Frederick F Samaha
- Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndromeFrederick F Samaha
Cardiovascular Division, Department of Medicine, Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Arterioscler Thromb Vasc Biol 26:624-30. 2006..However, the full spectrum of potentially antiatherogenic mechanisms of PPAR-gamma agonists have not been fully tested in nondiabetic patients with metabolic syndrome...
- Usefulness of the TIMI risk score in predicting both short- and long-term outcomes in the Veterans Affairs Non-Q-Wave Myocardial Infarction Strategies In-Hospital (VANQWISH) TrialFrederick F Samaha
Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Cardiol 90:922-6. 2002..76). No significant difference in outcomes between strategies was detected for a score > or =3. The TIMI risk score provides moderate incremental prognostic information in high-risk patients, during both short- and long-term follow-up...
- Effect of very high-fat diets on body weight, lipoproteins, and glycemic status in the obeseFrederick F Samaha
Division of Cardiovascular Disease, Department of Medicine, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Curr Atheroscler Rep 7:412-20. 2005..Although current national guidelines modestly liberalize unsaturated fat consumption, important questions still remain about the optimal percentage of unsaturated fats in the diet...
- A low-carbohydrate as compared with a low-fat diet in severe obesityFrederick F Samaha
Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, Philadelphia, USA
N Engl J Med 348:2074-81. 2003..The effects of a carbohydrate-restricted diet on weight loss and risk factors for atherosclerosis have been incompletely assessed...
- The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trialLinda Stern
Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Medical Center, and Drexel University College of Medicine, Philadelphia, Pennsylvania 19104, USA
Ann Intern Med 140:778-85. 2004..Weight loss was similar between groups, but effects on atherogenic dyslipidemia and glycemic control were still more favorable with a low-carbohydrate diet after adjustment for differences in weight loss...
- Free fatty acids, insulin resistance, and corrected qt intervals in morbid obesity: effect of weight loss during 6 months with differing dietary interventionsPrakash Seshadri
Division of Endocrinology, Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA
Endocr Pract 11:234-9. 2005..Improvements in insulin resistance seem to have a relatively weak mechanistic role, and a decrease in FFAs has no apparent role in the reduction of the QTc interval...
- Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE studyCatherine S Parker
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
J Gen Intern Med 22:1254-9. 2007..Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied...
- Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndromePhilippe O Szapary
Division of General Internal Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Arterioscler Thromb Vasc Biol 26:182-8. 2006..These results suggest that PIO has direct effects on HDL, which may contribute to its antiatherogenic effects...
- Low-carbohydrate diets, obesity, and metabolic risk factors for cardiovascular diseaseFrederick F Samaha
University of Pennsylvania Medical Center, Philadelphia VA Medical Center, 3900 Woodland Avenue, 8th Floor Cardiology MC 111C, Philadelphia, PA 19104, USA
Curr Atheroscler Rep 9:441-7. 2007..These studies should take into consideration that patients with insulin resistance syndromes would be the most likely group to benefit from carbohydrate restriction...
- Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivityCarmel Kealey
University of Pennsylvania, Department of Pharmacology and Center for Pharmacogenetics, School of Medicine, Philadelphia, PA, USA
Pharmacogenomics 8:217-25. 2007..0 and 3.0 were genotyped. Warfarin sensitivity stratified by genotype was investigated using univariate and multivariate analyses...
- Clinical exacerbations as a surrogate end point in heart failure researchSteven L Sayers
Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
Heart Lung 37:28-35. 2008..We examined the utility of an index of clinical exacerbations of heart failure (HF) as a surrogate measure of outcome for use in modestly sized clinical trials and observational studies...
- Social support and self-care of patients with heart failureSteven L Sayers
Philadelphia Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, PA, USA
Ann Behav Med 35:70-9. 2008..Social support can influence treatment adherence of patients with chronic illnesses, which may explain the positive effects of social support on heart failure (HF) outcomes...
- Stress test criteria used in the conservative arm of the FRISC-II trial underdetects surgical coronary artery disease when applied to patients in the VANQWISH trialAbhinav Goyal
University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, Pennsylvania 19104, USA
J Am Coll Cardiol 39:1601-7. 2002..A lower threshold for catheterization in the FRISC-II conservative patients might have improved their outcomes and therefore diminished the putative benefit of an invasive strategy...
- Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemiaFrederick F Samaha
Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Nat Clin Pract Cardiovasc Med 5:497-505. 2008..We tested the safety and LDL-cholesterol-lowering efficacy of an MTP inhibitor, AEGR-733 (Aegerion Pharmaceuticals Inc., Bridgewater, NJ), alone and in combination with ezetimibe...
- Cost-effectiveness of a low-carbohydrate diet and a standard diet in severe obesityAdam Gilden Tsai
Division of General Internal Medicine, Department of Medicine, Weight and Eating Disorders Program, University of Pennsylvania, Philadelphia, PA 19104, USA
Obes Res 13:1834-40. 2005..Low-carbohydrate diets have become a popular alternative to standard diets for weight loss. Our aim was to compare the cost-effectiveness of these two diets...
- Novel platelet and vascular roles for immunoreceptor signalingFrederick F Samaha
Department of Medicine and Division of Cardiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Arterioscler Thromb Vasc Biol 26:2588-93. 2006..Here we discuss some of these recent findings and their implications for vascular biology and the treatment of human vascular diseases...
- The influence of patient adherence on anticoagulation control with warfarin: results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) StudyStephen E Kimmel
Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
Arch Intern Med 167:229-35. 2007..Warfarin sodium is a highly efficacious drug, but proper levels of anticoagulation are difficult to maintain. Conflicting data exist on the influence of patient adherence on anticoagulation control...
- Density of platelet collagen receptors glycoprotein VI and alpha2beta1 and prior myocardial infarction in human subjects, a pilot studyFrederick F Samaha
Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Health System, 19104, USA
Med Sci Monit 11:CR224-229. 2005..An appropriately sized clinical study using this methodology is warranted to further investigate whether collagen receptor density serves as a novel risk factor for myocardial infarction...
- Modafinil and cocaine: a double-blind, placebo-controlled drug interaction studyCharles A Dackis
Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Drug Alcohol Depend 70:29-37. 2003..Furthermore, pretreatment with modafinil did not intensify cocaine euphoria or cocaine-induced craving. In fact, cocaine euphoria was significantly blunted (P=0.02) in one of our subjective measures...
- New international measuring stick for defining obesity in non-EuropeansFrederick F Samaha
Circulation 115:2089-90. 2007
- A randomized study comparing the effects of a low-carbohydrate diet and a conventional diet on lipoprotein subfractions and C-reactive protein levels in patients with severe obesityPrakash Seshadri
Department of Internal Medicine, Division of Endocrinology, University of Pennsylvania Health System, Philadelphia 19104, USA
Am J Med 117:398-405. 2004..Both diets had similar effects on LDL and HDL subfractions...
- Type III hyperlipoproteinemia unmasked by HIV anti-retroviral therapyFrederick F Samaha
Am J Med 118:691-2. 2005
- Measurement of platelet collagen receptor density in human subjectsFrederick F Samaha
Arterioscler Thromb Vasc Biol 24:e181-2. 2004
- Dyslipidemia in type 2 diabetes mellitusRamprasad Gadi
Curr Diab Rep 7:228-34. 2007..Lowering LDLC to less than 70 mg/dL may provide even greater benefits, particularly in very high risk patients with DM and coronary heart disease...
- Inflammatory response to sleep apnea in obese subjectsFrederick Samaha; Fiscal Year: 2007..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..