Frederick F Samaha

Summary

Country: USA

Publications

  1. ncbi request reprint Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome
    Frederick F Samaha
    Cardiovascular Division, Department of Medicine, Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 26:624-30. 2006
  2. ncbi request reprint Usefulness of the TIMI risk score in predicting both short- and long-term outcomes in the Veterans Affairs Non-Q-Wave Myocardial Infarction Strategies In-Hospital (VANQWISH) Trial
    Frederick F Samaha
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Cardiol 90:922-6. 2002
  3. ncbi request reprint Effect of very high-fat diets on body weight, lipoproteins, and glycemic status in the obese
    Frederick F Samaha
    Division of Cardiovascular Disease, Department of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Curr Atheroscler Rep 7:412-20. 2005
  4. ncbi request reprint A low-carbohydrate as compared with a low-fat diet in severe obesity
    Frederick F Samaha
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, Philadelphia, USA
    N Engl J Med 348:2074-81. 2003
  5. ncbi request reprint The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial
    Linda Stern
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, and Drexel University College of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 140:778-85. 2004
  6. ncbi request reprint Free fatty acids, insulin resistance, and corrected qt intervals in morbid obesity: effect of weight loss during 6 months with differing dietary interventions
    Prakash Seshadri
    Division of Endocrinology, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA
    Endocr Pract 11:234-9. 2005
  7. pmc Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study
    Catherine S Parker
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Gen Intern Med 22:1254-9. 2007
  8. ncbi request reprint Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome
    Philippe O Szapary
    Division of General Internal Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 26:182-8. 2006
  9. ncbi request reprint Low-carbohydrate diets, obesity, and metabolic risk factors for cardiovascular disease
    Frederick F Samaha
    University of Pennsylvania Medical Center, Philadelphia VA Medical Center, 3900 Woodland Avenue, 8th Floor Cardiology MC 111C, Philadelphia, PA 19104, USA
    Curr Atheroscler Rep 9:441-7. 2007
  10. ncbi request reprint Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity
    Carmel Kealey
    University of Pennsylvania, Department of Pharmacology and Center for Pharmacogenetics, School of Medicine, Philadelphia, PA, USA
    Pharmacogenomics 8:217-25. 2007

