Roger A Davis

Summary

Affiliation: San Diego State University
Country: USA

Publications

  1. ncbi request reprint Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP
    Roger A Davis
    Cell and Molecular Biology Laboratory, Department of Biology, San Diego State University, San Diego, CA 92182, USA
    J Lipid Res 43:533-43. 2002
  2. ncbi request reprint Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia
    Eric P Ratliff
    Heart Institute, BioScience Center, San Diego State University, CA 92182, USA
    J Lipid Res 47:1513-20. 2006
  3. ncbi request reprint Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4
    Alejandra Gutierrez
    Department of Biology and Heart Institute, San Diego State University, San Diego, CA 92182, USA
    Arterioscler Thromb Vasc Biol 26:301-6. 2006
  4. ncbi request reprint Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis
    Nathanael J Spann
    Department of Biology, The Heart Institute, San Diego State University, California 92182 4614, USA
    J Biol Chem 281:33066-77. 2006
  5. pmc Txnip balances metabolic and growth signaling via PTEN disulfide reduction
    Simon T Y Hui
    Department of Biology, The Molecular Biology and Heart Institutes, The BioSciences Center, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA
    Proc Natl Acad Sci U S A 105:3921-6. 2008
  6. pmc Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice
    Gary Bradshaw
    Department of Biology and Heart Institute, San Diego State University, San Diego, CA 92182, USA
    Proc Natl Acad Sci U S A 102:11029-34. 2005
  7. ncbi request reprint ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1
    Sohye Kang
    Mammalian Cell and Molecular Biology Laboratory, Department of Biology, Molecular Biology Institute, San Diego State University, San Diego, California 92182 4614, USA
    J Biol Chem 278:30478-86. 2003
  8. pmc Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
    J Clin Invest 114:1564-76. 2004
  9. ncbi request reprint Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals
    To Yuen Hui
    Mammalian Cell and Molecular Biology Laboratory, Department of Biology, Molecular Biology Institute and Heart Institute, San Diego State University, San Diego, California 92182, USA
    J Biol Chem 279:24387-93. 2004
  10. ncbi request reprint Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER
    Wei Liao
    Mammalian Cell and Molecular Biology Laboratory, San Diego State University, San Diego, CA 92182 4614, USA
    J Lipid Res 44:978-85. 2003

