74. 2011..Recent studies suggest that Bnip3 might have a dual function in the myocardium, where it regulates both mitochondrial turnover via autophagy and cell death and that these are two separate processes activated by Bnip3... - Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPASmadar Yitzhaki
BioScience Center, San Diego State University, San Diego, CA 92182 4650, USA
Basic Res Cardiol 104:157-67. 2009..Taken together, these results indicate that autophagy plays an important role in mediating the cardioprotective effects conferred by adenosine pretreatment... - Regulation of autophagy by metabolic and stress signaling pathways in the heartYoungil Lee
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0758, La Jolla, CA 92093 0758, USA
J Cardiovasc Pharmacol 60:118-24. 2012..In this review, we will discuss how this diverse cast of characters regulates the important autophagic process in the myocardium... - Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult miceChengqun Huang
San Diego State University, BioScience Center and Department of Biology, CA, USA
Circulation 121:675-83. 2010..To date, very little is known about the mechanism of this late-onset cardiotoxicity... - Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cellsRaquel S Carreira
BioScience Center, San Diego State University, San Diego, CA, USA
Autophagy 6:462-72. 2010..Starvation-induced autophagy regulated by CypD and the MPT may represent a homeostatic mechanism for cellular and mitochondrial quality control... - Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6Jason A Wall
SDSU Heart Institute and the Dept of Biology, San Diego State Univ, San Diego, CA 92182, USA
Am J Physiol Heart Circ Physiol 291:H2462-72. 2006.... - Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and RhoRanda Hilal-Dandan
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
J Mol Cell Cardiol 36:481-93. 2004.... - Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitorsDavid J Granville
Departments of Molecular and Experimental Medicine, Cell Biology, Chemistry, and Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 101:1321-6. 2004..We also showed that chloramphenicol reduced infarct size in an open chest rabbit model of regional ischemia. Taken together, these findings implicate CYPs in myocardial ischemia/reperfusion injury... - Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activationAsa B Gustafsson
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
J Biol Chem 279:21233-8. 2004..This suggests that ARC can protect against cell death by interfering with activation of the mitochondrial death pathway through the interaction with Bax, preventing mitochondrial dysfunction and release of pro-apoptotic factors... - Mechanisms of apoptosis in the heartAsa B Gustafsson
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Clin Immunol 23:447-59. 2003..This review is focused on the basic cellular mechanisms of apoptosis, as well as our current understanding of this process in the heart... - Ischemia/reperfusion injury at the intersection with cell deathSusan E Logue
National University of Ireland, Galway, Ireland
J Mol Cell Cardiol 38:21-33. 2005..The intersection of ischemic preconditioning and cell death can provide illumination to both signal transduction pathways... - TAT-mediated protein transduction: delivering biologically active proteins to the heartAsa B Gustafsson
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
Methods Mol Med 112:81-90. 2005..The present chapter outlines the methodology pertaining to the preparation of TAT-fusion proteins and how to efficiently transduce these proteins into cultured cells or isolated rat hearts perfused in Langendorff mode... - Bcl-2 family members and apoptosis, taken to heartAsa B Gustafsson
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Am J Physiol Cell Physiol 292:C45-51. 2007..This review summarizes the current understanding of the role of Bcl-2 proteins in the heart... - Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide productionM R Sayen
The Scripps Research Institute, La Jolla, California 92037, USA
Am J Physiol Cell Physiol 284:C562-70. 2003..Taken together, these data indicate that calcineurin signaling affects mitochondrial energetics and superoxide production. The excessive production of superoxide may contribute to the development of cardiac failure... - TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotectiveAsa B Gustafsson
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif 92037, USA
Circulation 106:735-9. 2002..CONCLUSIONS: Our results demonstrate that TAT-linked fusion protein transduction into the myocardium is feasible and that transduction of TAT-ARC is protective in cell culture and in the perfused heart... - Bnip3 mediates mitochondrial dysfunction and cell death through Bax and BakDieter A Kubli
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Biochem J 405:407-15. 2007..These results suggest that Bnip3 mediates mitochondrial dysfunction through activation of Bax or Bak which is independent of mPTP opening... - Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heartAnne Hamacher-Brady
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Autophagy 2:307-9. 2006..Here we present additional evidence that enhanced autophagic activity functions as a cytoprotective pathway to oppose ischemia/reperfusion-related apoptosis... - Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2Asa B Gustafsson
Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, California 92093, USA
Am J Physiol Cell Physiol 283:C463-71. 2002..Although NO reportedly acts by reducing AC activity in some cells, in cardiac fibroblasts NO production decreases cAMP accumulation largely by the cGMP-mediated activation of PDE2...
Research Grants
- Role of Bnip3 in Myocardial Ischemia/ReperfusionAsa Gustafsson; Fiscal Year: 2007..Further understanding of how BnipS functions in the heart has the potential to identify new therapeutic targets to treat or prevent heart disease. ..