Research Grants

Detail Information

Publications24

  1. ncbi request reprint Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome
    Frederick F Samaha
    Cardiovascular Division, Department of Medicine, Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 26:624-30. 2006
    ..However, the full spectrum of potentially antiatherogenic mechanisms of PPAR-gamma agonists have not been fully tested in nondiabetic patients with metabolic syndrome...
  2. ncbi request reprint Usefulness of the TIMI risk score in predicting both short- and long-term outcomes in the Veterans Affairs Non-Q-Wave Myocardial Infarction Strategies In-Hospital (VANQWISH) Trial
    Frederick F Samaha
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Cardiol 90:922-6. 2002
    ..76). No significant difference in outcomes between strategies was detected for a score > or =3. The TIMI risk score provides moderate incremental prognostic information in high-risk patients, during both short- and long-term follow-up...
  3. ncbi request reprint Effect of very high-fat diets on body weight, lipoproteins, and glycemic status in the obese
    Frederick F Samaha
    Division of Cardiovascular Disease, Department of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Curr Atheroscler Rep 7:412-20. 2005
    ..Although current national guidelines modestly liberalize unsaturated fat consumption, important questions still remain about the optimal percentage of unsaturated fats in the diet...
  4. ncbi request reprint A low-carbohydrate as compared with a low-fat diet in severe obesity
    Frederick F Samaha
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, Philadelphia, USA
    N Engl J Med 348:2074-81. 2003
    ..The effects of a carbohydrate-restricted diet on weight loss and risk factors for atherosclerosis have been incompletely assessed...
  5. ncbi request reprint The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial
    Linda Stern
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, and Drexel University College of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 140:778-85. 2004
    ..A previous paper reported the 6-month comparison of weight loss and metabolic changes in obese adults randomly assigned to either a low-carbohydrate diet or a conventional weight loss diet...
  6. ncbi request reprint Free fatty acids, insulin resistance, and corrected qt intervals in morbid obesity: effect of weight loss during 6 months with differing dietary interventions
    Prakash Seshadri
    Division of Endocrinology, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA
    Endocr Pract 11:234-9. 2005
    ..To assess whether shortening of the corrected QT (QTc) interval is most closely associated with changes in weight, insulin resistance, or free fatty acids (FFAs) (or some combination of these factors)...
  7. pmc Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study
    Catherine S Parker
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    J Gen Intern Med 22:1254-9. 2007
    ..Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied...
  8. ncbi request reprint Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome
    Philippe O Szapary
    Division of General Internal Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 26:182-8. 2006
    ..The purpose of this research was to evaluate the short-term effects of pioglitazone (PIO) on high-density lipoprotein cholesterol (HDL-C) and other metabolic parameters in nondiabetic patients with metabolic syndrome (MetSyn)...
  9. ncbi request reprint Low-carbohydrate diets, obesity, and metabolic risk factors for cardiovascular disease
    Frederick F Samaha
    University of Pennsylvania Medical Center, Philadelphia VA Medical Center, 3900 Woodland Avenue, 8th Floor Cardiology MC 111C, Philadelphia, PA 19104, USA
    Curr Atheroscler Rep 9:441-7. 2007
    ..These studies should take into consideration that patients with insulin resistance syndromes would be the most likely group to benefit from carbohydrate restriction...
  10. ncbi request reprint Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity
    Carmel Kealey
    University of Pennsylvania, Department of Pharmacology and Center for Pharmacogenetics, School of Medicine, Philadelphia, PA, USA
    Pharmacogenomics 8:217-25. 2007
    ..0 and 3.0 were genotyped. Warfarin sensitivity stratified by genotype was investigated using univariate and multivariate analyses...
  11. doi request reprint Clinical exacerbations as a surrogate end point in heart failure research
    Steven L Sayers
    Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    Heart Lung 37:28-35. 2008
    ..We examined the utility of an index of clinical exacerbations of heart failure (HF) as a surrogate measure of outcome for use in modestly sized clinical trials and observational studies...
  12. doi request reprint Social support and self-care of patients with heart failure
    Steven L Sayers
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, PA, USA
    Ann Behav Med 35:70-9. 2008
    ..Social support can influence treatment adherence of patients with chronic illnesses, which may explain the positive effects of social support on heart failure (HF) outcomes...
  13. ncbi request reprint Stress test criteria used in the conservative arm of the FRISC-II trial underdetects surgical coronary artery disease when applied to patients in the VANQWISH trial
    Abhinav Goyal
    University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 39:1601-7. 2002
    ....
  14. doi request reprint Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia
    Frederick F Samaha
    Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nat Clin Pract Cardiovasc Med 5:497-505. 2008
    ..We tested the safety and LDL-cholesterol-lowering efficacy of an MTP inhibitor, AEGR-733 (Aegerion Pharmaceuticals Inc., Bridgewater, NJ), alone and in combination with ezetimibe...
  15. ncbi request reprint Cost-effectiveness of a low-carbohydrate diet and a standard diet in severe obesity
    Adam Gilden Tsai
    Division of General Internal Medicine, Department of Medicine, Weight and Eating Disorders Program, University of Pennsylvania, Philadelphia, PA 19104, USA
    Obes Res 13:1834-40. 2005
    ..Low-carbohydrate diets have become a popular alternative to standard diets for weight loss. Our aim was to compare the cost-effectiveness of these two diets...
  16. ncbi request reprint Novel platelet and vascular roles for immunoreceptor signaling
    Frederick F Samaha
    Department of Medicine and Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 26:2588-93. 2006
    ..Here we discuss some of these recent findings and their implications for vascular biology and the treatment of human vascular diseases...
  17. ncbi request reprint The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Stephen E Kimmel
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Intern Med 167:229-35. 2007
    ..Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control...
  18. ncbi request reprint Density of platelet collagen receptors glycoprotein VI and alpha2beta1 and prior myocardial infarction in human subjects, a pilot study
    Frederick F Samaha
    Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Health System, 19104, USA
    Med Sci Monit 11:CR224-229. 2005
    ..Our objective in the current pilot study was to obtain preliminary information on the relationship between platelet collagen receptor density and prior MI...
  19. ncbi request reprint Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study
    Charles A Dackis
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 70:29-37. 2003
    ..Furthermore, pretreatment with modafinil did not intensify cocaine euphoria or cocaine-induced craving. In fact, cocaine euphoria was significantly blunted (P=0.02) in one of our subjective measures...
  20. ncbi request reprint New international measuring stick for defining obesity in non-Europeans
    Frederick F Samaha
    Circulation 115:2089-90. 2007
  21. ncbi request reprint A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesity
    Prakash Seshadri
    Department of Internal Medicine, Division of Endocrinology, University of Pennsylvania Health System, Philadelphia 19104, USA
    Am J Med 117:398-405. 2004
    ..To compare the effects of a low-carbohydrate diet and a conventional (fat- and calorie-restricted) diet on lipoprotein subfractions and inflammation in severely obese subjects...
  22. ncbi request reprint Type III hyperlipoproteinemia unmasked by HIV anti-retroviral therapy
    Frederick F Samaha
    Am J Med 118:691-2. 2005
  23. ncbi request reprint Measurement of platelet collagen receptor density in human subjects
    Frederick F Samaha
    Arterioscler Thromb Vasc Biol 24:e181-2. 2004
  24. ncbi request reprint Dyslipidemia in type 2 diabetes mellitus
    Ramprasad Gadi
    Curr Diab Rep 7:228-34. 2007
    ..Lowering LDLC to less than 70 mg/dL may provide even greater benefits, particularly in very high risk patients with DM and coronary heart disease...

Research Grants1

  1. Inflammatory response to sleep apnea in obese subjects
    Frederick Samaha; Fiscal Year: 2007
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..