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP
    Roger A Davis
    Cell and Molecular Biology Laboratory, Department of Biology, San Diego State University, San Diego, CA 92182, USA
    J Lipid Res 43:533-43. 2002
    ..These inflammatory cytokines, which include tumor necrosis factor alpha and interleukin-1beta, act upon liver parenchymal cells causing a rapid repression of the CYP7A1 gene...
  2. ncbi request reprint Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia
    Eric P Ratliff
    Heart Institute, BioScience Center, San Diego State University, CA 92182, USA
    J Lipid Res 47:1513-20. 2006
    ..The combined data show that enhanced expression of CYP7A1 is an effective means to prevent the accumulation of cholesterol in the liver and of atherogenic apolipoprotein B-containing lipoproteins in plasma...
  3. ncbi request reprint Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4
    Alejandra Gutierrez
    Department of Biology and Heart Institute, San Diego State University, San Diego, CA 92182, USA
    Arterioscler Thromb Vasc Biol 26:301-6. 2006
    ..The purpose of this research was to determine how dietary bile acids repress hepatic expression of paraoxonase 1 (PON1)...
  4. ncbi request reprint Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis
    Nathanael J Spann
    Department of Biology, The Heart Institute, San Diego State University, California 92182 4614, USA
    J Biol Chem 281:33066-77. 2006
    ..Our findings show that reducing both L-FABP and MTP is an effective means to reduce VLDL secretion without causing hepatic steatosis...
  5. pmc Txnip balances metabolic and growth signaling via PTEN disulfide reduction
    Simon T Y Hui
    Department of Biology, The Molecular Biology and Heart Institutes, The BioSciences Center, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA
    Proc Natl Acad Sci U S A 105:3921-6. 2008
    ..These findings indicate that, in nonlipogenic tissues, Txnip is required to maintain sufficient thioredoxin NADPH activity to reductively reactivate oxidized PTEN and oppose Akt downstream signaling...
  6. pmc Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice
    Gary Bradshaw
    Department of Biology and Heart Institute, San Diego State University, San Diego, CA 92182, USA
    Proc Natl Acad Sci U S A 102:11029-34. 2005
    ..GdCl(3)-facilated replacement of Kupffer cells may enhance the efficacy of other HSC-based gene therapies...
  7. ncbi request reprint ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1
    Sohye Kang
    Mammalian Cell and Molecular Biology Laboratory, Department of Biology, Molecular Biology Institute, San Diego State University, San Diego, California 92182 4614, USA
    J Biol Chem 278:30478-86. 2003
    ..This dual function of ARP-1/COUP-TFII may play an important role in determining the metabolic phenotype of individual liver cells...
  8. pmc Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
    J Clin Invest 114:1564-76. 2004
    ..In concert, these findings reveal receptor-specific mechanisms by which PPARs influence macrophage cholesterol homeostasis. In the future, these mechanisms may be exploited pharmacologically to inhibit the development of atherosclerosis...
  9. ncbi request reprint Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals
    To Yuen Hui
    Mammalian Cell and Molecular Biology Laboratory, Department of Biology, Molecular Biology Institute and Heart Institute, San Diego State University, San Diego, California 92182, USA
    J Biol Chem 279:24387-93. 2004
    ..Our findings implicate Txnip-modulated sulfhydryl redox as a central regulator of insulin secretion in beta-cells and regulation of many of the branch-points of gluconeogenesis/glycolysis/lipogenesis...
  10. ncbi request reprint Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER
    Wei Liao
    Mammalian Cell and Molecular Biology Laboratory, San Diego State University, San Diego, CA 92182 4614, USA
    J Lipid Res 44:978-85. 2003
    ..The rapid degradation of secretion-incompetent apoB in the ER may block the induction of proteins associated with unfolded protein and heat shock responses...
  11. ncbi request reprint Resolving the mechanism of bile acid negative-feedback regulation, a Journal of Lipid Research tradition
    Roger A Davis
    San Diego State University, CA, USA
    J Lipid Res 49:2-3. 2008
  12. ncbi request reprint Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J mice
    Jon H Miyake
    Mammalian Cell and Molecular Biology Laboratory, San Diego State University, San Diego, CA, USA
    Arterioscler Thromb Vasc Biol 22:121-6. 2002
    ..These data establish the integral role that cholesterol-7-alpha-hydroxylase has in maintaining hepatic cholesterol homeostasis and, thus, in the susceptibility to the formation of gallstones and atherosclerosis...
  13. ncbi request reprint Microsomal triglyceride transfer protein is essential for hepatic secretion of apoB-100 and apoB-48 but not triglyceride
    To Yuen Hui
    Cell and Molecular Biology Laboratory, Department of Biology, San Diego State University, San Diego, CA 92182, USA
    J Lipid Res 43:785-93. 2002
    ..Our findings support the concept that apoB and MTP co-evolved and provided a means to augment the secretion of triglyceride through the formation of lipoproteins containing large hydrophobic cores enriched with triglycerides...
  14. ncbi request reprint Expression of cholesterol-7alpha-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL
    Gina L Moore
    Mammalian Cell and Molecular Biology Laboratory, San Diego State University, San Diego, CA 92182 4614, USA
    J Lipid Res 43:629-35. 2002
    ..Thus, CYP7A1 expression in RAW cultured macrophages prevented the accumulation of cholesterol from acetyl-LDL via both increased metabolism and efflux of cholesterol...
  15. pmc Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate the bile acid pool
    Roger A Davis
    Department of Biology, Biosciences Center, San Diego State University, San Diego, CA 92182, USA
    Proc Natl Acad Sci U S A 105:4965-6. 2008